REBECCA TERNS

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. pmc Components of U3 snoRNA-containing complexes shuttle between nuclei and the cytoplasm and differentially localize in nucleoli: implications for assembly and function
    Daniel J Leary
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Biol Cell 15:281-93. 2004
  2. ncbi request reprint Macromolecular complexes: SMN--the master assembler
    M P Terns
    Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Building, Athens, Georgia 30602, USA
    Curr Biol 11:R862-4. 2001
  3. pmc CRISPR-based adaptive immune systems
    Michael P Terns
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA
    Curr Opin Microbiol 14:321-7. 2011
  4. ncbi request reprint Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin
    Michael P Terns
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Gene Expr 10:17-39. 2002
  5. pmc Circular box C/D RNAs in Pyrococcus furiosus
    Natalia G Starostina
    Department of Biochemistry and Molecular Biology, University of Georgia, Davison Life Science Building, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 101:14097-101. 2004
  6. ncbi request reprint Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita
    Rumana Rashid
    Department of Chemistry and Biochemistry, Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA
    Mol Cell 21:249-60. 2006
  7. pmc RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP
    Daniel L Baker
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Genes Dev 19:1238-48. 2005
  8. ncbi request reprint Archaeal guide RNAs function in rRNA modification in the eukaryotic nucleus
    Wayne A Speckmann
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Curr Biol 12:199-203. 2002
  9. pmc Dynamic interactions within sub-complexes of the H/ACA pseudouridylation guide RNP
    Osama A Youssef
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 35:6196-206. 2007
  10. pmc An H/ACA guide RNA directs U2 pseudouridylation at two different sites in the branchpoint recognition region in Xenopus oocytes
    Xinliang Zhao
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    RNA 8:1515-25. 2002

Research Grants

  1. Biogenesis and Trafficking of snoRNPs
    MICHAEL TERNS; Fiscal Year: 2006
  2. Telomerase Transport and Targeting
    MICHAEL TERNS; Fiscal Year: 2007
  3. Telomerase Transport and Targeting
    MICHAEL TERNS; Fiscal Year: 2007
  4. Non-Coding RNPs: From RNA Modification to Genome Defense
    REBECCA TERNS; Fiscal Year: 2010
  5. BIOGENESIS AND TRAFFICKING OF U3 SMALL NUCLEOLAR RNPS
    MICHAEL TERNS; Fiscal Year: 2002
  6. Non-Coding RNPs: From RNA Modification to Genome Defense
    MICHAEL TERNS; Fiscal Year: 2009

Collaborators

  • W Yang
  • S R Eddy
  • Sui Huang
  • Xiaodong Cheng
  • Hong Li
  • A Gregory Matera
  • MICHAEL TERNS
  • Michael P Terns
  • Osama A Youssef
  • Rebecca L Tomlinson
  • Daniel L Baker
  • Yusheng Zhu
  • Zhu Hong Li
  • Hui Qiu
  • Gael Cristofari
  • Sri Oruganti
  • Rumana Rashid
  • Martine Roovers
  • Anita H Corbett
  • Julia Eifert
  • Daniel J Leary
  • Natalia G Starostina
  • Aarthi Narayanan
  • Niamh M Cahill
  • Wayne A Speckmann
  • Katherine T Etheridge
  • Sarah E Whitehead
  • Xinliang Zhao
  • M P Terns
  • Ludivine Wacheul
  • John L Woolford
  • Adam C Berger
  • Marc Thiry
  • Jelena Jakovljevic
  • Denis L J Lafontaine
  • Katarzyna Sikora
  • Howard Robinson
  • Emem Adolf
  • Patrick Reichenbach
  • Joachim Lingner
  • Yanming Zhang
  • Henri Grosjean
  • Louis Droogmans
  • Catherine Tricot
  • Tania D Ziegler
  • Yang He
  • Bo Liang
  • Caryn Hale
  • Kathleen Phipps
  • Teerawit Supakorndej
  • David A Dy
  • Michael I R Chastkofsky
  • L Steven Johnson
  • Sarah Marshburn
  • Andrew A Lukowiak
  • Kavita A Marfatia
  • Ian G Macara
  • Todd M Lowe
  • Soma S R Banik
  • Blaine N Armbruster
  • Kyle Friend
  • Joan A Steitz
  • Christopher M Counter
  • Wayne Speckmann
  • Xing Zhang
  • Kevin W Jones
  • Yi Tao Yu

Detail Information

Publications21

  1. pmc Components of U3 snoRNA-containing complexes shuttle between nuclei and the cytoplasm and differentially localize in nucleoli: implications for assembly and function
    Daniel J Leary
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Biol Cell 15:281-93. 2004
    ....
  2. ncbi request reprint Macromolecular complexes: SMN--the master assembler
    M P Terns
    Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Building, Athens, Georgia 30602, USA
    Curr Biol 11:R862-4. 2001
    ....
  3. pmc CRISPR-based adaptive immune systems
    Michael P Terns
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA
    Curr Opin Microbiol 14:321-7. 2011
    ..Here we will review our current understanding of the remarkable CRISPR-Cas pathways with particular attention to studies relevant to systems found in the archaea...
  4. ncbi request reprint Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin
    Michael P Terns
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Gene Expr 10:17-39. 2002
    ..The unique properties of snoRNAs are now being harnessed for basic research and therapeutic applications...
  5. pmc Circular box C/D RNAs in Pyrococcus furiosus
    Natalia G Starostina
    Department of Biochemistry and Molecular Biology, University of Georgia, Davison Life Science Building, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 101:14097-101. 2004
    ..Moreover, the unexpected discovery of circular box C/D RNAs points to the existence of a previously unrecognized biogenesis pathway for box C/D RNAs in archaea...
  6. ncbi request reprint Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita
    Rumana Rashid
    Department of Chemistry and Biochemistry, Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA
    Mol Cell 21:249-60. 2006
    ..We have also identified a dyskeratosis congenita mutation cluster site within a modeled dyskerin structure...
  7. pmc RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP
    Daniel L Baker
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Genes Dev 19:1238-48. 2005
    ..Cbf5 is the protein that specifically recognizes and binds H/ACA guide RNAs. In addition, Cbf5 recruits the two other essential proteins, Gar1 and Nop10, to the pseudouridylation guide complex...
  8. ncbi request reprint Archaeal guide RNAs function in rRNA modification in the eukaryotic nucleus
    Wayne A Speckmann
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Curr Biol 12:199-203. 2002
    ..Our studies have revealed the remarkable ability of archaeal Box C/D RNAs to assemble into functional RNA-protein complexes in the eukaryotic nucleus...
  9. pmc Dynamic interactions within sub-complexes of the H/ACA pseudouridylation guide RNP
    Osama A Youssef
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 35:6196-206. 2007
    ....
  10. pmc An H/ACA guide RNA directs U2 pseudouridylation at two different sites in the branchpoint recognition region in Xenopus oocytes
    Xinliang Zhao
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    RNA 8:1515-25. 2002
    ..Our results clarify the mechanism of U2 snRNA pseudouridylation in Xenopus oocytes, and have interesting implications with regard to the intranuclear localization of U2 snRNA pseudouridylation...
  11. ncbi request reprint Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus
    Aarthi Narayanan
    Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Building, Athens, GA 30602, USA
    J Cell Sci 116:177-86. 2003
    ....
  12. pmc Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae
    Hui Qiu
    Department of Biochemistry and Molecular Biology, University of Georgia, Davison Life Sciences Complex, Green Street, Athens, GA 30602, USA
    Mol Cell Biol 28:3686-99. 2008
    ..Additional characterization of the mutants revealed impairment in specific steps of U3 snoRNA processing, demonstrating that snoRNA maturation and trafficking are linked processes...
  13. ncbi request reprint Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
    A Gregory Matera
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Nat Rev Mol Cell Biol 8:209-20. 2007
    ..The small nuclear and small nucleolar RNPs are two well studied classes of ncRNPs with elaborate assembly and trafficking pathways that provide paradigms for understanding the biogenesis of other ncRNPs...
  14. ncbi request reprint Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation
    Gael Cristofari
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges, Switzerland
    Mol Cell 27:882-9. 2007
    ..Collectively, these data identify subnuclear localization as an important regulatory mechanism for telomere length homeostasis in human cells...
  15. ncbi request reprint Alternative conformations of the archaeal Nop56/58-fibrillarin complex imply flexibility in box C/D RNPs
    Sri Oruganti
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA
    J Mol Biol 371:1141-50. 2007
    ..We propose that hinge motion within Nop56/58 has important implications for the possibility of simultaneously positioning two catalytic sites at the two target sites of a bipartite box C/D guide RNA...
  16. pmc Formation of the conserved pseudouridine at position 55 in archaeal tRNA
    Martine Roovers
    Institut de Recherches Microbiologiques J M Wiame, Avenue E Gryson, 1 B 1070 Bruxelles, Belgium
    Nucleic Acids Res 34:4293-301. 2006
    ..While we cannot unequivocally assign the function from our results, both possibilities represent unexpected functions of these proteins as discussed herein...
  17. pmc Cell cycle-regulated trafficking of human telomerase to telomeres
    Rebecca L Tomlinson
    Departments of Biochemistry and Molecular Biology and Genetics, University of Georgia, Athens, GA 30602, USA
    Mol Biol Cell 17:955-65. 2006
    ..Our results mark the first observation of human telomerase at telomeres and provide a mechanism for the cell cycle-dependent regulation of telomere synthesis in human cells...
  18. pmc Telomerase RNA accumulates in Cajal bodies in human cancer cells
    Yusheng Zhu
    Departments of Biochemistry and Molecular Biology, and Genetics, University of Georgia, Athens, Georgia 30602, USA
    Mol Biol Cell 15:81-90. 2004
    ..Moreover, we report that hTERT is also found in Cajal bodies. Our data suggest that Cajal bodies are involved in the assembly and/or function of human telomerase...
  19. ncbi request reprint Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1
    Sarah E Whitehead
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    J Biol Chem 277:48087-93. 2002
    ..Our results argue against post-translational arginine dimethylation as a general requirement for SMN recognition of proteins bearing arginine/glycine-rich domains...
  20. pmc Site-specific cross-linking analyses reveal an asymmetric protein distribution for a box C/D snoRNP
    Niamh M Cahill
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    EMBO J 21:3816-28. 2002
    ..Repositioning the guide sequence of U25 upstream of box D instead of D' revealed that both C/D motifs have the potential to function as guide centers, but, surprisingly, there was no alteration in protein cross-linking...
  21. ncbi request reprint The nucleolar localization domain of the catalytic subunit of human telomerase
    Katherine T Etheridge
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:24764-70. 2002
    ..Furthermore, the coincidental targeting of both the hTR and hTERT subunits to the nucleolus supports the premise that the assembly of telomerase occurs in the nucleolus...

Research Grants24

  1. Biogenesis and Trafficking of snoRNPs
    MICHAEL TERNS; Fiscal Year: 2006
    ....
  2. Telomerase Transport and Targeting
    MICHAEL TERNS; Fiscal Year: 2007
    ..abstract_text> ..
  3. Telomerase Transport and Targeting
    MICHAEL TERNS; Fiscal Year: 2007
    ..in vivo Aim 2: To examine the localization and trafficking of key human telomerase components in normal and cancer cells Aim 3: To develop efficacious anti-telomerase ribozymes capable of preventing growth of cancer cells ..
  4. Non-Coding RNPs: From RNA Modification to Genome Defense
    REBECCA TERNS; Fiscal Year: 2010
    ..Together, the proposed studies have great potential for significant contributions to human health and disease. ..
  5. BIOGENESIS AND TRAFFICKING OF U3 SMALL NUCLEOLAR RNPS
    MICHAEL TERNS; Fiscal Year: 2002
    ....
  6. Non-Coding RNPs: From RNA Modification to Genome Defense
    MICHAEL TERNS; Fiscal Year: 2009
    ..Together, the proposed studies have great potential for significant contributions to human health and disease. ..