R A Terkeltaub

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia
    K Jagadeesha Dammanahalli
    San Diego VA Healthcare System and Department of Medicine, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 7:e39106. 2012
  2. doi request reprint High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study
    Robert A Terkeltaub
    VAMC San Diego, and University of California, San Diego, CA 92161, USA
    Arthritis Rheum 62:1060-8. 2010
  3. pmc Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification
    Robert Terkeltaub
    University of California School of Medicine, VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA, USA
    Purinergic Signal 2:371-7. 2006
  4. ncbi request reprint Inorganic pyrophosphate generation and disposition in pathophysiology
    R A Terkeltaub
    Veterans Affairs Medical Center and School of Medicine, University of California, San Diego, California 92161, USA
    Am J Physiol Cell Physiol 281:C1-C11. 2001
  5. pmc Gout. Novel therapies for treatment of gout and hyperuricemia
    Robert Terkeltaub
    Rheumatology Section, San Diego Veterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Arthritis Res Ther 11:236. 2009
  6. pmc Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics
    Robert Terkeltaub
    San Diego VAMC Rheumatology Section, and University of California San Diego, La Jolla, California, USA
    Arthritis Res Ther 8:S4. 2006
  7. pmc The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
    R Terkeltaub
    VAMC Rheumatology, 111K, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Ann Rheum Dis 68:1613-7. 2009
  8. doi request reprint Update on gout: new therapeutic strategies and options
    Robert Terkeltaub
    Rheumatology Section, Veterans Affairs Medical Center, University of California, San Diego, 3350 La Jolla Village Drive, CA 92161, USA
    Nat Rev Rheumatol 6:30-8. 2010
  9. ncbi request reprint Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes
    Denise L Cecil
    Veterans Affairs Medical Center, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Arthritis Rheum 52:144-54. 2005
  10. doi request reprint Colchicine update: 2008
    Robert A Terkeltaub
    VA Medical Center, San Diego, CA 92161, USA
    Semin Arthritis Rheum 38:411-9. 2009

Research Grants

  1. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2001
  2. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
  3. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2006
  4. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2005
  5. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2007
  6. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2006
  7. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2004
  8. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
  9. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2004
  10. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2002

Collaborators

Detail Information

Publications42

  1. pmc Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia
    K Jagadeesha Dammanahalli
    San Diego VA Healthcare System and Department of Medicine, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 7:e39106. 2012
    ..Vanin-1 is a novel potential therapeutic target for neointimal hyperplasia following revascularization...
  2. doi request reprint High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study
    Robert A Terkeltaub
    VAMC San Diego, and University of California, San Diego, CA 92161, USA
    Arthritis Rheum 62:1060-8. 2010
    ....
  3. pmc Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification
    Robert Terkeltaub
    University of California School of Medicine, VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA, USA
    Purinergic Signal 2:371-7. 2006
    ..This review pays particular attention to the role of NPP1-catalyzed PP(i) generation in the pathogenesis of certain disorders associated with pathologic calcification...
  4. ncbi request reprint Inorganic pyrophosphate generation and disposition in pathophysiology
    R A Terkeltaub
    Veterans Affairs Medical Center and School of Medicine, University of California, San Diego, California 92161, USA
    Am J Physiol Cell Physiol 281:C1-C11. 2001
    ....
  5. pmc Gout. Novel therapies for treatment of gout and hyperuricemia
    Robert Terkeltaub
    Rheumatology Section, San Diego Veterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Arthritis Res Ther 11:236. 2009
    ....
  6. pmc Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics
    Robert Terkeltaub
    San Diego VAMC Rheumatology Section, and University of California San Diego, La Jolla, California, USA
    Arthritis Res Ther 8:S4. 2006
    ..For this reason, our discussion focuses on the development of the novel xanthine oxidase inhibitor febuxostat and modified recombinant uricase preparations...
  7. pmc The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
    R Terkeltaub
    VAMC Rheumatology, 111K, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Ann Rheum Dis 68:1613-7. 2009
    ..Recent studies suggest that blockade of the NLRP3 (cryopyrin) inflammasome interleukin 1beta (IL1beta) pathway may offer a new treatment strategy for gout...
  8. doi request reprint Update on gout: new therapeutic strategies and options
    Robert Terkeltaub
    Rheumatology Section, Veterans Affairs Medical Center, University of California, San Diego, 3350 La Jolla Village Drive, CA 92161, USA
    Nat Rev Rheumatol 6:30-8. 2010
    ..Collectively, novel approaches will hopefully lead to improved management of hyperuricemia and gout, and also to improvements in patient-centered outcomes, even for those who have previously failed to respond to treatment...
  9. ncbi request reprint Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes
    Denise L Cecil
    Veterans Affairs Medical Center, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Arthritis Rheum 52:144-54. 2005
    ..This study was undertaken to test the hypothesis that IL-8 promotes chondrocyte hypertrophy by modulating chondrocyte PiT-1 expression and sodium-dependent Pi uptake, and to assess differential roles in this activity...
  10. doi request reprint Colchicine update: 2008
    Robert A Terkeltaub
    VA Medical Center, San Diego, CA 92161, USA
    Semin Arthritis Rheum 38:411-9. 2009
    ..To review recent advances in the understanding of molecular mechanisms of drug disposition and cellular mechanisms of action and targets of colchicine, and disease applications and guidelines for oral colchicine use...
  11. ncbi request reprint Chemokines and atherosclerosis
    R Terkeltaub
    Department of Medicine, VA Medical Centre, University of California, San Diego, USA
    Curr Opin Lipidol 9:397-405. 1998
    ..We also discuss new studies that reveal how CD40 ligand and certain other stimuli can promote chemokine expression in atherosclerosis...
  12. doi request reprint Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors
    Robert A Terkeltaub
    VA San Diego Medical Center, San Diego, CA 92161, USA
    Arthritis Rheum 63:2226-37. 2011
    ..The objective was to develop colchicine-dosing algorithms with improved safety...
  13. ncbi request reprint Interleukin-8 and its receptor CXCR2 in atherosclerosis
    W A Boisvert
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Res 21:129-37. 2000
    ..Although the mechanism still needs to be worked out, it appears that CXCR2 expression on lesion Mphi is essential for these cells to be retained in the lesion...
  14. pmc A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice
    W A Boisvert
    The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 101:353-63. 1998
    ..Thus, the capacity of leukocytes to express mIL-8RH, and associated intralesional expression of its ligands such as KC/GROalpha, mediated the intimal accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice...
  15. ncbi request reprint Noninvasive evaluation of adult onset myopathy from carnitine palmitoyl transferase II deficiency using proton magnetic resonance spectroscopy
    J S Videen
    Veterans Affairs Medical Center and the Department of Medicine, University of California San Diego 92161, USA
    J Rheumatol 26:1757-63. 1999
    ..We describe a proton magnetic resonance spectroscopy (MRS) technique, using a standard clinical magnetic resonance imaging scanner, to diagnose and help monitor the response to therapy in adult CPT II deficiency...
  16. ncbi request reprint High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects
    R S Goomer
    Department of Orthopedics, University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, California, 92093 0630, USA
    Osteoarthritis Cartilage 9:248-56. 2001
    ..Transfection of these cells with a gene that induces chondrocytic phenotype may form an ideal method to affect tissue engineering of articular cartilage...
  17. pmc Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA
    J L Huebner
    Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 17:1056-64. 2009
    ..Moreover, glucosamine, which is currently under investigation as an OA therapy, binds and inhibits TG2. Here, we examined TG2 as a potential marker of cartilage hypertrophy in the spontaneous guinea pig model of OA...
  18. ncbi request reprint Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess
    K Johnson
    Veterans Affairs Medical Center, UCSD, La Jolla, CA 92161, USA
    Osteoarthritis Cartilage 12:321-35. 2004
    ..Therefore, we assessed if dysregulated wild-type ANK expression could contribute to pathogenesis of idiopathic degenerative arthropathy through elevated ecPP(i)...
  19. ncbi request reprint Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression
    D W Burton
    San Diego Veterans Administration Healthcare System, San Diego, CA 92161, USA
    Osteoarthritis Cartilage 13:395-404. 2005
    ..Hence, we examined chondrocyte CaR-mediated calcium-sensing in OA pathogenesis...
  20. pmc Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis
    H Mitsuyama
    University of California, San Diego, Department of Orthopaedic Surgery, CA 92093 0630, USA
    Osteoarthritis Cartilage 15:559-65. 2007
    ..The purpose of this study was to examine the relationship between cartilage calcification and aging in an unselected donor population of diverse age using highly sensitive calcification imaging...
  21. ncbi request reprint Parathyroid hormone-related protein induces interleukin 8 production by prostate cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence
    A Gujral
    The Department of Medicine, University of California, and the Veterans Affairs Medical Center, San Diego 92161, USA
    Cancer Res 61:2282-8. 2001
    ..This novel pathway could mediate the effects of PTHrP on the progression of prostate cancer...
  22. ncbi request reprint Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes
    K Johnson
    Department of Veterans Affairs Medical Center, University of California, San Diego 92161, USA
    Arthritis Rheum 42:1986-97. 1999
    ..This study compared the roles of the transforming growth factor beta (TGFbeta)-inducible plasma cell membrane glycoprotein-1 (PC-1) and the closely related B10 NTPPPH activities in chondrocyte PPi metabolism...
  23. ncbi request reprint Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification
    K Johnson
    VA Medical Center, San Diego, California 92161, USA
    Arthritis Rheum 44:1071-81. 2001
    ..Increased expression of PC-1 is both a marker and a potential pathogenic factor for knee meniscal cartilage matrix calcification...
  24. pmc Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-beta
    R Huang
    San Diego Veterans Affairs Medical Center, CA 92161
    J Clin Invest 94:560-7. 1994
    ..The identification of PC-1 as an NTPPPH expressed in cells derived from bone and cartilage may prove useful in furthering the understanding of the role of NTPPPH i n physiologic and pathologic mineralization...
  25. pmc Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa
    K Johnson
    Department of Medicine, Rheumatology Allergy-Immunology Division, Veterans Affairs Medical Center, University of California at San Diego, USA
    Am J Pathol 159:149-63. 2001
    ..Because TGase activity promoted apatite deposition, our findings potentially implicate inflammation in the pathogenesis of cartilage matrix calcification...
  26. ncbi request reprint Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues
    L J Deftos
    Dept of Medicine, San Diego VA Medical Center, University of California, La Jolla 92093 0822, USA
    Endocrine 15:217-24. 2001
    ..These results support the importance of these processing enzymes in their hypothesized roles in prohormone processing...
  27. ncbi request reprint Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy
    Kristen A Johnson
    Veterans Affairs Medical Center, University of California San Diego, La Jolla, California 92161, USA
    J Biol Chem 278:18824-32. 2003
    ..TG2 is a potential site for intervention in pathologic calcification promoted by IL-1 beta and ATRA...
  28. ncbi request reprint External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification
    Kristen A Johnson
    Veterans Affairs Medical Center, University of California, San Diego, La Jolla, California 92161, USA
    J Biol Chem 280:15004-12. 2005
    ....
  29. ncbi request reprint Gout: on the brink of novel therapeutic options for an ancient disease
    Jeffry D Bieber
    Veterans Affairs Medical Center and University of California San Diego, San Diego, California 92161, USA
    Arthritis Rheum 50:2400-14. 2004
  30. ncbi request reprint Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis
    Nicole Tramontini
    Pfizer Global Research and Development, Ann Arbor, Michigan, USA
    Arthritis Rheum 50:2633-9. 2004
    ..Hence, we studied rabbits deficient in the MAC component C6 to determine if MAC mediated urate crystal-induced arthritis...
  31. ncbi request reprint New developments in clinically relevant mechanisms and treatment of hyperuricemia
    Susan J Lee
    University of California, San Diego, Division of Rheumatology, Allergy, and Immunology, Center for Innovative Therapy, 9320 Campus Point Dr Suite 225, La Jolla, CA 92037 0943, USA
    Curr Rheumatol Rep 8:224-30. 2006
    ..These agents should provide novel options for patients with chronic, refractory gout and hyperuricemia, particularly in association with allopurinol hypersensitivity and renal insufficiency...
  32. ncbi request reprint Recent developments in diet and gout
    Susan J Lee
    Center for Innovative Therapy, University of San Diego, La Jolla, California 92037, USA
    Curr Opin Rheumatol 18:193-8. 2006
    ..This review focuses on recent developments and their implications for clinical practice, including how we advise patients on appropriate diets and alcoholic beverage consumption...
  33. ncbi request reprint Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate
    Yun Zhang
    Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    Arthritis Rheum 52:1110-7. 2005
    ..This study investigated the potential for ANKH sequence variants to promote sporadic chondrocalcinosis...
  34. ncbi request reprint Questions & answers. What's the difference between gout and pseudogout?
    Robert A Terkeltaub
    Rheumatology Section, University of California, San Diego, USA
    Health News 9:16. 2003
  35. ncbi request reprint What does cartilage calcification tell us about osteoarthritis?
    Robert A Terkeltaub
    J Rheumatol 29:411-5. 2002
  36. ncbi request reprint Clinical practice. Gout
    Robert A Terkeltaub
    Rheumatology Section, Department of Medicine, San Diego Veterans Affairs Medical Center and the University of California San Diego School of Medicine, San Diego, CA 92161, USA
    N Engl J Med 349:1647-55. 2003
  37. ncbi request reprint IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor
    Ingrid U Schraufstatter
    Department of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    J Immunol 171:6714-22. 2003
    ..These results indicate that IL-8-induced transactivation of the EGFR is mediated by the CXCR2 and involves cathepsin B, and that this pathway is important for the migratory and tumorigenic effects of IL-8...
  38. pmc Vanin-1 pantetheinase drives increased chondrogenic potential of mesenchymal precursors in ank/ank mice
    Kristen A Johnson
    Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
    Am J Pathol 172:440-53. 2008
    ....
  39. pmc Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells
    Kristen A Johnson
    Veterans Affairs Medical Center, University of California at San Diego, La Jolla, USA
    Circ Res 102:529-37. 2008
    ..Our results suggest that TG2 release in injured arteries is critical for programming chondro-osseous SMC differentiation and calcification in response to increased P(i) and bone morphogenetic protein-2...
  40. pmc Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression
    William A Boisvert
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    Am J Pathol 168:1385-95. 2006
    ....

Research Grants22

  1. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2001
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  2. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  3. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2006
    ..Completion of these studies will link alterations in VSMC PPi metabolism with modulation of oxidant stress and chemokine responses pertinent to pathologic calcification in both degenerative disorders and atherosclerosis. ..
  4. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will link alterations in VSMC PPi metabolism with modulation of oxidant stress and chemokine responses pertinent to pathologic calcification in both degenerative disorders and atherosclerosis. ..
  5. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2007
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  6. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2006
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  7. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2004
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  8. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  9. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2004
    ..Completion of these studies will link alterations in VSMC PPi metabolism with modulation of oxidant stress and chemokine responses pertinent to pathologic calcification in both degenerative disorders and atherosclerosis. ..
  10. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2002
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  11. Transglutaminase 2 in Arterial Calcification and Atherosclerosis
    Robert A Terkeltaub; Fiscal Year: 2010
    ..Completion of these studies will delineate the potential for modulation of arterial TG2 as a therapy to suppress artery calcification or atherosclerotic lesion progression. ..
  12. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2003
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  13. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2006
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  14. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2007
    ..Completion of these studies will link alterations in VSMC PPi metabolism with modulation of oxidant stress and chemokine responses pertinent to pathologic calcification in both degenerative disorders and atherosclerosis. ..
  15. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2007
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  16. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2005
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  17. Molecular Mechanisms in Arterial Calcification
    Robert A Terkeltaub; Fiscal Year: 2010
    ....
  18. Transglutaminase 2 in Arterial Calcification and Atherosclerosis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of these studies will delineate the potential for modulation of arterial TG2 as a therapy to suppress artery calcification or atherosclerotic lesion progression. ..
  19. Molecular Mechanisms in Arterial Calcification
    Robert Terkeltaub; Fiscal Year: 2009
    ....