Ei Terasawa

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta)
    Bret M Windsor-Engnell
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI 53715 1299, USA
    Am J Physiol Endocrinol Metab 292:E1000-9. 2007
  2. ncbi Kisspeptin and puberty in mammals
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI, 53715 1299, USA
    Adv Exp Med Biol 784:253-73. 2013
  3. ncbi Neuroestrogen, rapid action of estradiol, and GnRH neurons
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
    Front Neuroendocrinol 33:364-75. 2012
  4. ncbi Body weight impact on puberty: effects of high-calorie diet on puberty onset in female rhesus monkeys
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 153:1696-705. 2012
  5. ncbi Recent discoveries on the control of gonadotrophin-releasing hormone neurones in nonhuman primates
    E Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715 1299, USA
    J Neuroendocrinol 22:630-8. 2010
  6. ncbi Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: the role of GPR30
    E Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715 1299, USA
    J Neuroendocrinol 21:316-21. 2009
  7. ncbi Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons
    Sekoni D Noel
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299
    Mol Endocrinol 23:349-59. 2009
  8. ncbi Pulsatile release of luteinizing hormone-releasing hormone (LHRH) in cultured LHRH neurons derived from the embryonic olfactory placode of the rhesus monkey
    E Terasawa
    Wisconsin Regional Primate Research Center, and Department of Pediatrics, University of Wisconsin, Madison 53715 1299, USA
    Endocrinology 140:1432-41. 1999
  9. ncbi Postnatal remodeling of gonadotropin-releasing hormone I neurons: toward understanding the mechanism of the onset of puberty
    Ei Terasawa
    Department of Pediatrics and Wisconsin National Primate Research Center, University of Wisconsin-Madison, Wisconsin 53715-1299, USA
    Endocrinology 147:3650-1. 2006
  10. ncbi Possible role of 5'-adenosine triphosphate in synchronization of Ca2+ oscillations in primate luteinizing hormone-releasing hormone neurons
    Ei Terasawa
    Wisconsin National Primate Research Center, Department of Pediatrics, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Mol Endocrinol 19:2736-47. 2005

Research Grants

  1. HYPOTHALAMIC CONTROL OF PUBERTY
    EI NONE TERASAWAGRILLEY; Fiscal Year: 2010
  2. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 2000
  3. HYPOTHALAMIC CONTROL OF PUBERTY
    EI TERASAWAGRILLEY; Fiscal Year: 2009
  4. HYPOTHALAMIC CONTROL OF PUBERTY
    EI NONE TERASAWAGRILLEY; Fiscal Year: 2010
  5. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    EI NONE TERASAWAGRILLEY; Fiscal Year: 2010
  6. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 2007
  7. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 2004
  8. HYPOTHALAMIC CONTROL OF PUBERTY
    EI TERASAWAGRILLEY; Fiscal Year: 2004
  9. HYPOTHALAMIC CONTROL OF PUBERTY
    Ei Terasawa; Fiscal Year: 1980
  10. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 1993

Collaborators

Detail Information

Publications34

  1. ncbi An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta)
    Bret M Windsor-Engnell
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI 53715 1299, USA
    Am J Physiol Endocrinol Metab 292:E1000-9. 2007
    ....
  2. ncbi Kisspeptin and puberty in mammals
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI, 53715 1299, USA
    Adv Exp Med Biol 784:253-73. 2013
    ..Rather, as a component of the neural network responsible for GnRH pulse generation, they subserve upstream regulatory mechanisms that are responsible for the timing of puberty...
  3. ncbi Neuroestrogen, rapid action of estradiol, and GnRH neurons
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
    Front Neuroendocrinol 33:364-75. 2012
    ..Either way, estradiol synthesized in interneurons in the hypothalamus may play a significant role in the control of the GnRH surge and/or pulsatility of GnRH release...
  4. ncbi Body weight impact on puberty: effects of high-calorie diet on puberty onset in female rhesus monkeys
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 153:1696-705. 2012
    ..The findings of this study suggest the importance of close monitoring of juvenile feeding behaviors as an important intervention to reduce the prevalence of precocious development and metabolic diseases in adulthood...
  5. ncbi Recent discoveries on the control of gonadotrophin-releasing hormone neurones in nonhuman primates
    E Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715 1299, USA
    J Neuroendocrinol 22:630-8. 2010
    ..Third, oestradiol causes rapid, direct, excitatory action in GnRH neurones and this action of oestradiol appears to be mediated through a membrane receptor, such as G-protein coupled receptor 30...
  6. ncbi Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: the role of GPR30
    E Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715 1299, USA
    J Neuroendocrinol 21:316-21. 2009
    ..In this review, we discuss the possible role of G-protein coupled receptors in the rapid action of oestrogen in neuronal cells...
  7. ncbi Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons
    Sekoni D Noel
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299
    Mol Endocrinol 23:349-59. 2009
    ..Collectively, E(2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E(2) appears to be mediated, in part, through GPR30...
  8. ncbi Pulsatile release of luteinizing hormone-releasing hormone (LHRH) in cultured LHRH neurons derived from the embryonic olfactory placode of the rhesus monkey
    E Terasawa
    Wisconsin Regional Primate Research Center, and Department of Pediatrics, University of Wisconsin, Madison 53715 1299, USA
    Endocrinology 140:1432-41. 1999
    ....
  9. ncbi Postnatal remodeling of gonadotropin-releasing hormone I neurons: toward understanding the mechanism of the onset of puberty
    Ei Terasawa
    Department of Pediatrics and Wisconsin National Primate Research Center, University of Wisconsin-Madison, Wisconsin 53715-1299, USA
    Endocrinology 147:3650-1. 2006
  10. ncbi Possible role of 5'-adenosine triphosphate in synchronization of Ca2+ oscillations in primate luteinizing hormone-releasing hormone neurons
    Ei Terasawa
    Wisconsin National Primate Research Center, Department of Pediatrics, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Mol Endocrinol 19:2736-47. 2005
    ....
  11. ncbi An increase in glutamate release follows a decrease in gamma aminobutyric acid and the pubertal increase in luteinizing hormone releasing hormone release in the female rhesus monkeys
    E Terasawa
    Wisconsin Regional Primate Research Center and Department of Pediatrics, University of Wisconsin Madison, 53715 1299, USA
    J Neuroendocrinol 11:275-82. 1999
    ..The data further support our hypothesis that GAD plays an important role in the mechanism of the onset of puberty...
  12. ncbi Presence of luteinizing hormone-releasing hormone fragments in the rhesus monkey forebrain
    E Terasawa
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715 1299, USA
    J Comp Neurol 439:491-504. 2001
    ..These extrahypothalamic neurons contain LHRH fragments, rather than fully mature mammalian LHRH. The origin and function of these neurons remain to be determined...
  13. ncbi A role for non-neuronal cells in synchronization of intracellular calcium oscillations in primate LHRH neurons
    Ei Terasawa
    Wisconsin National Primate Research Center, 1223 Capitol Court, Madison, WI 53715-1299, USA
    Prog Brain Res 141:283-91. 2002
  14. ncbi Neurobiological mechanisms of the onset of puberty in primates
    E Terasawa
    Department of Pediatrics, Wisconsin Regional Primate Research Center, and University of Wisconsin Madison, 53715 1299, USA
    Endocr Rev 22:111-51. 2001
    ..In this review, developmental changes in several neurotransmitter systems controlling pulsatile LHRH release are extensively reviewed...
  15. ncbi Gonadotropin-releasing hormone II: is this neuropeptide important for mammalian reproduction?
    Ei Terasawa
    Wisconsin National Primate Research Center, Department of Pediatrics and Center for Neuroscience, University of Wisconsin Madison, Madison, Wisconsin 53715 1299, USA
    Endocrinology 144:3-4. 2003
  16. ncbi Epigenetic changes coincide with in vitro primate GnRH neuronal maturation
    Joseph R Kurian
    Wisconsin National Primate Research Center, University of Wisconsin Madison, 1223 Capitol Court, Madison, Wisconsin 53715, USA
    Endocrinology 151:5359-68. 2010
    ..To our knowledge, this is the first report that developmental DNA demethylation occurs in postmitotic neurons toward a stable neuronal phenotype...
  17. ncbi Rapid action of estrogens on intracellular calcium oscillations in primate luteinizing hormone-releasing hormone-1 neurons
    Hideki Abe
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 149:1155-62. 2008
    ....
  18. ncbi An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo
    Kim L Keen
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53715 1299, USA
    Endocrinology 149:4151-7. 2008
    ..Kisspeptin-10 infusion through a microdialysis probe significantly stimulated LHRH-1 release in a dose-dependent manner. Collectively, the results are consistent with the hypothesis that kisspeptin plays a role in puberty...
  19. ncbi Developmental increase in kisspeptin-54 release in vivo is independent of the pubertal increase in estradiol in female rhesus monkeys (Macaca mulatta)
    Kathryn A Guerriero
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53715, USA
    Endocrinology 153:1887-97. 2012
    ..Rather, after puberty onset, the increase in KP release contributes to further increase GnRH release during the progression of puberty...
  20. ncbi Developmental changes in GnRH release in response to kisspeptin agonist and antagonist in female rhesus monkeys (Macaca mulatta): implication for the mechanism of puberty
    Kathryn A Guerriero
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53715 1299, USA
    Endocrinology 153:825-36. 2012
    ....
  21. ncbi Tonic control of kisspeptin release in prepubertal monkeys: implications to the mechanism of puberty onset
    Joseph R Kurian
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 153:3331-6. 2012
    ..This implies that a reduction in tonic GABA inhibition of GnRH release is, at least in part, mediated through kisspeptin neurons...
  22. ncbi Postmenopausal increase in KiSS-1, GPR54, and luteinizing hormone releasing hormone (LHRH-1) mRNA in the basal hypothalamus of female rhesus monkeys
    Wooram Kim
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI 53715 1299, USA
    Peptides 30:103-10. 2009
    ..Collectively, in the primate the reduction in the negative feedback control by ovarian steroids appears to be responsible for the aging changes in kisspeptin-GPR54 signaling and the elevated state of the LHRH-1 neuronal system...
  23. ncbi Aging-related changes in release of growth hormone and luteinizing hormone in female rhesus monkeys
    Michael J Woller
    Wisconsin Primate Research Center, 1223 Capitol Court, Madison, Wisconsin 53715, USA
    J Clin Endocrinol Metab 87:5160-7. 2002
    ..These results indicate that the rhesus monkey is an excellent model for studies of the neuroendocrine mechanisms of aging...
  24. ncbi Role of GABA in the mechanism of the onset of puberty in non-human primates
    Ei Terasawa
    Department of Pediatrics and Wisconsin National Primate Research Center, University of Wisconsin, Madison 53715, USA
    Int Rev Neurobiol 71:113-29. 2005
  25. ncbi Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons
    Hideki Abe
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715-1299, USA
    Endocrinology 146:4312-20. 2005
    ....
  26. ncbi Colocalization of FM1-43, Bassoon, and GnRH-1: GnRH-1 release from cell bodies and their neuroprocesses
    Lidia C Fuenzalida
    Department of Pediatrics and Wisconsin National Primate Research Center, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 152:4310-21. 2011
    ..Collectively, we hypothesize that soma-dendritic release of the peptide may be a mechanism of synchronized activity among GnRH-1 neurons...
  27. ncbi Aging-related changes in in vivo release of growth hormone-releasing hormone and somatostatin from the stalk-median eminence in female rhesus monkeys (Macaca mulatta)
    Shinichiro Nakamura
    Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715, USA
    J Clin Endocrinol Metab 88:827-33. 2003
    ..There were no significant changes in the pulse frequency of SS release. Therefore, the aging-related decrease in GH release is due to a substantial decrease in GHRH release and an increase in SS release from the hypothalamus...
  28. ncbi Microdialysis methods for in vivo neuropeptide measurement in the stalk-median eminence in the Rhesus monkey
    Samuel I Frost
    Wisconsin National Primate Research Center, Northwestern University, Evanston, IL 60208 7180, USA
    J Neurosci Methods 168:26-34. 2008
    ..Therefore, the microdialysis method described here is a highly useful tool for neuroendocrine studies in non-human primates...
  29. ncbi Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression
    Andrea C Wilson
    Department of Pathology and Laboratory Medicine, Veterans Administration Hospital, University of Wisconsin, 2500 Overlook Terrace, Madison, Wisconsin 53705, USA
    J Endocrinol 191:651-63. 2006
    ..Post-reproductive surges in GnRH I secretion may explain the accumulation of LH in pyramidal neurons of the aged human and rat...
  30. ncbi STX, a novel nonsteroidal estrogenic compound, induces rapid action in primate GnRH neuronal calcium dynamics and peptide release
    B P Kenealy
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 152:3182-91. 2011
    ..Collectively, the rapid action of E(2) mediated through GPR30 differs from that mediated through STX-sensitive receptors. The molecular structure of the STX-sensitive receptor remains to be identified...
  31. ncbi Estrogen receptor-alpha immunoreactive neurons in the ventrolateral periaqueductal gray receive monosynaptic input from the lumbosacral cord in the rhesus monkey
    Veronique G J M Vanderhorst
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 443:27-42. 2002
    ..This pathway might be involved in the mechanisms of analgesia, blood pressure, mating behavior, and micturition...
  32. ncbi Axonal sprouting of a brainstem-spinal pathway after estrogen administration in the adult female rhesus monkey
    Veronique G J M Vanderhorst
    Department of Anatomy, University California San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 454:82-103. 2002
    ..Moreover, they demonstrated that a long descending brainstem-spinal tract in adult nonhuman primates retains the capacity for axonal sprouting...
  33. ncbi Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons
    Ronald J Knox
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8066, USA
    Biochem Biophys Res Commun 366:48-53. 2008
    ....
  34. ncbi Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta)
    Andrea C Gore
    University of Texas at Austin, Division of Pharmacology Toxicology, Austin, Texas 78712, USA
    Endocrinology 145:4653-9. 2004
    ..To our knowledge, this is the first direct demonstration of elevated pulsatile GnRH concentrations in a primate species during reproductive senescence, a result that may have implications for menopausal symptoms...

Research Grants64

  1. HYPOTHALAMIC CONTROL OF PUBERTY
    EI NONE TERASAWAGRILLEY; Fiscal Year: 2010
    ....
  2. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 2000
    ..Results from the proposed project will provide insight into the mechanisms by which the hypothalamus controls gonadotropin release in primates and ultimately will be useful for clinical management. ..
  3. HYPOTHALAMIC CONTROL OF PUBERTY
    EI TERASAWAGRILLEY; Fiscal Year: 2009
    ....
  4. HYPOTHALAMIC CONTROL OF PUBERTY
    EI NONE TERASAWAGRILLEY; Fiscal Year: 2010
    ....
  5. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    EI NONE TERASAWAGRILLEY; Fiscal Year: 2010
    ..Results from the. proposed project will provide insight into the mechanisms through which the hypothalamus controls gonadotropin release in primates and ultimately will be useful for clinical management and the control of fertility. ..
  6. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 2007
    ..Results from the. proposed project will provide insight into the mechanisms through which the hypothalamus controls gonadotropin release in primates and ultimately will be useful for clinical management and the control of fertility. ..
  7. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 2004
    ..The studies in Specific Aim 3 will test the hypothesis that estrogen acts directly on GnRH neurons in vitro to stimulate calcium oscillations and GnRH release or to alter their responsiveness to NPY, glutamate, or GABA. ..
  8. HYPOTHALAMIC CONTROL OF PUBERTY
    EI TERASAWAGRILLEY; Fiscal Year: 2004
    ....
  9. HYPOTHALAMIC CONTROL OF PUBERTY
    Ei Terasawa; Fiscal Year: 1980
    ..Furthermore, somewhat similar results obtained in the guinea pig on pubertal mechanisms suggest that the guinea pig may be a useful model for primate research. ..
  10. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    Ei Terasawa; Fiscal Year: 1993
    ..It is our hope to obtain a clear picture of the LHRH pulse generating system. Results from the project will provide further insight into the mechanisms by which the hypothalamus controls the release of gonadotropin in primates...
  11. HYPOTHALAMIC CONTROL OF PUBERTY
    Ei Terasawa; Fiscal Year: 1992
    ..Results from these projects will not only provide evidence to support the proposed hypothesis, but also clarify the mechanism of the onset of puberty controlled by the hypothalamus...