J E Tepper
Affiliation: University of North Carolina
- Adjuvant postoperative fluorouracil-modulated chemotherapy combined with pelvic radiation therapy for rectal cancer: initial results of intergroup 0114J E Tepper
Department of Radiation Oncology, University of North Carolina at Chapel Hill, School of Medicine 27599 7512, USA
J Clin Oncol 15:2030-9. 1997..We attempted to determine whether the efficacy of this postoperative therapy could be improved by the addition of leucovorin and/or levamisole...
- Radiation treatment parameters in the adjuvant postoperative therapy of gastric cancerJoel E Tepper
Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Semin Radiat Oncol 12:187-95. 2002..These should be used as guides for defining appropriate field arrangements for the adjuvant postoperative therapy of gastric cancer...
- Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control--final report of intergroup 0114J E Tepper
Department of Radiation Oncology, University of North Carolina, Chapel Hill 27599 7512, USA
J Clin Oncol 20:1744-50. 2002....
- Impact of number of nodes retrieved on outcome in patients with rectal cancerJ E Tepper
Department of Radiation Oncology, University of North Carolina, Chapel Hill 27599 7512, USA
J Clin Oncol 19:157-63. 2001..We postulated that the pathologic evaluation of the lymph nodes of surgical specimens from patients with rectal cancer can have a substantial impact on time to relapse and survival...
- Analysis of surgical salvage after failure of primary therapy in rectal cancer: results from Intergroup Study 0114J E Tepper
Department of Radiation Oncology, Campus Box No 7512, University of North Carolina, Chapel Hill, NC 27599 7512, USA
J Clin Oncol 21:3623-8. 2003..A subset analysis was undertaken to investigate the prevalence and influence of salvage therapy among patients with recurrent disease...
- Phase I trial of twice-weekly gemcitabine and concurrent radiation in patients with advanced pancreatic cancerA W Blackstock
Department of Radiation Oncology, Wake Forest University Baptist Medical Center, Winston Salem, NC 27516, USA
J Clin Oncol 17:2208-12. 1999..To determine the maximum-tolerated dose, dose-limiting toxicities, and potential antitumor activity of twice-weekly gemcitabine and concurrent radiation in patients with locally advanced pancreatic cancer...
- Chemoradiation for locally advanced squamous cell carcinoma of the head and neck for organ preservation and palliationM E Poole
Division of Hematology Oncology, Department of Medicine, 3009 Old Clinic Bldg, CB 7305, University of North Carolina School of Medicine, Chapel Hill, NC 25799 7305, USA
Arch Otolaryngol Head Neck Surg 127:1446-50. 2001....
- Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II studyA W Blackstock
Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Br J Cancer 95:260-5. 2006..These results confirm the feasibility of delivering adjuvant concurrent gemcitabine and radiation to the upper abdomen. This strategy produced good local regional tumour control...
- Gemcitabine radiosensitization for rectal cancer: step forward or dance step?BERT H O'NEIL
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cancer J 11:110-2. 2005
- Rectal cancer radiotherapyShelileah Ramsey
Department of Radiation Oncology, University of North Carolina School of Medicine, UNC Lineberger Clinical Cancer Center, Chapel Hill, NC 27599 7512, USA
Cancer J 13:204-9. 2007....
- In vivo intraoperative radiotherapy: a novel approach to radiotherapy for early stage breast cancerKaryn B Stitzenberg
Department of Surgery, University of North Carolina, Chapel Hill, NC, USA
Ann Surg Oncol 14:1515-6. 2007..We are investigating the feasibility of partial breast irradiation using a single fraction of IORT delivered to the tumor in vivo prior to surgical resection...
- Staging of colorectal cancer: past, present, and futureJanet K Horton
Department of Radiation Oncology, University of North Carolina, Chapel Hill 27599, USA
Clin Colorectal Cancer 4:302-12. 2005..Staging in the future is likely to be a complicated combination of anatomic and biologic markers used together in mathematic modeling to group patients into prognostic risk groups, which can be used to guide tailored therapy...
- Current options for the management of rectal cancerBERT H O'NEIL
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
Curr Treat Options Oncol 8:331-8. 2007....
- Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational statusRandall J Kimple
Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA
Clin Cancer Res 16:912-23. 2010..We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provide evidence in support of further clinical investigations...
- Dose optimization via index-dose gradient minimizationSha X Chang
Department of Radiation Oncology, University of North Carolina at Chapel Hill, 27599 7512, USA
Med Phys 29:1130-46. 2002..The primary advantages of our optimization algorithm include computational efficiency, intensity modulation selection choice, and performance reliability for a wide range of clinical beam setups and optimization objectives...
- Evidence-based review of three-dimensional conformal radiotherapy for localized prostate cancer: an ASTRO outcomes initiativeDavid E Morris
Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
Int J Radiat Oncol Biol Phys 62:3-19. 2005....
- Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor responseA W Blackstock
Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27156, USA
Clin Cancer Res 7:3263-8. 2001..To test this hypothesis, we examined dFdCyd/dFdCTP uptake and clearance in HT-29 human colon carcinoma xenografts in nude mice by high-performance liquid chromatography (HPLC) and fluorine-19 magnetic resonance spectroscopy (F-19 MRS)...
- Diabetes mellitus affects response to neoadjuvant chemoradiotherapy in the management of rectal cancerA S Caudle
Division of Surgical Oncology, University of North Carolina, Chapel Hill, NC, USA
Ann Surg Oncol 15:1931-6. 2008..This study compares the neoadjuvant chemoradiotherapy (CRT) response in diabetic and nondiabetic patients with locally advanced rectal cancers...
- Biomarkers for response to neoadjuvant chemoradiation for rectal cancerJeffrey G Kuremsky
Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, NC 27599 7360, USA
Int J Radiat Oncol Biol Phys 74:673-88. 2009..Epidermal growth factor receptor, thymidylate synthase, and p21 should be evaluated in larger prospective clinical trials for their ability to guide preoperative therapy choices in LARC...
- Impact of T and N substage on survival and disease relapse in adjuvant rectal cancer: a pooled analysisLeonard L Gunderson
Department of Radiation Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
Int J Radiat Oncol Biol Phys 54:386-96. 2002..For future trial design, it may be preferable to perform separate studies, or a planned statistical analysis, for the "intermediate-risk" vs. the "moderately high" or "high-risk" subsets of patients...
- Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomasAbigail S Caudle
Department of Surgery, Division of Surgical Oncology, University of North Carolina School of Medicine, 3010 Old Clinic Building, CB 7213, Chapel Hill, NC 27599, USA
Ann Surg Oncol 14:577-82. 2007..Preoperative RT offers theoretical advantages in the multidisciplinary care of RPS. The purpose of our study was to evaluate our experience using preoperative radiotherapy (PRT) in the treatment of RPS...
- A phase I study of bortezomib in combination with standard 5-fluorouracil and external-beam radiation therapy for the treatment of locally advanced or metastatic rectal cancerBERT H O'NEIL
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill
Clin Colorectal Cancer 9:119-25. 2010..The purpose of this study was to determine the maximum tolerated dose (MTD) of bortezomib in combination with chemotherapy and radiation...
- NF-kB and Bcl-3 activation are prognostic in metastatic colorectal cancerSoham D Puvvada
Department of Internal Medicine, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
Oncology 78:181-8. 2010..The goal of this study was to correlate the activation status of NF-kappaB and Bcl-3 with clinical outcome in a group of patients with metastatic colorectal cancer (CRC)...
- Cancer and leukemia group B gastrointestinal cancer committeeRichard M Goldberg
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Clin Cancer Res 12:3589s-95s. 2006..Future efforts aim to evolve new standards of care, evaluate new therapies, and answer relevant biological questions in gastrointestinal cancer...
- Rectal cancer: can we throw away the scalpel?Michael O Meyers
Ann Surg Oncol 12:95-7. 2005
- Impact of hospital procedure volume on surgical operation and long-term outcomes in high-risk curatively resected rectal cancer: findings from the Intergroup 0114 StudyJeffrey A Meyerhardt
Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 22:166-74. 2004..However, because these studies often lack detailed information on tumor and treatment characteristics as well as cancer recurrence, the true nature of this relation remains uncertain...
- Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114Jeffrey A Meyerhardt
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 22:648-57. 2004..To study the relationship between body mass index (BMI) and rates of sphincter-preserving operations, overall survival, cancer recurrence, and treatment-related toxicities in patients with rectal cancer...
- Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysisLeonard L Gunderson
Radiation Oncology Department, Mayo Clinic Cancer Center, Scottsdale, AZ 85259, USA
J Clin Oncol 22:1785-96. 2004..To determine survival and relapse rates by T and N stage and treatment method in five randomized phase III North American rectal adjuvant studies...
- Patient selection, realism, and randomized clinical trialsJoel E Tepper
J Clin Oncol 22:3215-7. 2004
- An embarrassment of riches: neoadjuvant therapy of rectal cancerJoel E Tepper
J Clin Oncol 23:1339-41. 2005
- Cancer and leukemia group B (CALGB) 89805: phase II chemoradiation trial using gemcitabine in patients with locoregional adenocarcinoma of the pancreasA William Blackstock
Radiation Oncology, Wake Forest University Comprehensive Cancer Center, Winston Salem, NC 277516, USA
Int J Gastrointest Cancer 34:107-16. 2003..Determine the safety and efficacy of twice weekly gemcitabine and concurrent radiation to the upper abdomen followed by weekly gemcitabine in patients with surgically staged, locally advanced pancreatic cancer...
- Impact of preoperative radiation for rectal cancer on subsequent lymph node evaluation: a population-based analysisNancy N Baxter
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
Int J Radiat Oncol Biol Phys 61:426-31. 2005..To determine the impact of preoperative radiotherapy (RT) on the accuracy of lymph node staging (LNS). Preoperative RT is a well-established component of rectal cancer treatment but its impact on LNS is unknown...
- Phase I/II study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer: Cancer and Leukemia Group B 89901David P Ryan
Massachusetts General Hospital Cancer Center, Boston MA 02114, USA
J Clin Oncol 24:2557-62. 2006..This phase I/II study evaluated the addition of weekly oxaliplatin to preoperative continuous infusion fluorouracil (FU) and external-beam radiation therapy (RT) in patients with locally advanced rectal adenocarcinoma...
- ASTRO 45th annual meeting presidential address: Medicine's arrow, medicine's cycle: lessons for radiation oncologyJoel E Tepper
Int J Radiat Oncol Biol Phys 59:623-33. 2004
- Risk of pelvic fractures in older women following pelvic irradiationNancy N Baxter
Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis 55455, USA
JAMA 294:2587-93. 2005..Pelvic fractures, including hip fractures, are a major source of morbidity and mortality in older women. Although therapeutic pelvic irradiation could increase the risk of such fractures, this effect has not been studied...
- Increased risk of rectal cancer after prostate radiation: a population-based studyNancy N Baxter
Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Gastroenterology 128:819-24. 2005..Radiation therapy for prostate cancer has been associated with an increased rate of pelvic malignancies, particularly bladder cancer. The association between radiation therapy and colorectal cancer has not been established...
- Is less more? Lessons in radiation schedules in breast cancerCarolyn I Sartor
J Natl Cancer Inst 94:1114-5. 2002
- Postoperative irradiation for rectal cancer increases the risk of small bowel obstruction after surgeryNancy N Baxter
Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Ann Surg 245:553-9. 2007..To determine the risk of small bowel obstruction (SBO) after irradiation (RT) for rectal cancer..