T N Teknos

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Reconstruction of complex parotidectomy defects using the lateral arm free tissue transfer
    Theodoros N Teknos
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor, MI 48109 0312, USA
    Otolaryngol Head Neck Surg 129:183-91. 2003
  2. ncbi The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
    Arch Otolaryngol Head Neck Surg 131:204-11. 2005
  3. ncbi Raynaud's phenomenon in radial forearm free-tissue transfer
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, USA
    Ear Nose Throat J 81:467-9. 2002
  4. ncbi Tumor angiogenesis as a predictive marker for organ preservation in patients with advanced laryngeal carcinoma
    Theodoros N Teknos
    University of Michigan Health System, Department of Otolaryngology Head and Neck Surgery, Ann Arbor 48109 0312, USA
    Laryngoscope 112:844-51. 2002
  5. ncbi Positron emission tomography in the evaluation of stage III and IV head and neck cancer
    T N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor Veterans Administration Hospital, 1904 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0312, USA
    Head Neck 23:1056-60. 2001
  6. ncbi Free tissue reconstruction of the hypopharynx after organ preservation therapy: analysis of wound complications
    T N Teknos
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Laryngoscope 111:1192-6. 2001
  7. ncbi Microvascular free tissue transfer in reconstructing skull base defects: lessons learned
    Theodoros N Teknos
    Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Laryngoscope 112:1871-6. 2002
  8. ncbi Conservation laryngeal surgery for malignant tumors of the larynx and pyriform sinus
    T N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan, USA
    Hematol Oncol Clin North Am 15:261-76. 2001
  9. ncbi Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1500 E Medical Center Dr, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 24:1004-11. 2002
  10. ncbi Conformal re-irradiation of recurrent and new primary head-and-neck cancer
    L A Dawson
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Int J Radiat Oncol Biol Phys 50:377-85. 2001

Detail Information

Publications80

  1. ncbi Reconstruction of complex parotidectomy defects using the lateral arm free tissue transfer
    Theodoros N Teknos
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor, MI 48109 0312, USA
    Otolaryngol Head Neck Surg 129:183-91. 2003
    ..The posterior cutaneous nerve of the forearm (PCNF) was used as a facial nerve cable graft in 14 patients. Facial disability outcomes were measured using the Facial Clinimetric Evaluation scale...
  2. ncbi The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
    Arch Otolaryngol Head Neck Surg 131:204-11. 2005
    ..To assess the effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth rate in human squamous cell carcinoma (SCC)...
  3. ncbi Raynaud's phenomenon in radial forearm free-tissue transfer
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, USA
    Ear Nose Throat J 81:467-9. 2002
    ..A salvage procedure was unsuccessful. In this article, we discuss the perioperative course, proposed pathophysiology, and treatment strategies aimed at optimizing hand and flap outcomes in patients with Raynaud's phenomenon...
  4. ncbi Tumor angiogenesis as a predictive marker for organ preservation in patients with advanced laryngeal carcinoma
    Theodoros N Teknos
    University of Michigan Health System, Department of Otolaryngology Head and Neck Surgery, Ann Arbor 48109 0312, USA
    Laryngoscope 112:844-51. 2002
    ..The purpose of this study was to retrospectively investigate tumor angiogenesis as a predictive marker for response to neoadjuvant chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma...
  5. ncbi Positron emission tomography in the evaluation of stage III and IV head and neck cancer
    T N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor Veterans Administration Hospital, 1904 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0312, USA
    Head Neck 23:1056-60. 2001
    ..Conventional radiographic modalities, such as CT and MR, give excellent anatomic detail but poorly identify unenlarged lymph nodes harboring metastatic disease...
  6. ncbi Free tissue reconstruction of the hypopharynx after organ preservation therapy: analysis of wound complications
    T N Teknos
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Laryngoscope 111:1192-6. 2001
    ..The purpose of this study is to determine the incidence of wound complications in these patients when microvascular free tissue transfers are used for reconstruction of the hypopharynx...
  7. ncbi Microvascular free tissue transfer in reconstructing skull base defects: lessons learned
    Theodoros N Teknos
    Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Laryngoscope 112:1871-6. 2002
    ..To demonstrate the effectiveness of microvascular free tissue transfer in reconstructing complex skull base defects...
  8. ncbi Conservation laryngeal surgery for malignant tumors of the larynx and pyriform sinus
    T N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan, USA
    Hematol Oncol Clin North Am 15:261-76. 2001
    ..The medical surgical decision making is complex and requires precise delineation of tumor extent, careful patient evaluation, and thorough interdisciplinary discussion to select an optimal course of treatment for the individual patient...
  9. ncbi Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1500 E Medical Center Dr, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 24:1004-11. 2002
    ..Comparisons with a cohort of normal healthy controls were also performed to determine the potential usefulness of s-VEGF as a screening tool...
  10. ncbi Conformal re-irradiation of recurrent and new primary head-and-neck cancer
    L A Dawson
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Int J Radiat Oncol Biol Phys 50:377-85. 2001
    ..To review the outcome of head-and-neck cancer patients re-irradiated using conformal radiation...
  11. ncbi Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study
    A Eisbruch
    Departments of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI, USA
    J Clin Oncol 19:792-9. 2001
    ..Tumor incorporation of gemcitabine triphosphate (dFdCTP) was measured to assess whether adequate concentrations were achieved at each dose level...
  12. ncbi RhoC expression and head and neck cancer metastasis
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, Ohio State University, Columbus, OH 43210, USA
    Mol Cancer Res 7:1771-80. 2009
    ..These findings suggest that RhoC warrants further investigation to delineate its robustness as a novel potentially therapeutic target...
  13. ncbi Sentinel node localization in oral cavity and oropharynx squamous cell cancer
    R J Taylor
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Arch Otolaryngol Head Neck Surg 127:970-4. 2001
    ..The sentinel node technique has the potential to decrease the number of neck dissections performed in clinically negative necks, thus reducing the associated morbidity for patients in this group...
  14. ncbi Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer
    Basil Hassouneh
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 East Medical Centre Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 6:1039-45. 2007
    ..Taken together, these results show that tetrathiomolybdate can act long-term as a suppressor of vascularity and inhibit the growth of metastasis in this model of HNSCC...
  15. ncbi RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck
    Celina G Kleer
    Department of Pathology, University of Michigan, Ann Arbor, 48109, USA
    Clin Cancer Res 12:4485-90. 2006
    ..This study evaluated the expression of RhoC in head and neck carcinoma and investigated the prognostic use of this marker on a large cohort of previously untreated patients with SCCHN...
  16. ncbi High incidence of chest malignancy detected by FDG PET in patients suspected of recurrent squamous cell carcinoma of the upper aerodigestive tract
    Alain Perlow
    Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    J Comput Assist Tomogr 28:704-9. 2004
    ..Fifty percent were unsuspected prior to FDG PET. This result suggests that FDG PET of the lungs should be routinely included in the evaluation of high-risk patients...
  17. ncbi Predictive factors of local-regional recurrences following parotid sparing intensity modulated or 3D conformal radiotherapy for head and neck cancer
    Mary Feng
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Radiother Oncol 77:32-8. 2005
    ..These factors may aid in the selection of patients for studies of treatment intensification using IMRT...
  18. ncbi Voice and swallowing outcomes of an organ-preservation trial for advanced laryngeal cancer
    Kevin Fung
    Head and Neck Oncology Program, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 63:1395-9. 2005
    ....
  19. ncbi Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma
    Benjamin Marcus
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48103, USA
    Cancer 101:2779-87. 2004
    ..0001). CONCLUSIONS: Primary tumor macrophage content is a strong predictor of tumor aggressiveness in HNSCC...
  20. ncbi Prevention of wound complications following salvage laryngectomy using free vascularized tissue
    Kevin Fung
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Head Neck 29:425-30. 2007
    ..The purpose of this study was to outline our technique and determine the effectiveness of this new approach...
  21. ncbi Acceleration of hyperfractionated chemoradiation regimen for advanced head and neck cancer
    Aaron M Allen
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 29:137-42. 2007
    ..Our aim was to evaluate the acceleration of a hyperfractionated, concurrent chemoradiation regimen (HxCRT) for advanced head and neck squamous cell carcinoma (HNSCC)...
  22. ncbi EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Comprehensive Cancer Center Head and Neck Cancer Program, Ann Arbor, MI 48109, USA
    J Clin Oncol 26:3128-37. 2008
    ..To prospectively identify markers of response to therapy and outcome in an organ-sparing trial for advanced oropharyngeal cancer...
  23. ncbi Skin cancer of the head and neck with perineural invasion: defining the clinical target volumes based on the pattern of failure
    Iris Gluck
    Department of Radiation Oncology, University of Michigan, Ann Arbor MI, USA
    Int J Radiat Oncol Biol Phys 74:38-46. 2009
    ....
  24. ncbi The pattern of failure after reirradiation of recurrent squamous cell head and neck cancer: implications for defining the targets
    Aron Popovtzer
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 74:1342-7. 2009
    ..Limiting the re-RT targets to the recurrent gross tumor volume (rGTV) would reduce the volumes of reirradiated tissues; however, its effect on tumor recurrence pattern is unknown...
  25. ncbi Chemotherapy alone for organ preservation in advanced laryngeal cancer
    Vasu Divi
    Department of Otolaryngology Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA
    Head Neck 32:1040-7. 2010
    ....
  26. ncbi Correlation between initial and early follow-up CT perfusion parameters with endoscopic tumor response in patients with advanced squamous cell carcinomas of the oropharynx treated with organ-preservation therapy
    D Gandhi
    Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    AJNR Am J Neuroradiol 27:101-6. 2006
    ....
  27. ncbi Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life
    A Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Acta Otorhinolaryngol Belg 53:271-5. 1999
    ..The pattern of recurrence suggests that careful escalation of the dose to targets judged to be at highest risk may improve tumor control...
  28. ncbi TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis
    Naoki Ashimori
    Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, 1011 North University Room 2309, Ann Arbor, MI 48109 1078, USA
    Mol Cancer Ther 8:893-903. 2009
    ..Collectively, these data reveal that therapeutic inhibition of Bcl-2 function with TW-37 is sufficient to arrest endothelial cells and HNSCC in the S phase of the cell cycle and to inhibit head and neck tumor angiogenesis...
  29. ncbi Immune reactivity does not predict chemotherapy response, organ preservation, or survival in advanced laryngeal cancer
    Gregory T Wolf
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312, USA
    Laryngoscope 112:1351-6. 2002
    ..Lymphocyte subsets were not significant predictors of responding patients or survival. Further study of other biological markers useful in selecting patients for organ preservation are needed...
  30. ncbi Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer
    LiWei Bao
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 69:5829-34. 2009
    ..02) retards the growth of UMSCC1 xenografts in nude mice. Our work indicates that the bifunctional HN1-PKCepsilon inhibitory peptide represents a promising novel therapeutic strategy for HNSCC...
  31. ncbi Primary versus secondary tracheoesophageal puncture in salvage total laryngectomy following chemoradiation
    Kevin S Emerick
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Otolaryngol Head Neck Surg 140:386-90. 2009
    ..To compare the rate of postoperative wound-healing complications and voice fluency in primary vs secondary tracheoesophageal puncture (TEP) following chemoradiation...
  32. ncbi Metabolic abnormalities associated with weight loss during chemoirradiation of head-and-neck cancer
    Alexander Lin
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0010, USA
    Int J Radiat Oncol Biol Phys 63:1413-8. 2005
    ..These intensive measures should be enacted before a 10% weight loss is reached...
  33. ncbi microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ
    J Datta
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Oncogene 31:4045-53. 2012
    ..Our results demonstrate that PKCɛ is directly regulated by miR-107 and, moreover, suggest that miR-107 may be a potential anti-cancer therapeutic for HNSCC...
  34. ncbi The role of copper suppression as an antiangiogenic strategy in head and neck squamous cell carcinoma
    C Cox
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Laryngoscope 111:696-701. 2001
    ....
  35. ncbi Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma
    Quintin Pan
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Cancer Res 66:9379-84. 2006
    ..Our study shows, for the first time, that PKC epsilon is involved in a coordinated regulation of RhoA and RhoC activation, possibly through direct post-translational phosphorylation...
  36. ncbi Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence
    Jessica H Maxwell
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 16:1226-35. 2010
    ....
  37. ncbi Advanced squamous cell carcinoma of the oropharynx: efficacy of positron emission tomography and computed tomography for determining primary tumor response during induction chemotherapy
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 31:452-60. 2009
    ....
  38. ncbi Targeting apoptosis to overcome cisplatin resistance: a translational study in head and neck cancer
    Joshua A Bauer
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 69:S106-8. 2007
    ..Cisplatin resistance remains a barrier to organ-sparing and survival of patients with advanced head and neck squamous cell carcinoma (HNSCC). Targeted therapies to overcome cisplatin-resistant HNSCC are being developed...
  39. ncbi Oropharyngoplasty with template-based reconstruction of oropharynx defects
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 135:887-94. 2009
    ....
  40. ncbi Lateral oromandibular defect: when is it appropriate to use a bridging reconstruction plate combined with a soft tissue revascularized flap?
    Douglas B Chepeha
    Department Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 30:709-17. 2008
    ..A quasi-experimental retrospective study was undertaken to evaluate a new concept of free tissue volume restoration combined with bridging reconstruction plate (compartment approach) to reduce plate-related complication rates...
  41. ncbi Pharmacotherapy of head and neck squamous cell carcinoma
    Quintin Pan
    The Ohio State University Medical Center, Department of Otolaryngology Head and Neck Surgery, 456 West Tenth Avenue, Cramblett Medical Clinic, Suite 4A, Columbus, OH 43210, USA
    Expert Opin Pharmacother 10:2291-302. 2009
    ..Historically, locally advanced HNSCC has been primarily managed with surgery and radiation (RT). The integration of pharmacotherapy has rapidly expanded over the years into the multimodality treatment paradigm of locally advanced HNSCC...
  42. ncbi Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number
    Francis P Worden
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 26:3138-46. 2008
    ..To test induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) or surgery/radiotherapy (RT) for advanced oropharyngeal cancer and to assess the effect of human papilloma virus (HPV) on response and outcome...
  43. ncbi Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion
    Francis P Worden
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Laryngoscope 119:1510-7. 2009
    ..Patients were treated with chemoradiation after a >50% primary tumor response to one cycle of neoadjuvant chemotherapy (IC). We analyzed outcomes for T4 patients with cartilage invasion from both studies...
  44. ncbi Interleukin-6 predicts recurrence and survival among head and neck cancer patients
    Sonia A Duffy
    Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, Michigan 48113 0170, USA
    Cancer 113:750-7. 2008
    ....
  45. ncbi Rectangle tongue template for reconstruction of the hemiglossectomy defect
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 134:993-8. 2008
    ..To determine if a rectangular template free tissue transfer is effective for the reconstruction of the hemiglossectomy defect...
  46. ncbi Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan Hospital, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 53:23-8. 2002
    ..To objectively assess swallowing function after an intensive chemoradiation regimen for locally advanced head-and-neck cancer and to assess the clinical implications of swallowing dysfunction...
  47. ncbi Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 69:S109-11. 2007
    ..Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile...
  48. ncbi Clinical predictors of quality of life in patients with head and neck cancer
    Jeffrey E Terrell
    Department of Otolaryngology, University of Michigan, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 130:401-8. 2004
    ..To identify clinical predictors of quality of life (QoL) in a head and neck cancer patient population...
  49. ncbi Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma
    Cecelia E Schmalbach
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0656, USA
    Arch Otolaryngol Head Neck Surg 130:295-302. 2004
    ..To investigate differences in gene expression profiles between oral cavity/oropharynx squamous cell carcinoma (OC/OP SCC) primary tumors that have metastasized to cervical lymph nodes and nonmetastatic OC/OP SCC tumors...
  50. ncbi Pectoralis major myocutaneous flap vs revascularized free tissue transfer: complications, gastrostomy tube dependence, and hospitalization
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 130:181-6. 2004
    ..To evaluate the factors related to surgical complications, rate of gastrostomy tube (G-tube) dependence, and hospitalization in patients undergoing reconstruction with a pectoralis myocutaneous flap vs a soft-tissue revascularized flap...
  51. ncbi Restoration of the orbital aesthetic subunit in complex midface defects
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, 1904 Taubman Health Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, U S A
    Laryngoscope 114:1706-13. 2004
    ..The study describes an approach using free tissue transfer for restoration of the native orbital aesthetic subunit...
  52. ncbi Radial forearm free tissue transfer reduces complications in salvage skull base surgery
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Otolaryngol Head Neck Surg 131:958-63. 2004
    ..To determine whether the complication rate could be reduced, fasciocutaneous free tissue transfer was used to reinforce the dural closure in patients who had prior skull base surgery or radiation...
  53. ncbi Use of cross-sectional imaging in predicting facial nerve sacrifice during surgery for parotid neoplasms
    Vasu Divi
    Department of Otolaryngology-Head and Neck Surgery, Division of Neuroradiology, University of Michigan Medical Center, Ann Arbor, MI 48105, USA
    ORL J Otorhinolaryngol Relat Spec 66:262-6. 2004
    ..CT and MRI have a high negative predictive value for facial nerve sacrifice...
  54. ncbi Generation of vaccine-primed lymphocytes for the treatment of head and neck cancer
    Alfred E Chang
    Division of Surgical Oncology, 3302 Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Head Neck 25:198-209. 2003
    ..CONCLUSIONS: Both CD4(+) and CD8(+) responses can be induced to SCC by autologous tumor vaccination. However, additional approaches need to be identified to enhance the therapeutic efficacy of this approach...
  55. ncbi Use of cross-sectional imaging in predicting surgical location of parotid neoplasms
    Vasu Divi
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48105 0312, USA
    J Comput Assist Tomogr 29:315-9. 2005
    ..The purpose of this study was to determine the diagnostic accuracy of using the retromandibular vein as seen on cross-sectional imaging to help differentiate superficial lobe from deep lobe tumors...
  56. ncbi Osseocutaneous radial forearm free tissue transfer for repair of complex midfacial defects
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 131:513-7. 2005
    ..To evaluate the resulting aesthetics, function, and donor site morbidity of the osseocutaneous radial forearm free flap (OCRFFF) used for midface reconstruction...
  57. ncbi Functional assessment using Constant's Shoulder Scale after modified radical and selective neck dissection
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 E Medical Center Drive, Taubman Center 1904, Ann Arbor 48109 0312, USA
    Head Neck 24:432-6. 2002
    ..We used this instrument to assess which treatment and demographic variables contribute to shoulder dysfunction after neck dissection in head and neck cancer patients...
  58. ncbi Selective neck dissection for the treatment of neck metastasis from squamous cell carcinoma of the head and neck
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Laryngoscope 112:434-8. 2002
    ....
  59. ncbi Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 59:28-42. 2004
    ..Locoregional (LR) failures near the base of the skull, and their relationships to the targets in the high neck, were examined in a series of patients who underwent intensity-modulated radiotherapy (IMRT) for head-and-neck cancer...
  60. ncbi Leech therapy for patients with surgically unsalvageable venous obstruction after revascularized free tissue transfer
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 128:960-5. 2002
    ..To assess the efficacy and associated complications of a leech therapy protocol used for patients with a head and neck free tissue transfer in whom flap viability is threatened because of surgically unsalvageable venous obstruction...
  61. ncbi Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Cancer Res 65:8366-71. 2005
    ..Taken together, these results revealed that PKC epsilon plays a critical and causative role in promoting an aggressive metastatic breast cancer phenotype and as a target for anticancer therapy...
  62. ncbi Head and neck squamous cell carcinoma: CT perfusion can help noninvasively predict intratumoral microvessel density
    Lorraine Ash
    Department of Radiology, Division of NeuroradiologyUniversity of Michigan Health Systems, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0030, USA
    Radiology 251:422-8. 2009
    ..To determine the correlation between computed tomographic (CT) perfusion parameters and intratumoral microvessel density (MVD) in the evaluation of head and neck squamous cell carcinoma (HNSCC)...
  63. ncbi Microvascular reconstruction of the orbital complex
    Jeffrey S Moyer
    University of Michigan Medical Center, 1500 East Medical Center Drive, TC1904, Ann Arbor, MI 48109, USA
    Facial Plast Surg Clin North Am 17:225-37. 2009
    ..This article summarizes the approach to orbitomaxillary reconstruction and discusses the use of free tissue transfer in the rehabilitation of this complex region...
  64. ncbi Paranasal sinus malignancies: an 18-year single institution experience
    Larry L Myers
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas 75390 9035, USA
    Laryngoscope 112:1964-9. 2002
    ..To characterize a single institution experience with management of paranasal sinus malignancies during an 18-year time period, report long-term survival rates, and identify prognostic factors...
  65. ncbi Inhibition of the growth of squamous cell carcinoma by tetrathiomolybdate-induced copper suppression in a murine model
    Claudell Cox
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, 48109, USA
    Arch Otolaryngol Head Neck Surg 129:781-5. 2003
    ....
  66. ncbi Development and validation of the neck dissection impairment index: a quality of life measure
    Rodney J Taylor
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Otolaryngol Head Neck Surg 128:44-9. 2002
    ..CONCLUSIONS: The NDII is a valid, reliable instrument for assessing neck dissection impairment. Patient's age, weight, radiation treatment, and neck dissection type were important factors that affect QOL following neck dissection...
  67. ncbi Improved outcomes in patients with head and neck cancer using a standardized care protocol for postoperative alcohol withdrawal
    Christopher D Lansford
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Arch Otolaryngol Head Neck Surg 134:865-72. 2008
    ..To show clinical benefit in the main outcome measures by the use of a standardized protocol for identification, characterization, and treatment of alcohol withdrawal syndrome (AWS) in postoperative patients with head and neck cancer...
  68. ncbi Variables associated with feeding tube placement in head and neck cancer
    Sara S Cheng
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, USA
    Arch Otolaryngol Head Neck Surg 132:655-61. 2006
    ..Since feeding tube placement has been linked to decreased quality of life in head and neck cancer, such counseling is an integral part of the clinical management of these patients...
  69. ncbi Contemporary skull base reconstruction
    Jeffrey S Moyer
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0312, USA
    Curr Opin Otolaryngol Head Neck Surg 12:294-9. 2004
    ..Regional flap reconstruction should be reserved for cases where alternative reconstructive techniques are not available...
  70. ncbi HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans
    Jessica H Maxwell
    University of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI, USA
    Head Neck 32:562-7. 2010
    ..The HPV, p16, and EBV status was examined in current University of Michigan patients with NPC...
  71. ncbi Marjolin's ulcer arising in a previously grafted burn of the scalp
    Andrew Wong
    University of Michigan Medical School and Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Arbor, Michigan 48109, USA
    Otolaryngol Head Neck Surg 128:915-6. 2003
  72. ncbi Reliability of sentinel lymph node biopsy for regional staging of head and neck Merkel cell carcinoma
    Cecelia E Schmalbach
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor 48109-0312, USA
    Arch Otolaryngol Head Neck Surg 131:610-4. 2005
    ..The use of anti-CK-20 antibody allows accurate identification of micrometastatic MCC...
  73. ncbi Tissue engineering: the current status of this futuristic modality in head neck reconstruction
    Brian Nussenbaum
    Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri, USA
    Curr Opin Otolaryngol Head Neck Surg 12:311-5. 2004
    ..Applications in the head and neck are limited, at present, due to the immunogenicity of the scaffolds and the challenging wounds encountered in both cancer and cosmetic patients...
  74. ncbi Combination tetrathiomolybdate and radiation therapy in a mouse model of head and neck squamous cell carcinoma
    Mohamed K Khan
    Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Arch Otolaryngol Head Neck Surg 132:333-8. 2006
    ..To assess the effect of combining tetrathiomolybdate therapy and radiation treatment (RT) on tumor growth in the mouse head and neck squamous cell carcinoma (HNSCC) model...
  75. ncbi State-of-the-art mandible reconstruction using revascularized free-tissue transfer
    Kevin S Emerick
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Expert Rev Anticancer Ther 7:1781-8. 2007
    ..There are ongoing investigations into new techniques and materials, such as distraction osteogenesis and tissue engineering, which will hopefully advance our ability to reconstruct the mandible...
  76. ncbi Management of chyle fistula utilizing thoracoscopic ligation of the thoracic duct
    Chad B Gunnlaugsson
    Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-0312, USA
    ORL J Otorhinolaryngol Relat Spec 66:148-54. 2004
    ....
  77. ncbi Ex vivo gene therapy for skeletal regeneration in cranial defects compromised by postoperative radiotherapy
    Brian Nussenbaum
    Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Hum Gene Ther 14:1107-15. 2003
    ..This approach may represent a new strategy for regenerating skeletal elements lost due to head and neck cancer...
  78. ncbi Early-onset postirradiation sarcoma of the head and neck: report of three cases
    Michael M Johns
    Department of Otolaryngology, University of Michigan, 1500 E. Medical Center Dr, TC1904, Ann Arbor, MI 48109, USA
    Ear Nose Throat J 81:402-6. 2002
    ..Electron microscopy can be useful in differentiating sarcomatous-appearing epithelial lesions from true soft-tissue sarcomas, and thus can be helpful in guiding therapy...
  79. ncbi Evaluation of the thyroid nodule
    Christopher D Lansford
    Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Cancer Control 13:89-98. 2006
    ..Other laboratory and imaging evaluations have specific and more limited roles. An algorithm for the evaluation of the thyroid nodule is presented...
  80. ncbi Is there a clinical significance to the "small dark tonsil"?
    Suresh K Mukherji
    AJNR Am J Neuroradiol 26:206-7. 2005