RAJESHWAR TEKMAL

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Use of letrozole as a chemopreventive agent in aromatase overexpressing transgenic mice
    Roopa Luthra
    Department of Gynecology and Obstetrics, Emory University School of Medicine, 4217 Woodruff Memorial Building, Atlanta, GA 30322 4710, USA
    J Steroid Biochem Mol Biol 86:461-7. 2003
  2. pmc Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells
    Binoj C Nair
    Department of Obstetrics and Gynecology, CTRC at UT Health Science Center, San Antonio, Texas 78229, USA
    Breast Cancer Res 13:R80. 2011
  3. pmc BU-32: a novel proteasome inhibitor for breast cancer
    Joseph K Agyin
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Breast Cancer Res 11:R74. 2009
  4. pmc HER-2/neu x aromatase double transgenic mice model: the effects of aromatase overexpression on mammary tumorigenesis
    Rajeshwar Rao Tekmal
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Steroid Biochem Mol Biol 106:111-8. 2007
  5. ncbi request reprint Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice
    Rajeshwar Rao Tekmal
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, MSC7836, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Steroid Biochem Mol Biol 95:9-15. 2005
  6. pmc Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells
    Rajib Rajhans
    Department of Obstetrics and Gynecology, University of Texas Health Science Center, Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Mol Endocrinol 22:649-64. 2008
  7. ncbi request reprint Induction of aromatase expression in cervical carcinomas: effects of endogenous estrogen on cervical cancer cell proliferation
    Hareesh B Nair
    Department of Gynecology and Obstetrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Cancer Res 65:11164-73. 2005
  8. pmc Regulation of aromatase induction by nuclear receptor coregulator PELP1
    Ratna K Vadlamudi
    Department of Obstetrics and Gynecology, and CTRC, San Antonio, TX, USA
    J Steroid Biochem Mol Biol 118:211-8. 2010
  9. doi request reprint Role of PELP1/MNAR signaling in ovarian tumorigenesis
    Chakravarty Dimple
    Department of Obstetrics and Gynecology and Cancer Research and Therapy Center at The University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Res 68:4902-9. 2008
  10. pmc Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway
    Jatin K Nagpal
    Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7836, San Antonio, TX 78229 3900, USA
    Mol Cancer Res 6:851-61. 2008

Research Grants

  1. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
  2. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
  3. INT-5/AROMATASE--EFFECT OF BREAST ESTROGEN IN NEOPLASIA
    RAJESHWAR TEKMAL; Fiscal Year: 2000

Collaborators

  • Ratna K Vadlamudi
  • RAKESH F KUMAR
  • Shiuan Chen
  • Darrell W Brann
  • Joseph K Agyin
  • Shahriar Koochekpour
  • Xiao Feng Le
  • Jinsong Liu
  • K S Korach
  • I Tien Yeh
  • Richard Santen
  • N Sidell
  • Wei Yue
  • Nameer Kirma
  • Dimple Chakravarty
  • Sujit S Nair
  • Rajib Rajhans
  • Binoj C Nair
  • Hareesh B Nair
  • Luciano S Hammes
  • Roopa Luthra
  • Ya Guang Liu
  • Poornachand Veerapaneni
  • Gui jian Liu
  • Chakravarty Dimple
  • Jatin K Nagpal
  • Sujit Nair
  • Philip T Valente
  • Jeremy Jones
  • Tomi Streng
  • Sreeram Vallabhaneni
  • Lu Zhe Sun
  • Francis Y Lee
  • P Renee Yew
  • Rambabu Challa
  • Long Wang
  • Abhik Bandyopadhyay
  • Bramanandam Manavathi
  • Bindu Santhamma
  • Kevin L Hall
  • Anne Gompel
  • Matthew E Burow
  • David Brenin
  • Alan E Holden
  • Dujin Zhou
  • Yu Sheen Wu
  • Saikumar Pothana
  • Giujian Liu
  • Ji Ping Wang
  • Nameer B Kirma
  • Seetharaman Balasenthil
  • Perla R Pitcheswara
  • Kijima Ikuko
  • Valerie Cortez
  • Sarah Aiyar
  • Russell R Broaddus
  • Nelly Auersperg
  • Hsing Jien Kung
  • Yun Qiu
  • Judith M Mueller
  • Joao Sabino Cunha-Filho
  • Shantha Kumar
  • Roland Schüle
  • Paulo Naud
  • Lisa C Flowers
  • Zhiyong Guo
  • Maria Isabel Edelweiss
  • Kari J Syrjanen
  • Alan H Holden
  • Lisa Flowers
  • Dean Evans
  • Usha Mandava
  • Risto Santti
  • Antti Talo
  • Matti Poutanen
  • SARI MAKELA
  • Mari Lehtoranta
  • Xiangdong Li

Detail Information

Publications22

  1. ncbi request reprint Use of letrozole as a chemopreventive agent in aromatase overexpressing transgenic mice
    Roopa Luthra
    Department of Gynecology and Obstetrics, Emory University School of Medicine, 4217 Woodruff Memorial Building, Atlanta, GA 30322 4710, USA
    J Steroid Biochem Mol Biol 86:461-7. 2003
    ..These observations indicate that aromatase inhibitors such as letrozole can be used as chemopreventive agents without effecting normal physiology in aromatase transgenic mice...
  2. pmc Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells
    Binoj C Nair
    Department of Obstetrics and Gynecology, CTRC at UT Health Science Center, San Antonio, Texas 78229, USA
    Breast Cancer Res 13:R80. 2011
    ..In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells...
  3. pmc BU-32: a novel proteasome inhibitor for breast cancer
    Joseph K Agyin
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Breast Cancer Res 11:R74. 2009
    ..This underscores the need to find new and more efficacious proteasome inhibitors. In this study, we evaluate the efficacy of the novel proteasome inhibitor BU-32 (NSC D750499-S) using in vitro and in vivo breast cancer models...
  4. pmc HER-2/neu x aromatase double transgenic mice model: the effects of aromatase overexpression on mammary tumorigenesis
    Rajeshwar Rao Tekmal
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Steroid Biochem Mol Biol 106:111-8. 2007
    ....
  5. ncbi request reprint Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice
    Rajeshwar Rao Tekmal
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, MSC7836, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Steroid Biochem Mol Biol 95:9-15. 2005
    ....
  6. pmc Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells
    Rajib Rajhans
    Department of Obstetrics and Gynecology, University of Texas Health Science Center, Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Mol Endocrinol 22:649-64. 2008
    ....
  7. ncbi request reprint Induction of aromatase expression in cervical carcinomas: effects of endogenous estrogen on cervical cancer cell proliferation
    Hareesh B Nair
    Department of Gynecology and Obstetrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Cancer Res 65:11164-73. 2005
    ....
  8. pmc Regulation of aromatase induction by nuclear receptor coregulator PELP1
    Ratna K Vadlamudi
    Department of Obstetrics and Gynecology, and CTRC, San Antonio, TX, USA
    J Steroid Biochem Mol Biol 118:211-8. 2010
    ....
  9. doi request reprint Role of PELP1/MNAR signaling in ovarian tumorigenesis
    Chakravarty Dimple
    Department of Obstetrics and Gynecology and Cancer Research and Therapy Center at The University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Res 68:4902-9. 2008
    ..Collectively, these results suggest that PELP1/MNAR signaling plays a role in ovarian cancer cell proliferation and survival, and that its expression is deregulated in ovarian carcinomas...
  10. pmc Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway
    Jatin K Nagpal
    Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7836, San Antonio, TX 78229 3900, USA
    Mol Cancer Res 6:851-61. 2008
    ....
  11. pmc Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor
    Rajib Rajhans
    Department of Obstetrics and Gynecology and San Antonio Cancer Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Cancer Res 67:5505-12. 2007
    ..Our data suggest that PELP1 is a potential oncogene, that its expression is deregulated during cancer progression, and that PELP1 may play a role in oncogenesis...
  12. ncbi request reprint Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation
    Nameer Kirma
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 78229, USA
    Cancer Res 64:4162-70. 2004
    ..These findings, along with the histological data, support the hypothesis that CSF-1 and its receptor are involved in the etiology of breast cancer...
  13. pmc PELP1: A novel therapeutic target for hormonal cancers
    Dimple Chakravarty
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 78229, USA
    IUBMB Life 62:162-9. 2010
    ..Thus, PELP1 may be useful as prognostic marker for hormonal cancers and PELP1 signaling may be useful to generate targeted therapeutics to overcome hormonal therapy resistance...
  14. pmc Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cells
    Dimple Chakravarty
    Department of Obstetrics and Gynecology and CTRC at The UT Health Science Center, San Antonio, Texas 78229 3900, USA
    Cancer Res 70:4092-101. 2010
    ....
  15. pmc Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1
    Binoj C Nair
    Department of Obstetrics and Gynecology, University of Texas Health Science Center, 7703 Floyd Curl Drive, Mail Code 7836, San Antonio, TX 78229 3900, USA
    Cancer Res 70:7166-75. 2010
    ..Because the expression of both PELP1 and CDKs is deregulated in breast tumors, CDK-PELP1 interactions will have implications in breast cancer progression...
  16. pmc Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2
    Sujit S Nair
    Department of Obstetrics and Gynecology, University of Texas Health Science Center, Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Mol Endocrinol 21:613-24. 2007
    ..Our results suggest that PELP1 functions as a molecular adaptor, coupling FHL2 with nuclear receptors, and PELP1-FHL2 interactions may have a role in prostate cancer progression...
  17. ncbi request reprint Elevated expression of the oncogene c-fms and its ligand, the macrophage colony-stimulating factor-1, in cervical cancer and the role of transforming growth factor-beta1 in inducing c-fms expression
    Nameer Kirma
    Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cancer Res 67:1918-26. 2007
    ..Additionally, our data suggest that transforming growth factor-beta1 may be a factor in inducing the expression of c-fms in cervical cancer cells. The data suggest that c-fms may be a valuable therapeutic target in cervical cancer...
  18. doi request reprint Elevated aromatase expression correlates with cervical carcinoma progression
    Poornachand Veerapaneni
    Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Gynecol Oncol 114:496-500. 2009
    ..g., IL-6 and TNFalpha) may correlate with aromatase expression...
  19. pmc Development of a high sensitivity, nested Q-PCR assay for mouse and human aromatase
    Gui jian Liu
    Department of Internal Medicine and Surgery, University of Virginia, Charlottesville, VA 22908, USA
    Breast Cancer Res Treat 111:343-51. 2008
    ..The human assay was sufficiently sensitive to detect aromatase in a single human JAR (choriocarcinoma) cell, in all breast biopsies measured, and in 7/23 ductal lavage fluids...
  20. ncbi request reprint Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression--clinicopathological correlation
    Luciano S Hammes
    Department of Obstetrics and Gynecology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Gynecol Oncol 105:157-65. 2007
    ..To evaluate the population of macrophages during the cervical malignant transformation and its influence in CIN outcome...
  21. pmc Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
    Cancer Lett 251:302-10. 2007
    ..The data suggest that 4-CPA is a novel therapeutic agent that could be used in the prevention or treatment of estrogen-sensitive breast cancer...
  22. ncbi request reprint Infravesical obstruction in aromatase over expressing transgenic male mice with increased ratio of serum estrogen-to-androgen concentration
    Tomi Streng
    Department of Anatomy, Institute of Biomedicine, Laboratory of Animal Physiology, University of Turku, Finland
    J Urol 168:298-302. 2002
    ..Two aromatase over expressing transgenic mouse strains with different prostatic phenotypes (reduced and normal size, respectively) were compared in urodynamic studies with each other and with the wild-type strain...

Research Grants13

  1. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ....
  2. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
    ..abstract_text> ..
  3. INT-5/AROMATASE--EFFECT OF BREAST ESTROGEN IN NEOPLASIA
    RAJESHWAR TEKMAL; Fiscal Year: 2000
    ....