Michael Teitell

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues
    M Teitell
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:9809-14. 1999
  2. ncbi request reprint OCA-B regulation of B-cell development and function
    Michael A Teitell
    Departments of Pathology and Pediatrics, David Geffen School of Medicine at UCLA, University of California Los Angeles, 675 Charles Young Drive South, Los Angeles, CA 90095, USA
    Trends Immunol 24:546-53. 2003
  3. ncbi request reprint Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development
    Michael A Teitell
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles, 90095, USA
    Pediatr Res 59:33R-9R. 2006
  4. ncbi request reprint DNA methylation in the immune system
    Michael Teitell
    Department of Pathology and Department of Pediatrics, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095 1732, USA
    Clin Immunol 109:2-5. 2003
  5. doi request reprint Molecular genetics of acute lymphoblastic leukemia
    Michael A Teitell
    Department of Pathology, Jonsson Comprehensive Cancer Center, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, CA 90095 1732, USA
    Annu Rev Pathol 4:175-98. 2009
  6. doi request reprint Alternative control: what's WASp doing in the nucleus?
    Michael A Teitell
    Department of Pathology, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Sci Transl Med 2:37ps31. 2010
  7. ncbi request reprint EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts
    M A Teitell
    Department of Pathology, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, USA
    Lab Invest 79:1535-43. 1999
  8. ncbi request reprint The TCL1 family of oncoproteins: co-activators of transformation
    Michael A Teitell
    Department of Pathology and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4 762 MacDonald Research Laboratories, Los Angeles, California 90095 1732, USA
    Nat Rev Cancer 5:640-8. 2005
  9. pmc Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions
    Ken ichiro Kamei
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1113-9. 2010
  10. doi request reprint High-speed droplet generation on demand driven by pulse laser-induced cavitation
    Sung Yong Park
    Department of Mechanical and Aerospace Engineering, University of California at Los Angeles UCLA, 43 147 Eng IV, 420 Westwood Plaza, Los Angeles, CA 90095 1597, USA
    Lab Chip 11:1010-2. 2011

Research Grants

  1. GENES INVOLVED IN AIDS LYMPHOMAGENESIS
    Michael Teitell; Fiscal Year: 2002

Collaborators

Detail Information

Publications44

  1. pmc TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues
    M Teitell
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:9809-14. 1999
    ..High-level expression in nonproliferating B cells suggests that TCL1 may function in protecting naïve preactivated B cells from apoptosis...
  2. ncbi request reprint OCA-B regulation of B-cell development and function
    Michael A Teitell
    Departments of Pathology and Pediatrics, David Geffen School of Medicine at UCLA, University of California Los Angeles, 675 Charles Young Drive South, Los Angeles, CA 90095, USA
    Trends Immunol 24:546-53. 2003
    ..p35 can traffic to the nucleus and probably activates octamer-dependent transcription, although this OCA-B isoform might regulate B cells through membrane-related signal transduction...
  3. ncbi request reprint Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development
    Michael A Teitell
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles, 90095, USA
    Pediatr Res 59:33R-9R. 2006
    ....
  4. ncbi request reprint DNA methylation in the immune system
    Michael Teitell
    Department of Pathology and Department of Pediatrics, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095 1732, USA
    Clin Immunol 109:2-5. 2003
  5. doi request reprint Molecular genetics of acute lymphoblastic leukemia
    Michael A Teitell
    Department of Pathology, Jonsson Comprehensive Cancer Center, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, CA 90095 1732, USA
    Annu Rev Pathol 4:175-98. 2009
    ..Here, we review the spectrum of genetic aberrations that promote acute B and T cell leukemias and the mechanisms of cell transformation and malignant progression that are reinforced by mouse models of human ALL...
  6. doi request reprint Alternative control: what's WASp doing in the nucleus?
    Michael A Teitell
    Department of Pathology, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Sci Transl Med 2:37ps31. 2010
    ....
  7. ncbi request reprint EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts
    M A Teitell
    Department of Pathology, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, USA
    Lab Invest 79:1535-43. 1999
    ..This murine model, created in mesenchyme-derived NIH 3T3 cells, demonstrated new characteristics of both neuroectodermal and epithelial differentiation and resembled small round cell tumors microscopically...
  8. ncbi request reprint The TCL1 family of oncoproteins: co-activators of transformation
    Michael A Teitell
    Department of Pathology and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4 762 MacDonald Research Laboratories, Los Angeles, California 90095 1732, USA
    Nat Rev Cancer 5:640-8. 2005
    ..How TCL1 proteins are regulated and dysregulated, how they promote transformation and the potential for therapies modelled on TCL1 interactions have important implications for understanding and treating lymphocyte cancers...
  9. pmc Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions
    Ken ichiro Kamei
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1113-9. 2010
    ..Using clustering analysis, we were able to systematically compare the characteristics of various hPSC lines in different conditions...
  10. doi request reprint High-speed droplet generation on demand driven by pulse laser-induced cavitation
    Sung Yong Park
    Department of Mechanical and Aerospace Engineering, University of California at Los Angeles UCLA, 43 147 Eng IV, 420 Westwood Plaza, Los Angeles, CA 90095 1597, USA
    Lab Chip 11:1010-2. 2011
    ..Injected droplet volumes can be continuously tuned between 1 pL and 150 pL with less than 1% volume variation...
  11. pmc Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation
    Rhine R Shen
    Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Blood 108:1991-8. 2006
    ..We conclude that pEmu-B29-TCL1 transgenic B cells primed for transformation must experience the GC environment and, for at least some, develop genome instability to become fully malignant...
  12. pmc AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling
    Mara H Sherman
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell 39:873-85. 2010
    ..Combined, our data show that CRTC2 inactivation, via physiologic DNA damage response signaling, promotes B cell differentiation in response to genotoxic stress...
  13. ncbi request reprint T cell leukemia-1 modulates TCR signal strength and IFN-gamma levels through phosphatidylinositol 3-kinase and protein kinase C pathway activation
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 175:864-73. 2005
    ..These results also provide a more detailed mechanism for TCL1-augmented signaling and help explain the delayed occurrence of mature T cell expansions and leukemias despite tumorigenic TCL1 dysregulation that begins in early thymocytes...
  14. ncbi request reprint Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasia
    Samuel W French
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1732, USA
    Immunol Rev 187:22-39. 2002
    ..This review examines recent findings in nuclear reprogramming and cell fusion as potential causative mechanisms for transdifferentiation during normal and malignant hematopoiesis...
  15. doi request reprint Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells
    Tae Sub Park
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA
    Stem Cells 27:783-95. 2009
    ....
  16. pmc Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor
    Sanaz Memarzadeh
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cancer Cell 12:572-85. 2007
    ..We also show that transient exposure to a paracrine growth factor may be sufficient for the initiation of oncogenic transformation...
  17. ncbi request reprint Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis
    Sinisa Dovat
    Mattel Children s Hospital and Department of Pediatrics, University of California, Los Angeles, CA 90095, USA
    J Immunol 175:3508-15. 2005
    ..Taken together, these results demonstrate that silencing of Helios is critical for normal B cell function...
  18. pmc TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation
    Ali I Kuraishy
    Department of Human Genetics, and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:10175-80. 2007
    ..Our results also reconcile a paradox in which signals that activate pCREB/CBP/p300 genes concurrently repress TCL1 to initiate its silencing...
  19. doi request reprint Single-sided continuous optoelectrowetting (SCOEW) for droplet manipulation with light patterns
    Sung Yong Park
    Department of Mechanical and Aerospace Engineering, University of California at Los Angeles UCLA, 43 147 Eng IV, 420 Westwood Plaza, Los Angeles, CA 90095 1597, USA
    Lab Chip 10:1655-61. 2010
    ....
  20. ncbi request reprint A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane
    Samuel W French
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1732, USA
    Biochemistry 41:6376-82. 2002
    ..Identification of an AKT binding domain on TCL1 is an important step in deciphering the complex interactions that regulate AKT kinase activity in lymphocyte development and neoplasia within the immune system...
  21. pmc Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:14392-7. 2002
    ..Together these data demonstrate that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas...
  22. pmc ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells
    Yang Zong
    Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:12465-70. 2009
    ..Our results provide direct evidence for selective cooperating events in ERG-induced prostate tumorigenesis and offer a rational basis for combined therapeutic interventions against multiple oncogenic pathways in prostate cancer...
  23. pmc A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors
    Anne E Conway
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, USA
    Stem Cells 27:18-28. 2009
    ....
  24. pmc Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas
    Matthew J Frank
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1732, USA
    Blood 113:2478-87. 2009
    ..Combined, these results implicate epigenetic silencing of Spry2 expression in B lymphoma progression and suggest it as a companion lesion to ectopic TCL1 expression in enhancing MAPK-ERK pathway signaling...
  25. ncbi request reprint TCL1 expression and Epstein-Barr virus status in pediatric Burkitt lymphoma
    Michael A Teitell
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Clin Pathol 124:569-75. 2005
    ..However, persistent EBV is not essential for increased TCL1 expression, although elevated TCL1 and c-MYC coexpression might cooperate in the development of most pediatric and adult BL cases...
  26. doi request reprint Copy number variant analysis of human embryonic stem cells
    Hao Wu
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California 90095 1732, USA
    Stem Cells 26:1484-9. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  27. pmc An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Am J Pathol 164:893-902. 2004
    ..This pattern of expression suggests that aberrantly increased galectin-3 levels in specific B-cell populations may yield a protective advantage during transformation and/or progression of certain B-cell neoplasms...
  28. ncbi request reprint DNA methylation profiling: a new tool for evaluating hematologic malignancies
    Samuel W French
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 675 Charles E Young Dr South, MRL 4 760, Los Angeles, CA 90095 1732, USA
    Clin Immunol 103:217-30. 2002
  29. ncbi request reprint Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation
    Miranda L Moore
    Department of Pathology, Section on Tumor Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Prostate 68:139-51. 2008
    ..However, its function is unknown. We studied the effect of targeted gene deletion of PSCA on normal organ development and prostate carcinogenesis...
  30. ncbi request reprint Sp1 transactivation of the TCL1 oncogene
    Samuel W French
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Center for the Health Sciences, Los Angeles, California 90095 1732, USA
    J Biol Chem 278:948-55. 2003
    ..Together, these results indicate that Sp1 mediates transactivation of the TCL1 core promoter and that TCL1 gene silencing is not dependent on mechanisms involving Sp1 and NotI site methylation...
  31. ncbi request reprint Gene expression patterns in AIDS versus non-AIDS-related diffuse large B-cell lymphoma
    Lisa Patrone
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095 1732, USA
    Exp Mol Pathol 74:129-39. 2003
    ..Our data suggest that the increased incidence and severity of AIDS-DLBCL compared to DLBCL is likely due to crippled immune surveillance rather than to markedly different gene expression profiles...
  32. ncbi request reprint Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines
    Jeanette R Doerr
    Department of Microbiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Mol Biol 350:631-40. 2005
    ....
  33. ncbi request reprint Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks
    Sarah E Henson
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mutat Res 601:113-24. 2006
    ..Our results provide the first example of a Rad51-binding protein that influences DNA crosslink repair without affecting homologous recombination repair...
  34. ncbi request reprint The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity
    Samuel W French
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Cancer Lett 248:198-210. 2007
    ..Our data provide a novel protein interaction for mammalian PNPase that may impact TCL1 mediated transformation...
  35. pmc Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor
    Li V Yang
    Howard Hughes Medical Institute, University of California Los Angeles, 675 Charles E Young Drive South, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 27:1334-47. 2007
    ..These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing...
  36. pmc Negative regulation of NF-kappaB signaling by PIAS1
    Bin Liu
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    Mol Cell Biol 25:1113-23. 2005
    ..Consistently, Pias1 null mice showed elevated proinflammatory cytokines. Our results identify PIAS1 as a novel negative regulator of NF-kappaB...
  37. pmc Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress
    Cynthia E Balatoni
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Pathol 175:1653-61. 2009
    ..Taken together, these data indicate that SPAK loss in B-cell lymphomas promotes increased cell survival with DNA damage and provides a potential mechanism for increased resistance to genotoxic stress in cancer...
  38. ncbi request reprint Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome
    Yan Ouyang
    Department of Human Genetics, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 337:875-80. 2005
    ..Atm and Atr, therefore, not only function in responding to DNA damage but perhaps also are involved in gene silencing via the maintenance of heterochromatin...
  39. ncbi request reprint TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin
    Marco Herling
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Blood 101:5007-9. 2003
    ..These results further support derivation of BTs from DC2s, and demonstrate that TCL1 expression in this tumor is common to the immature blastoid, lymphoid-appearing, and subsequent myelomonocytic phases of this disease...
  40. ncbi request reprint TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutis
    Tony Petrella
    Centre de Pathologie, Department of Pathology, centre hospitalo universitaire du Bocage, Dijon, France
    Am J Clin Pathol 122:307-13. 2004
    ..These results suggest that TCL1 and CLA are good markers for CD4/CD56 HN tumor cells and add support for a plasmacytoid dendritic cell origin. The high skin tropism of CD4/CD56 HN might be related to the skin-homing property of CLA...
  41. pmc High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia
    Marco Herling
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, USA
    Blood 111:328-37. 2008
    ..Experimental introduction and knockdown of TCL1 influence the kinetics and strength of TCR-mediated AKT activation. We propose that in T-PLL, TCL1 represents a highly regulated, targetable modulator of TCR-mediated AKT growth signaling...
  42. ncbi request reprint Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme
    Hong Zhou
    Department of Radiation Oncology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Clin Cancer Res 13:2344-53. 2007
    ..In this study, we analyzed SOCS1 and SOCS3 gene expression in glioblastoma multiforme (GBM) and studied the role of each protein in GBM cell signaling and radiation resistance...
  43. pmc Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations
    Dominic J Smiraglia
    Department of Cancer Genetics, and Comprehensive Cancer Center, Roswell Park Cancer Institute, Buffalo, NY, USA
    BMC Genomics 8:446. 2007
    ..However, a limitation to the utility of this method has been the ability to assign specific genomic sequences to RLGS spots, a process commonly referred to as "RLGS spot cloning."..
  44. pmc B29 gene silencing in pituitary cells is regulated by its 3' enhancer
    Cindy S Malone
    Department of Biology, California State University Northridge, Northridge, CA 91330, USA
    J Mol Biol 362:173-83. 2006
    ....

Research Grants1

  1. GENES INVOLVED IN AIDS LYMPHOMAGENESIS
    Michael Teitell; Fiscal Year: 2002
    ..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..