Research Topics
Species | Michael TeitellSummaryAffiliation: University of California Country: USA Publications
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Publications
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissuesM Teitell
Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 96:9809-14. 1999..High-level expression in nonproliferating B cells suggests that TCL1 may function in protecting naïve preactivated B cells from apoptosis...
OCA-B regulation of B-cell development and functionMichael A Teitell
Departments of Pathology and Pediatrics, David Geffen School of Medicine at UCLA, University of California Los Angeles, 675 Charles Young Drive South, Los Angeles, CA 90095, USA
Trends Immunol 24:546-53. 2003..p35 can traffic to the nucleus and probably activates octamer-dependent transcription, although this OCA-B isoform might regulate B cells through membrane-related signal transduction...- Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell developmentMichael A Teitell
Department of Pathology and Laboratory Medicine, University of California at Los Angeles, 90095, USA
Pediatr Res 59:33R-9R. 2006.... - DNA methylation in the immune systemMichael Teitell
Department of Pathology and Department of Pediatrics, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095-1732, USA
Clin Immunol 109:2-5. 2003 
Molecular genetics of acute lymphoblastic leukemiaMichael A Teitell
Department of Pathology, Jonsson Comprehensive Cancer Center, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, CA 90095 1732, USA
Annu Rev Pathol 4:175-98. 2009..Here, we review the spectrum of genetic aberrations that promote acute B and T cell leukemias and the mechanisms of cell transformation and malignant progression that are reinforced by mouse models of human ALL...- Alternative control: what's WASp doing in the nucleus?Michael A Teitell
Department of Pathology, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
Sci Transl Med 2:37ps31. 2010.... - EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblastsM A Teitell
Department of Pathology, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, USA
Lab Invest 79:1535-43. 1999..This murine model, created in mesenchyme-derived NIH 3T3 cells, demonstrated new characteristics of both neuroectodermal and epithelial differentiation and resembled small round cell tumors microscopically... - The TCL1 family of oncoproteins: co-activators of transformationMichael A Teitell
Department of Pathology and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4 762 MacDonald Research Laboratories, Los Angeles, California 90095 1732, USA
Nat Rev Cancer 5:640-8. 2005..How TCL1 proteins are regulated and dysregulated, how they promote transformation and the potential for therapies modelled on TCL1 interactions have important implications for understanding and treating lymphocyte cancers... - Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditionsKen ichiro Kamei
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
Lab Chip 10:1113-9. 2010..Using clustering analysis, we were able to systematically compare the characteristics of various hPSC lines in different conditions... - High-speed droplet generation on demand driven by pulse laser-induced cavitationSung Yong Park
Department of Mechanical and Aerospace Engineering, University of California at Los Angeles UCLA, 43 147 Eng IV, 420 Westwood Plaza, Los Angeles, CA 90095 1597, USA
Lab Chip 11:1010-2. 2011..Injected droplet volumes can be continuously tuned between 1 pL and 150 pL with less than 1% volume variation... - Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformationRhine R Shen
Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
Blood 108:1991-8. 2006..We conclude that pEmu-B29-TCL1 transgenic B cells primed for transformation must experience the GC environment and, for at least some, develop genome instability to become fully malignant... - AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signalingMara H Sherman
Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Mol Cell 39:873-85. 2010..Combined, our data show that CRTC2 inactivation, via physiologic DNA damage response signaling, promotes B cell differentiation in response to genotoxic stress... - T cell leukemia-1 modulates TCR signal strength and IFN-gamma levels through phosphatidylinositol 3-kinase and protein kinase C pathway activationKatrina K Hoyer
Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Immunol 175:864-73. 2005..These results also provide a more detailed mechanism for TCL1-augmented signaling and help explain the delayed occurrence of mature T cell expansions and leukemias despite tumorigenic TCL1 dysregulation that begins in early thymocytes... - Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasiaSamuel W French
Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1732, USA
Immunol Rev 187:22-39. 2002..This review examines recent findings in nuclear reprogramming and cell fusion as potential causative mechanisms for transdifferentiation during normal and malignant hematopoiesis... - Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cellsTae Sub Park
Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA
Stem Cells 27:783-95. 2009.... - Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptorSanaz Memarzadeh
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cancer Cell 12:572-85. 2007..We also show that transient exposure to a paracrine growth factor may be sufficient for the initiation of oncogenic transformation... - Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesisSinisa Dovat
Mattel Children s Hospital and Department of Pediatrics, University of California, Los Angeles, CA 90095, USA
J Immunol 175:3508-15. 2005..Taken together, these results demonstrate that silencing of Helios is critical for normal B cell function... - TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformationAli I Kuraishy
Department of Human Genetics, and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:10175-80. 2007..Our results also reconcile a paradox in which signals that activate pCREB/CBP/p300 genes concurrently repress TCL1 to initiate its silencing... - Single-sided continuous optoelectrowetting (SCOEW) for droplet manipulation with light patternsSung Yong Park
Department of Mechanical and Aerospace Engineering, University of California at Los Angeles UCLA, 43 147 Eng IV, 420 Westwood Plaza, Los Angeles, CA 90095 1597, USA
Lab Chip 10:1655-61. 2010.... - A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membraneSamuel W French
Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1732, USA
Biochemistry 41:6376-82. 2002..Identification of an AKT binding domain on TCL1 is an important step in deciphering the complex interactions that regulate AKT kinase activity in lymphocyte development and neoplasia within the immune system... - Dysregulated TCL1 promotes multiple classes of mature B cell lymphomaKatrina K Hoyer
Department of Pathology and Laboratory Medicine, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 99:14392-7. 2002..Together these data demonstrate that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas... - ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cellsYang Zong
Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:12465-70. 2009..Our results provide direct evidence for selective cooperating events in ERG-induced prostate tumorigenesis and offer a rational basis for combined therapeutic interventions against multiple oncogenic pathways in prostate cancer... - A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumorsAnne E Conway
Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, USA
Stem Cells 27:18-28. 2009.... - Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomasMatthew J Frank
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1732, USA
Blood 113:2478-87. 2009..Combined, these results implicate epigenetic silencing of Spry2 expression in B lymphoma progression and suggest it as a companion lesion to ectopic TCL1 expression in enhancing MAPK-ERK pathway signaling... - TCL1 expression and Epstein-Barr virus status in pediatric Burkitt lymphomaMichael A Teitell
Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Clin Pathol 124:569-75. 2005..However, persistent EBV is not essential for increased TCL1 expression, although elevated TCL1 and c-MYC coexpression might cooperate in the development of most pediatric and adult BL cases... - Copy number variant analysis of human embryonic stem cellsHao Wu
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California 90095 1732, USA
Stem Cells 26:1484-9. 2008..Disclosure of potential conflicts of interest is found at the end of this article... - An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomasKatrina K Hoyer
Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90095-1732, USA
Am J Pathol 164:893-902. 2004..This pattern of expression suggests that aberrantly increased galectin-3 levels in specific B-cell populations may yield a protective advantage during transformation and/or progression of certain B-cell neoplasms... - DNA methylation profiling: a new tool for evaluating hematologic malignanciesSamuel W French
Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 675 Charles E. Young Dr. South, MRL 4-760, Los Angeles, CA 90095-1732, USA
Clin Immunol 103:217-30. 2002 - Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formationMiranda L Moore
Department of Pathology, Section on Tumor Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
Prostate 68:139-51. 2008..However, its function is unknown. We studied the effect of targeted gene deletion of PSCA on normal organ development and prostate carcinogenesis... - Sp1 transactivation of the TCL1 oncogeneSamuel W French
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Center for the Health Sciences, Los Angeles, California 90095 1732, USA
J Biol Chem 278:948-55. 2003..Together, these results indicate that Sp1 mediates transactivation of the TCL1 core promoter and that TCL1 gene silencing is not dependent on mechanisms involving Sp1 and NotI site methylation... - Gene expression patterns in AIDS versus non-AIDS-related diffuse large B-cell lymphomaLisa Patrone
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095-1732, USA
Exp Mol Pathol 74:129-39. 2003..Our data suggest that the increased incidence and severity of AIDS-DLBCL compared to DLBCL is likely due to crippled immune surveillance rather than to markedly different gene expression profiles... - Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell linesJeanette R Doerr
Department of Microbiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
J Mol Biol 350:631-40. 2005.... - Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaksSarah E Henson
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Mutat Res 601:113-24. 2006..Our results provide the first example of a Rad51-binding protein that influences DNA crosslink repair without affecting homologous recombination repair... - The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activitySamuel W French
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
Cancer Lett 248:198-210. 2007..Our data provide a novel protein interaction for mammalian PNPase that may impact TCL1 mediated transformation... - Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensorLi V Yang
Howard Hughes Medical Institute, University of California Los Angeles, 675 Charles E Young Drive South, Los Angeles, CA 90095 1662, USA
Mol Cell Biol 27:1334-47. 2007..These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing... - Negative regulation of NF-kappaB signaling by PIAS1Bin Liu
Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
Mol Cell Biol 25:1113-23. 2005..Consistently, Pias1 null mice showed elevated proinflammatory cytokines. Our results identify PIAS1 as a novel negative regulator of NF-kappaB... - Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stressCynthia E Balatoni
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Pathol 175:1653-61. 2009..Taken together, these data indicate that SPAK loss in B-cell lymphomas promotes increased cell survival with DNA damage and provides a potential mechanism for increased resistance to genotoxic stress in cancer... - Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosomeYan Ouyang
Department of Human Genetics, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Biochem Biophys Res Commun 337:875-80. 2005..Atm and Atr, therefore, not only function in responding to DNA damage but perhaps also are involved in gene silencing via the maintenance of heterochromatin... - TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skinMarco Herling
Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
Blood 101:5007-9. 2003..These results further support derivation of BTs from DC2s, and demonstrate that TCL1 expression in this tumor is common to the immature blastoid, lymphoid-appearing, and subsequent myelomonocytic phases of this disease... - TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutisTony Petrella
Centre de Pathologie, Department of Pathology, Centre Hospitalo-Universitaire du Bocage, Dijon, France
Am J Clin Pathol 122:307-13. 2004..These results suggest that TCL1 and CLA are good markers for CD4/CD56 HN tumor cells and add support for a plasmacytoid dendritic cell origin. The high skin tropism of CD4/CD56 HN might be related to the skin-homing property of CLA... - High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemiaMarco Herling
Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, USA
Blood 111:328-37. 2008..Experimental introduction and knockdown of TCL1 influence the kinetics and strength of TCR-mediated AKT activation. We propose that in T-PLL, TCL1 represents a highly regulated, targetable modulator of TCR-mediated AKT growth signaling... - Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiformeHong Zhou
Department of Radiation Oncology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
Clin Cancer Res 13:2344-53. 2007..In this study, we analyzed SOCS1 and SOCS3 gene expression in glioblastoma multiforme (GBM) and studied the role of each protein in GBM cell signaling and radiation resistance... - Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinationsDominic J Smiraglia
Department of Cancer Genetics, and Comprehensive Cancer Center, Roswell Park Cancer Institute, Buffalo, NY, USA
BMC Genomics 8:446. 2007..However, a limitation to the utility of this method has been the ability to assign specific genomic sequences to RLGS spots, a process commonly referred to as "RLGS spot cloning.".. - B29 gene silencing in pituitary cells is regulated by its 3' enhancerCindy S Malone
Department of Biology, California State University Northridge, Northridge, CA 91330, USA
J Mol Biol 362:173-83. 2006....
Research Grants
- GENES INVOLVED IN AIDS LYMPHOMAGENESISMichael Teitell; Fiscal Year: 2002..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..