Daniel Teitelbaum

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc A decade of experience with the primary pull-through for hirschsprung disease in the newborn period: a multicenter analysis of outcomes
    D H Teitelbaum
    Department of Surgery, Section of Pediatric Surgery, the University of Michigan Medical Center and the C S Mott Children s Hospital, Ann Arbor, Michigan 48109, USA
    Ann Surg 232:372-80. 2000
  2. pmc Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition
    Weidong Xiao
    1Section of Pediatric Surgery, University of Michigan, Mott Children s Hospital F3970, Ann Arbor, MI 48109 5245, USA
    FASEB J 28:2073-87. 2014
  3. pmc Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation
    Farokh R Demehri
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Health System Ann Arbor, MI, USA
    Front Cell Infect Microbiol 3:105. 2013
  4. pmc Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition
    Yongjia Feng
    Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 4211, USA
    J Physiol 591:3709-23. 2013
  5. doi request reprint Drug shortage-associated increase in catheter-related blood stream infection in children
    Matthew W Ralls
    Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and The CS Mott Children s Hospital, Ann Arbor, Michigan, USA
    Pediatrics 130:e1369-73. 2012
  6. ncbi request reprint Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasis
    Daniel H Teitelbaum
    Department of Surgery, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109 0245, USA
    Pediatrics 115:1332-40. 2005
  7. ncbi request reprint Primary pull-through for Hirschsprung's disease
    Daniel H Teitelbaum
    Section of Pediatric Surgery, F 3970, C S Mott Children s Hospital, University of Michigan Medical School, P O Box 0245, Ann Arbor, MI 48109, USA
    Semin Neonatol 8:233-41. 2003
  8. pmc Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition
    Yongjia Feng
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, Michigan MI 48109 5245, USA
    Am J Physiol Gastrointest Liver Physiol 302:G236-49. 2012
  9. ncbi request reprint Excision of large cystic ovarian tumors: combining minimal invasive surgery techniques and cancer surgery--the best of both worlds
    Peter F Ehrlich
    Department of Pediatric Surgery, University of Michigan Medical School, C S Mott Children s Hospital Box 0231, Ann Arbor, MI 48109, USA
    J Pediatr Surg 42:890-3. 2007
  10. ncbi request reprint Parenteral nutrition-associated cholestasis in neonates: multivariate analysis of the potential protective effect of taurine
    Ariel U Spencer
    Department of Surgery, University of Michigan, and C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
    JPEN J Parenter Enteral Nutr 29:337-43; discussion 343-4. 2005

Research Grants

  1. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2004
  2. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2005
  3. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2006
  4. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel H Teitelbaum; Fiscal Year: 2010
  5. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2007
  6. Enterogenesis with the Use of an Implanted Mechanotransduction Device
    Daniel Teitelbaum; Fiscal Year: 2007

Collaborators

  • R B Hirschl
  • Saleem Islam
  • Peter F Ehrlich
  • R J Shulman
  • Risto J Rintala
  • Patricia A DeRusso
  • Hua Yang
  • Arnold G Coran
  • Kristine D Slam
  • A I Koivusalo
  • M P Pakarinen
  • Jacob Langer
  • M Petrea Cober
  • Yongjia Feng
  • Barbara E Wildhaber
  • Ariel U Spencer
  • Yuko Tazuke
  • Xiaoyi Sun
  • Robert A Drongowski
  • James D Geiger
  • Matthew W Ralls
  • Eiichi A Miyasaka
  • Anne C Kim
  • Ryan P Davis
  • Keisuke Nose
  • Hiroyuki Koga
  • Enno Stranzinger
  • Peter J Strouse
  • Weidong Xiao
  • Farokh R Demehri
  • Jennifer D Lobo
  • George B Mychaliska
  • Julia Serber
  • Irfan Kiristioglu
  • Satoko Nose
  • Chaojun Zhang
  • Rupa Seetharamaiah
  • Jennifer N Chamberlain
  • Mohamed I El-Sawaf
  • Emir Q Haxhija
  • Susan Tsai
  • Imad Btaiche
  • Aladdein F Mattar
  • Marjorie J Arca
  • Joseph L Lelli
  • Jens J Holst
  • Kathleen Van Leeuwen
  • Bolette Hartmann
  • Meredith Barrett
  • Meghan A Arnold
  • R Alexander Blackwood
  • M Luisa Partipilo
  • James Dimond
  • Mary Beth Harris
  • Erin K Tkach
  • Pamela I Brown
  • Matthew D Neal
  • Eiichi Miyasaka
  • Cornelius E J Sloots
  • Aimee C Pastor
  • Bradley J Segura
  • David J Hackam
  • Hilary Alpert
  • Nicolaas M A Bax
  • Patrick A Dillon
  • Nicholas A Hamilton
  • Shirley Kadoura
  • Brian T Craig
  • Jonathan E McDunn
  • Lingling Zhang
  • Kathleen Skipton
  • Donald C Liu
  • Sarah J Ignash
  • Brady T West
  • Marjorie C Treadwell
  • Michael A DiPietro
  • Michelle McKinney-Barnett
  • Julie Canham
  • Debra Kovacevich
  • Christopher Maksym
  • Deanna Hair
  • Joseph Washburn
  • Andreea Neaga
  • Jonathan I Groner
  • Jacqueline Dahlgren
  • Thomas F Tracy
  • Morton B Brown
  • Pamela Brown
  • Adolfo Llanos
  • Sunkyung Yu

Detail Information

Publications56

  1. pmc A decade of experience with the primary pull-through for hirschsprung disease in the newborn period: a multicenter analysis of outcomes
    D H Teitelbaum
    Department of Surgery, Section of Pediatric Surgery, the University of Michigan Medical Center and the C S Mott Children s Hospital, Ann Arbor, Michigan 48109, USA
    Ann Surg 232:372-80. 2000
    ..To determine whether use of a primary pull-through would result in equivalent perioperative and long-term complications compared with the two-stage approach...
  2. pmc Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition
    Weidong Xiao
    1Section of Pediatric Surgery, University of Michigan, Mott Children s Hospital F3970, Ann Arbor, MI 48109 5245, USA
    FASEB J 28:2073-87. 2014
    ..Xiao, W., Feng, Y., Holst, J. J., Hartmann, B., Yang, H., Teitelbaum, D. H. Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition. ..
  3. pmc Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation
    Farokh R Demehri
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Health System Ann Arbor, MI, USA
    Front Cell Infect Microbiol 3:105. 2013
    ..These mechanisms identify potential strategies of protecting against TPN-related complications, such as modification of luminal bacteria, blockade of proinflammatory cytokines, or growth factor replacement. ..
  4. pmc Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition
    Yongjia Feng
    Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 4211, USA
    J Physiol 591:3709-23. 2013
    ..Nuclear factor-B and MLCK signalling appear to be important downstream mediators involved in this TNF-α signalling process...
  5. doi request reprint Drug shortage-associated increase in catheter-related blood stream infection in children
    Matthew W Ralls
    Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and The CS Mott Children s Hospital, Ann Arbor, Michigan, USA
    Pediatrics 130:e1369-73. 2012
    ..To conserve supply, we reduced ELT frequency from a daily regimen. We examined the impact that reduction in ELT frequency had on CRBSI in pediatric IF patients...
  6. ncbi request reprint Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasis
    Daniel H Teitelbaum
    Department of Surgery, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109 0245, USA
    Pediatrics 115:1332-40. 2005
    ..To determine whether cholecystokinin-octapeptide (CCK-OP) would prevent or ameliorate parenteral nutrition-associated cholestasis (PNAC) among high-risk neonates treated with total parenteral nutrition...
  7. ncbi request reprint Primary pull-through for Hirschsprung's disease
    Daniel H Teitelbaum
    Section of Pediatric Surgery, F 3970, C S Mott Children s Hospital, University of Michigan Medical School, P O Box 0245, Ann Arbor, MI 48109, USA
    Semin Neonatol 8:233-41. 2003
    ..The purpose of this review is to discuss the technique of primary pull-through, the peri-operative management and a summary of clinical results...
  8. pmc Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition
    Yongjia Feng
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, Michigan MI 48109 5245, USA
    Am J Physiol Gastrointest Liver Physiol 302:G236-49. 2012
    ..It emphasizes the importance of both TNFR1 and TNFR2 pathways, as well as the strong interdependence on an intact EGF/ErbB1 pathway...
  9. ncbi request reprint Excision of large cystic ovarian tumors: combining minimal invasive surgery techniques and cancer surgery--the best of both worlds
    Peter F Ehrlich
    Department of Pediatric Surgery, University of Michigan Medical School, C S Mott Children s Hospital Box 0231, Ann Arbor, MI 48109, USA
    J Pediatr Surg 42:890-3. 2007
    ..Up to 57% of malignant ovarian tumors have a cystic component. We present an approach to these neoplasms that adheres to oncologic principles using minimally invasive techniques...
  10. ncbi request reprint Parenteral nutrition-associated cholestasis in neonates: multivariate analysis of the potential protective effect of taurine
    Ariel U Spencer
    Department of Surgery, University of Michigan, and C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
    JPEN J Parenter Enteral Nutr 29:337-43; discussion 343-4. 2005
    ..We determined whether taurine supplementation reduces the incidence of PNAC in premature or critically ill neonates...
  11. doi request reprint Risk stratification in gastroschisis: can prenatal evaluation or early postnatal factors predict outcome?
    Ryan P Davis
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Hospitals, Mott Children s Hospital F3970, Box 0245, Ann Arbor, MI 48109, USA
    Pediatr Surg Int 25:319-25. 2009
    ..We evaluated the prognostic value of prenatal ultrasonographic parameters and early postnatal factors in predicting clinical outcomes...
  12. ncbi request reprint Prevention of parenteral nutrition-associated liver disease: lipid minimization
    M Petrea Cober
    Department of Pharmacy, University of Michigan Hospitals and Health Centers, and CS Mott Children s Hospital, Ann Arbor, Michigan, USA
    Curr Opin Organ Transplant 15:330-3. 2010
    ..The cause of parenteral nutrition-associated liver disease (PNALD) is unknown. Evidence over the past decade has suggested soybean oil-based intravenous emulsions are a contributing factor to the development of PNALD...
  13. ncbi request reprint Failure of cholecystokinin-octapeptide to prevent TPN-associated gallstone disease
    Susan Tsai
    Section of Pediatric Surgery, CS Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Pediatr Surg 40:263-7. 2005
    ..The authors hypothesized that the use of cholecystokinin-octapeptide (CCK), given at the time of TPN administration, would prevent gallstone formation in a high-risk group of patients with TPN...
  14. pmc Alteration of canalicular transporters in a mouse model of total parenteral nutrition
    Yuko Tazuke
    Department of Surgery, University of Michigan Medical School, Ann Arbor, USA
    J Pediatr Gastroenterol Nutr 48:193-202. 2009
    ..The present study hypothesized that these changes would lead to functional changes in the liver, and would contribute to the development of liver dysfunction...
  15. ncbi request reprint Hepatic P-glycoprotein changes with total parenteral nutrition administration
    Yuko Tazuke
    University of Michigan Medical School, Section of Pediatric Surgery, Department of Surgery, F3970 Mott Children s Hospital, Ann Arbor, Michigan 48109 0245, USA
    JPEN J Parenter Enteral Nutr 28:1-6. 2004
    ..Mice lacking mdr2 expression develop liver disease that appears similar to PNALD. This study investigated the alteration in the expression of these transport proteins during the administration of total parenteral nutrition (TPN)...
  16. doi request reprint Association of gastroschisis and choledochal cyst
    Julia Serber
    Section of Pediatric Surgery, C S Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Pediatr Surg 44:e23-6. 2009
    ..The cases are a novel association not previously reported and should heighten the awareness that anatomical causes of a direct hyperbilirubinemia need to be ruled out in all neonates...
  17. pmc Pediatric short bowel syndrome: redefining predictors of success
    Ariel U Spencer
    Departments of Surgery, University of Michigan, C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
    Ann Surg 242:403-9; discussion 409-12. 2005
    ..To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients...
  18. pmc Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administration
    Hua Yang
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Ann Surg 248:849-56. 2008
    ..Previous work shows that TPN results in a loss of intestinal epithelial cell-derived interleukin-7 (IL-7), and this loss may play an important role in development of such TPN-associated IEL changes...
  19. doi request reprint Imaging of total colonic Hirschsprung disease
    Enno Stranzinger
    Section of Pediatric Radiology, University of Michigan Health System, Ann Arbor, MI 48109 0252, USA
    Pediatr Radiol 38:1162-70. 2008
    ..The diagnosis of total colonic HD (TCHD) based on contrast enemas is difficult in newborns because radiological findings vary...
  20. doi request reprint The adolescent child with short bowel syndrome: new onset of failure to thrive and need for increased nutritional supplementation
    Eiichi A Miyasaka
    Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0245, USA
    J Pediatr Surg 45:1280-6. 2010
    ..This study aims to identify characteristics of adolescent SBS patients to better understand their nutritional status...
  21. ncbi request reprint Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition
    Xiaoyi Sun
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 0245, USA
    Am J Physiol Gastrointest Liver Physiol 294:G139-47. 2008
    ..As the decline was partially attenuated with the administration of exogenous IL-10, our findings suggest that loss of IL-10 may be a contributing mechanism to TPN-associated epithelial barrier loss...
  22. ncbi request reprint Multiple sequential intussusceptions causing bowel obstruction in a preterm neonate
    Kristine D Slam
    Department of Surgery, University of Toledo, Health Science Campus, Toledo, Ohio, USA
    J Pediatr Surg 42:1279-81. 2007
    ..1955;47:87-94; Pediatr Surg Int. 1998;13:232-236; Ann Saudi Med. 2000; 20:310-312; Eur J Pediatr. 1999;158:830-832; J Paedatr Child Health. 2004;40:388-391; Radiology. 1977;125:463-466; J Perinat Med. 2004;32:190-194)...
  23. ncbi request reprint Pediatric short-bowel syndrome: the cost of comprehensive care
    Ariel U Spencer
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Am J Clin Nutr 88:1552-9. 2008
    ..Little information is available about the financial charges incurred by patients with short-bowel syndrome (SBS). This is particularly true for pediatric SBS patients who receive some of the most complex medical care...
  24. doi request reprint Endorectal pull-through for Hirschsprung's disease-a multicenter, long-term comparison of results: transanal vs transabdominal approach
    Anne C Kim
    Department of Surgery, Section of Pediatric Surgery, University of Michigan, Ann Arbor, Michigan 48109 0245, USA
    J Pediatr Surg 45:1213-20. 2010
    ..To address this, we examined long-term stooling outcomes in a large, multicenter cohort of patients undergoing either TERP or TAA...
  25. pmc Dissociation of E-cadherin and beta-catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophy
    Yongjia Feng
    Section of Pediatric Surgery, University of Michigan, Mott Children s Hospital F3970, Ann Arbor, MI 48109 5245, USA
    J Physiol 587:641-54. 2009
    ..This potential pathway may well explain many of the findings of mucosal atrophy associated with TPN...
  26. ncbi request reprint MUC-2 mucin production in Hirschsprung's disease: possible association with enterocolitis development
    Aladdein F Mattar
    Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, Michigan 48109, USA
    J Pediatr Surg 38:417-21; discussion 417-21. 2003
    ..Based on this, it was hypothesized that those patients with Hirschsprung's disease (HD) would have an abnormal production of MUC-2 compared with normal patients...
  27. pmc The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition
    Chaojun Zhang
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
    J Nutr 139:1315-21. 2009
    ..The results suggest that the BMP signaling pathway may be involved in the development of intestinal mucosal atrophy due to TPN administration...
  28. doi request reprint No free ride? The hidden costs of delayed operative management using a spring-loaded silo for gastroschisis
    Jennifer D Lobo
    Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and The C S Mott Children s Hospital, Box 0245, Ann Arbor, MI 48109, USA
    J Pediatr Surg 45:1426-32. 2010
    ..Despite the ease of silo placement, anecdotal experience shows that silos do not always offer benefit. The aim of this study was to highlight concerns regarding use of spring loaded silos and compare outcomes to primary closure...
  29. pmc Enteral versus parenteral nutrition: effect on intestinal barrier function
    Hua Yang
    Department of Surgery, The University of Michigan Medical School, Ann Arbor, Michigan, USA
    Ann N Y Acad Sci 1165:338-46. 2009
    ..This article discusses the potential mechanisms responsible for these changes, and potential strategies to alleviate this loss in EBF...
  30. ncbi request reprint Outcomes in pediatric patients undergoing straight vs J pouch ileoanal anastomosis: a multicenter analysis
    Rupa Seetharamaiah
    Section of Pediatric Surgery, C S Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Pediatr Surg 44:1410-7. 2009
    ..Our 3 centers have had extensive experience with both techniques. Thus, we had the unique opportunity to compare outcomes within the same centers...
  31. pmc Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function
    Keisuke Nose
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and the C S Mott Children s Hospital, Ann Arbor, Michigan 48109 0245, USA
    J Interferon Cytokine Res 30:67-80. 2010
    ..Glutamine-supplemented TPN leads to a specific IEL-derived cytokine profile, which may account for the preservation of EBF; and such action may be due to a direct action of glutamine on the IEL...
  32. pmc Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy
    Yongjia Feng
    Section of Pediatric Surgery, Univ of Michigan, Mott Children s Hospital F3970, Ann Arbor, MI 48109 5245, USA
    Am J Physiol Gastrointest Liver Physiol 298:G833-41. 2010
    ....
  33. ncbi request reprint The 2 STEP: an approach to repeating a serial transverse enteroplasty
    Peter F Ehrlich
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Pediatr Surg 42:819-22. 2007
    ..However, postlengthening dilatation may occur, which can lead to bacterial overgrowth and malabsorption. We addressed this problem by reperforming the STEP in 2 patients...
  34. ncbi request reprint Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: modulation by keratinocyte growth factor
    Barbara E Wildhaber
    Section of Pediatric Surgery, C S Mott Children s Hospital, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Surg Res 112:144-51. 2003
    ..We further determined mRNA expression of Bcl-2 family members (major mediators of epithelial cell apoptosis) with TPN and whether KGF administration influences Bcl-2 family expression in EC...
  35. ncbi request reprint Gene alteration of intestinal intraepithelial lymphocytes with administration of total parenteral nutrition
    Barbara E Wildhaber
    Section of Pediatric Surgery, Department of Surgery, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    J Pediatr Surg 38:840-3. 2003
    ..This may be a mechanism by which bacteria and toxins endanger individuals receiving TPN. To identify altered IEL gene expression during TPN administration, microarray assays were used...
  36. ncbi request reprint Reoperative surgery for Hirschsprung's disease
    Daniel H Teitelbaum
    Section of Pediatric Surgery F3970, Department of Surgery, C S Mott Children s Hospital, Box 0245, University of Michigan, Ann Arbor, MI 48109, USA
    Semin Pediatr Surg 12:124-31. 2003
    ..This article reviews the workup, indications, and techniques for these procedures and discusses previously published, as well as the authors' outcome, with these 2 procedures...
  37. ncbi request reprint Alteration in epithelial permeability and ion transport in a mouse model of total parenteral nutrition
    Hua Yang
    Section of Pediatric Surgery, University of Michigan Hospitals, Mott F3970, Box 0245, Ann Arbor, MI 48109, USA
    Crit Care Med 31:1118-25. 2003
    ..Additionally, to assess the role of interferon-gamma on the total parenteral nutrition-induced loss of epithelial barrier function...
  38. ncbi request reprint Keratinocyte growth factor decreases total parenteral nutrition-induced apoptosis in mouse intestinal epithelium via Bcl-2
    Barbara E Wildhaber
    University of Michigan, Department of Pediatric Surgery, C S Mott Children s Hospital, Ann Arbor, MI, USA
    J Pediatr Surg 38:92-6; discussion 92-6. 2003
    ..This study aims to determine if mRNA expression of Bcl-2 proteins (major mediators of epithelial cell apoptosis) is altered with TPN, and if KGF-administration influences Bcl-2 family expression...
  39. ncbi request reprint Intraepithelial lymphocyte-derived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in mice
    Hua Yang
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 284:G629-37. 2003
    ..This may well be one of the mediators of increased EC apoptosis observed with TPN administration...
  40. ncbi request reprint 2002 Harry M. Vars Research Award. Keratinocyte growth factor stimulates the recovery of epithelial structure and function in a mouse model of total parenteral nutrition
    Hua Yang
    Department of Surgery, University of Michigan Medical School, C S Mott Children s Hospital, Ann Arbor, USA
    JPEN J Parenter Enteral Nutr 26:333-40; discussion 340-1. 2002
    ..Because total parenteral nutrition (TPN) leads to villus atrophy and a loss of epithelial function, we hypothesized that KGF administration could reverse these changes...
  41. ncbi request reprint Stooling and manometric findings after primary pull-throughs in Hirschsprung's disease: Perineal versus abdominal approaches
    Kathleen Van Leeuwen
    Section of Pediatric Surgery, Division of Gastroenterology, Department of Surgery, The University of Michigan Medical Center, Ann Arbor, MI, USA
    J Pediatr Surg 37:1321-5. 2002
    ..This study examined early stooling patterns, anal sphincteric pressures, and number of enterocolitic episodes in infants who underwent a PA. Results were compared with a conventional combined transabdominal and perineal approach (TA)...
  42. pmc Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutrition
    Hua Yang
    Section of Pediatric Surgery, The University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, Michigan, USA
    Ann Surg 236:226-34. 2002
    ..To determine the etiology of the loss of epithelial barrier function observed with the administration of total parenteral nutrition (TPN) in a mouse model...
  43. ncbi request reprint The Kasai portoenterostomy for biliary atresia: A review of a 27-year experience with 81 patients
    Barbara E Wildhaber
    Department of Surgery, Section of Pediatric Surgery, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    J Pediatr Surg 38:1480-5. 2003
    ..The aim of this study was to utilize clinical outcome methodology through multivariable analysis of perioperative factors to predict a successful Kasai-portoenterostomy (PE)...
  44. ncbi request reprint Early experience with minimally invasive repair of congenital diaphragmatic hernias: results and lessons learned
    Marjorie J Arca
    Department of Surgery, University of Michigan Medical School and the C S Mott Children s Hospital, Ann Arbor, MI 53226, USA
    J Pediatr Surg 38:1563-8. 2003
    ..Minimally invasive surgery (MIS) for the repair of congenital diaphragmatic hernias (CDH) had been described. This report reviews the authors' experience with MIS repairs of CDH and discusses the technical development of this approach...
  45. ncbi request reprint Esophagogastric separation for failed fundoplication in neurologically impaired children
    Saleem Islam
    Section of Pediatric Surgery, CS Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI 48109 0245, USA
    J Pediatr Surg 39:287-91; discussion 287-91. 2004
    ..The authors report a series of esophagogastric separation (EGS) procedures aimed at the management of failed fundoplication in neurologically impaired children...
  46. ncbi request reprint Total parenteral nutrition leads to alteration of hepatocyte cell cycle gene expression and proliferation in the mouse
    Yuko Tazuke
    Section of Pediatric Surgery, C S Mott Children s Hospital, Department of Surgery, University of Michigan Medical School, F3970 Mott Children s Hospital, Box 0245, Ann Arbor, MI 48109, USA
    Dig Dis Sci 52:920-30. 2007
    ..This study demonstrates significant alterations in cell cycle gene expression with TPN. The findings correlate with a loss of hepatocyte proliferation and may give insight into the potential mechanism of TPN-induced hepatocyte injury...
  47. pmc Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition
    Hua Yang
    Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and The C S Mott Children s Hospital, Ann Arbor, Michigan, USA
    Am J Physiol Gastrointest Liver Physiol 292:G84-91. 2007
    ..These findings suggest that a decrease in EC-derived IL-7 expression may be a contributing mechanism to account for the observed TPN-associated IEL changes...
  48. ncbi request reprint Are the long-term results of the transanal pull-through equal to those of the transabdominal pull-through? A comparison of the 2 approaches for Hirschsprung disease
    Mohamed I El-Sawaf
    Section of Pediatric Surgery, The C S Mott s Children s Hospital, University of Michigan, Ann Arbor, MI 48109 0245, USA
    J Pediatr Surg 42:41-7; discussion 47. 2007
    ..This study examined the long-term outcome of TERPT versus conventional transabdominal (ABD) pull-through for HD...
  49. pmc Impact of caloric intake on parenteral nutrition-associated intestinal morphology and mucosal barrier function
    Xiaoyi Sun
    Department of Surgery, Section of Pediatric Surgery, University of Michigan, Mott Children s Hospital, Ann Arbor, Michigan 48109, USA
    JPEN J Parenter Enteral Nutr 30:474-9. 2006
    ..The study hypothesized that increasing amounts of energy delivery to mice would result in the best outcome, with the least effects on the mucosa...
  50. ncbi request reprint Total colonic Hirschsprung's disease: a 28-year experience
    Barbara E Wildhaber
    Section of Pediatric Surgery, CS Mott Children s Hospital, University of Michigan Medical School, Health System, Ann Arbor, MI 48109 0245, USA
    J Pediatr Surg 40:203-6; discussion 206-7. 2005
    ..The aim of this study was to review outcomes after surgical treatment of total colonic Hirschsprung's disease (TCH)...
  51. ncbi request reprint Lack of enteral nutrition--effects on the intestinal immune system
    Barbara E Wildhaber
    Section of Pediatric Surgery, C S Mott Children s Hospital, University of Michigan Health System, Ann Arbor, Michigan 48109 0245, USA
    J Surg Res 123:8-16. 2005
    ..We hypothesized that the observed changes with TPN administration are caused by the lack of enteral feeding, and not to the TPN solution itself...
  52. ncbi request reprint Posterior myotomy/myectomy for persistent stooling problems in Hirschsprung's disease
    Barbara E Wildhaber
    Section of Pediatric Surgery, C S Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI, USA
    J Pediatr Surg 39:920-6; discussion 920-6. 2004
    ..Posterior myotomy/myectomy (POMM) are possible options for these problems. This study analyzed the outcome of POMM in HD patients post-PT...
  53. ncbi request reprint Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)
    Yuko Tazuke
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children s Hospital, Ann Arbor, MI 48109 0245, USA
    Pediatr Surg Int 20:224-8. 2004
    ..05). These changes may contribute to TPN-induced hepatocyte injury (apoptosis) or suppress the ability of liver hepatocytes to regenerate...
  54. ncbi request reprint Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse
    Hua Yang
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 172:4151-8. 2004
    ..These results show that KGF from IELs is an important factor for maintenance of intestinal epithelial cell proliferation and villus growth...
  55. ncbi request reprint Total parenteral nutrition-associated changes in mouse intestinal intraepithelial lymphocytes
    Irfan Kiristioglu
    Department of Surgery, University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor 48109, USA
    Dig Dis Sci 47:1147-57. 2002
    ..Functionally, the IEL showed a significant decline in proliferation. Such changes demonstrate the important role luminal nutrients have on IEL phenotype and function...
  56. pmc One-stage transanal Soave pullthrough for Hirschsprung disease: a multicenter experience with 141 children
    Jacob C Langer
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Ann Surg 238:569-83; discussion 583-5. 2003
    ..We reviewed the early results of the transanal Soave pullthrough from 6 of the original centers to use it...

Research Grants8

  1. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2004
    ..This may lead to methods to prevent such problems. ..
  2. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2005
    ..This may lead to methods to prevent such problems. ..
  3. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2006
    ..This may lead to methods to prevent such problems. ..
  4. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel H Teitelbaum; Fiscal Year: 2010
    ....
  5. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel Teitelbaum; Fiscal Year: 2007
    ..This may lead to methods to prevent such problems. ..
  6. Enterogenesis with the Use of an Implanted Mechanotransduction Device
    Daniel Teitelbaum; Fiscal Year: 2007
    ..Knowledge gained from this project could greatly improve the care of patients who suffer from short bowel syndrome. ..