Research Topics
| K L TeffSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in womenKaren L Teff
Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
J Clin Endocrinol Metab 89:2963-72. 2004....- Tasting fat: cephalic phase hormonal responses and food intake in restrained and unrestrained eatersSusan R Crystal
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, United States
Physiol Behav 89:213-20. 2006..05). In conclusion, the sensory experience of tasting fat increases food intake in restrained eaters and increases vagal efferent activity compared to a non-fat food in both populations... - Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and genderK L Teff
Monell Chemical Senses Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Physiol 276:R707-14. 1999..These data suggest that obese subjects exhibit altered gastric cholinergic activity compared with lean subjects and that gender differences in gastric emptying rate may be due to differences in autonomic tone... 
How neural mediation of anticipatory and compensatory insulin release helps us tolerate foodKaren L Teff
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, United States
Physiol Behav 103:44-50. 2011..The necessary stimuli required to elicit CPIR and vagal activation are discussed and the role of CPIR and vagal efferent activation in intra-meal metabolic homeostasis and during chronic nutritional challenges are reviewed...- Cephalic phase pancreatic polypeptide responses to liquid and solid stimuli in humansKaren L Teff
Monell Chemical Senses Center, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, PA 19104, United States
Physiol Behav 99:317-23. 2010..4+/-88.7 pg/ml/30 min; p<0.05). These data suggest that liquids and chewing gum do not provide adequate stimulation for vagal efferent activation in humans and that mixed nutrient foods are the optimal stimuli... - Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responsesKaren L Teff
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 94:1562-9. 2009..The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied... 
Visceral nerves: vagal and sympathetic innervationKaren L Teff
Monell Chemical Senses Center and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, 3500 Market Street, Philadelphia, PA, USA
JPEN J Parenter Enteral Nutr 32:569-71. 2008..In conclusion, the vagus nerve, part of the parasympathetic nervous system, plays a critical role in the regulation of blood glucose levels and is an often overlooked factor contributing to glucose homeostasis...- 48-h glucose infusion in humans: effect on hormonal responses, hunger and food intakeKaren L Teff
Monell Chemical Senses Center, Philadelphia, PA 19104, United States
Physiol Behav 90:733-43. 2007..These data are the first to demonstrate a relationship between leptin and hunger in normal weight, non-calorically restricted human subjects... - Atypical antipsychotics and the neural regulation of food intake and peripheral metabolismKaren L Teff
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Physiol Behav 104:590-8. 2011..Furthermore, we examine how inhibition of the histaminergic pathway may mediate increases in food intake and the potential role of the vagus nerve in the reported peripheral metabolic effects... - Learning hunger: conditioned anticipatory ghrelin responses in energy homeostasisKaren Teff
National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, Maryland 20892, USA
Endocrinology 147:20-2. 2006 - Early phase insulin infusion and muscarinic blockade in obese and lean subjectsK L Teff
Monell Chemical Senses Center and the Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Physiol 277:R198-208. 1999..Thus the effects of muscarinic blockade on postprandial insulin levels cannot be evaluated. These data suggest that insulin supplementation during the preabsorptive time period may contribute to glucoregulation in the obese population... - Insulin sensitivity and premenstrual syndromeKimberly K Trout
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Curr Diab Rep 4:273-80. 2004..Treatment of PMS with serotonin reuptake inhibitors may alleviate the symptoms of PMS, as well as improve insulin sensitivity and help regulate blood glucose levels... - Prolonged mild hyperglycemia induces vagally mediated compensatory increase in C-Peptide secretion in humansKaren L Teff
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 89:5606-13. 2004..In summary, we found that prolonged mild hyperglycemia results in a compensatory increase in C-peptide secretion, which is partially mediated by an induction in vagal efferent activity... - {beta}-Cell function following human islet transplantation for type 1 diabetesMichael R Rickels
University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, Metabolism, 778 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
Diabetes 54:100-6. 2005..Because AR(max) provides an estimate of the functional beta-cell mass, these results suggest that a low engrafted beta-cell mass may account for the functional defects observed after islet transplantation... - Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetesMichael R Rickels
Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
Diabetes 54:3205-11. 2005..01). These results suggest that after islet transplantation and in response to insulin-induced hypoglycemia, endogenous insulin secretion is appropriately suppressed and glucagon secretion may be partially restored... - {beta}-Cell secretory capacity and demand in recipients of islet, pancreas, and kidney transplantsMichael R Rickels
University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 95:1238-46. 2010..control groups. Conclusions: Impaired beta-cell secretory capacity in islet transplantation is best explained by a low engrafted beta-cell mass and not by a deleterious effect of tacrolimus... - Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipientsMichael R Rickels
University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 92:873-9. 2007..Islet transplantation can ameliorate occurrences of hypoglycemia in these patients... - Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantationMichael R Rickels
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
Transplantation 84:1357-60. 2007..02). Also, the measures of beta-cell secretory capacity were highly correlated (n=7, r2=0.98, P<0.0001). These results support the use of AIR(arg) as a surrogate indicator of beta-cell secretory capacity in islet transplantation... - Insulin sensitivity, glucose effectiveness, and free fatty acid dynamics after human islet transplantation for type 1 diabetesMichael R Rickels
University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 91:2138-44. 2006..Islet transplantation results in impaired insulin secretion, but whether defects in insulin sensitivity contribute to impaired glucose disposal after islet transplantation under modern immunosuppression is not known... - Prolonged (48-hour) modest hyperinsulinemia decreases nocturnal heart rate variability and attenuates the nocturnal decrease in blood pressure in lean, normotensive humansMaja Petrova
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 91:851-9. 2006..Early changes in the neural control of cardiac activity may provide a potential mechanism mediating the pathophysiological link between impaired glucose tolerance and cardiovascular disease... - Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot studyKimberly K Trout
University of Pennsylvania School of Nursing, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes Technol Ther 9:176-82. 2007..This pilot study's objective was to evaluate possible differences in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes... - Molecular signatures of obstructive sleep apnea in adults: a review and perspectiveErna S Arnardottir
Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Sleep 32:447-70. 2009..Such changes will be at least partly a consequence of chronic intermittent hypoxia and sleep fragmentation that occurs during sleep... - Insulin sensitivity, food intake, and cravings with premenstrual syndrome: a pilot studyKimberly K Trout
University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
J Womens Health (Larchmt) 17:657-65. 2008..The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular and luteal phases of the menstrual cycle in women with premenstrual syndrome (PMS)... - Acute alcohol consumption disrupts the hormonal milieu of lactating womenJulie A Mennella
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104 3308, USA
J Clin Endocrinol Metab 90:1979-85. 2005..In the short term, mothers may be more relaxed, but the hormonal milieu underlying lactational performance is disrupted, and, in turn, the infant's milk supply is diminished...