K L Teff

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
  2. ncbi request reprint Tasting fat: cephalic phase hormonal responses and food intake in restrained and unrestrained eaters
    Susan R Crystal
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, United States
    Physiol Behav 89:213-20. 2006
  3. ncbi request reprint Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender
    K L Teff
    Monell Chemical Senses Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol 276:R707-14. 1999
  4. pmc How neural mediation of anticipatory and compensatory insulin release helps us tolerate food
    Karen L Teff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, United States
    Physiol Behav 103:44-50. 2011
  5. pmc Cephalic phase pancreatic polypeptide responses to liquid and solid stimuli in humans
    Karen L Teff
    Monell Chemical Senses Center, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, PA 19104, United States
    Physiol Behav 99:317-23. 2010
  6. pmc Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:1562-9. 2009
  7. doi request reprint Visceral nerves: vagal and sympathetic innervation
    Karen L Teff
    Monell Chemical Senses Center and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, 3500 Market Street, Philadelphia, PA, USA
    JPEN J Parenter Enteral Nutr 32:569-71. 2008
  8. pmc 48-h glucose infusion in humans: effect on hormonal responses, hunger and food intake
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, PA 19104, United States
    Physiol Behav 90:733-43. 2007
  9. pmc Atypical antipsychotics and the neural regulation of food intake and peripheral metabolism
    Karen L Teff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Physiol Behav 104:590-8. 2011
  10. ncbi request reprint Learning hunger: conditioned anticipatory ghrelin responses in energy homeostasis
    Karen Teff
    National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, Maryland 20892, USA
    Endocrinology 147:20-2. 2006

Detail Information

Publications24

  1. ncbi request reprint Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
    ....
  2. ncbi request reprint Tasting fat: cephalic phase hormonal responses and food intake in restrained and unrestrained eaters
    Susan R Crystal
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, United States
    Physiol Behav 89:213-20. 2006
    ..05). In conclusion, the sensory experience of tasting fat increases food intake in restrained eaters and increases vagal efferent activity compared to a non-fat food in both populations...
  3. ncbi request reprint Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender
    K L Teff
    Monell Chemical Senses Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol 276:R707-14. 1999
    ..These data suggest that obese subjects exhibit altered gastric cholinergic activity compared with lean subjects and that gender differences in gastric emptying rate may be due to differences in autonomic tone...
  4. pmc How neural mediation of anticipatory and compensatory insulin release helps us tolerate food
    Karen L Teff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, United States
    Physiol Behav 103:44-50. 2011
    ..The necessary stimuli required to elicit CPIR and vagal activation are discussed and the role of CPIR and vagal efferent activation in intra-meal metabolic homeostasis and during chronic nutritional challenges are reviewed...
  5. pmc Cephalic phase pancreatic polypeptide responses to liquid and solid stimuli in humans
    Karen L Teff
    Monell Chemical Senses Center, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, PA 19104, United States
    Physiol Behav 99:317-23. 2010
    ..4+/-88.7 pg/ml/30 min; p<0.05). These data suggest that liquids and chewing gum do not provide adequate stimulation for vagal efferent activation in humans and that mixed nutrient foods are the optimal stimuli...
  6. pmc Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:1562-9. 2009
    ..The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied...
  7. doi request reprint Visceral nerves: vagal and sympathetic innervation
    Karen L Teff
    Monell Chemical Senses Center and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, 3500 Market Street, Philadelphia, PA, USA
    JPEN J Parenter Enteral Nutr 32:569-71. 2008
    ..In conclusion, the vagus nerve, part of the parasympathetic nervous system, plays a critical role in the regulation of blood glucose levels and is an often overlooked factor contributing to glucose homeostasis...
  8. pmc 48-h glucose infusion in humans: effect on hormonal responses, hunger and food intake
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, PA 19104, United States
    Physiol Behav 90:733-43. 2007
    ..These data are the first to demonstrate a relationship between leptin and hunger in normal weight, non-calorically restricted human subjects...
  9. pmc Atypical antipsychotics and the neural regulation of food intake and peripheral metabolism
    Karen L Teff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Physiol Behav 104:590-8. 2011
    ..Furthermore, we examine how inhibition of the histaminergic pathway may mediate increases in food intake and the potential role of the vagus nerve in the reported peripheral metabolic effects...
  10. ncbi request reprint Learning hunger: conditioned anticipatory ghrelin responses in energy homeostasis
    Karen Teff
    National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, Maryland 20892, USA
    Endocrinology 147:20-2. 2006
  11. ncbi request reprint Early phase insulin infusion and muscarinic blockade in obese and lean subjects
    K L Teff
    Monell Chemical Senses Center and the Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol 277:R198-208. 1999
    ..Thus the effects of muscarinic blockade on postprandial insulin levels cannot be evaluated. These data suggest that insulin supplementation during the preabsorptive time period may contribute to glucoregulation in the obese population...
  12. ncbi request reprint Insulin sensitivity and premenstrual syndrome
    Kimberly K Trout
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Curr Diab Rep 4:273-80. 2004
    ..Treatment of PMS with serotonin reuptake inhibitors may alleviate the symptoms of PMS, as well as improve insulin sensitivity and help regulate blood glucose levels...
  13. ncbi request reprint Prolonged mild hyperglycemia induces vagally mediated compensatory increase in C-Peptide secretion in humans
    Karen L Teff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 89:5606-13. 2004
    ..In summary, we found that prolonged mild hyperglycemia results in a compensatory increase in C-peptide secretion, which is partially mediated by an induction in vagal efferent activity...
  14. ncbi request reprint {beta}-Cell function following human islet transplantation for type 1 diabetes
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, Metabolism, 778 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
    Diabetes 54:100-6. 2005
    ..Because AR(max) provides an estimate of the functional beta-cell mass, these results suggest that a low engrafted beta-cell mass may account for the functional defects observed after islet transplantation...
  15. ncbi request reprint Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes
    Michael R Rickels
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    Diabetes 54:3205-11. 2005
    ..01). These results suggest that after islet transplantation and in response to insulin-induced hypoglycemia, endogenous insulin secretion is appropriately suppressed and glucagon secretion may be partially restored...
  16. pmc {beta}-Cell secretory capacity and demand in recipients of islet, pancreas, and kidney transplants
    Michael R Rickels
    University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 95:1238-46. 2010
    ..control groups. Conclusions: Impaired beta-cell secretory capacity in islet transplantation is best explained by a low engrafted beta-cell mass and not by a deleterious effect of tacrolimus...
  17. ncbi request reprint Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 92:873-9. 2007
    ..Islet transplantation can ameliorate occurrences of hypoglycemia in these patients...
  18. ncbi request reprint Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    Transplantation 84:1357-60. 2007
    ..02). Also, the measures of beta-cell secretory capacity were highly correlated (n=7, r2=0.98, P<0.0001). These results support the use of AIR(arg) as a surrogate indicator of beta-cell secretory capacity in islet transplantation...
  19. ncbi request reprint Insulin sensitivity, glucose effectiveness, and free fatty acid dynamics after human islet transplantation for type 1 diabetes
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 91:2138-44. 2006
    ..Islet transplantation results in impaired insulin secretion, but whether defects in insulin sensitivity contribute to impaired glucose disposal after islet transplantation under modern immunosuppression is not known...
  20. ncbi request reprint Prolonged (48-hour) modest hyperinsulinemia decreases nocturnal heart rate variability and attenuates the nocturnal decrease in blood pressure in lean, normotensive humans
    Maja Petrova
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 91:851-9. 2006
    ..Heart rate variability (HRV), an index of cardiac vagal activity, is decreased in individuals with metabolic disease. The relationship between decreased HRV and metabolic disease is unclear...
  21. ncbi request reprint Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot study
    Kimberly K Trout
    University of Pennsylvania School of Nursing, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Technol Ther 9:176-82. 2007
    ..This pilot study's objective was to evaluate possible differences in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes...
  22. pmc Molecular signatures of obstructive sleep apnea in adults: a review and perspective
    Erna S Arnardottir
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 32:447-70. 2009
    ..Such changes will be at least partly a consequence of chronic intermittent hypoxia and sleep fragmentation that occurs during sleep...
  23. pmc Insulin sensitivity, food intake, and cravings with premenstrual syndrome: a pilot study
    Kimberly K Trout
    University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
    J Womens Health (Larchmt) 17:657-65. 2008
    ..The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular and luteal phases of the menstrual cycle in women with premenstrual syndrome (PMS)...
  24. pmc Acute alcohol consumption disrupts the hormonal milieu of lactating women
    Julie A Mennella
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104 3308, USA
    J Clin Endocrinol Metab 90:1979-85. 2005
    ..In the short term, mothers may be more relaxed, but the hormonal milieu underlying lactational performance is disrupted, and, in turn, the infant's milk supply is diminished...