Laurence H Tecott

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Mouse molecular genetic technologies: promise for psychiatric research
    L H Tecott
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, 401 Parnassus Ave, San Francisco, CA 94143 0984, USA
    Arch Gen Psychiatry 58:995-1004. 2001
  2. ncbi request reprint The genes and brains of mice and men
    Laurence H Tecott
    Department of Psychiatry, University of California, San Francisco, School of Medicine, 94143 0984, USA
    Am J Psychiatry 160:646-56. 2003
  3. pmc Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice
    L H Tecott
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Proc Natl Acad Sci U S A 95:15026-31. 1998
  4. ncbi request reprint Neurobehavioral assessment in the information age
    Laurence H Tecott
    Center for Neurobiology and Psychiatry and Institute for Neurodegenerative Diseases, University of California San Francisco School of Medicine, 401 Parnassus Avenue, San Francisco, California 94143 0984, USA
    Nat Neurosci 7:462-6. 2004
  5. ncbi request reprint Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice
    Laurence H Tecott
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, California 94143 0984, USA
    CNS Spectr 8:584-8. 2003
  6. pmc Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function
    Luna Abdallah
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 29:8156-65. 2009
  7. pmc Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors
    Jennifer M Wade
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
    Endocrinology 149:955-61. 2008
  8. pmc Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    Baoji Xu
    Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    Nat Neurosci 6:736-42. 2003
  9. pmc Convergence of the insulin and serotonin programs in the pancreatic β-cell
    Yasuharu Ohta
    Diabetes Center, University of California, San Francisco, San Francisco, California, USA
    Diabetes 60:3208-16. 2011
  10. pmc Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Neurosci 10:77-86. 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Mouse molecular genetic technologies: promise for psychiatric research
    L H Tecott
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, 401 Parnassus Ave, San Francisco, CA 94143 0984, USA
    Arch Gen Psychiatry 58:995-1004. 2001
    ..Future directions in technology development that promise to further enhance the utility of these approaches for translational research are also described...
  2. ncbi request reprint The genes and brains of mice and men
    Laurence H Tecott
    Department of Psychiatry, University of California, San Francisco, School of Medicine, 94143 0984, USA
    Am J Psychiatry 160:646-56. 2003
    ..To maximize the extent to which the revolution in mammalian genetics may be effectively applied to psychiatric research, new technologies and strategies for mouse behavioral assessment must be developed...
  3. pmc Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice
    L H Tecott
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Proc Natl Acad Sci U S A 95:15026-31. 1998
    ..These results indicate that a genetic perturbation of serotonin receptor function can modulate dentate gyrus plasticity and that plasticity in this structure may contribute to neural mechanisms underlying hippocampus-dependent behaviors...
  4. ncbi request reprint Neurobehavioral assessment in the information age
    Laurence H Tecott
    Center for Neurobiology and Psychiatry and Institute for Neurodegenerative Diseases, University of California San Francisco School of Medicine, 401 Parnassus Avenue, San Francisco, California 94143 0984, USA
    Nat Neurosci 7:462-6. 2004
    ..These hold promise, both for improving the throughput of mouse behavioral assessment and for providing new insights into the neurobiology of mammalian behavioral regulation...
  5. ncbi request reprint Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice
    Laurence H Tecott
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, California 94143 0984, USA
    CNS Spectr 8:584-8. 2003
    ..quot; These findings are presented to illustrate considerations in the use of mouse molecular genetic technologies to investigate genetic influences on ingestive behavior and energy balance...
  6. pmc Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function
    Luna Abdallah
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 29:8156-65. 2009
    ..We conclude that 5-HT(2C)Rs regulate nigrostriatal dopaminergic activity and function both at SNc dopaminergic neurons and at a locus downstream of the DSt...
  7. pmc Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors
    Jennifer M Wade
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
    Endocrinology 149:955-61. 2008
    ..These pharmacological and genetic findings provide evidence that the serotonin 2C receptor has direct effects on glucose homeostasis...
  8. pmc Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    Baoji Xu
    Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    Nat Neurosci 6:736-42. 2003
    ..These results show that MC4R signaling controls BDNF expression in the VMH and support the hypothesis that BDNF is an important effector through which MC4R signaling controls energy balance...
  9. pmc Convergence of the insulin and serotonin programs in the pancreatic β-cell
    Yasuharu Ohta
    Diabetes Center, University of California, San Francisco, San Francisco, California, USA
    Diabetes 60:3208-16. 2011
    ..Therefore, we tested whether these developmental parallels have functional consequences...
  10. pmc Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Neurosci 10:77-86. 2007
    ..These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration...
  11. pmc A robust automated system elucidates mouse home cage behavioral structure
    Evan H Goulding
    Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:20575-82. 2008
    ..The robust, automated, reproducible quantification of mouse home cage behavioral structure detailed here should have wide applicability for the study of mammalian physiology, behavior, and disease...
  12. ncbi request reprint Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice
    Katsunori Nonogaki
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, 94143, USA
    Diabetes 52:315-20. 2003
    ..Moreover, age-dependent reductions in the energy cost of physical activity could contribute to the subsequent development of late-onset obesity in 5-HT(2C) receptor mutant mice...
  13. ncbi request reprint A null mutation of the serotonin 6 receptor alters acute responses to ethanol
    Stephen J Bonasera
    Division of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuropsychopharmacology 31:1801-13. 2006
    ..No differences in ethanol metabolism were evident between wild-type and 5-HT6R mutant mice. These findings implicate 5-HT6Rs in the serotonergic modulation of responses to ethanol...
  14. pmc A novel method for automatic quantification of psychostimulant-evoked route-tracing stereotypy: application to Mus musculus
    Stephen J Bonasera
    Division of Geriatrics, Department of Medicine, University of California, San Francisco, 1550 4th St, Box 2822, San Francisco, CA 94158 2822, USA
    Psychopharmacology (Berl) 196:591-602. 2008
    ..Measurements of route-tracing stereotypy in an automated, high throughput, easily quantified, and replicable manner would facilitate functional studies of this central nervous system region...
  15. pmc Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload
    Timothy D O'Connell
    Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Clin Invest 116:1005-15. 2006
    ....
  16. ncbi request reprint Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems
    Marco Giorgetti
    Center for Neurobiology and Psychiatry, University of California, San Francisco School of Medicine, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Eur J Pharmacol 488:1-9. 2004
    ..Pharmacological and genetic studies reveal these receptors to influence feeding, glucose homeostasis and the energy efficiency of physical activity...
  17. pmc Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line
    Gerard Honig
    Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA
    J Biomed Sci 17:82. 2010
    ..1Dam), in which the expression of Cre recombinase is driven by regulatory elements upstream of the pdx1 (pancreatic-duodenal homeobox 1) gene...
  18. pmc Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity
    Rochelle Urban
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Pain 152:990-1000. 2011
    ....
  19. pmc A flexible estimating equations approach for mapping function-valued traits
    Hao Xiong
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0560, USA
    Genetics 189:305-16. 2011
    ..It provides a good compromise between model simplicity, statistical efficiency, and computational speed. We illustrate our method and its advantages using circadian mouse behavioral data...
  20. ncbi request reprint 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission
    L H Parsons
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, USA Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California San Francisco, San Francisco, USA
    J Neurochem 77:607-17. 2001
    ....
  21. ncbi request reprint Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the li
    R A Memon
    Department of Medicine, University of California, San Francisco 94143, USA
    Endocrinology 141:4021-31. 2000
    ..Taken together, our results suggest that the effects of PPAR-gamma activators on lipid metabolism and energy homeostasis in obesity and type 2 diabetes may be partly mediated through their effects on PPAR-gamma in the liver...
  22. pmc Serotonin regulates pancreatic beta cell mass during pregnancy
    Hail Kim
    Diabetes Center, University of California San Francisco, San Francisco, California, USA
    Nat Med 16:804-8. 2010
    ..These studies reveal an integrated signaling pathway linking beta cell mass to anticipated insulin need during pregnancy. Modulators of this pathway, including medications and diet, may affect the risk of gestational diabetes...
  23. ncbi request reprint Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    L H Tecott
    Department of Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 374:542-6. 1995
    ..Mutant animals are also prone to spontaneous death from seizures, suggesting that 5-HT2C receptors mediate tonic inhibition of neuronal network excitability...
  24. ncbi request reprint Sound-induced seizures in serotonin 5-HT2c receptor mutant mice
    T J Brennan
    Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Nat Genet 16:387-90. 1997
    ..This AGS syndrome is the first produced by a known genetic defect; it provides a robust model for the examination of serotoninergic mechanisms in epilepsy...
  25. ncbi request reprint Serotonin and the orchestration of energy balance
    Laurence H Tecott
    Department of Psychiatry, Center for Neurobiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2324, USA
    Cell Metab 6:352-61. 2007
    ....
  26. ncbi request reprint Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice
    Katsunori Nonogaki
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 295:249-54. 2002
    ..These results indicate that a mutation of 5-HT(2C) receptor gene leads to a secondary decrease in beta 3-AR gene expression that is related to enhanced adiposity...
  27. pmc Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain
    Gerard Honig
    Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 4:e6797. 2009
    ..Here, we describe effects of chronic administration of the SSRI citalopram (CIT) on 5-HT synthesis and content in the mouse forebrain...
  28. pmc Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor
    Marcos G Frank
    W M Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA 94143, USA
    Neuropsychopharmacology 27:869-73. 2002
    ..These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin...
  29. pmc Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice
    L K Heisler
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Proc Natl Acad Sci U S A 95:15049-54. 1998
    ..5-HT1A receptor-null mutant mice have potential as a model for investigating mechanisms through which serotonergic systems modulate affective state and mediate the actions of psychiatric drugs...
  30. pmc Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
    S F Kash
    Department of Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 94:14060-5. 1997
    ....
  31. ncbi request reprint A paradoxical locomotor response in serotonin 5-HT(2C) receptor mutant mice
    L K Heisler
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Neurosci 20:RC71. 2000
    ..This genetically based paradoxical drug effect provides a model for considering the effects of genetic load on neurobehavioral responses to drugs...
  32. ncbi request reprint Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    K Nonogaki
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California at San Francisco, 94143 0984, USA
    Nat Med 4:1152-6. 1998
    ..These findings demonstrate a dissociation of serotonin and leptin signaling in the regulation of feeding and indicate that a perturbation of brain serotonin systems can predispose to type 2 diabetes...
  33. ncbi request reprint Social circuits: peptidergic regulation of mammalian social behavior
    Elaine E Storm
    Department of Psychiatry, Center for Neurobiology and Psychiatry, Insitute for Neurodegenerative Diseases, University of California, San Francisco School of Medicine, San Francisco, CA 94143, USA
    Neuron 47:483-6. 2005
    ..New insights into social neuroscience are discussed, along with the relevance of this rapidly developing field to human relationships and disease processes...
  34. pmc Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
    S F Kash
    Departments of Medicine and Microbiology Immunology, and Hormone Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 96:1698-703. 1999
    ..We propose that stress-induced GABA release is impaired in GAD65-deficient mice, resulting in increased anxiety-like responses and a diminished response to the acute effects of drugs that facilitate the actions of released GABA...
  35. ncbi request reprint Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice
    Beatriz A Rocha
    National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 22:10039-45. 2002
    ..These findings strongly implicate 5-HT2C receptors in the serotonergic suppression of DA-mediated behavioral responses to cocaine and as a potential therapeutic target for cocaine abuse...
  36. ncbi request reprint Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice
    Claire Matson Cannon
    Department of Biochemistry and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Neuron 44:509-20. 2004
    ..We suggest that, at this moderate dose of AMPH, dysregulation of striatal DA is the primary cause of AMPH-induced hypophagia and that regulated striatal dopaminergic signaling may be necessary for normal feeding behaviors...
  37. ncbi request reprint Activation of central melanocortin pathways by fenfluramine
    Lora K Heisler
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 297:609-11. 2002
    ..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments...
  38. ncbi request reprint Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors
    Juan F Lopez-Gimenez
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC IDIBAPS, Barcelona, Spain
    J Neurosci Res 67:69-85. 2002
    ....
  39. ncbi request reprint Central serotonin and melanocortin pathways regulating energy homeostasis
    Lora K Heisler
    Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 994:169-74. 2003
    ..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus...
  40. ncbi request reprint Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital and the University of Cambridge, Cambridge CB2 2QR, United Kingdom
    J Neurosci 27:6956-64. 2007
    ....
  41. pmc Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress
    Sharyl L Fyffe
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 59:947-58. 2008
    ..This study demonstrates that deleting Mecp2 in a defined brain region is an excellent approach to map the neuronal origins of complex behaviors and provides new insight about the function of MeCP2 in specific neurons...
  42. ncbi request reprint Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade
    Thomas I F H Cremers
    Department of Medicinal Chemistry, Pharmacy, University of Groningen, Groningen, The Netherlands
    Neuropsychopharmacology 29:1782-9. 2004
    ..These findings reveal an unanticipated pharmacological action of 5-HT(2C) receptors that warrants consideration in the development of novel strategies for the treatment of depression...