Susan S Taylor

Summary

Affiliation: University of California
Country: USA

Publications

  1. England J, Hao Y, Bai L, Glick V, Hodges H, Taylor S, et al. Switching of the folding-energy landscape governs the allosteric activation of protein kinase A. Proc Natl Acad Sci U S A. 2018;115:E7478-E7485 pubmed publisher
    ..Taken together, our results provide a thermodynamic foundation for the conformational plasticity that enables protein kinases to adapt and respond to signaling molecules. ..
  2. Kim J, Masterson L, Cembran A, Verardi R, Shi L, Gao J, et al. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A. 2015;112:3716-21 pubmed publisher
  3. Hu J, Ahuja L, Meharena H, Kannan N, Kornev A, Taylor S, et al. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015;35:264-76 pubmed publisher
    ..Many hydrophobic mutations strategically localized along the C-helix can thus drive kinase activation. ..
  4. Bachmann V, Mayrhofer J, Ilouz R, Tschaikner P, Raffeiner P, Röck R, et al. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016;113:7786-91 pubmed publisher
  5. Gogl G, Kornev A, Remenyi A, Taylor S. Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores. Trends Biochem Sci. 2019;: pubmed publisher
  6. request reprint
    Taylor S, Kim C, Vigil D, Haste N, Yang J, Wu J, et al. Dynamics of signaling by PKA. Biochim Biophys Acta. 2005;1754:25-37 pubmed
    ..Using small angle X-ray scattering, the overall shape of the regulatory subunits and corresponding holoenzymes have been elucidated. These studies reveal striking and surprising isoform differences. ..
  7. Taylor S, Zhang P, Steichen J, Keshwani M, Kornev A. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013;1834:1271-8 pubmed publisher
    ..Understanding these dynamic macromolecular complexes is the challenge that we now face. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012). ..
  8. Taylor S, Keshwani M, Steichen J, Kornev A. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012;367:2517-28 pubmed publisher
    ..In this way, the cell creates discrete foci that most likely represent the physiological environment for cyclic AMP-mediated signalling. ..
  9. Taylor S, Kim C, Cheng C, Brown S, Wu J, Kannan N. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta. 2008;1784:16-26 pubmed
    ..This targeting mechanism, which localizes PKA near to its protein substrates, is also a target for therapeutic intervention of PKA signaling. ..

More Information

Publications21

  1. Keshwani M, Kanter J, Ma Y, Wilderman A, Darshi M, Insel P, et al. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015;112:12681-6 pubmed publisher
    ..The findings for Dex-promoted apoptosis imply that these lymphoma cells have adapted to selective pressure that promotes cell death by altering canonical signaling pathways. ..
  2. Hu J, Stites E, Yu H, Germino E, Meharena H, Stork P, et al. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013;154:1036-1046 pubmed publisher
    ..Our work illuminates distinct steps in RAF activation that function to assemble the active conformation of the RAF kinase. ..
  3. Taylor S, Ilouz R, Zhang P, Kornev A. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012;13:646-58 pubmed publisher
  4. Kornev A, Taylor S. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015;40:628-47 pubmed publisher
    ..Dynamics is proposed to be the underlying mechanism for allosteric regulation in protein kinases. ..
  5. Taylor S, Kornev A. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011;36:65-77 pubmed publisher
    ..Protein kinases thus represent a unique, highly dynamic, and precisely regulated set of switches that control most biological events in eukaryotic cells. ..
  6. Ahuja L, Kornev A, McClendon C, Veglia G, Taylor S. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017;114:E931-E940 pubmed publisher
    ..These studies pave the way for understanding how mutations far from the kinase active site can alter its dynamic properties and catalytic function even when major structural perturbations are not obvious from static crystal structures. ..
  7. Taylor S, Shaw A, Hu J, Meharena H, Kornev A. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013;41:981-6 pubmed publisher
  8. Bubis J, Martinez J, Calabokis M, Ferreira J, Sanz Rodríguez C, Navas V, et al. The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides. Biochimie. 2018;146:166-180 pubmed publisher
  9. Haushalter K, Casteel D, Raffeiner A, Stefan E, Patel H, Taylor S. Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem. 2018;293:4411-4421 pubmed publisher
    ..We have thus proposed a model to explain how PKG phosphorylation of RIα creates a "sensitized intermediate" state that is in effect primed to trigger PKAc activity. ..
  10. Bruystens J, Wu J, Fortezzo A, Kornev A, Blumenthal D, Taylor S. PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014;22:59-69 pubmed publisher
    ..Mutagenesis of residues on this interface not only leads to structural and biochemical changes, but is also linked to Carney complex disease. ..
  11. Zhang P, Ye F, Bastidas A, Kornev A, Wu J, Ginsberg M, et al. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015;23:1563-1572 pubmed publisher
    ..This membrane-anchoring myristylation switch is independent of A Kinase Anchoring Proteins (AKAPs) that target PKA to membranes by other mechanisms. ..
  12. Bruystens J, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal D, et al. Structure of a PKA RI? Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J Mol Biol. 2016;428:4890-4904 pubmed publisher