Research Topics
Species | R N TaylorSummaryAffiliation: University of California Country: USA Publications
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Publications
Emerging role of genomics in endometriosis researchRobert N Taylor
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco School of Medicine, 94143 0556, USA
Fertil Steril 78:694-8. 2002..In this report we briefly review some of the seminal technological advances that inspired the genomics revolution and describe their application in the field of endometriosis research...- Endocrine and paracrine regulation of endometrial angiogenesisR N Taylor
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143 0556, USA
Ann N Y Acad Sci 943:109-21. 2001..g., endometriosis), a proinflammatory cytokine, IL-1beta, can mediate neoangiogenesis by inducing VEGF-A gene transcription. Thus, endometrial vascularization is effected by both endocrine and paracrine pathways... - Angiogenic factors in endometriosisRobert N Taylor
Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 94143 0556, USA
Ann N Y Acad Sci 955:89-100; discussion 118, 396-406. 2002..We postulate that interference with angiogenic principles expressed in the peritoneum may constitute novel therapeutic opportunities for the prevention, amelioration, or treatment of pelvic endometriosis... - Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cellsD Hornung
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco 94143 0556, USA
J Clin Endocrinol Metab 82:1621-8. 1997..The results indicate that RANTES is a normal constituent of the eutopic endometrium. We propose that secretion of RANTES by ectopic endometriosis implants provides a mechanism for peritoneal leukocyte recruitment... - Histocompatibility leukocyte antigen-G is not expressed by endometriosis or endometrial tissueD Hornung
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143-0556, USA
Fertil Steril 75:814-7. 2001..Moreover, ectopic and normal endometrial tissues and stromal cells did not express HLA-G. CONCLUSION(S): Immune cell inhibition in endometriosis must be mediated by factors other than HLA-G... - Placental peroxisome proliferator-activated receptor-gamma is up-regulated by pregnancy serumL L Waite
Departments of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco 94143, USA
J Clin Endocrinol Metab 85:3808-14. 2000..The results suggest that increased activation of PPARgamma may play an important role in maternal metabolism during human pregnancy... - Anti-angiogenic treatment of endometriosis: biochemical aspectsR N Taylor
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, USA
Gynecol Obstet Invest 57:54-6. 2004 - The future of endometriosis research: genomics and proteomics?R N Taylor
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA
Gynecol Obstet Invest 57:47-9. 2004 - Nuclear peroxisome proliferator-activated receptors alpha and gamma have opposing effects on monocyte chemotaxis in endometriosisD Hornung
Center for Reproductive Sciences, University of California, San Francisco, California 94143, USA
J Clin Endocrinol Metab 86:3108-14. 2001..Inhibitors of PPAR-alpha or activators of PPAR-gamma could be developed for the treatment of inflammation associated with endometriosis... - Impact of the ovulatory cycle on virologic and immunologic markers in HIV-infected womenR M Greenblatt
University of California, Infectious Diseases Division, San Francisco, CA 94122, USA
J Infect Dis 181:82-90. 2000..Thus, the ovulatory cycle influenced circulating HIV-1 RNA levels, a finding that is plausible because of the known effect of sex hormones on lymphocyte function and cytokine production... - Purification and characterization of an immunomodulatory endometrial protein, glycodelinJ L Vigne
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
J Biol Chem 276:17101-5. 2001..Our findings support the hypothesis that glycodelin reduces the local maternal inflammatory response toward the implantation of a semiallogeneic conceptus... - Preeclampsia, an implantation disorderLeslie L Waite
University of California at San Francisco, 513 Parnassus Avenue, San Francisco CA 94143, USA
Rev Endocr Metab Disord 3:151-8. 2002 - Medicine. Consent from donors for embryo and stem cell researchBernard Lo
Program in Medical Ethics, School of Medicine at the University of California, San Francisco, CA 94143, USA
Science 301:921. 2003..Some gamete donors who are willing to help women and couples bear children may object to the use of their genetic materials for certain types of research... - Informed consent in human oocyte, embryo, and embryonic stem cell researchBernard Lo
Program in Medical Ethics and the Division of General Internal Medicine, Department of Medicine, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0903, USA
Fertil Steril 82:559-63. 2004..Treating assisted reproduction technology physicians can help with the consent process, provided that they are not involved in the research... - Circulating activators of peroxisome proliferator-activated receptors are reduced in preeclamptic pregnancyLeslie L Waite
Center for Reproductive Sciences, University of California San Francisc, CA 94143, USA
J Clin Endocrinol Metab 90:620-6. 2005..We speculate that endogenous regulators of PPAR play a role in maternal metabolism and immune function in normal and pathological pregnancies... - All-trans retinoic acid inhibits vascular endothelial growth factor expression in a cell model of neutrophil activationMeng Kian Tee
Department of Gynecology and Obstetrics and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Endocrinology 147:1264-70. 2006.... - Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnanciesRobert N Taylor
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
Am J Obstet Gynecol 188:177-82. 2003.... - Altered expression of a cell-cycle suppressor gene, Tob-1, in endometriotic cells by cDNA array analysesDan I Lebovic
Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA
Fertil Steril 78:849-54. 2002..These findings are the first to associate IL-1beta with an alteration of cell-cycle gene expression in cells derived from endometriotic implants... - Sulindac suppresses nuclear factor-kappaB activation and RANTES gene and protein expression in endometrial stromal cells from women with endometriosisFritz Wieser
Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Austria
J Clin Endocrinol Metab 90:6441-7. 2005..These results suggest that drugs targeting the NF-kappaB pathway may be beneficial in the treatment of endometriosis-associated symptoms... - Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramniosStephanie E Mann
Phoenix Integrated Residency in Obstetrics and Gynecology, Maricopa Medical Center, Phoenix, AZ 85008, USA
Am J Obstet Gynecol 194:884-7. 2006..Therefore, we hypothesized that in pregnancies with idiopathic polyhydramnios, AQP1 expression might be reduced in fetal membranes from pregnancies with this AF volume disorder... - Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilizationHong Xu
Department of Gynecology and Obstetrics, University of Schleswig Holstein, Luebeck, Germany
Fertil Steril 86:1616-20. 2006.... - Evolution of medical treatment for endometriosis: back to the roots?Fritz Wieser
Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, 1090 Vienna, Austria
Hum Reprod Update 13:487-99. 2007..We encourage the development of herbal analogues and establishment of special, simplified registration procedures for certain medicinal products, particularly herbal derivates with a long tradition of safe use... - Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the humanQuanxi Li
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
J Biol Chem 282:31725-32. 2007..Collectively, our studies uncovered a unique conserved pathway involving BMP2 and Wnt4 that mediates P-induced stromal decidualization in the mouse and the human... - Basal and cytokine-stimulated production of epithelial neutrophil activating peptide-78 (ENA-78) and interleukin-8 (IL-8) by cultured human endometrial epithelial and stromal cellsNick A Bersinger
Department of Obstetrics and Gynecology, University of Berne, Berne, Switzerland
Fertil Steril 89:1530-6. 2008..To analyze the constitutive production of epithelial neutrophil activating peptide 78 (ENA-78) and interleukin-8 (IL-8) by epithelial cells and the response of these cells to cytokine stimulation... - Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancersAdmir Agic
Department of Gynecology and Obstetrics, University of Schleswig Holstein, Lubeck, Germany
Reprod Sci 14:486-97. 2007..6 +/- 2.0 ng/mL, n = 33, P = .31). They hypothesize that vitamin D might influence the local activity of immune cells and cytokines thought to play important pathogenic roles in the development and maintenance of endometriosis... 
Natural and recombinant human glycodelin activate a proapoptotic gene cascade in monocyte cellsMeng Kian Tee
Department of Pediatrics, Center for Reproductive Sciences, University of California, San Francisco, California, USA
J Leukoc Biol 83:843-52. 2008..We postulate that infiltrating monocytes and potentially other innate immune cells of the decidua might be manipulated by this glycoprotein to enhance embryonic implantation rates or conversely, to develop novel contraceptive strategies...- Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancyShang-mian Yie
Department of Obstetrics and Gynecology, Sunnybrook and Women's College Health Sciences Centre (SWCHSC, Toronto, Ontario, Canada
Am J Obstet Gynecol 193:204-8. 2005..This suggests that determination of circulating HLA-G protein concentration may be useful as an early predictor for the development of PE... - Effects of phorbol dibutyrate on cell proliferation, apoptosis, and tumor necrosis factor-alpha expression in human endometrial adenocarcinoma cellsFritz Wieser
Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Vienna, Austria
J Soc Gynecol Investig 12:370-5. 2005..EACs provide an informative model to investigate aspects of endometrial epithelial remodeling that may occur under physiologic conditions of progesterone withdrawal... - A novel model of polyhydramnios: amniotic fluid volume is increased in aquaporin 1 knockout miceStephanie E Mann
Department of Obstetrics, Gynecology, and Reproductive Sciences and Medicine, University of California, San Francisco, USA
Am J Obstet Gynecol 192:2041-4; discussion 2044-6. 2005..To test the hypothesis that amniotic fluid volume is increased in aquaporin 1 knockout mice... - Dioxin stimulates RANTES expression in an in-vitro model of endometriosisDong Zhao
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, HSE 1689, CA 94143 0556, USA
Mol Hum Reprod 8:849-54. 2002.... - Epithelial neutrophil-activating peptide 78 concentrations are elevated in the peritoneal fluid of women with endometriosisMichael D Mueller
Department of Obstetrics and Gynecology, Inselspital, University of Bern, Bern, Switzerland
Fertil Steril 79:815-20. 2003..To investigate the presence of epithelial neutrophil-activating peptide 78 (ENA-78) in peritoneal fluid of women with and without endometriosis and to identify the cells that produce this inflammatory protein... - Thiazolidinedione inhibition of peritoneal inflammationDaniela Hornung
Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, Calif, USA
Gynecol Obstet Invest 55:20-4. 2003..This animal model suggests that treatment of endometriosis patients with TZDs may diminish symptoms associated with intraperitoneal inflammation... - Regulation of vascular endothelial growth factor by tamoxifen in vitro and in vivoMichael D Mueller
Universitats Frauenklinik, Inselspital Bern, Switzerland
Gynecol Obstet Invest 55:119-24. 2003..To evaluate the effects of tamoxifen on human endometrial vascular endothelial growth factor (VEGF) gene expression in vitro and in vivo... - Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter elementElizabeth A Pritts
Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA
Fertil Steril 80:415-20. 2003..Transcriptional repression appears to be mediated through a specific PPRE at -344 to -322 bp upstream from the RNA polymerase start site... - An evidence-based evaluation of endometriosis-associated infertilityElizabeth A Pritts
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin, H4 630 CSC, 600 Highland Avenue, Madison, WI 53792 6188, USA
Endocrinol Metab Clin North Am 32:653-67. 2003..As the data from these scientific inquiries emerge, clinicians will have a clearer view of effective treatment regimens for endometriosis... - First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsiaRavi Thadhani
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 89:770-5. 2004..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE... - S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasmaRobin E Gandley
Magee Womens Research Institute and Department of Environmental and Occupational Health, University of Pittsburgh, 204 Craft Ave, Pittsburgh, PA 15213, USA
Hypertension 45:21-7. 2005..We suggest that the higher circulating levels of SNO-Alb, in women with preeclampsia, reflect a deficiency in Asc/Cu-mediated release of NO from SNO-Alb... - Expression and regulation of CCR1 in peritoneal macrophages from women with and without endometriosisFritz Wieser
Center for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California, San Francisco, California, USA
Fertil Steril 83:1878-81. 2005.... 
Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survivalMary J Laws
Department of Veterinary Biosciences, and University of Illinois Urbana Champaign, Urbana, IL 61802, USA
Development 135:2659-68. 2008....