Research Topics
Species | PALMER WILLIAM TAYLORSummaryAffiliation: University of California Country: USA Publications
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Publications
Cholinesterase confabs and cousins: Approaching forty yearsPalmer Taylor
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, Mail Code 0657, La Jolla, CA 92093, United States Electronic address
Chem Biol Interact 203:10-3. 2013....
Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templatesJohn G Yamauchi
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA
Mol Pharmacol 82:687-99. 2012....- Contemporary paradigms for cholinergic ligand design guided by biological structurePalmer Taylor
Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
Bioorg Med Chem Lett 14:1875-7. 2004..Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission... - Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypesPalmer Taylor
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0657, USA
Biochem Pharmacol 74:1164-71. 2007.... - From Split to Sibenik: the tortuous pathway in the cholinesterase fieldPalmer Taylor
Department of Pharmacology 0636, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0650, USA
Chem Biol Interact 187:3-9. 2010..Those engaged in cholinesterase research should take great pride in our accomplishments punctuated by the series of ten meetings. The momentum established and initial studies with related proteins all hold great promise for the future... 
Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectorsPalmer Taylor
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0657, USA
Arh Hig Rada Toksikol 58:339-45. 2007....- Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposurePalmer Taylor
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0650, USA
Toxicology 233:70-8. 2007..Since external reagents do not have to be added to detect the fluorescence change, the modified enzyme would serve as a remote sensor... - Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1betaDavide Comoletti
Department of Pharmacology, University of California, La Jolla, California 92093 0636, USA
J Biol Chem 278:50497-505. 2003..We show here that glycosylation processing of neuroligin, in addition to mRNA splicing and gene selection, contributes to the specificity of the neurexin-beta/neuroligin-1 association... - Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonatesZrinka Kovarik
Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0636, USA
Biochem J 373:33-40. 2003..Rather, the individual aromatic residues may mutually interact to confer a distinctive stereospecificity pattern towards organophosphates... - Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding proteinRyan E Hibbs
Department of Pharmacology, University of California-San Diego, La Jolla, CA 92093-0636, USA
J Biol Chem 279:28483-91. 2004..Labeling at other residue positions around the predicted binding pocket also reveals distinctive spectral changes for alpha-bungarotoxin, agonists, and alkaloid antagonists... - Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesteraseJianxin Shi
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 277:43301-8. 2002..The fluorescence changes induced by the modified enzyme may prove useful in the detection of organophosphates or exposure to cholinesterase inhibitors... - Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californicaScott B Hansen
Department of Pharmacology, University of California, San Diego, La Jolla 92093-0636, USA
J Biol Chem 279:24197-202. 2004..Hence, the two soluble proteins from mollusks, which can be studied by a variety of physical methods, become discrete surrogate proteins for the extracellular domains of distinct subtypes of nicotinic acetylcholine receptors... - Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding proteinRyan E Hibbs
Department of Pharmacology, University of California San Diego, La Jolla, California 92093, USA
J Biol Chem 281:39708-18. 2006..The results reveal that agonists and antagonists produced distinctive changes in the flexibility of a portion of loop F... - Nanosecond dynamics of acetylcholinesterase near the active center gorgeAileen E Boyd
Department of Pharmacology, University of California, La Jolla, California 92093 0636, USA
J Biol Chem 279:26612-8. 2004.... - The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processingDavide Comoletti
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
J Neurosci 24:4889-93. 2004..Other substitutions for Arg451 allow for normal cellular expression but diminished affinity for NX1beta. Our findings reveal a cellular phenotype and loss of function for a congenital mutation associated with autistic spectrum disorders... - Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophoreTodd T Talley
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 99093 0657, USA
Proc Natl Acad Sci U S A 105:7606-11. 2008..This template defines the association of interacting amino acids and their energetic contributions to the distinctive interactions of neonicotinoids... - A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein familyAntonella De Jaco
Department of Pharmacology, University of California San Diego, La Jolla, California 92093 0636, USA
J Biol Chem 281:9667-76. 2006..The mutation may alter the capacity of these proteins to dissociate from their chaperone prior to oligomerization and processing for export... - Defining nicotinic agonist binding surfaces through photoaffinity labelingMotohiro Tomizawa
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
Biochemistry 46:8798-806. 2007..These findings enabled us to use AChBP as a structural surrogate to define the nAChR agonist site... - Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonatesZrinka Kovarik
Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0636, USA
Toxicology 233:79-84. 2007..Our results confirm that a mixture of a mutant enzyme and an oxime might serve as an in vivo catalytic scavenger of organophosphates... - Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometryJianxin Shi
Department of Pharmacology and Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 281:12170-7. 2006..These results reveal dynamic states and fluctuating movements in the vicinity of the binding site for unligated AChBP that can be influenced selectively by ligands... - Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface siteBrian E Molles
Department of Pharmacology, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA92093-0636, USA
Biochemistry 41:7895-906. 2002..We use the binding and interaction energies for Wtx-1 to generate structural models of the alpha-epsilon, alpha-gamma, and alpha-delta binding sites containing the nonhomologous insertion... - Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein familyAntonella De Jaco
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 285:28674-82. 2010..Our results suggest that disease-related mutations in the alpha/beta-hydrolase fold domain share common trafficking deficiencies yet lead to discrete congenital disorders of differing severity in the endocrine and nervous systems... - Atypical nicotinic agonist bound conformations conferring subtype selectivityMotohiro Tomizawa
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
Proc Natl Acad Sci U S A 105:1728-32. 2008..Accordingly, the subtype selectivity is based on two disparate bound conformations of nicotinic agonists, thereby establishing an atypical concept for neonicotinoid versus nicotinoid selectivity between insect and vertebrate nAChRs... - Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: hydrodynamic and fluorescence anisotropy decay analysesRyan E Hibbs
Department of Pharmacology and Biomedical Sciences Graduate Program, University of California-San Diego, La Jolla, California 92093-0636, USA
Biochemistry 44:16602-11. 2005..The results indicate that bound alpha-neurotoxin is not rigidly oriented on the surface of AChBP but rather exhibits segmental motion by virtue of flexibility in its fingerlike structure... - Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugatesZrinka Kovarik
Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0636, USA
Biochemistry 43:3222-9. 2004..Rates of reactivation reach values sufficient for consideration of mixtures of a mutant enzyme and an oxime as a scavenging strategy in protection and treatment of organophosphate exposure... - Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformationsScott B Hansen
Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0636, USA
EMBO J 24:3635-46. 2005..This comprehensive set of structures reflects a dynamic template for delineating further conformational changes of the LBD of the nicotinic receptor... - An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductanceScott B Hansen
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 0650, USA
J Biol Chem 283:36066-70. 2008.... - Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labelingMotohiro Tomizawa
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
J Med Chem 52:3735-41. 2009..Methionine and tyrosine are the only residues found derivatized, and their reactivity exquisitely depends on the direction of the azido moiety and its apposition to the reactive amino acid side chains... - Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptorRyan E Hibbs
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA
EMBO J 28:3040-51. 2009.... - Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loopJianxin Shi
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
J Biol Chem 278:30905-11. 2003.... - Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometryRoss C Hoffman
Department of Pharmacology and Howard Hughes Medical Institute Mass Spectrometry Facility, University of California, San Diego, La Jolla 92093, USA
Biochemistry 43:1496-506. 2004..From predictions based on sequence homology of NL1 to acetylcholinesterase and the molecular features of NL1 established from mass spectrometric analysis, a novel topology model for NL three-dimensional structure has been constructed... - Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptorsScott B Hansen
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0650, USA
J Mol Biol 369:895-901. 2007.... - LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formationJoris De Wit
Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 64:799-806. 2009..These observations indicate that an LRRTM2-Neurexin1 interaction plays a critical role in regulating excitatory synapse development... - Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivationTuba Küçükkilinç
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093 0650, USA
Chem Biol Interact 187:238-40. 2010..These results indicate that selected residues outside the active center influence inhibition, reactivation and catalysis rates through longer range interactions... - Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intronShelley Camp
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 0650, USA
J Neurosci 28:2459-70. 2008.... - In situ click chemistry: enzyme inhibitors made to their own specificationsRoman Manetsch
Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Am Chem Soc 126:12809-18. 2004..All in situ-generated compounds were extremely potent AChE inhibitors, because of the presence of multiple sites of interaction, which include the newly formed triazole nexus as a significant pharmacophore... - Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactionsTodd T Talley
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0636, USA
Biochemistry 45:8894-902. 2006.... - Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptorsTodd T Talley
Department of Pharmacology, University of California, La Jolla, California 92093-0636, USA
J Biol Chem 281:24678-86. 2006.... - Tryptophan fluorescence reveals conformational changes in the acetylcholine binding proteinScott B Hansen
Department of Pharmacology, University of California, San Diego, La Jolla 92093-0636, USA
J Biol Chem 277:41299-302. 2002..Thus, the marked tryptophan quenching not only documents the importance of aromatic residues in ligand recognition, but establishes that the AChBP will be a useful functional as well as structural surrogate of the nicotinic receptor... - Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretionArthur T Suckow
Department of Medicine, Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093, USA
Endocrinology 149:6006-17. 2008..Analogous to their role in synaptic neurotransmission, neurexin-neuroligin interactions may play a role in the formation of the submembrane insulin secretory apparatus... - Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairsBrinda K Rana
Departments of Psychiatry, University of California at San Diego, La Jolla, California 92093 0657, USA
J Pharmacol Exp Ther 331:419-28. 2009..These cellular events suggest a homeostatic mechanism underlying the pleiotropic actions of CHRNA3 genetic variation on autonomic function observed in twins... - Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptorsBrian E Molles
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
J Biol Chem 277:5433-40. 2002..The overall results show that non-conserved residues at the nAChR binding site, although not crucial for activation by ACh, govern the potency of neuromuscular toxins... - Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathwaysImran Khan
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
J Comp Neurol 467:44-59. 2003..These studies reveal a dense and distinguishable distribution of nAChR subunits in the spinal cord and point toward future therapeutic targeting for specific spinal actions... - Contributions of selective knockout studies to understanding cholinesterase disposition and functionShelley Camp
Department Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences 0657, University of California San Diego, La Jolla, CA 92093 0657, USA
Chem Biol Interact 187:72-7. 2010..The studies generated by these knockout mouse strains have yielded valuable insights into the function and localization of AChE in mammalian systems that cannot be approached in cell culture or in vitro... - Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometryLori L Jennings
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
Biochemistry 42:11083-91. 2003..For dimethyl phosphorylated AChE, OP exposure has been monitored by the ratio of tryptic peptide peaks that correspond to unmodified (uninhibited and/or reactivated), inhibited, and aged enzyme... - Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesteraseZoran Radic
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093 0650, United States
Chem Biol Interact 187:163-6. 2010..Dealkylation of phosphonylated enzyme, however opens space in the gorge allowing oximes to bind tighter... - Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocksWarren G Lewis
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Angew Chem Int Ed Engl 41:1053-7. 2002 - Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsivenessImran M Khan
Department of Pharmacology, University of California, San Diego, California 92093 0636, USA
Physiol Genomics 11:65-72. 2002.... - The macromolecular architecture of extracellular domain of alphaNRXN1: domain organization, flexibility, and insights into trans-synaptic dispositionDavide Comoletti
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Structure 18:1044-53. 2010..We thus provide the first structural insights into the architecture of the extracellular region of neurexin-1alpha, show how the protein may fit in the synaptic cleft, and how partnering proteins could bind simultaneously... - Structural dynamics of the acetylcholine binding protein: hydrodynamic and fluorescence anisotropy decay analysesRyan E Hibbs
Department of Pharmacology, University of California San Diego, La Jolla, CA 92093 0636, USA
J Mol Neurosci 30:73-4. 2006..As a structural and functional surrogate of the nicotinic acetylcholine receptor, the AChBP reveals ligand-mediated changes in conformation, mimicking that of the receptor... - A virtual screening study of the acetylcholine binding protein using a relaxed-complex approachArneh Babakhani
Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Dr MC 0365, La Jolla, CA 92093 0365, USA
Comput Biol Chem 33:160-70. 2009..These novel ligands could serve as potential pharmaceuticals in the AChBP/nAChR systems... - Tetrameric mouse acetylcholinesterase: continuum diffusion rate calculations by solving the steady-state Smoluchowski equation using finite element methodsDeqiang Zhang
Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093, USA
Biophys J 88:1659-65. 2005..This study also shows that the finite element solver is well suited for solving the diffusion problem within complicated geometries... - Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scatteringDavide Comoletti
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA
Structure 15:693-705. 2007..As mutations of neurexin and neuroligin genes appear to be linked to autism, these models provide a structural framework for understanding altered recognition by these proteins in neurodevelopmental disorders... - Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesteraseJennifer M Bui
Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093 0365, USA
Biophys J 90:3280-7. 2006..It seems likely that the more stable apo form binds rapidly to AChE and conformational readjustments then occur in the resulting encounter complex... - Molecular basis of interactions of cholinesterases with tight binding inhibitorsZoran Radic
Department of Pharmacology 0636, University of California at San Diego, La Jolla, CA 92093, USA
Chem Biol Interact 157:133-41. 2005..These tight binding inhibitor interactions reveal useful information not only on the conformational flexibility of ChEs, but also on the diversity of modes of interaction that achieve inhibition... - Influence of the 5' intron in the control of acetylcholinesterase gene expression during myogenesisAntonella De Jaco
Department of Pharmacology, University of California San Diego, La Jolla, CA 92093 0636, USA
Chem Biol Interact 157:372-3. 2005..Marquez, B. de La Torre, J.M. Long, G. Bucht, P. Taylor, Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion, VIII IMC Proceedings]... - A single mutation near the C-terminus in alpha/beta hydrolase fold protein family causes a defect in protein processingAntonella De Jaco
Department of Pharmacology and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA 92093 0636, USA
Chem Biol Interact 157:371-2. 2005.... - Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletionShelley Camp
University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
Chem Biol Interact 157:79-86. 2005..Rizzino, R.D. McComb, P. Taylor, S.H. Hinrichs, O. Lockridge, Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase. J. Pharmacol. Exp. Ther. 293 (3) (2000) 896-902]... - Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cordImran M Khan
Department of Pharmacology, University of California, San Diego, CA 92093 0636, USA
J Neurocytol 33:543-56. 2004..Conversely, spinal nicotinic receptors not located on C-fibers play a primary role in the spinal pathways evoking spinally coordinated autonomic cardiovascular responses... - Characterization of the solution structure of a neuroligin/beta-neurexin complexDavide Comoletti
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093 0650, USA
Chem Biol Interact 175:150-5. 2008.... - Trafficking of cholinesterases and neuroligins mutant proteins. An association with autismAntonella De Jaco
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093 0657, USA
Chem Biol Interact 175:349-51. 2008..We identified several proteins belonging to distinct ER resident chaperones families, including calnexin, responsible for playing a role in the folding steps of the AChE and NLs... - Probing gorge dimensions of cholinesterases by freeze-frame click chemistryZoran Radic
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0650, USA
Chem Biol Interact 175:161-5. 2008..Thus, in addition to synthesizing high affinity, lead inhibitors in situ, freeze-frame, click chemistry has capacity to generate species-specific AChE ligands that conform to the determinants in the gorge... - Ligand-induced conformational change in the alpha7 nicotinic receptor ligand binding domainRichard H Henchman
Howard Hughes Medical Institute, NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
Biophys J 88:2564-76. 2005.... - Folding anomalies of neuroligin3 caused by a mutation in the alpha/beta-hydrolase fold domainAntonella De Jaco
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States
Chem Biol Interact 187:56-8. 2010..These findings highlight the role of proper protein folding in protein processing and localization... - Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traitsAnne M Valle
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093 0657, USA
J Pharmacol Exp Ther 338:125-33. 2011..A substantial fraction of the D134H instability could be reversed in the D134H/R136Q mutant. Hence, common genetic variations at ACHE and BCHE loci were associated with changes in corresponding enzymatic activities in blood...
Research Grants
- FACILITIES CONSTRUCTION CENTERALIZED PHARMCOGENOMICSPalmer Taylor; Fiscal Year: 2003..The Centralized Animal Facility is critically needed to support this effort and allow economies of scale for animal research. ..
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2010....
- Oxime-Assisted Catalysis of Organophosphates and Reactivation of AChEPalmer Taylor; Fiscal Year: 2007..Hence, our approach will both augment catalytic scavenging of organophosphates in the circulation and enhance reactivation at the target tissues. ..
- GRADUATE TRAINING IN CELLULAR AND MOLECULAR PHARMACOLOGYPalmer Taylor; Fiscal Year: 2007..abstract_text> ..
- Nicotinic Receptor Template-guided Drug DesignPalmer Taylor; Fiscal Year: 2007..The final stages of investigation will include studies in rodents to determine efficacy and toxicity. ..
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPalmer Taylor; Fiscal Year: 2007..abstract_text> ..
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2011....