M R G Taylor

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Use of the Internet by patients and their families to obtain genetics-related information
    M R Taylor
    Division of Genetics and Metabolism, University of Colorado Health Sciences Center, Denver 80218, USA
    Mayo Clin Proc 76:772-6. 2001
  2. ncbi Pharmacogenetics of the human beta-adrenergic receptors
    M R G Taylor
    Adult Medical Genetics Program, University of Colorado at Denver and Health Sciences, Aurora, CO 80045, USA
    Pharmacogenomics J 7:29-37. 2007
  3. ncbi Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
    Matthew R G Taylor
    CU Cardiovascular Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Hum Mutat 26:566-74. 2005
  4. ncbi Lost in transition: challenges in the expanding field of adult genetics
    Matthew R G Taylor
    Adult Medical Genetics Program, Department of Medicine, University of Colorado Health Sciences, 12635 East Montview Boulevard, Aurora, CO 80045, USA
    Am J Med Genet C Semin Med Genet 142:294-303. 2006
  5. ncbi Prevalence of desmin mutations in dilated cardiomyopathy
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Denver, Colo, USA
    Circulation 115:1244-51. 2007
  6. ncbi The emerging pharmacogenomics of the beta-adrenergic receptors
    Matthew R G Taylor
    CU Cardiovascular Institute, Division of Cardiology, Adult Medical Genetics Program, University of Colorado Health Sciences Center, Aurora, CO, USA
    Congest Heart Fail 10:281-8. 2004
  7. pmc Cardiomyopathy, familial dilated
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute and Adult Medical Genetics Program, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Orphanet J Rare Dis 1:27. 2006
  8. ncbi Danon disease presenting with dilated cardiomyopathy and a complex phenotype
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
    J Hum Genet 52:830-5. 2007
  9. ncbi Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing
    Matthew R G Taylor
    Adult medical Genetics Clinic, Department of Internal Medicine, UCHSC, Aurora, Colorado 80010, USA
    Expert Rev Mol Diagn 4:99-113. 2004
  10. ncbi Natural history of dilated cardiomyopathy due to lamin A/C gene mutations
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute, Denver, Colorado 80010, USA
    J Am Coll Cardiol 41:771-80. 2003

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi Use of the Internet by patients and their families to obtain genetics-related information
    M R Taylor
    Division of Genetics and Metabolism, University of Colorado Health Sciences Center, Denver 80218, USA
    Mayo Clin Proc 76:772-6. 2001
    ..To characterize use of the Internet by patients and their families referred to general genetics clinics...
  2. ncbi Pharmacogenetics of the human beta-adrenergic receptors
    M R G Taylor
    Adult Medical Genetics Program, University of Colorado at Denver and Health Sciences, Aurora, CO 80045, USA
    Pharmacogenomics J 7:29-37. 2007
    ..This paper reviews the current state of knowledge and understanding of ADRB genetic variation and explores the likely direction of future studies in this area...
  3. ncbi Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
    Matthew R G Taylor
    CU Cardiovascular Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Hum Mutat 26:566-74. 2005
    ..The Arg690Cys mutation altered the observed LAP2alpha interaction with A-type lamins. Our finding implicates a novel nuclear lamina-associated protein in the pathogenesis of genetic forms of dilated cardiomyopathy...
  4. ncbi Lost in transition: challenges in the expanding field of adult genetics
    Matthew R G Taylor
    Adult Medical Genetics Program, Department of Medicine, University of Colorado Health Sciences, 12635 East Montview Boulevard, Aurora, CO 80045, USA
    Am J Med Genet C Semin Med Genet 142:294-303. 2006
    ..Potential solutions and the practicality of implementation of a team-based approach to adult genetic medicine, including the application of genetic counseling, are also discussed...
  5. ncbi Prevalence of desmin mutations in dilated cardiomyopathy
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Denver, Colo, USA
    Circulation 115:1244-51. 2007
    ..Mutations in the central 2B domain of DES cause skeletal muscle disease that typically precedes cardiac involvement. However, the prevalence of DES mutations in dilated cardiomyopathy (DCM) without skeletal muscle disease is not known...
  6. ncbi The emerging pharmacogenomics of the beta-adrenergic receptors
    Matthew R G Taylor
    CU Cardiovascular Institute, Division of Cardiology, Adult Medical Genetics Program, University of Colorado Health Sciences Center, Aurora, CO, USA
    Congest Heart Fail 10:281-8. 2004
    ....
  7. pmc Cardiomyopathy, familial dilated
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute and Adult Medical Genetics Program, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Orphanet J Rare Dis 1:27. 2006
    ..Patients with severe heart failure, severe reduction of the functional capacity and depressed left ventricular ejection fraction have a low survival rate and may require heart transplant...
  8. ncbi Danon disease presenting with dilated cardiomyopathy and a complex phenotype
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
    J Hum Genet 52:830-5. 2007
    ..Furthermore, the absence of vacuolar myopathy in biopsies from young patients may not exclude Danon disease...
  9. ncbi Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing
    Matthew R G Taylor
    Adult medical Genetics Clinic, Department of Internal Medicine, UCHSC, Aurora, Colorado 80010, USA
    Expert Rev Mol Diagn 4:99-113. 2004
    ..In this review, the clinical and molecular genetics of hypertrophic cardiomyopathy are described...
  10. ncbi Natural history of dilated cardiomyopathy due to lamin A/C gene mutations
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute, Denver, Colorado 80010, USA
    J Am Coll Cardiol 41:771-80. 2003
    ..We examined the prevalence, genotype-phenotype correlation, and natural history of lamin A/C gene (LMNA) mutations in subjects with dilated cardiomyopathy (DCM)...
  11. ncbi Management of polycystic liver disease
    Gregory T Everson
    Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, 4200 East Ninth Avenue, B 154, Denver, CO 80262, USA
    Curr Gastroenterol Rep 7:19-25. 2005
    ..There is no effective medical therapy. Treatment options include cyst aspiration and sclerosis, open or laparoscopic cyst fenestration, hepatic resection, and liver transplantation...
  12. ncbi Modifier genes play a significant role in the phenotypic expression of PKD1
    Pamela R Fain
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Kidney Int 67:1256-67. 2005
    ..There are significant familial phenotype differences; but it is not clear if this is due to differences in PKD1 mutations, differences in genetic background, or both...
  13. ncbi Polycystic disease of the liver
    Gregory T Everson
    Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Hepatology 40:774-82. 2004
    ..There is no effective medical therapy. Interventional and surgical options include cyst aspiration and sclerosis, open or laparoscopic cyst fenestration, hepatic resection, and liver transplantation...
  14. ncbi Analysis of genetic variations of lamin A/C gene (LMNA) by denaturing high-performance liquid chromatography
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute, Denver, USA
    J Biomol Screen 9:625-8. 2004
    ..LMNA mutations are clinically relevant in at least 6 human diseases. This study provides a protocol for high-throughput LMNA analysis applicable both in the research and in the clinical diagnostic setting...
  15. ncbi SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia
    William P McNair
    University of Colorado Cardiovascular Institute, Denver, Colo, USA
    Circulation 110:2163-7. 2004
    ....
  16. pmc Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure
    Matthew R G Taylor
    University of Colorado Denver, Aurora, CO, USA
    Pharmacogenet Genomics 19:35-43. 2009
    ..We hypothesized that variation in genes of the endothelin system mediate the clinical response to beta-blockers in heart failure...
  17. doi High prevalence of array comparative genomic hybridization abnormalities in adults with unexplained intellectual disability
    Matthew R G Taylor
    Department of Medicine, Adult Medical Genetics Program, University of Colorado Denver, Denver, Colorado, USA
    Genet Med 12:32-8. 2010
    ..Here, we report our initial experience with array comparative genomic hybridization testing on 45 adults with unexplained intellectual disability referred to an adult genetics clinic...
  18. ncbi Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome
    Sogol Nowbar
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Med 116:1-7. 2004
    ..Severe obesity is associated with hypoventilation, a disorder that may adversely affect morbidity and mortality. We sought to determine the prevalence and effects of obesity-associated hypoventilation in hospitalized patients...
  19. ncbi [Dilated cardiomyopathy: etiology, clinical criteria for diagnosis and screening of the familial form]
    Umberto Startari
    University of Colorado Cardiovascular Institute, Adult Medical Genetics Program, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Ital Heart J Suppl 3:378-85. 2002
    ..The family screening should be followed-up every 2 to 3 years, in particular in unaffected relatives (in the absence of a molecular diagnosis), to exclude a late onset of the disease...
  20. ncbi Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy
    Elisa Carniel
    Familial Cardiomyopathy Registry Research Group, USA
    Circulation 112:54-9. 2005
    ..In failing human hearts, downregulation of alphaMyHC mRNA or protein has been correlated with systolic dysfunction. We hypothesized that mutations in alphaMyHC could also lead to pleiotropic cardiac phenotypes, including HCM and DCM...
  21. ncbi Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2
    Eeva Liisa Eskelinen
    University of Kiel, Institute of Biochemistry, Kiel, Germany
    Traffic 6:1058-61. 2005
    ..To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C...
  22. pmc Cardiomyopathy and carnitine deficiency
    Cristina Amat di San Filippo
    Division of Medical Genetics, Departments of Pediatrics and Pathology, University of Utah, 2C412 SOM, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Mol Genet Metab 94:162-6. 2008
    ..These results indicate that heterozygosity for primary carnitine deficiency is not more frequent in patients with unselected types of cardiomyopathy and is unlikely to be an important cause of cardiomyopathy in humans...
  23. pmc Lamin A/C gene and the heart: how genetics may impact clinical care
    Luisa Mestroni
    J Am Coll Cardiol 52:1261-2. 2008

Research Grants1

  1. Familial Dilated Cardiomyopathy:Genetic Characterization
    Matthew Taylor; Fiscal Year: 2006
    ..In addition, a diverse collection of consultants has been assembled to provide ongoing expertise that is sensitive to the needs of both the research and career development plans of the candidate. ..