DOUGLAS DILLON TAYLOR

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Shed membrane fragment-associated markers for endometrial and ovarian cancers
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Gynecol Oncol 84:443-8. 2002
  2. ncbi request reprint Modulation of T-cell CD3-zeta chain expression during normal pregnancy
    Douglas D Taylor
    Department of Obstetrics and Gynecology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Reprod Immunol 54:15-31. 2002
  3. pmc Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    D D Taylor
    Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Br J Cancer 92:305-11. 2005
  4. ncbi request reprint Pregnancy-linked suppression of TcR signaling pathways by a circulating factor absent in recurrent spontaneous pregnancy loss (RPL)
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, Division of Gynecologic Oncology, University of Louisville School of Medicine, 511 South Floyd Street, MDR 420, Louisville, KY 40292, USA
    Mol Immunol 43:1872-80. 2006
  5. ncbi request reprint Pregnancy-associated exosomes and their modulation of T cell signaling
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 176:1534-42. 2006
  6. doi request reprint MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Gynecol Oncol 110:13-21. 2008
  7. pmc Alterations of T cell activation signalling and cytokine production by postmenopausal estrogen levels
    Lowell T Ku
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Immun Ageing 6:1. 2009
  8. pmc Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer
    Douglas D Taylor
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Gynecol Oncol 115:112-20. 2009
  9. doi request reprint Characterization of humoral responses of ovarian cancer patients: antibody subclasses and antigenic components
    Douglas D Taylor
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Gynecol Oncol 116:213-21. 2010
  10. doi request reprint Exosome isolation for proteomic analyses and RNA profiling
    Douglas D Taylor
    James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA
    Methods Mol Biol 728:235-46. 2011

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Shed membrane fragment-associated markers for endometrial and ovarian cancers
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Gynecol Oncol 84:443-8. 2002
    ..The objective of this study was to assess circulating tumor-derived membrane fragments (MFs) and specific proteins associated with them as diagnostic and prognostic markers for ovarian and endometrial cancers...
  2. ncbi request reprint Modulation of T-cell CD3-zeta chain expression during normal pregnancy
    Douglas D Taylor
    Department of Obstetrics and Gynecology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Reprod Immunol 54:15-31. 2002
    ..Suppression of zeta expression appears to be due to a circulating low-molecular-weight protein that suppresses CD3-zeta in a concentration-dependent manner...
  3. pmc Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    D D Taylor
    Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Br J Cancer 92:305-11. 2005
    ..These results indicate that, while 'exosomes' express tumour antigens, leading to their proposed utility as tumour vaccines, they also can suppress T-cell signalling molecules and induce apoptosis...
  4. ncbi request reprint Pregnancy-linked suppression of TcR signaling pathways by a circulating factor absent in recurrent spontaneous pregnancy loss (RPL)
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, Division of Gynecologic Oncology, University of Louisville School of Medicine, 511 South Floyd Street, MDR 420, Louisville, KY 40292, USA
    Mol Immunol 43:1872-80. 2006
    ..The 14 kDa circulating ZIP from normal pregnancies suppressed components within the JAK/STAT pathway and induced suppressors of cytokine stimulation, SOCS2...
  5. ncbi request reprint Pregnancy-associated exosomes and their modulation of T cell signaling
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 176:1534-42. 2006
    ....
  6. doi request reprint MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Gynecol Oncol 110:13-21. 2008
    ..Tumors actively release exosomes into the peripheral circulation and we now demonstrate the association of microRNAs with circulating tumor-derived exosomes...
  7. pmc Alterations of T cell activation signalling and cytokine production by postmenopausal estrogen levels
    Lowell T Ku
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Immun Ageing 6:1. 2009
    ..Lower signalling protein levels appear to result from decreased CD3-zeta, JAK2, and JAK3 gene expressions. These findings may provide a molecular basis for immunosenescence associated with the postmenopausal state...
  8. pmc Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer
    Douglas D Taylor
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Gynecol Oncol 115:112-20. 2009
    ..Our objective was to validate our array assay for the identification of ovarian cancer based on quantitation of tumor-reactive IgG...
  9. doi request reprint Characterization of humoral responses of ovarian cancer patients: antibody subclasses and antigenic components
    Douglas D Taylor
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Gynecol Oncol 116:213-21. 2010
    ..In contrast, tumor antigen immunorecognition is observed following initial transformation events. Our objective was to characterize humoral antitumor responses in terms of IgG subclasses generated and tumor antigens recognized...
  10. doi request reprint Exosome isolation for proteomic analyses and RNA profiling
    Douglas D Taylor
    James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA
    Methods Mol Biol 728:235-46. 2011
    ....
  11. ncbi request reprint Alterations in T-cell signal transduction molecules associated with recurrent spontaneous pregnancy loss
    Douglas D Taylor
    Department of Obstetrics and Gynecology, University of Louisville, School of Medicine, 511 S Floyd Street, MDR 420, Louisville, KY 40202, USA
    J Reprod Immunol 63:137-54. 2004
    ..Our findings indicate that women experiencing RSA fail to suppress CD3-zeta and JAK3, suggesting a deficiency in this circulating factor that induces their suppression in normal pregnancy...
  12. ncbi request reprint Modulation of CD3-zeta as a marker of clinical response to IL-2 therapy in ovarian cancer patients
    Douglas D Taylor
    Division of Gynecologic Oncology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Gynecol Oncol 94:54-60. 2004
    ..The aims of this study were to identify the circulating component that modulated zeta expression and to define whether this suppressive activity could serve as a marker of biotherapy responsiveness...
  13. doi request reprint Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments
    Douglas D Taylor
    Department of Obstetrics, Gynecology and Women s Health and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA
    Semin Immunopathol 33:441-54. 2011
    ..By understanding the nature of these tumor-derived exosomes/microvesicles and their roles in mediating cancer progression and modulating the host immune response will significantly impact therapeutic approaches targeting exosomes...
  14. ncbi request reprint T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors
    Douglas D Taylor
    Departments of Obstetrics and Gynecology and Radiation Oncology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Clin Cancer Res 9:5113-9. 2003
    ....
  15. doi request reprint Genistein reverses diminished T-cell signal transduction, induced by post-menopausal estrogen levels
    J Preston Parry
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Am J Reprod Immunol 61:26-33. 2009
    ..This study addressed the ability of genistein to reverse the loss of T-cell signaling components, induced by estrogen deficiency associated with aging...
  16. ncbi request reprint Potentiation of the radiation effect with genistein in cervical cancer cells
    Catheryn M Yashar
    Department of Radiation Oncology, University of Louisville School of Medicine, 511 South Floyd Street, Room 416, Louisville, KY 40202, USA
    Gynecol Oncol 99:199-205. 2005
    ..Radiation is used for curative therapy of locally advanced disease and is combined with additional anti-tumor agents to improve control. We determined the potential role of genistein as a radiosensitizer for cervical cancer cells...
  17. ncbi request reprint Shed membrane fragment modulation of CD3-zeta during pregnancy: link with induction of apoptosis
    Cicek Gercel-Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, 511 South Floyd Street, MDR 420, Louisville, KY 40292, USA
    J Reprod Immunol 56:29-44. 2002
    ..These membrane fragment isolates are capable of inducing FasL-mediated apoptosis and down-regulating CD3-zeta expression, which may contribute to the immune tolerance of the fetus...
  18. ncbi request reprint Loss of communication in ovarian cancer
    Chris R Toler
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY, USA
    Am J Obstet Gynecol 194:e27-31. 2006
    ..This study was undertaken to investigate the expression of connexins in ovarian cancer cell lines and assess correlation with chemosensitivity...
  19. ncbi request reprint Induction of p53 and drug resistance following treatment with cisplatin or paclitaxel in ovarian cancer cell lines
    Daniel S Metzinger
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Louisville School of Medicine, 511 South Floyd Street, MDR Building, Room 416, Louisville, KY 40202, USA
    Cancer Lett 236:302-8. 2006
    ..9 microg/ml, while UL-3B clones ranged from 11.8-252.0 microg/ml, with a mean value of 73.2 microg/ml for Cis, and 260.0-4400.0 nM (mean 2555.0 nM) for Tax. Selection pressures during treatment may contribute to drug resistance...
  20. ncbi request reprint Inhibitory effect of genistein and daidzein on ovarian cancer cell growth
    Cicek Gercel-Taylor
    Department of Obstetrics, Gynecology and Women s Health, University of Louisville, School of Medicine, Louisville, KY 40202, USA
    Anticancer Res 24:795-800. 2004
    ..Survival from ovarian cancer has not changed significantly in the past twenty years requiring development of additional treatment protocols. We studied the effect of genistein and daidzein on ovarian cancer cell growth...
  21. ncbi request reprint HSP-10 in ovarian cancer: expression and suppression of T-cell signaling
    Sibel Akyol
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, 511 South Floyd Street, MDR 420, Louisville, KY 40292, USA
    Gynecol Oncol 101:481-6. 2006
    ..quot; This pilot study addresses the presence of HSP10 in the circulation of ovarian cancer patients and assesses its role in suppressing CD3-zeta...
  22. ncbi request reprint Endometriosis markers: immunologic alterations as diagnostic indicators for endometriosis
    Henry C Bohler
    Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Reprod Sci 14:595-604. 2007
    ..Alterations in autoreactivity and NK activity are observed in endometriosis and may be useful as diagnostic markers, even in early stage disease...
  23. ncbi request reprint Effect of chemotherapy on the mutation frequency of ovarian cancer cells at the HPRT locus
    Cicek Gercel-Taylor
    Department of Obstetrics and Gynecology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Anticancer Res 25:2113-7. 2005
    ..Our objective was to demonstrate the effect of chemotherapeutic agents, used in the treatment of ovarian cancer, on the mutation frequency of ovarian cancer cells at the HPRT locus...
  24. ncbi request reprint Cellular response to chemotherapy and radiation in cervical cancer
    Angela Saxena
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, KY 40202, USA
    Am J Obstet Gynecol 192:1399-403. 2005
    ..These data provide correlation of response to combined therapeutic modalities with HPV status of cervical cancer and expression of survivin and AKT...
  25. ncbi request reprint Gene expression profiling in response to estradiol and genistein in ovarian cancer cells
    Lynn P Parker
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Cancer Genomics Proteomics 6:189-94. 2009
    ..We analyzed the gene-expression in response to estradiol (E2) and genistein (Gen) in ovarian cancer cells...
  26. doi request reprint Exosomal microRNA: a diagnostic marker for lung cancer
    Guilherme Rabinowits
    J G Brown Cancer Center, University of Louisville, KY, USA
    Clin Lung Cancer 10:42-6. 2009
    ..No correlation between the exosomal miRNA levels and the stage of disease can be made at this point...
  27. ncbi request reprint Modulation of T-cell CD3-zeta chain expression in early pregnancy
    Abby C Eblen
    Department of Obstetrics, Gynecology and Women s Health, University of Louisville School of Medicine, KY, USA
    Am J Reprod Immunol 47:167-73. 2002
    ..To assess the modulation of T-cell CD3-zeta chain expression by a factor in the sera of women, prior to egg retrieval and 14 days after an in vitro fertilization (IVF) and to delineate the mechanism of this modulation...
  28. ncbi request reprint A novel approach to cancer immunotherapy: tumor cells decorated with CD80 generate effective antitumor immunity
    Narendra P Singh
    Institute for Cellular Therapeutics, University of Louisville, Louisville, Kentucky 40202, USA
    Cancer Res 63:4067-73. 2003
    ..This technology may serve as a fast, efficient, and safe alternative to gene transfer approaches for engineering tumor cells for use in immunotherapy and research...
  29. ncbi request reprint Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences
    Anuradha Sabapatha
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Am J Reprod Immunol 56:345-55. 2006
    ..In normal pregnancy, as factors linked with early immunomodulation decline, placental exosomes become critical in modulating T-cell activation, suppressing effector T cells by enhancing lymphocyte apoptosis and CD3-zeta loss...
  30. ncbi request reprint Differential expression of TcR-CD3 zeta as evidence for altered immunoregulation in preeclamptic versus normotensive women
    Garrett K Lam
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, USA
    Am J Obstet Gynecol 189:843-7. 2003
    ..The study was undertaken to exhibit and quantify the difference in modulation of CD3-zeta protein (an integral component of the T-cell receptor) in preeclamptic and normotensive women...
  31. ncbi request reprint Primary tumor cells resected from cancer patients and decorated with a novel form of CD80 protein serve as effective antigen-presenting cells for the induction of autologous T cell immune responses ex vivo
    Narendra P Singh
    Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA
    Hum Gene Ther 17:334-46. 2006
    ..Taken together, these data demonstrate that primary tumor cells can be effectively decorated with CD80-SA and that such cells serve as APCs to induce autologous antitumor T cell responses...
  32. ncbi request reprint Urinary matrix metalloproteinases as a potential screening test for gynecologic malignancies
    Lisa B Bazzett
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Ochnsner Clinic Foundation, New Orleans, LA 70121, USA
    Gynecol Oncol 90:435-42. 2003
    ..This was a pilot study to determine the feasibility of using urinary matrix metalloproteinases (MMPs) as a screening test for gynecologic malignancies...

Research Grants1

  1. Tumor-reactive IgG in the diagnosis of ovarian cancer
    Douglas Taylor; Fiscal Year: 2005
    ..Ultimately, antigenic proteins, linked with histologic type and stage of disease, will be combined into the development of protein arrays to screen for circulating reactive IgG as an early diagnostic test. ..