O W Tawfik

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Vitamin d receptor, retinoid x receptor, ki-67, survivin, and ezrin expression in canine osteosarcoma
    John Davies
    BluePearl Veterinary Partners, Overland Park, KS 66210, USA Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Vet Med Int 2012:761034. 2012
  2. ncbi request reprint Low grade B cell lymphoma arising in a background of multifocal extra-adrenal myelolipoma
    Aaron Noll
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA phone 913 588 1180, fax 913 588 1185, E mail
    Ann Clin Lab Sci 43:441-6. 2013
  3. pmc Integrating pathology and radiology disciplines: an emerging opportunity?
    James Sorace
    Office of Science and Data Policy, Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, 200 Independence Ave, SW Washington, DC 20201, USA
    BMC Med 10:100. 2012
  4. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
  5. ncbi request reprint Comparison of immunohistochemistry by automated cellular imaging system (ACIS) versus fluorescence in-situ hybridization in the evaluation of HER-2/neu expression in primary breast carcinoma
    O W Tawfik
    Department of Radiation Oncology, Division of Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Histopathology 48:258-67. 2006
  6. ncbi request reprint Grading invasive ductal carcinoma of the breast: advantages of using automated proliferation index instead of mitotic count
    Ossama Tawfik
    Department of Pathology and Laboratory Medicine, Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Virchows Arch 450:627-36. 2007
  7. ncbi request reprint Clinicopathological characteristics of triple-negative invasive mammary carcinomas in African-American versus Caucasian women
    Ossama Tawfik
    Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, 66160, USA
    Ann Clin Lab Sci 40:315-23. 2010
  8. ncbi request reprint Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinoma
    Ossama W Tawfik
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Arch Pathol Lab Med 131:261-7. 2007
  9. ncbi request reprint Neuroendocrine differentiation of a metastatic basal cell carcinoma in a patient with basal cell nevus syndrome
    O Tawfik
    Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA
    J Cutan Pathol 26:306-10. 1999
  10. ncbi request reprint Salivary gland neoplasms with basaloid cell features: report of two cases diagnosed by fine-needle aspiration cytology
    O Tawfik
    Department of Pathology, Kansas University Medical Center, Kansas City 66160, USA
    Diagn Cytopathol 21:46-50. 1999

Collaborators

Detail Information

Publications45

  1. pmc Vitamin d receptor, retinoid x receptor, ki-67, survivin, and ezrin expression in canine osteosarcoma
    John Davies
    BluePearl Veterinary Partners, Overland Park, KS 66210, USA Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Vet Med Int 2012:761034. 2012
    ..374). A significant relationship exists between VDR and RXR expression in OSs and proliferative/apoptosis markers. These results establish a foundation for elucidating mechanisms by which vitamin D induces antineoplastic activity in OS...
  2. ncbi request reprint Low grade B cell lymphoma arising in a background of multifocal extra-adrenal myelolipoma
    Aaron Noll
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA phone 913 588 1180, fax 913 588 1185, E mail
    Ann Clin Lab Sci 43:441-6. 2013
    ..To our knowledge, this is only the third reported case to feature such a rare combination of diseases. The clinical, radiological, and pathological differential diagnostic findings are discussed...
  3. pmc Integrating pathology and radiology disciplines: an emerging opportunity?
    James Sorace
    Office of Science and Data Policy, Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, 200 Independence Ave, SW Washington, DC 20201, USA
    BMC Med 10:100. 2012
    ....
  4. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
    ..In this study, we explored the impact of HIV protein induced oxidative stress on production of hypoxia inducible factor (HIF)-1α and platelet-derived growth factor (PDGF), critical mediators implicated in the pathogenesis of HIV-PAH...
  5. ncbi request reprint Comparison of immunohistochemistry by automated cellular imaging system (ACIS) versus fluorescence in-situ hybridization in the evaluation of HER-2/neu expression in primary breast carcinoma
    O W Tawfik
    Department of Radiation Oncology, Division of Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Histopathology 48:258-67. 2006
    ..Our aim was to compare the results of HER-2/neu expression and gene amplification in the same patients by IHC using the ACIS system and by FISH...
  6. ncbi request reprint Grading invasive ductal carcinoma of the breast: advantages of using automated proliferation index instead of mitotic count
    Ossama Tawfik
    Department of Pathology and Laboratory Medicine, Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Virchows Arch 450:627-36. 2007
    ..Distinction among the different histologic grades for overall survival curves was better indicated by the N+P than the SBR system...
  7. ncbi request reprint Clinicopathological characteristics of triple-negative invasive mammary carcinomas in African-American versus Caucasian women
    Ossama Tawfik
    Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, 66160, USA
    Ann Clin Lab Sci 40:315-23. 2010
    ..There were minor differences in histopathologic features, biomarker expressions, and survival in AA and Caucasian women with TN tumors. The absence of LVI in AA patients predicted an excellent probability of survival...
  8. ncbi request reprint Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinoma
    Ossama W Tawfik
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Arch Pathol Lab Med 131:261-7. 2007
    ..Pathologic stage is the main prognostic factor for predicting outcome in renal cell carcinoma (RCC). Because of its unreliability in predicting tumor progression, other factors are needed to provide additional prognostic information...
  9. ncbi request reprint Neuroendocrine differentiation of a metastatic basal cell carcinoma in a patient with basal cell nevus syndrome
    O Tawfik
    Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA
    J Cutan Pathol 26:306-10. 1999
    ..Neuroendocrine differentiation has rarely been associated with basal cell carcinoma. The histologic, immunohistochemical, and electron microscopic studies of this rare tumor are described...
  10. ncbi request reprint Salivary gland neoplasms with basaloid cell features: report of two cases diagnosed by fine-needle aspiration cytology
    O Tawfik
    Department of Pathology, Kansas University Medical Center, Kansas City 66160, USA
    Diagn Cytopathol 21:46-50. 1999
    ..Review of the literature and cytomorphologic distinction between both tumors and others are discussed...
  11. ncbi request reprint Vernix caseosa peritonitis as a rare complication of cesarean section. A case report
    O Tawfik
    Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA
    J Reprod Med 43:547-50. 1998
    ..Vernix caseosa peritonitis is a rare complication of cesarean section with distinctive histopathologic findings...
  12. ncbi request reprint Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2
    Gopal Dhar
    Cancer Research Unit, VA Medical Center, Kansas City, Missouri, USA
    Cancer Res 68:4580-7. 2008
    ..Thus, these studies suggest that CCN5 inactivation could be an essential molecular event for p53 mutant-induced invasive phenotypes...
  13. ncbi request reprint Differential expression of human leukocyte antigen-G (HLA-G) messenger RNAs and proteins in normal human prostate and prostatic adenocarcinoma
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    J Reprod Immunol 71:75-86. 2006
    ..The results are consistent with this molecule may influencing female immune receptivity to sperm and suggest that such immunosuppression could be disturbed in men with prostatic adenocarcinomas...
  14. ncbi request reprint Endoscopic techniques in resection of anterior skull base/paranasal sinus malignancies
    Luke Buchmann
    Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA
    Laryngoscope 116:1749-54. 2006
    ..The objective of this study was to examine the role of endoscopic approaches to the resection of anterior skull base and paranasal sinus malignancies at one tertiary care medical center...
  15. doi request reprint CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells
    Snigdha Banerjee
    Cancer Research Unit, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    Cancer Res 68:7606-12. 2008
    ..These include Snail-E-cadherin signaling and matrix metalloproteinase (MMP)-9 and MMP-2. Collectively, these studies suggest that the protective effect of CCN5 in breast cancer progression may have important therapeutic implications...
  16. ncbi request reprint Mechanisms of focal calcification in rabbit aortas: role of calcifying vesicles
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Investig Med 54:402-11. 2006
    ..Whether osteogenesis or a local increase in calcifying vesicles underlies the focal calcification remains to be established...
  17. pmc Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes
    Jinxi Wang
    Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, 66160, USA
    J Pathol 219:163-72. 2009
    ..These results may provide new insights into the aetiology, pathogenesis and potential therapeutic strategies for osteoarthritis...
  18. pmc Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sl(d) mice
    Kottarappat N Dileepan
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mediators Inflamm 13:335-41. 2004
    ..Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sl(d) mice...
  19. ncbi request reprint BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Genet 36:1117-21. 2004
    ..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number...
  20. ncbi request reprint Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor)
    Christopher J Stasik
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7410, USA
    Arch Pathol Lab Med 130:1878-81. 2006
    ..In this review we discuss the clinical, histopathological, immunohistochemical, and prognostic features of this rare neoplasm...
  21. ncbi request reprint Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
    Atherosclerosis 161:85-94. 2002
    ....
  22. ncbi request reprint Mechanisms of calcification by vesicles isolated from atherosclerotic rabbit aortas
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 66160 7410, USA
    Biochim Biophys Acta 1563:18-22. 2002
    ..Taken together, these observations suggest that ATP hydrolysis, CaxP ion products, and vesicle-associated carbohydrates are implicated in vesicle-mediated calcification...
  23. pmc WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation
    Snigdha Banerjee
    Cancer Research Unit, Research Division, V A Medical Center, Kansas City, MO 64128, USA
    Neoplasia 5:63-73. 2003
    ..The results are consistent with the conclusion that WISP-2 expression is a requirement for breast tumor cells proliferation...
  24. doi request reprint Potential role of platelet-derived growth factor receptor inhibition using imatinib in combination with docetaxel in the treatment of recurrent non-small cell lung cancer
    Chao H Huang
    Department of Internal Medicine, Division of Hematology and Medical Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Thorac Oncol 6:372-7. 2011
    ..Hypothesis: We hypothesized that Im plus docetaxel (D) would have a synergistic effect detectable by an increase in response rate in patients with recurrent non-small cell lung cancer (NSCLC)...
  25. ncbi request reprint Mechanism of dystrophic calcification in rabbit aortas: temporal and spatial distributions of calcifying vesicles and calcification-related structural proteins
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
    Cardiovasc Pathol 13:3-10. 2004
    ..Whether the distributions of other structural proteins related to calcification such as collagen and elastin fibers undergo coordinated modifications has not been established...
  26. ncbi request reprint Bowel necrosis caused by water in jejunal feeding
    Paul R Schloerb
    Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    JPEN J Parenter Enteral Nutr 28:27-9. 2004
    ..Fifteen reports of bowel necrosis in patients receiving jejunal feeding have been reported. Etiology remains unexplained...
  27. doi request reprint Acellular dermis compared to skin grafts in oral cavity reconstruction
    Douglas A Girod
    Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Laryngoscope 119:2141-9. 2009
    ..To compare the efficacy of acellular dermal matrix (ADM) and split thickness skin grafts (STSG) in oral cavity reconstruction...
  28. ncbi request reprint Myoepithelial carcinoma of the breast arising in an adenomyoepithelioma: mammographic, ultrasound and histologic features
    Fang Fan
    Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Breast J 13:203-4. 2007
  29. ncbi request reprint Sex does not seem to influence the formation of aortic lesions in the P-407-induced mouse model of hyperlipidemia and atherosclerosis
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    J Cardiovasc Pharmacol 39:404-11. 2002
    ..Thus, male C57BL/6 mice form atherosclerotic lesions as extensive as female mice in the P-407 mouse model of atherosclerosis...
  30. ncbi request reprint CD44s expression is reduced in endometriotic lesions compared to eutopic endometrium in women with endometriosis
    W B Nothnick
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Int J Gynecol Pathol 20:140-6. 2001
    ..This cyclic pattern of CD44s expression was lost in corresponding endometriotic tissue. Reduced expression of CD44s in endometriotic tissue may provide insight into the pathophysiology of endometriosis...
  31. pmc Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    Bo Kong
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 328:116-22. 2009
    ....
  32. ncbi request reprint Factors associated with success of the extreme drug resistance assay in primary breast cancer specimens
    Robert J Ellis
    Department of Internal Medicine, University of Kansas Medical Center, Kansas City 66160, USA
    Breast Cancer Res Treat 71:95-102. 2002
    ..These results may be helpful for designing possible future trials that evaluate the assay's role in adjuvant chemotherapy selection...
  33. ncbi request reprint Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer
    Jonathan J Li
    Hormonal Carcinogenesis Laboratory, Division of Etiology and Prevention of Hormonal Cancers, Kansas Cancer Institute, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Mol Carcinog 33:56-65. 2002
    ....
  34. ncbi request reprint Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer
    L Krishnan
    Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas 66160 7321, USA
    Breast J 7:91-6. 2001
    ..There were no long-term complications. It is feasible to treat a select group of patients with tumor bed irradiation, using relatively low doses of interstitial irradiation, with excellent local control and no significant morbidity...
  35. ncbi request reprint Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats
    S John Weroha
    Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Carcinogenesis 27:491-8. 2006
    ....
  36. doi request reprint EGFR and HER-2/neu expression in invasive apocrine carcinoma of the breast
    Semir Vranic
    Department of Pathology, Creighton University Medical Center, Omaha, NE 68131, USA
    Mod Pathol 23:644-53. 2010
    ..Pure apocrine carcinomas show consistent overexpression of either EGFR or HER-2/neu, which could have significant therapeutic implications...
  37. pmc Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies
    Bradley P Sullivan
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 115:286-94. 2010
    ..In contrast, severe thrombocytopenia induces parenchymal-type peliosis in the livers of ANIT-treated mice, a rare hepatic lesion associated with pooling of blood in the liver...
  38. ncbi request reprint Phyllodes tumor of borderline malignancy: seven year follow up with immunohistochemical study
    Tatsuo Tomita
    Division of Surgical Pathology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
    Pathol Int 55:585-9. 2005
    ..These findings support the notion that Ki-67 and p53 immunohistochemical staining may be used as simple and practical markers for the evaluation of the malignant potential of PT...
  39. ncbi request reprint Prognostic significance of ploidy, MIB-1 proliferation marker, and p53 in renal cell carcinoma
    Brandon A Kramer
    Department of Urology, The University of Kansas Medical Center, Kansas City 66160, USA
    J Am Coll Surg 201:565-70. 2005
    ..The objective of this study was to evaluate the role of DNA ploidy, p53, and Ki-67 (MIB-1) as individual and combined prognostic factors for survival in patients with renal cell carcinoma (RCC)...
  40. ncbi request reprint Small cell undifferentiated (neuroendocrine) carcinoma of the uterine cervix
    John C Weed
    University of Kansas School of Medicine, Kansas City, USA
    J Am Coll Surg 197:44-51. 2003
    ..Most medical centers have little experience with this tumor. The purposes of our study were to evaluate our experience and compare our findings with those reported in current literature...
  41. ncbi request reprint Telomerase reverse transcriptase subunit immunoreactivity: a marker for high-grade prostate carcinoma
    Kenneth A Iczkowski
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Cancer 95:2487-93. 2002
    ..One study used in situ hybridization in nine patients; however, to date, no immunohistochemical results have been published...
  42. ncbi request reprint A comparison of prognostic tumor markers obtained on image-guided breast biopsies and final surgical specimens
    Carol S Connor
    Department of Surgery, University of Kansas Medical Center, Kansas City 66160, USA
    Am J Surg 184:322-4. 2002
    ..This study was initiated to determine whether tumor markers obtained on image-guided breast biopsy specimens provide accurate prognostic information for women with invasive breast cancer...
  43. ncbi request reprint Proposed prognostic score for breast carcinoma on fine needle aspiration based on nuclear grade, cellular dyscohesion and bare atypical nuclei
    Fang Fan
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Diagn Cytopathol 34:542-6. 2006
    ..In conclusion, cytoprognostic score is performed with ease and shows a great promise as a cost-effective way to predict biological behavior of breast carcinoma and guide clinical management...
  44. ncbi request reprint Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulator
    Carol J Fabian
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Clin Cancer Res 10:5403-17. 2004
    ..We performed a multi-institutional evaluation of arzoxifene in women with newly diagnosed ductal carcinoma in situ or T1/T2 invasive cancer...
  45. ncbi request reprint Adrenal pseudocyst: a unique case with adrenal renal fusion, mimicking a cystic renal mass
    Fang Fan
    Departments of Pathology and Laboratory Medicine, Urology, and Radiology, University of Kansas Medical Center, Kansas City, KS, USA
    Ann Diagn Pathol 8:87-90. 2004
    ..The cyst measured 12 cm in diameter and had a fibrotic external envelope that was fused with the renal capsule. The possible diagnostic pitfalls encountered in this case are discussed...