Research Topics
| O W TawfikSummaryAffiliation: University of Kansas Medical Center Country: USA Publications
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Detail Information
Publications
Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodelingJoel Mermis
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
Respir Res 12:103. 2011..In this study, we explored the impact of HIV protein induced oxidative stress on production of hypoxia inducible factor (HIF)-1α and platelet-derived growth factor (PDGF), critical mediators implicated in the pathogenesis of HIV-PAH...
Vernix caseosa peritonitis as a rare complication of cesarean section. A case reportO Tawfik
Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA
J Reprod Med 43:547-50. 1998..Vernix caseosa peritonitis is a rare complication of cesarean section with distinctive histopathologic findings...- Salivary gland neoplasms with basaloid cell features: report of two cases diagnosed by fine-needle aspiration cytologyO Tawfik
Department of Pathology, Kansas University Medical Center, Kansas City 66160, USA
Diagn Cytopathol 21:46-50. 1999..Review of the literature and cytomorphologic distinction between both tumors and others are discussed... - Neuroendocrine differentiation of a metastatic basal cell carcinoma in a patient with basal cell nevus syndromeO Tawfik
Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA
J Cutan Pathol 26:306-10. 1999..Neuroendocrine differentiation has rarely been associated with basal cell carcinoma. The histologic, immunohistochemical, and electron microscopic studies of this rare tumor are described... - Clinicopathological characteristics of triple-negative invasive mammary carcinomas in African-American versus Caucasian womenOssama Tawfik
Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, 66160, USA
Ann Clin Lab Sci 40:315-23. 2010..There were minor differences in histopathologic features, biomarker expressions, and survival in AA and Caucasian women with TN tumors. The absence of LVI in AA patients predicted an excellent probability of survival... - Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinomaOssama W Tawfik
Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Arch Pathol Lab Med 131:261-7. 2007..Pathologic stage is the main prognostic factor for predicting outcome in renal cell carcinoma (RCC). Because of its unreliability in predicting tumor progression, other factors are needed to provide additional prognostic information... - Grading invasive ductal carcinoma of the breast: advantages of using automated proliferation index instead of mitotic countOssama Tawfik
Department of Pathology and Laboratory Medicine, Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Virchows Arch 450:627-36. 2007..Distinction among the different histologic grades for overall survival curves was better indicated by the N+P than the SBR system... - Comparison of immunohistochemistry by automated cellular imaging system (ACIS) versus fluorescence in-situ hybridization in the evaluation of HER-2/neu expression in primary breast carcinomaO W Tawfik
Department of Radiation Oncology, Division of Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Histopathology 48:258-67. 2006..Our aim was to compare the results of HER-2/neu expression and gene amplification in the same patients by IHC using the ACIS system and by FISH... 
Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2Gopal Dhar
Cancer Research Unit, VA Medical Center, Kansas City, Missouri, USA
Cancer Res 68:4580-7. 2008..Thus, these studies suggest that CCN5 inactivation could be an essential molecular event for p53 mutant-induced invasive phenotypes...- Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sl(d) miceKottarappat N Dileepan
Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
Mediators Inflamm 13:335-41. 2004..Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sl(d) mice... - CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cellsSnigdha Banerjee
Cancer Research Unit, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
Cancer Res 68:7606-12. 2008..These include Snail-E-cadherin signaling and matrix metalloproteinase (MMP)-9 and MMP-2. Collectively, these studies suggest that the protective effect of CCN5 in breast cancer progression may have important therapeutic implications... - BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signalingXi C He
Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
Nat Genet 36:1117-21. 2004..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number... - Myoepithelial carcinoma of the breast arising in an adenomyoepithelioma: mammographic, ultrasound and histologic featuresFang Fan
Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Breast J 13:203-4. 2007 - Differential expression of human leukocyte antigen-G (HLA-G) messenger RNAs and proteins in normal human prostate and prostatic adenocarcinomaDaudi K Langat
Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
J Reprod Immunol 71:75-86. 2006..The results are consistent with this molecule may influencing female immune receptivity to sperm and suggest that such immunosuppression could be disturbed in men with prostatic adenocarcinomas... - Mechanisms of focal calcification in rabbit aortas: role of calcifying vesiclesHoward H T Hsu
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Investig Med 54:402-11. 2006..Whether osteogenesis or a local increase in calcifying vesicles underlies the focal calcification remains to be established... - Endoscopic techniques in resection of anterior skull base/paranasal sinus malignanciesLuke Buchmann
Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA
Laryngoscope 116:1749-54. 2006..The objective of this study was to examine the role of endoscopic approaches to the resection of anterior skull base and paranasal sinus malignancies at one tertiary care medical center... - Bowel necrosis caused by water in jejunal feedingPaul R Schloerb
Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
JPEN J Parenter Enteral Nutr 28:27-9. 2004..Fifteen reports of bowel necrosis in patients receiving jejunal feeding have been reported. Etiology remains unexplained... - Acellular dermis compared to skin grafts in oral cavity reconstructionDouglas A Girod
Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Laryngoscope 119:2141-9. 2009..To compare the efficacy of acellular dermal matrix (ADM) and split thickness skin grafts (STSG) in oral cavity reconstruction... - Potential role of platelet-derived growth factor receptor inhibition using imatinib in combination with docetaxel in the treatment of recurrent non-small cell lung cancerChao H Huang
Department of Internal Medicine, Division of Hematology and Medical Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA
J Thorac Oncol 6:372-7. 2011..Hypothesis: We hypothesized that Im plus docetaxel (D) would have a synergistic effect detectable by an increase in response rate in patients with recurrent non-small cell lung cancer (NSCLC)... - Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcificationHoward H T Hsu
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
Atherosclerosis 161:85-94. 2002.... - Mechanisms of calcification by vesicles isolated from atherosclerotic rabbit aortasHoward H T Hsu
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 66160 7410, USA
Biochim Biophys Acta 1563:18-22. 2002..Taken together, these observations suggest that ATP hydrolysis, CaxP ion products, and vesicle-associated carbohydrates are implicated in vesicle-mediated calcification... - Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytesJinxi Wang
Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, 66160, USA
J Pathol 219:163-72. 2009..These results may provide new insights into the aetiology, pathogenesis and potential therapeutic strategies for osteoarthritis... - WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferationSnigdha Banerjee
Cancer Research Unit, Research Division, V A Medical Center, Kansas City, MO 64128, USA
Neoplasia 5:63-73. 2003..The results are consistent with the conclusion that WISP-2 expression is a requirement for breast tumor cells proliferation... - Mechanism of dystrophic calcification in rabbit aortas: temporal and spatial distributions of calcifying vesicles and calcification-related structural proteinsHoward H T Hsu
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
Cardiovasc Pathol 13:3-10. 2004..Whether the distributions of other structural proteins related to calcification such as collagen and elastin fibers undergo coordinated modifications has not been established... - Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor)Christopher J Stasik
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7410, USA
Arch Pathol Lab Med 130:1878-81. 2006..In this review we discuss the clinical, histopathological, immunohistochemical, and prognostic features of this rare neoplasm... - Sex does not seem to influence the formation of aortic lesions in the P-407-induced mouse model of hyperlipidemia and atherosclerosisThomas P Johnston
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
J Cardiovasc Pharmacol 39:404-11. 2002..Thus, male C57BL/6 mice form atherosclerotic lesions as extensive as female mice in the P-407 mouse model of atherosclerosis... - CD44s expression is reduced in endometriotic lesions compared to eutopic endometrium in women with endometriosisW B Nothnick
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Int J Gynecol Pathol 20:140-6. 2001..This cyclic pattern of CD44s expression was lost in corresponding endometriotic tissue. Reduced expression of CD44s in endometriotic tissue may provide insight into the pathophysiology of endometriosis... - Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat dietBo Kong
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, Kansas City, KS 66160, USA
J Pharmacol Exp Ther 328:116-22. 2009.... - Factors associated with success of the extreme drug resistance assay in primary breast cancer specimensRobert J Ellis
Department of Internal Medicine, University of Kansas Medical Center, Kansas City 66160, USA
Breast Cancer Res Treat 71:95-102. 2002..These results may be helpful for designing possible future trials that evaluate the assay's role in adjuvant chemotherapy selection... - Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancerJonathan J Li
Hormonal Carcinogenesis Laboratory, Division of Etiology and Prevention of Hormonal Cancers, Kansas Cancer Institute, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160-7417, USA
Mol Carcinog 33:56-65. 2002.... - Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancerL Krishnan
Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas 66160 7321, USA
Breast J 7:91-6. 2001..There were no long-term complications. It is feasible to treat a select group of patients with tumor bed irradiation, using relatively low doses of interstitial irradiation, with excellent local control and no significant morbidity... - Prognostic significance of ploidy, MIB-1 proliferation marker, and p53 in renal cell carcinomaBrandon A Kramer
Department of Urology, The University of Kansas Medical Center, Kansas City 66160, USA
J Am Coll Surg 201:565-70. 2005..Individually and combined with p53, MIB-1, and ploidy were of prognostic significance on univariate analysis. Pathologic stage and presence of metastasis remain the best predictors of disease-free survival... - EGFR and HER-2/neu expression in invasive apocrine carcinoma of the breastSemir Vranic
Department of Pathology, Creighton University Medical Center, Omaha, NE 68131, USA
Mod Pathol 23:644-53. 2010..Pure apocrine carcinomas show consistent overexpression of either EGFR or HER-2/neu, which could have significant therapeutic implications... - Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategiesBradley P Sullivan
Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Toxicol Sci 115:286-94. 2010..In contrast, severe thrombocytopenia induces parenchymal-type peliosis in the livers of ANIT-treated mice, a rare hepatic lesion associated with pooling of blood in the liver... - Phyllodes tumor of borderline malignancy: seven year follow up with immunohistochemical studyTatsuo Tomita
Division of Surgical Pathology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Pathol Int 55:585-9. 2005..These findings support the notion that Ki-67 and p53 immunohistochemical staining may be used as simple and practical markers for the evaluation of the malignant potential of PT... - Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI ratsS John Weroha
Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
Carcinogenesis 27:491-8. 2006.... - Small cell undifferentiated (neuroendocrine) carcinoma of the uterine cervixJohn C Weed
University of Kansas School of Medicine, Kansas City, USA
J Am Coll Surg 197:44-51. 2003..Present therapy has not significantly improved outcomes. Tumor lysis syndrome is a possible risk when treating these patients... - A comparison of prognostic tumor markers obtained on image-guided breast biopsies and final surgical specimensCarol S Connor
Department of Surgery, University of Kansas Medical Center, Kansas City 66160, USA
Am J Surg 184:322-4. 2002..This study was initiated to determine whether tumor markers obtained on image-guided breast biopsy specimens provide accurate prognostic information for women with invasive breast cancer... - Telomerase reverse transcriptase subunit immunoreactivity: a marker for high-grade prostate carcinomaKenneth A Iczkowski
Department of Pathology, University of Florida, Gainesville, Florida, USA
Cancer 95:2487-93. 2002..One study used in situ hybridization in nine patients; however, to date, no immunohistochemical results have been published... - Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulatorCarol J Fabian
University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Clin Cancer Res 10:5403-17. 2004..We performed a multi-institutional evaluation of arzoxifene in women with newly diagnosed ductal carcinoma in situ or T1/T2 invasive cancer... - Proposed prognostic score for breast carcinoma on fine needle aspiration based on nuclear grade, cellular dyscohesion and bare atypical nucleiFang Fan
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
Diagn Cytopathol 34:542-6. 2006..In conclusion, cytoprognostic score is performed with ease and shows a great promise as a cost-effective way to predict biological behavior of breast carcinoma and guide clinical management... - Adrenal pseudocyst: a unique case with adrenal renal fusion, mimicking a cystic renal massFang Fan
Departments of Pathology and Laboratory Medicine, Urology, and Radiology, University of Kansas Medical Center, Kansas City, KS, USA
Ann Diagn Pathol 8:87-90. 2004..The cyst measured 12 cm in diameter and had a fibrotic external envelope that was fused with the renal capsule. The possible diagnostic pitfalls encountered in this case are discussed...