MARK TAUBMAN

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint The role of smooth muscle derived tissue factor in mediating thrombosis and arterial injury
    Mark B Taubman
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY, USA
    Thromb Res 122:S78-81. 2008
  2. ncbi request reprint EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability
    Jian Fu
    Cardiovascular Research Institute and Department of Medicine, Univeristy of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 282:12410-8. 2007
  3. ncbi request reprint Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer
    Alok A Khorana
    James P Wilmot Cancer Center, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Clin Cancer Res 13:2870-5. 2007
  4. ncbi request reprint Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension
    R James White
    Division of Pulmonary and Critical Care Medicine, Univ of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY, USA
    Am J Physiol Lung Cell Mol Physiol 293:L583-90. 2007
  5. doi request reprint Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model
    Jeffrey D Alexis
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
    J Vasc Res 45:538-46. 2008
  6. doi request reprint Protein kinase Cδ mediates MCP-1 mRNA stabilization in vascular smooth muscle cells
    Bin Liu
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell Biochem 344:73-9. 2010
  7. ncbi request reprint MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injury
    William J H Kim
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Biochem Biophys Res Commun 310:936-42. 2003
  8. doi request reprint Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study
    Jorge L Yao
    Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA jorge
    Cancer Invest 27:430-4. 2009
  9. pmc Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway
    Jian Fu
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 285:8927-35. 2010
  10. ncbi request reprint Tissue factor is induced in a rodent model of severe pulmonary hypertension characterized by neointimal lesions typical of human disease
    R James White
    Division of Pulmonary and Critical Care Medicine, Center for Cellular and Molecular Cardiology, Aab Institute for Biomedical Sciences, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Chest 128:612S-613S. 2005

Collaborators

Detail Information

Publications26

  1. doi request reprint The role of smooth muscle derived tissue factor in mediating thrombosis and arterial injury
    Mark B Taubman
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY, USA
    Thromb Res 122:S78-81. 2008
    ..This latter role may be related to non-procoagulant properties of TF...
  2. ncbi request reprint EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability
    Jian Fu
    Cardiovascular Research Institute and Department of Medicine, Univeristy of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 282:12410-8. 2007
    ..In addition, this report provides evidence for a novel pathway that regulates myogenin expression and skeletal muscle differentiation...
  3. ncbi request reprint Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer
    Alok A Khorana
    James P Wilmot Cancer Center, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Clin Cancer Res 13:2870-5. 2007
    ..We correlated TF expression with vascular endothelial growth factor (VEGF) expression, microvessel density, and venous thromboembolism in resected pancreatic cancer...
  4. ncbi request reprint Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension
    R James White
    Division of Pulmonary and Critical Care Medicine, Univ of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY, USA
    Am J Physiol Lung Cell Mol Physiol 293:L583-90. 2007
    ..Increased TF expression may contribute to the prothrombotic diathesis and vascular cell proliferation typical of human disease...
  5. doi request reprint Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model
    Jeffrey D Alexis
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
    J Vasc Res 45:538-46. 2008
    ..Using knockout mice, we have now examined the role of MCP-1 and CCR2 in the development of the intimal proliferation of transplant arteriopathy...
  6. doi request reprint Protein kinase Cδ mediates MCP-1 mRNA stabilization in vascular smooth muscle cells
    Bin Liu
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell Biochem 344:73-9. 2010
    ..This study identifies a novel role for PKCδ in mediating mRNA stability in smooth muscle cells...
  7. ncbi request reprint MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injury
    William J H Kim
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Biochem Biophys Res Commun 310:936-42. 2003
    ..These data suggest that MCP-1 and CCR2 deficiencies have distinct effects on arterial injury. The effects of MCP-1 on intimal hyperplasia may be mediated largely through SMC migration...
  8. doi request reprint Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study
    Jorge L Yao
    Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA jorge
    Cancer Invest 27:430-4. 2009
    ..001). Our findings reinforce the link between angiogenesis and TF expression in PCa. We suggest further exploration of TF-mediated pathways leading to increased tumor aggressiveness in PCa, and the possible use of anti-TF agents in PCa...
  9. pmc Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway
    Jian Fu
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 285:8927-35. 2010
    ..This study demonstrates a novel role for EGLN3 in the regulation of NF-kappaB and suggests that it is involved in mediating myogenic differentiation, which is HIF-independent...
  10. ncbi request reprint Tissue factor is induced in a rodent model of severe pulmonary hypertension characterized by neointimal lesions typical of human disease
    R James White
    Division of Pulmonary and Critical Care Medicine, Center for Cellular and Molecular Cardiology, Aab Institute for Biomedical Sciences, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Chest 128:612S-613S. 2005
  11. pmc Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury
    Li Wang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, NY, USA
    Blood 113:705-13. 2009
    ..This mouse model should be valuable in determining the contribution of VSMC-derived TF in other TF-mediated phenomena, such as restenosis...
  12. ncbi request reprint CCL11 (Eotaxin) induces CCR3-dependent smooth muscle cell migration
    Ravindra B Kodali
    Zena and Michael A Wiener Cardiovascular Institute and Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA
    Arterioscler Thromb Vasc Biol 24:1211-6. 2004
    ..The major receptor for CCL11 is CCR3, which is found on leukocytes and on some nonleukocytic cells. We sought to determine whether vascular smooth muscle cells (SMCs) possessed functional CCR3...
  13. pmc Foxp3 regulates megakaryopoiesis and platelet function
    Jamie J Bernard
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:1874-82. 2009
    ..Scurfy mice and some humans with IPEX are also thrombocytopenic. The purpose of this study was to determine whether the absence of functional Foxp3 leads to defects in megakaryocytes and platelets...
  14. ncbi request reprint CCR2 deficiency decreases intimal hyperplasia after arterial injury
    Merce Roque
    Zena and Michael A Wiener Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Arterioscler Thromb Vasc Biol 22:554-9. 2002
    ..CCR2 may thus be an important target for inhibiting the response to acute arterial injury...
  15. pmc Platelets and megakaryocytes contain functional nuclear factor-kappaB
    Sherry L Spinelli
    Department of Environmental Medicine, Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 30:591-8. 2010
    ..We discovered that human megakaryocytes and platelets express the majority of NF-kappaB family members, including the regulatory inhibitor-kappaB (I-kappaB) and I-kappa kinase (IKK) molecules...
  16. ncbi request reprint A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability
    Latika Dhawan
    Cardiovascular Research Institute, University of Rochester, Rochester, New York 14620, USA
    J Biol Chem 282:10146-52. 2007
    ..These data suggest a novel role for the GR in binding to and facilitating mRNA degradation. These results provide novel insights into GR function and may provide a new approach to attenuate the inflammatory response mediated by MCP-1...
  17. ncbi request reprint Mammalian EGLN genes have distinct patterns of mRNA expression and regulation
    Mark E Lieb
    Wiener Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Cell Biol 80:421-6. 2002
    ....
  18. ncbi request reprint MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells
    Alison D Schecter
    The Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Leukoc Biol 75:1079-85. 2004
    ..This alternative receptor may be important in mediating some of the effects of MCP-1 in atherosclerotic arteries and in other inflammatory processes...
  19. pmc Inhibition of intimal hyperplasia in transgenic mice conditionally expressing the chemokine-binding protein M3
    Robert Pyo
    Department of Medicine, and the Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Pathol 164:2289-97. 2004
    ..This transgenic mouse model should be a valuable tool for investigating the role of chemokines in a variety of pathological states...
  20. ncbi request reprint Mice deficient in tissue factor demonstrate attenuated intimal hyperplasia in response to vascular injury and decreased smooth muscle cell migration
    Robert T Pyo
    The Cardiovascular Institute and Department of Medicine, Mount Sinai Center, New York, New York, USA
    Thromb Haemost 92:451-8. 2004
    ..These data suggest that TF may mediate intimal hyperplasia by regulating smooth muscle cell migration...
  21. ncbi request reprint Chemokines in the pathogenesis of vascular disease
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141 9100, USA
    Circ Res 95:858-66. 2004
    ....
  22. ncbi request reprint Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells
    Keon Menzies
    The Zena and Michael A Wiener Cardiovascular Institute, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 317:801-10. 2004
    ....
  23. ncbi request reprint Does tissue factor expression by vascular smooth muscle cells provide a link between C-reactive protein and cardiovascular disease?
    Nigel Mackman
    Arterioscler Thromb Vasc Biol 28:601-3. 2008
  24. ncbi request reprint Angiotensin II: a vasoactive hormone with ever-increasing biological roles
    Mark B Taubman
    Circ Res 92:9-11. 2003
  25. ncbi request reprint Lysophosphatidylcholine stimulates monocyte chemoattractant protein-1 gene expression in rat aortic smooth muscle cells
    James X Rong
    Department of Medicine and The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 22:1617-23. 2002
    ..We investigated whether lysophosphatidylcholine (LPC), enriched in oxidized low density lipoprotein, can modulate the expression of MCP-1 in arterial wall cells...
  26. pmc EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury
    Luisa Campagnolo
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, Mail CVN 26, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Pathol 167:275-84. 2005
    ....

Research Grants18

  1. A Novel Form of Tissue Factor and Cardiovascular Disease
    MARK TAUBMAN; Fiscal Year: 2006
    ..These studies will provide insights into a novel form of circulating TF that may play a key role in cardiovascular disease. ..
  2. Regulation of mRNA stability in vascular smooth muscle
    MARK TAUBMAN; Fiscal Year: 2004
    ..It may also provide novel approaches to inhibiting MCP-1 expression and macrophage accumulation by mimicking the effect of Dex or by blocking the effect of PDGF on MCP- 1 mRNA. ..
  3. GROWTH RELATED GENES IN VASCULAR SMOOTH MUSCLE
    MARK TAUBMAN; Fiscal Year: 2003
    ..These aims represent a comprehensive approach to establish the function of a novel gene family expressed in the cardiovasculature and to provide new insights into SMC gene regulation in vivo. ..
  4. GLUCOCORTICOIDS, MACROPHAGES AND THE VULNERABLE PLAQUE
    MARK TAUBMAN; Fiscal Year: 2001
    ..Overall, the 3 projects represent highly interactive efforts of experienced investigators who will develop new approaches to the vulnerable plaque using molecular biology, animal models, clinical investigation and MRI. ..
  5. GROWTH RELATED GENES IN VASCULAR SMOOTH MUSCLE
    MARK TAUBMAN; Fiscal Year: 1999
    ..In addition to providing new insights into the regulation of VSMC growth, these studies will evaluate intravascular approaches to blocking gene induction in the vessel wall. ..
  6. Smooth Muscle Cell Tissue Factor and Cardiovascular Disease
    Mark B Taubman; Fiscal Year: 2010
    ..Tissue factor is thought to play a major role in coronary thrombosis, the leading cause of heart attacks, and venous thromboembolism, the second leading cause of death in patients with cancer. ..