Genomes and Genes
Affiliation: University of Rochester
- The role of smooth muscle derived tissue factor in mediating thrombosis and arterial injuryMark B Taubman
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY, USA
Thromb Res 122:S78-81. 2008..This latter role may be related to non-procoagulant properties of TF...
- EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stabilityJian Fu
Cardiovascular Research Institute and Department of Medicine, Univeristy of Rochester Medical Center, Rochester, NY 14642, USA
J Biol Chem 282:12410-8. 2007..In addition, this report provides evidence for a novel pathway that regulates myogenin expression and skeletal muscle differentiation...
- Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancerAlok A Khorana
James P Wilmot Cancer Center, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
Clin Cancer Res 13:2870-5. 2007..We correlated TF expression with vascular endothelial growth factor (VEGF) expression, microvessel density, and venous thromboembolism in resected pancreatic cancer...
- Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertensionR James White
Division of Pulmonary and Critical Care Medicine, Univ of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY, USA
Am J Physiol Lung Cell Mol Physiol 293:L583-90. 2007..Increased TF expression may contribute to the prothrombotic diathesis and vascular cell proliferation typical of human disease...
- Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant modelJeffrey D Alexis
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
J Vasc Res 45:538-46. 2008..Using knockout mice, we have now examined the role of MCP-1 and CCR2 in the development of the intimal proliferation of transplant arteriopathy...
- Protein kinase Cδ mediates MCP-1 mRNA stabilization in vascular smooth muscle cellsBin Liu
Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Mol Cell Biochem 344:73-9. 2010..This study identifies a novel role for PKCδ in mediating mRNA stability in smooth muscle cells...
- MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injuryWilliam J H Kim
The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
Biochem Biophys Res Commun 310:936-42. 2003..These data suggest that MCP-1 and CCR2 deficiencies have distinct effects on arterial injury. The effects of MCP-1 on intimal hyperplasia may be mediated largely through SMC migration...
- Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray studyJorge L Yao
Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA jorge
Cancer Invest 27:430-4. 2009..001). Our findings reinforce the link between angiogenesis and TF expression in PCa. We suggest further exploration of TF-mediated pathways leading to increased tumor aggressiveness in PCa, and the possible use of anti-TF agents in PCa...
- Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathwayJian Fu
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 285:8927-35. 2010..This study demonstrates a novel role for EGLN3 in the regulation of NF-kappaB and suggests that it is involved in mediating myogenic differentiation, which is HIF-independent...
- Tissue factor is induced in a rodent model of severe pulmonary hypertension characterized by neointimal lesions typical of human diseaseR James White
Division of Pulmonary and Critical Care Medicine, Center for Cellular and Molecular Cardiology, Aab Institute for Biomedical Sciences, University of Rochester School of Medicine, Rochester, NY 14642, USA
Chest 128:612S-613S. 2005
- Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injuryLi Wang
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, NY, USA
Blood 113:705-13. 2009..This mouse model should be valuable in determining the contribution of VSMC-derived TF in other TF-mediated phenomena, such as restenosis...
- CCL11 (Eotaxin) induces CCR3-dependent smooth muscle cell migrationRavindra B Kodali
Zena and Michael A Wiener Cardiovascular Institute and Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA
Arterioscler Thromb Vasc Biol 24:1211-6. 2004..The major receptor for CCL11 is CCR3, which is found on leukocytes and on some nonleukocytic cells. We sought to determine whether vascular smooth muscle cells (SMCs) possessed functional CCR3...
- Foxp3 regulates megakaryopoiesis and platelet functionJamie J Bernard
Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 29:1874-82. 2009..Scurfy mice and some humans with IPEX are also thrombocytopenic. The purpose of this study was to determine whether the absence of functional Foxp3 leads to defects in megakaryocytes and platelets...
- CCR2 deficiency decreases intimal hyperplasia after arterial injuryMerce Roque
Zena and Michael A Wiener Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Arterioscler Thromb Vasc Biol 22:554-9. 2002..CCR2 may thus be an important target for inhibiting the response to acute arterial injury...
- Platelets and megakaryocytes contain functional nuclear factor-kappaBSherry L Spinelli
Department of Environmental Medicine, Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
Arterioscler Thromb Vasc Biol 30:591-8. 2010..We discovered that human megakaryocytes and platelets express the majority of NF-kappaB family members, including the regulatory inhibitor-kappaB (I-kappaB) and I-kappa kinase (IKK) molecules...
- A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stabilityLatika Dhawan
Cardiovascular Research Institute, University of Rochester, Rochester, New York 14620, USA
J Biol Chem 282:10146-52. 2007..These data suggest a novel role for the GR in binding to and facilitating mRNA degradation. These results provide novel insights into GR function and may provide a new approach to attenuate the inflammatory response mediated by MCP-1...
- Mammalian EGLN genes have distinct patterns of mRNA expression and regulationMark E Lieb
Wiener Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Biochem Cell Biol 80:421-6. 2002....
- MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cellsAlison D Schecter
The Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Leukoc Biol 75:1079-85. 2004..This alternative receptor may be important in mediating some of the effects of MCP-1 in atherosclerotic arteries and in other inflammatory processes...
- Inhibition of intimal hyperplasia in transgenic mice conditionally expressing the chemokine-binding protein M3Robert Pyo
Department of Medicine, and the Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Am J Pathol 164:2289-97. 2004..This transgenic mouse model should be a valuable tool for investigating the role of chemokines in a variety of pathological states...
- Mice deficient in tissue factor demonstrate attenuated intimal hyperplasia in response to vascular injury and decreased smooth muscle cell migrationRobert T Pyo
The Cardiovascular Institute and Department of Medicine, Mount Sinai Center, New York, New York, USA
Thromb Haemost 92:451-8. 2004..These data suggest that TF may mediate intimal hyperplasia by regulating smooth muscle cell migration...
- Chemokines in the pathogenesis of vascular diseaseIsrael F Charo
Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141 9100, USA
Circ Res 95:858-66. 2004....
- Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cellsKeon Menzies
The Zena and Michael A Wiener Cardiovascular Institute, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA
Biochem Biophys Res Commun 317:801-10. 2004....
- Does tissue factor expression by vascular smooth muscle cells provide a link between C-reactive protein and cardiovascular disease?Nigel Mackman
Arterioscler Thromb Vasc Biol 28:601-3. 2008
- Angiotensin II: a vasoactive hormone with ever-increasing biological rolesMark B Taubman
Circ Res 92:9-11. 2003
- Lysophosphatidylcholine stimulates monocyte chemoattractant protein-1 gene expression in rat aortic smooth muscle cellsJames X Rong
Department of Medicine and The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Arterioscler Thromb Vasc Biol 22:1617-23. 2002..We investigated whether lysophosphatidylcholine (LPC), enriched in oxidized low density lipoprotein, can modulate the expression of MCP-1 in arterial wall cells...
- EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injuryLuisa Campagnolo
Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, Mail CVN 26, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
Am J Pathol 167:275-84. 2005....
- A Novel Form of Tissue Factor and Cardiovascular DiseaseMARK TAUBMAN; Fiscal Year: 2006..These studies will provide insights into a novel form of circulating TF that may play a key role in cardiovascular disease. ..
- Regulation of mRNA stability in vascular smooth muscleMARK TAUBMAN; Fiscal Year: 2004..It may also provide novel approaches to inhibiting MCP-1 expression and macrophage accumulation by mimicking the effect of Dex or by blocking the effect of PDGF on MCP- 1 mRNA. ..
- GROWTH RELATED GENES IN VASCULAR SMOOTH MUSCLEMARK TAUBMAN; Fiscal Year: 2003..These aims represent a comprehensive approach to establish the function of a novel gene family expressed in the cardiovasculature and to provide new insights into SMC gene regulation in vivo. ..
- GLUCOCORTICOIDS, MACROPHAGES AND THE VULNERABLE PLAQUEMARK TAUBMAN; Fiscal Year: 2001..Overall, the 3 projects represent highly interactive efforts of experienced investigators who will develop new approaches to the vulnerable plaque using molecular biology, animal models, clinical investigation and MRI. ..
- GROWTH RELATED GENES IN VASCULAR SMOOTH MUSCLEMARK TAUBMAN; Fiscal Year: 1999..In addition to providing new insights into the regulation of VSMC growth, these studies will evaluate intravascular approaches to blocking gene induction in the vessel wall. ..
- Smooth Muscle Cell Tissue Factor and Cardiovascular DiseaseMark B Taubman; Fiscal Year: 2010..Tissue factor is thought to play a major role in coronary thrombosis, the leading cause of heart attacks, and venous thromboembolism, the second leading cause of death in patients with cancer. ..