SUREN TATULIAN

Summary

Affiliation: University of Central Florida
Country: USA

Publications

  1. ncbi request reprint The inhibitory action of phospholamban involves stabilization of alpha-helices within the Ca-ATPase
    Suren A Tatulian
    Biochemistry and Biophysics Section, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045 2106, USA
    Biochemistry 41:741-51. 2002
  2. pmc Structural effects of covalent inhibition of phospholipase A2 suggest allosteric coupling between membrane binding and catalytic sites
    Suren A Tatulian
    Biomolecular Science Center and Department of Molecular Biology and Microbiology, University of Central Florida, Orlando 32826, USA
    Biophys J 84:1773-83. 2003
  3. ncbi request reprint Attenuated total reflection Fourier transform infrared spectroscopy: a method of choice for studying membrane proteins and lipids
    Suren A Tatulian
    Biomolecular Science Center and Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida 32826, USA
    Biochemistry 42:11898-907. 2003
  4. doi request reprint Determination of helix orientations in proteins
    Suren A Tatulian
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA
    Comput Biol Chem 32:370-4. 2008
  5. ncbi request reprint Positioning membrane proteins by novel protein engineering and biophysical approaches
    Suren A Tatulian
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA
    J Mol Biol 351:939-47. 2005
  6. pmc Conformational instability of the cholera toxin A1 polypeptide
    Abhay H Pande
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL 32826, USA
    J Mol Biol 374:1114-28. 2007
  7. ncbi request reprint Structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2
    Kathleen N Nemec
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 45:12448-60. 2006
  8. ncbi request reprint Isoform-specific membrane insertion of secretory phospholipase A2 and functional implications
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    Biochemistry 45:12436-47. 2006
  9. ncbi request reprint Evidence for the regulatory role of the N-terminal helix of secretory phospholipase A(2) from studies on native and chimeric proteins
    Shan Qin
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    J Biol Chem 280:36773-83. 2005
  10. pmc Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, 32826, USA
    Biophys J 88:4084-94. 2005

Research Grants

Collaborators

  • C Russell Middaugh
  • Diana J Bigelow
  • Abhay H Pande
  • Kathleen N Nemec
  • Shan Qin
  • David Moe
  • Patricia Scaglione
  • Ken Teter
  • Supriyo Ray
  • Xiaomei He
  • Shuhua Tan
  • Fernando Navarro-Garcia
  • Kaitlin E Burlingame
  • Jazmin Huerta
  • Agnieszka Grabon
  • Michael Taylor
  • Randall K Holmes
  • Jennifer L Scott
  • Summer Tuthill
  • Maneesha Jamnadas
  • Ramona J Bieber Urbauer

Detail Information

Publications15

  1. ncbi request reprint The inhibitory action of phospholamban involves stabilization of alpha-helices within the Ca-ATPase
    Suren A Tatulian
    Biochemistry and Biophysics Section, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045 2106, USA
    Biochemistry 41:741-51. 2002
    ....
  2. pmc Structural effects of covalent inhibition of phospholipase A2 suggest allosteric coupling between membrane binding and catalytic sites
    Suren A Tatulian
    Biomolecular Science Center and Department of Molecular Biology and Microbiology, University of Central Florida, Orlando 32826, USA
    Biophys J 84:1773-83. 2003
    ..These findings provide further evidence for an allosteric coupling between the membrane-binding (regulatory) site and the catalytic center of PLA(2), which contributes to the interfacial activation of the enzyme...
  3. ncbi request reprint Attenuated total reflection Fourier transform infrared spectroscopy: a method of choice for studying membrane proteins and lipids
    Suren A Tatulian
    Biomolecular Science Center and Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida 32826, USA
    Biochemistry 42:11898-907. 2003
  4. doi request reprint Determination of helix orientations in proteins
    Suren A Tatulian
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA
    Comput Biol Chem 32:370-4. 2008
    ....
  5. ncbi request reprint Positioning membrane proteins by novel protein engineering and biophysical approaches
    Suren A Tatulian
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA
    J Mol Biol 351:939-47. 2005
    ..Given the functional significance of the orientation and location of membrane-bound proteins with respect to the membrane, we propose to specify this structural feature as the "quinary" structure of membrane proteins...
  6. pmc Conformational instability of the cholera toxin A1 polypeptide
    Abhay H Pande
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL 32826, USA
    J Mol Biol 374:1114-28. 2007
    ..Thermal instability in the reduced CTA1 polypeptide has not been reported before, yet both the translocation and degradation of CTA1 may depend upon this physical property...
  7. ncbi request reprint Structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2
    Kathleen N Nemec
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 45:12448-60. 2006
    ....
  8. ncbi request reprint Isoform-specific membrane insertion of secretory phospholipase A2 and functional implications
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    Biochemistry 45:12436-47. 2006
    ....
  9. ncbi request reprint Evidence for the regulatory role of the N-terminal helix of secretory phospholipase A(2) from studies on native and chimeric proteins
    Shan Qin
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    J Biol Chem 280:36773-83. 2005
    ..Altogether, the data provide evidence that the N-terminal helix of group I/II PLA(2)s acts as a regulatory domain that mediates interfacial activation of these enzymes...
  10. pmc Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, 32826, USA
    Biophys J 88:4084-94. 2005
    ..The data presented in this article and earlier data allow construction of a model for membrane-bound 5-LO, including the angular orientation and membrane insertion of the protein...
  11. ncbi request reprint Modulation of human 5-lipoxygenase activity by membrane lipids
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    Biochemistry 43:14653-66. 2004
    ..Our results provide insight into the understanding of the effects of membrane surface properties on 5-LO-membrane interactions and the interfacial activation of 5-LO...
  12. ncbi request reprint The N-terminal alpha-helix of pancreatic phospholipase A2 determines productive-mode orientation of the enzyme at the membrane surface
    Shan Qin
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA
    J Mol Biol 344:71-89. 2004
    ....
  13. pmc Structural characteristics of the plasmid-encoded toxin from enteroaggregative Escherichia coli
    Patricia Scaglione
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 47:9582-91. 2008
    ....
  14. pmc The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasome
    Abhay H Pande
    Department of Molecular Biology and Microbiology, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 45:13734-40. 2006
    ..These observations support a model of intoxication in which toxin translocation, degradation, and activity are all influenced by the heat-labile nature of the isolated toxin A chain...
  15. ncbi request reprint Effects of lipid phase transition and membrane surface charge on the interfacial activation of phospholipase A2
    Supriyo Ray
    Biomolecular Science Center, Burnett College of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 46:13089-100. 2007
    ..The data show that membrane structural disorder, and not the depth of membrane insertion, plays a major role in PLA2 activity...

Research Grants5

  1. Regulatory Mechanisms of Secretory Phospholipases A2
    SUREN TATULIAN; Fiscal Year: 2004
    ..Collectively, our results will help develop new strategies for regulation of PLA2s, enzymes of profound biomedical importance. ..