Donald Tashkin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Roflumilast : the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA 1 310 825 3163 1 310 206 5088
    Expert Opin Pharmacother 15:85-96. 2014
  2. doi request reprint Annual rates of change in pre- vs. post-bronchodilator FEV1 and FVC over 4 years in moderate to very severe COPD
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA Electronic address
    Respir Med 107:1904-11. 2013
  3. pmc Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease
    Bartolome R Celli
    Pulmonary Division, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 13:66. 2012
  4. pmc HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation
    Guillermina J Baay-Guzman
    Hospital Infantil de Mexico, Federico Gomez, Unidad de Investigación en Enfermedades Oncológicas, Dr, Marquez No 262, Col, Doctores, Delegacion Cuahutemos, Mexico City CP 06720, Mexico
    Respir Res 13:60. 2012
  5. ncbi request reprint Effects of marijuana smoking on the lung
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Ann Am Thorac Soc 10:239-47. 2013
  6. pmc Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
    Respir Res 14:49. 2013
  7. doi request reprint Variations in FEV₁ decline over time in chronic obstructive pulmonary disease and its implications
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Pulm Med 19:116-24. 2013
  8. doi request reprint Association of dopamine-related gene alleles, smoking behavior and decline in FEV1 in subjects with COPD: findings from the lung health study
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
    COPD 9:620-8. 2012
  9. doi request reprint Impact of changes in regular use of marijuana and/or tobacco on chronic bronchitis
    Donald P Tashkin
    Departments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    COPD 9:367-74. 2012
  10. pmc Comparison of the variability of the annual rates of change in FEV₁ determined from serial measurements of the pre- versus post-bronchodilator FEV₁ over 5 years in mild to moderate COPD: results of the lung health study
    Donald P Tashkin
    Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Respir Res 13:70. 2012

Research Grants

  1. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
  2. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2002
  3. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2004
  4. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2005
  5. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2006
  6. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2007
  7. MOCSLID-CCC
    Donald Tashkin; Fiscal Year: 2009
  8. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2002
  9. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2003
  10. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 1999

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Roflumilast : the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA 1 310 825 3163 1 310 206 5088
    Expert Opin Pharmacother 15:85-96. 2014
    ....
  2. doi request reprint Annual rates of change in pre- vs. post-bronchodilator FEV1 and FVC over 4 years in moderate to very severe COPD
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA Electronic address
    Respir Med 107:1904-11. 2013
    ..While the reasons for these differences are not completely clear, they are important to consider when assessing treatment effects on rates of decline in FEV1 and FVC...
  3. pmc Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease
    Bartolome R Celli
    Pulmonary Division, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 13:66. 2012
    ..The changes in inspiratory capacity (IC) over time in chronic obstructive pulmonary disease (COPD) patients are unknown. The Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT®) trial included IC measurements...
  4. pmc HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation
    Guillermina J Baay-Guzman
    Hospital Infantil de Mexico, Federico Gomez, Unidad de Investigación en Enfermedades Oncológicas, Dr, Marquez No 262, Col, Doctores, Delegacion Cuahutemos, Mexico City CP 06720, Mexico
    Respir Res 13:60. 2012
    ..We hypothesized that the expression of HIF-1 and CCL2 may be correlated and that the expression of CCL2 may be under the regulation of HIF-1. Several lines of evidence are presented to support this hypothesis...
  5. ncbi request reprint Effects of marijuana smoking on the lung
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Ann Am Thorac Soc 10:239-47. 2013
    ..In summary, the accumulated weight of evidence implies far lower risks for pulmonary complications of even regular heavy use of marijuana compared with the grave pulmonary consequences of tobacco...
  6. pmc Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
    Respir Res 14:49. 2013
    ..This review outlines the existing data for LAMA/LABA combinations in the treatment of COPD, summarizes the ongoing trials, and considers the evidence required to inform the role of LAMA/LABA combinations in treatment of this disease...
  7. doi request reprint Variations in FEV₁ decline over time in chronic obstructive pulmonary disease and its implications
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Pulm Med 19:116-24. 2013
    ..The purpose of the review is to describe the individual variability in rates of decline in FEV₁ within these populations, explore the factors contributing to this variability and discuss its implications...
  8. doi request reprint Association of dopamine-related gene alleles, smoking behavior and decline in FEV1 in subjects with COPD: findings from the lung health study
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
    COPD 9:620-8. 2012
    ....
  9. doi request reprint Impact of changes in regular use of marijuana and/or tobacco on chronic bronchitis
    Donald P Tashkin
    Departments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    COPD 9:367-74. 2012
    ..These findings demonstrate the benefit of marijuana smoking cessation in resolving pre-existing symptoms of chronic bronchitis...
  10. pmc Comparison of the variability of the annual rates of change in FEV₁ determined from serial measurements of the pre- versus post-bronchodilator FEV₁ over 5 years in mild to moderate COPD: results of the lung health study
    Donald P Tashkin
    Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Respir Res 13:70. 2012
    ..We therefore compared the yearly slope and the variability of the slope of the pre- versus the post-bronchodilator FEV₁ in men and women with mild to moderate COPD who participated in the 5-year Lung Health Study (LHS)...
  11. doi request reprint Efficacy of tiotropium in COPD patients with FEV1 ≥ 60% participating in the UPLIFT® trial
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    COPD 9:289-96. 2012
    ..66 [0.45, 0.96]). Tiotropium treatment provides clinical efficacy in patients with GOLD stage II disease with an FEV₁ ≥60% predicted, supporting current GOLD guidelines for COPD treatment. (ClinicalTrials.gov number NCT00144339)...
  12. pmc Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Chron Obstruct Pulmon Dis 7:73-86. 2012
    ....
  13. pmc Efficacy and safety of a fixed-dose combination of mometasone furoate and formoterol fumarate in subjects with moderate to very severe COPD: results from a 52-week Phase III trial
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Chron Obstruct Pulmon Dis 7:43-55. 2012
    ....
  14. pmc Adverse health consequences in COPD patients with rapid decline in FEV1--evidence from the UPLIFT trial
    Steven Kesten
    Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA
    Respir Res 12:129. 2011
    ..The rate of decline in forced expiratory volume in 1 second (FEV1) is representative of the natural history of COPD. Sparse information exists regarding the associations between the magnitude of annualised loss of FEV1 with other endpoints...
  15. pmc Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial
    Nicola A Hanania
    Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA
    Respir Res 12:6. 2011
    ..Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR...
  16. ncbi request reprint Is a long-acting inhaled bronchodilator the first agent to use in stable chronic obstructive pulmonary disease?
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Curr Opin Pulm Med 11:121-8. 2005
    ....
  17. ncbi request reprint Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trial
    Donald Tashkin
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1690, USA
    Respir Med 104:1495-504. 2010
    ..Gender differences may occur in many chronic diseases. We have examined the influence of gender in chronic obstructive pulmonary disease (COPD) on long-term responses to tiotropium...
  18. ncbi request reprint Skin manifestations of inhaled corticosteroids in COPD patients: results from Lung Health Study II
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, Los Angeles, CA 90095 1690, USA
    Chest 126:1123-33. 2004
    ..To explore the relationship between easy skin bruising and other systemic effects of ICS therapy, including adrenal suppression and loss of bone mineral density (BMD)...
  19. ncbi request reprint Impact of tiotropium on the course of moderate-to-very severe chronic obstructive pulmonary disease: the UPLIFT trial
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90272, USA
    Expert Rev Respir Med 4:279-89. 2010
    ..Adverse events were consistent with the drug's known anticholinergic pharmacology...
  20. ncbi request reprint Indacaterol maleate for the treatment of chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Expert Opin Pharmacother 11:2077-85. 2010
    ..Indacaterol maleate has been developed as a new once-daily inhaled beta(2)-selective agonist...
  21. pmc Preventing and managing exacerbations in COPD--critical appraisal of the role of tiotropium
    Donald P Tashkin
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Int J Chron Obstruct Pulmon Dis 5:41-53. 2010
    ....
  22. ncbi request reprint Comparing COPD treatment: nebulizer, metered dose inhaler, and concomitant therapy
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1690, USA
    Am J Med 120:435-41. 2007
    ..This study compared the 2 methods of delivering medication and the concomitant use of both nebulizer and inhaler, with respect to health-related quality of life, patient symptoms, and efficacy...
  23. pmc Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 176:1026-34. 2007
    ..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear...
  24. doi request reprint A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  25. ncbi request reprint Cyclophosphamide versus placebo in scleroderma lung disease
    Donald P Tashkin
    University of California at Los Angeles, Los Angeles, USA
    N Engl J Med 354:2655-66. 2006
    ....
  26. ncbi request reprint Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD
    D P Tashkin
    David Geffen School of Medicine UCLA, Los Angeles, CA 90095 1690, USA
    Respir Med 103:516-24. 2009
    ..This 2-week, multi-center (34 sites), randomized, modified-blind, parallel group study evaluated the efficacy and safety of concomitant treatment with nebulized arformoterol (the formoterol(R,R)-isomer) BID and tiotropium DPI QD...
  27. doi request reprint Formoterol and tiotropium compared with tiotropium alone for treatment of COPD
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    COPD 6:17-25. 2009
    ..04) were seen at endpoint with combination FORM + TIO versus TIO monotherapy. Both treatments were well tolerated. This study demonstrated that concurrent treatment with FORM + TIO results in greater therapeutic benefits than TIO alone...
  28. doi request reprint Smoking cessation in chronic obstructive pulmonary disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1690, USA
    Respir Med 103:963-74. 2009
    ..We also discuss the pharmacologic therapies used to enhance the likelihood of quitting, including nicotine replacement, bupropion SR and varenicline, along with novel nicotine vaccines, which are currently undergoing clinical trials...
  29. ncbi request reprint Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
    Drugs 68:1975-2000. 2008
    ..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD...
  30. doi request reprint Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: a placebo-controlled trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Respir Med 102:479-87. 2008
    ..2% vs. 1.5%). Nebulized formoterol fumarate in combination with tiotropium provided statistically and clinically significant improvements in bronchodilation and symptom control over tiotropium alone and demonstrated good tolerability...
  31. ncbi request reprint The role of patient-centered outcomes in the course of chronic obstructive pulmonary disease: how long-term studies contribute to our understanding
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Am J Med 119:63-72. 2006
    ..This article examines the rationale for each of these studies and provides an overview of study methodology as well as preliminary demographic data...
  32. doi request reprint Long-term efficacy of tiotropium in relation to smoking status in the UPLIFT trial
    D P Tashkin
    Dept of Medicine, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1690, USA
    Eur Respir J 35:287-94. 2010
    ..63 units, p = 0.0006) and the least in IS (-0.60 units, p = 0.51), [corrected] compared with control. Tiotropium provided long-term benefits irrespective of smoking status, although differences among categories were observed...
  33. ncbi request reprint Smoked marijuana as a cause of lung injury
    D P Tashkin
    Division of Pulmonaiy and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1690, USA
    Monaldi Arch Chest Dis 63:93-100. 2005
    ..In view of the growing interest in medicinal marijuana, further epidemiologic studies are needed to clarify the true risks of regular marijuana smoking on respiratory health...
  34. doi request reprint Bronchodilator responsiveness in patients with COPD
    D P Tashkin
    David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA
    Eur Respir J 31:742-50. 2008
    ..The majority of patients with moderate-to-very-severe chronic obstructive pulmonary disease demonstrate meaningful increases in lung function following administration of inhaled anticholinergic plus sympathomimetic bronchodilators...
  35. doi request reprint Long-acting anticholinergic use in chronic obstructive pulmonary disease: efficacy and safety
    Donald P Tashkin
    Division of Pulmonary and Critical Care, David Geffen School of Medicine at UCLA, California 90095 1690, USA
    Curr Opin Pulm Med 16:97-105. 2010
    ....
  36. doi request reprint Combined treatment with formoterol and tiotropium is more efficacious than treatment with tiotropium alone in patients with chronic obstructive pulmonary disease, regardless of smoking status, inhaled corticosteroid use, baseline severity, or gender
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Pulm Pharmacol Ther 24:147-52. 2011
    ..We conclude that coadministered FOR + TIO significantly improves lung function compared with TIO treatment alone in COPD patients regardless of differences in patient subgroups...
  37. doi request reprint Nebulized formoterol provides added benefits to tiotropium treatment in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Adv Ther 26:1024-34. 2009
    ..This analysis pooled the results of two double-blind studies evaluating the efficacy and safety of adding nebulized formoterol fumarate inhalation solution (FFIS) to maintenance tiotropium (TIO) treatment...
  38. ncbi request reprint Airway effects of marijuana, cocaine, and other inhaled illicit agents
    D P Tashkin
    Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Curr Opin Pulm Med 7:43-61. 2001
    ..Heroin inhalation can induce severe and even fatal exacerbations of asthma. Pulmonary consequences of inhaled amyl and butyl nitrites, crystalline methamphetamine (ice), and phencyclidine have been less well documented...
  39. ncbi request reprint Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial
    D Tashkin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles CA, USA
    Lancet 357:1571-5. 2001
    ..Our aim was to investigate the effect of sustained-release bupropion (amfebutamone) (SR) in promoting abstinence from smoking in patients with COPD...
  40. ncbi request reprint Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses
    Donald Tashkin
    Pulmonary Division, David Geffen School of Medicine at the University of California at Los Angeles, 90095, USA
    Chest 123:1441-9. 2003
    ....
  41. doi request reprint Budesonide and formoterol in a single pressurized metered-dose inhaler for treatment of COPD
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Expert Rev Respir Med 4:703-14. 2010
    ..It also has a satisfactory safety profile and has not been shown to increase the risk of pneumonia...
  42. pmc Long-acting beta-agonists in the management of chronic obstructive pulmonary disease: current and future agents
    Donald P Tashkin
    David Geffen School of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA, Los Angeles, California, USA
    Respir Res 11:149. 2010
    ..Once-daily LABAs used both alone and in combination with long-acting muscarinic antagonists represent a promising advance in the treatment of COPD, and are likely to further improve outcomes for patients...
  43. ncbi request reprint Effects of varenicline on smoking cessation in patients with mild to moderate COPD: a randomized controlled trial
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095 1690, USA
    Chest 139:591-9. 2011
    ..To our knowledge, this is the first randomized clinical trial to compare the efficacy and safety of varenicline tartrate vs placebo in smokers with mild to moderate COPD...
  44. ncbi request reprint Evidence implicating cocaine as a possible risk factor for HIV infection
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1690, USA
    J Neuroimmunol 147:26-7. 2004
    ..The huPBL SCID mouse and SCID-hu mouse provide potentially useful models for evaluating the impact of other drugs of abuse on HIV infection and the mechanisms mediating these effects...
  45. ncbi request reprint The role of long-acting bronchodilators in the management of stable COPD
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine and the UCLA Pulmonary Function and Exercise Physiology Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Chest 125:249-59. 2004
    ..Based on this review, a treatment algorithm for the introduction of long-acting bronchodilators to patients with COPD is proposed, which includes the use of long-acting bronchodilators early in the treatment algorithm...
  46. ncbi request reprint Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivors of non-small cell lung cancer
    Linda Sarna
    School of Nursing, University of California Los Angeles, 700 Tiverton Avenue, Box 9569182, Factor 4 262, Los Angeles, CA 90095 6918, USA
    Chest 125:439-45. 2004
    ..To describe respiratory symptoms and pulmonary function among long-term survivors of non-small cell lung cancer (NSCLC), and their relationship to quality of life (QOL)...
  47. pmc Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    AIDS Res Hum Retroviruses 25:149-56. 2009
    ..46 (1.01-2.13)]. However, no clear dose-response relationship was observed. These findings do not support a biological association between use of these substances and KS development in HIV- and HHV-8-coinfected homosexual men...
  48. pmc Course of dermal ulcers and musculoskeletal involvement in systemic sclerosis patients in the scleroderma lung study
    Karen Au
    University of California, Los Angeles, Los Angeles, CA 90025, USA
    Arthritis Care Res (Hoboken) 62:1772-8. 2010
    ..Subjects were then followed off the study agent for an additional 12 months...
  49. doi request reprint A 56-year-old woman with COPD and multiple pulmonary nodules
    Ammar Sakkour
    Division of Pulmonary and Pulmonary and Critical Care, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Chest 133:566-9. 2008
  50. ncbi request reprint Subacute lack of asthma control and acute asthma exacerbation history as predictors of subsequent acute asthma exacerbations: evidence from managed care data
    Richard D O'Connor
    Department of Quality Management, Sharp Rees Stealy Medical Group, San Diego, California, CA 92101, USA
    J Asthma 47:422-8. 2010
    ..Monitoring indicators of subacute lack of asthma control (SALAC) may help to reduce asthma morbidity...
  51. ncbi request reprint Household smoking behavior and ETS exposure among children with asthma in low-income, minority households
    Barbara A Berman
    Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, A2 125 CHS, Box 956900, Los Angeles, CA 90095 6900, USA
    Addict Behav 28:111-28. 2003
    ..Over 47% of the respondents reported absolute restrictions against smoking in the home, and these restrictions were associated with lower reported levels of smoking, ETS exposure, and air nicotine and urine cotinine concentrations...
  52. ncbi request reprint Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisole
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
    Toxicol Lett 133:171-9. 2002
    ..The combination was synergistic in this respect, reducing ATP levels to <15% of control. Exposure to marijuana smoke in conjunction with BHA, a common food additive, may promote deleterious health effects in the lung...
  53. pmc Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
    Drug Alcohol Depend 94:165-71. 2008
    ..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM...
  54. ncbi request reprint Marijuana use and increased risk of squamous cell carcinoma of the head and neck
    Z F Zhang
    Department of Epidemiology, University of California at Los Angeles School of Public Health, and Jonsson Comprehensive Cancer Center, 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 8:1071-8. 1999
    ..The results need to be interpreted with some caution in drawing causal inferences because of certain methodological limitations, especially with regard to interactions...
  55. ncbi request reprint Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco
    S H Barsky
    Department of Pathology, University of California, Los Angeles, USA
    J Natl Cancer Inst 90:1198-205. 1998
    ....
  56. ncbi request reprint Airway inflammation in young marijuana and tobacco smokers
    M D Roth
    Department of Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 157:928-37. 1998
    ..We conclude that regular smoking of marijuana by young adults is associated with significant airway inflammation that is similar in frequency, type, and magnitude to that observed in the lungs of tobacco smokers...
  57. ncbi request reprint Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol
    M D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Am J Respir Cell Mol Biol 24:339-44. 2001
    ..This complex regulation of CYP1A1 by marijuana smoke and the Delta(9)-THC that it contains has implications for the role of marijuana as a cancer risk factor...
  58. ncbi request reprint Results of a multicenter study of nebulized inhalant bronchodilator solutions
    D P Tashkin
    Department of Medicine, University of California Los Angeles 90095 1690, USA
    Am J Med 100:62S-69. 1996
    ....
  59. ncbi request reprint Unpredictability of deception in compliance with physician-prescribed bronchodilator inhaler use in a clinical trial
    M S Simmons
    UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    Chest 118:290-5. 2000
    ..To identify subject characteristics that may be predictive of intentional dumping of metered-dose inhalers (MDIs) during a clinical trial...
  60. ncbi request reprint Environmental tobacco smoking, mutagen sensitivity, and head and neck squamous cell carcinoma
    Z F Zhang
    Department of Epidemiology, University of California Los Angeles School of Public Health, and Jonsson Comprehensive Cancer Center, 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 9:1043-9. 2000
    ..Our results need to be interpreted with caution because of potential residual confounding effects of active tobacco smoking and other methodological limitations. Future large-scale studies are warranted to confirm our findings...
  61. pmc A computer-aided diagnosis system for quantitative scoring of extent of lung fibrosis in scleroderma patients
    H G Kim
    Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024 2926, USA
    Clin Exp Rheumatol 28:S26-35. 2010
    ....
  62. ncbi request reprint Montelukast improves regional air-trapping due to small airways obstruction in asthma
    M R Zeidler
    Division of Pulmonary, Critical Care Medicine and Hospitalists, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 1690, USA
    Eur Respir J 27:307-15. 2006
    ..In conclusion, distal airways disease improves in asthmatic subjects treated with montelukast. This improvement can be detected with high-resolution computed tomography, but not with conventional physiological studies...
  63. pmc Recent developments in inhaled therapy in stable chronic obstructive pulmonary disease
    C B Cooper
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    BMJ 330:640-4. 2005
  64. ncbi request reprint Smoking reduction and the rate of decline in FEV(1): results from the Lung Health Study
    M S Simmons
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Eur Respir J 25:1011-7. 2005
    ..In conclusion, compensatory changes in smoking behaviour may account for the limited and unpredictable impact of smoking reduction on lung function decline and symptom prevalence when compared with smoking cessation...
  65. ncbi request reprint Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis
    T A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, UCLA School of Medicine, Room 37 131, Center for Health Sciences, Los Angeles, California 90095 1690, USA
    Toxicol Appl Pharmacol 174:264-72. 2001
    ..This shift may affect both the carcinogenic and immunologic consequences of marijuana smoke exposure...
  66. pmc Can a minimal intervention reduce secondhand smoke exposure among children with asthma from low income minority families? Results of a randomized trial
    Leanne Streja
    Division of Cancer Prevention and Control Research and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA
    J Immigr Minor Health 16:256-64. 2014
    ..There continues to be a need for effective culturally and linguistically appropriate strategies that support reduction of household SHS exposure among children with asthma in low income, minority households. ..
  67. ncbi request reprint Quality of life of long-term survivors of non-small-cell lung cancer
    Linda Sarna
    School of Nursing, University of California Los Angeles, Los Angeles, CA 90095 6918, USA
    J Clin Oncol 20:2920-9. 2002
    ..To describe the quality of life (QOL) among survivors of non-small-cell lung cancer (NSCLC)...
  68. ncbi request reprint Physiologic characteristics of malignant unilateral main-stem bronchial obstruction. Diagnosis and Nd-YAG laser treatment
    A F Gelb
    Department of Medicine, Doctors Hospital of Lakewood, California
    Am Rev Respir Dis 138:1382-5. 1988
    ..0 +/- 0.6 to 1.8 +/- 0.5 s-1 in patients without emphysema and from 0.8 +/- 0.3 to 0.8 +/- 0.1 s-1 in patients with emphysema.(ABSTRACT TRUNCATED AT 250 WORDS)..
  69. ncbi request reprint The importance of control in asthma management: do leukotriene receptor antagonists meet patient and physician needs?
    D P Tashkin
    University of California, Los Angeles School of Medicine, 10833 Le Conte Avenue, Room 37 121 CHS, Los Angeles, CA 90095 1690, USA
    Allergy Asthma Proc 22:311-9. 2001
    ....
  70. ncbi request reprint Effects of inhaled thiazinamium chloride on histamine-induced and exercise-induced bronchoconstriction
    H Gong
    Department of Medicine, UCLA School of Medicine
    Ann Allergy 62:230-5. 1989
    ..We conclude that aerosolized TC is effective in attenuating histamine-induced but not exercise-induced bronchoconstriction in the doses studied. Further studies are warranted to evaluate the role of TC in asthma therapy...
  71. ncbi request reprint IL-10 mediates sigma 1 receptor-dependent suppression of antitumor immunity
    Li X Zhu
    University of California Los Angeles Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 1690, USA
    J Immunol 170:3585-91. 2003
    ..We report that sigma(1) receptor ligands, including cocaine, augment tumor growth through an IL-10 dependent mechanism...
  72. ncbi request reprint Evaluation of efficacy and safety of flunisolide hydrofluoroalkane for the treatment of asthma
    Jonathan Corren
    Allergy Research Foundation, Inc, Los Angeles, California 90023, USA
    Clin Ther 25:776-98. 2003
    ..HFA replaces the chlorofluorocarbon (CFC) propellant of the previous formulation, producing aerosols of smaller average particle size...
  73. ncbi request reprint The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 124:449-58. 2003
    ..This report evaluates the effects of these interventions, demographic characteristics, smoking status, and FEV(1) changes on airway responsiveness (AR)...
  74. ncbi request reprint Methanandamide increases COX-2 expression and tumor growth in murine lung cancer
    Brian Gardner
    UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90095 1690, USA
    FASEB J 17:2157-9. 2003
    ..These results suggest that methanandamide augments tumor growth by a cannabinoid receptor-independent pathway that is associated with the up-regulation of COX-2...
  75. ncbi request reprint All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Chest 124:1724-32. 2003
    ..This study was designed to evaluate the impact of all-trans retinoic acid (ATRA) on the balance of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with emphysema...
  76. ncbi request reprint Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Neuroimmunol 147:82-6. 2004
    ..These findings confirm a significant role for NO as an antibacterial effector molecule used by normal human AM and suggest that this host defense mechanism is suppressed by habitual exposure to inhaled marijuana or crack cocaine in vivo...
  77. ncbi request reprint Cocaine modulates cytokine and enhances tumor growth through sigma receptors
    Brian Gardner
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    J Neuroimmunol 147:95-8. 2004
    ..We conclude that sigma(1) receptor ligands, including cocaine, augment tumor growth via a cytokine-dependent, receptor-mediated mechanism that involves regulation of T helper 1/T helper 2 cytokine balance...
  78. ncbi request reprint Exhaled nitric oxide in the assessment of asthma
    Michelle R Zeidler
    David Geffen School of Medicine at University of California, Los Angeles, USA
    Curr Opin Pulm Med 10:31-6. 2004
    ..This review examines the role of exhaled nitric oxide in assessing and directing therapy of asthmatic airways inflammation...
  79. ncbi request reprint Regional differences in bronchoalveolar lavage and thoracic high-resolution computed tomography results in dyspneic patients with systemic sclerosis
    Philip J Clements
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Arthritis Rheum 50:1909-17. 2004
    ..This study was undertaken to investigate the utility of high-resolution computed tomography (HRCT) of the chest, in comparison with bronchoalveolar lavage (BAL), in the diagnosis of alveolitis in these patients...
  80. ncbi request reprint Loss of bone density with inhaled triamcinolone in Lung Health Study II
    Paul D Scanlon
    Mayo Clinic, Rochester, MN, USA
    Am J Respir Crit Care Med 170:1302-9. 2004
    ..In summary, the use of inhaled triamcinolone acetonide was associated with loss of BMD at the femoral neck and lumbar spine after 3 years of treatment...
  81. ncbi request reprint Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance use
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Am J Addict 15:297-302. 2006
    ..These findings suggest areas for further research on spontaneous recovery from marijuana use...
  82. ncbi request reprint Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    J Infect Dis 185:701-5. 2002
    ..This report describes a model for evaluating HIV cofactors and supports cocaine's role in the development and progression of AIDS...
  83. ncbi request reprint Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta
    Brian Gardner
    Pulmonary Immunology Laboratory, Division of Pulmonary and Critical Care Medicine, 37 131 CHS, UCLA School of Medicine, Los Angeles, California 90073, USA
    Biochem Biophys Res Commun 290:91-6. 2002
    ..We conclude that one mechanism by which THC contributes to immune suppression is by stimulating an enhanced production of lymphocyte TGF-beta...
  84. ncbi request reprint A pilot study of all-trans-retinoic acid for the treatment of human emphysema
    Jenny T Mao
    Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 99095 1690, USA
    Am J Respir Crit Care Med 165:718-23. 2002
    ..We conclude that ATRA is well tolerated in patients with emphysema, and trials evaluating higher doses, longer treatment, or different dosing schedules are feasible...
  85. ncbi request reprint Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal ("crack") cocaine
    Gayle Cocita Baldwin
    Division of Hematology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    Chest 121:1231-8. 2002
    ..To evaluate BAL cells obtained from habitual users of alkaloidal ("crack") cocaine alone or in combination with tobacco, for evidence of cocaine-associated alveolar injury...
  86. ncbi request reprint Chronic and acute effects of "crack" cocaine on diffusing capacity, membrane diffusion, and pulmonary capillary blood volume in the lung
    Eric C Kleerup
    Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1690, USA
    Chest 122:629-38. 2002
    ....
  87. ncbi request reprint The role of small airway inflammation in asthma
    Donald P Tashkin
    Division of Pulmonary and Critical Care, University of California at Los Angeles, School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Allergy Asthma Proc 23:233-42. 2002
    ..Their potential to treat inflammation at peripheral sites may account for the significant improvements in asthma outcomes that have been reported in clinical trials of these new formulations...
  88. ncbi request reprint Respiratory and immunologic consequences of marijuana smoking
    Donald P Tashkin
    Deportment of Medicine, UCLA School of Medicine, 90095 1690, USA
    J Clin Pharmacol 42:71S-81S. 2002
    ..Additional well designed epidemiological and immune monitoring studies are required to determine the potential causal relationship between marijuana use and the development of respiratory infection and/or cancer...
  89. ncbi request reprint Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells
    Michael Yuan
    Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    J Neuroimmunol 133:124-31. 2002
    ..The CB2 receptor antagonist, SR144528, abrogated the majority of these effects. We conclude that cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway...
  90. ncbi request reprint Effects of delta-9-tetrahydrocannabinol on human immune function and host defense
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine and Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Chem Phys Lipids 121:229-39. 2002
    ..Macrophage function is restored by treatment with interferon-gamma, a type 1 cytokine. Habitual exposure to THC appears capable of impacting on human cell-mediated immunity and host defense...
  91. ncbi request reprint Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003
    ..These results suggest that exposure of the bronchopulmonary epithelium to THC may have important health and physiological consequences...
  92. ncbi request reprint Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaine
    Angela Hanchi Shay
    Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Infect Dis 187:700-4. 2003
    ..These results confirm that NO plays a significant role as an effector molecule used by normal human AMs, but this capacity is suppressed in AMs from MS and CS because of a lack of intrinsic cytokine priming...
  93. ncbi request reprint Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung Study
    Dinesh Khanna
    David Geffen School of Medicine, University of California, Los Angeles, USA
    Arthritis Rheum 52:592-600. 2005
    ....
  94. ncbi request reprint Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Life Sci 77:1711-22. 2005
    ..These results suggest that exposure to THC in vivo can suppress immune function, increase HIV coreceptor expression, and act as a cofactor to significantly enhance HIV replication...
  95. ncbi request reprint Small airways response to naturalistic cat allergen exposure in subjects with asthma
    Michelle R Zeidler
    Division of Pulmonary, David Geffen School of Medicine and Allergy Research Foundation, University of California, Los Angeles, CA 90025, USA
    J Allergy Clin Immunol 118:1075-81. 2006
    ..It is currently unclear whether the small airways (diameter <2 microm) contribute significantly to late asthmatic reactions to inhaled allergen...
  96. ncbi request reprint Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial
    Marc Decramer
    Respiratory Division, University Hospitals, Leuven, Belgium
    COPD 1:303-12. 2004
    ....
  97. ncbi request reprint Oral vs IV corticosteroids for in-hospital treatment of COPD exacerbations
    Donald P Tashkin
    Chest 132:1728-9. 2007
  98. pmc Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease
    Charlie Strange
    Division of Pulmonary and Critical Care Medicine, MUSC, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
    Am J Respir Crit Care Med 177:91-8. 2008
    ..The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease...
  99. ncbi request reprint Pharmacologic therapy: novel approaches for chronic obstructive pulmonary disease
    William C Bailey
    University of Alabama Lung Health Center, University of Alabama at Birmingham, 620 South 20th Street, Suite NHB 104, Birmingham, AL 35249 7337, USA
    Proc Am Thorac Soc 4:543-8. 2007
    ..A number of new drugs are available, and more will be brought to market in the future. We have highlighted the details of this important area...
  100. ncbi request reprint Menthol cigarettes and health risks in Lung Health Study data
    Robert P Murray
    Department of Community Health Sciences, University of Manitoba Winnipeg, MB, Canada
    Nicotine Tob Res 9:101-7. 2007
    ..We found no difference in success at smoking cessation with or without menthol. We conclude that our data contain no evidence that mentholation of cigarettes increases the hazards of smoking...
  101. ncbi request reprint Optimizing treatment of chronic obstructive pulmonary disease: an assessment of current therapies
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Med 120:S4-13. 2007
    ..A treatment algorithm that combines both pharmacologic and nonpharmacologic interventions for the management of COPD is presented...

Research Grants22

  1. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  2. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2002
    ..findings which relate to susceptibility to opportunistic infections in HIV-infected cocaine smokers. ..
  3. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2004
    ..abstract_text> ..
  4. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2005
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  5. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2006
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  6. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2007
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  7. MOCSLID-CCC
    Donald Tashkin; Fiscal Year: 2009
    ..End of Abstract) ..
  8. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2002
    ..findings which relate to susceptibility to opportunistic infections in HIV-infected cocaine smokers. ..
  9. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  10. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 1999
    ..findings which relate to susceptibility to opportunistic infections in HIV-infected cocaine smokers. ..
  11. COCAINE SMOKING EFFECTS ON LUNG PHYSIOLOGY, HOST DEFENSE
    Donald Tashkin; Fiscal Year: 1993
    ..aureus and E. coli; and c) pulmonary interstitial lymphocytes, epithelial cells and components of alveolar epithelial lining fluid that are important in the lung's defense against infection...
  12. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2000
    ..findings which relate to susceptibility to opportunistic infections in HIV-infected cocaine smokers. ..
  13. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Donald Tashkin; Fiscal Year: 2001
    ..findings which relate to susceptibility to opportunistic infections in HIV-infected cocaine smokers. ..
  14. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  15. MOCSLID-CCC
    Donald P Tashkin; Fiscal Year: 2010
    ..End of Abstract) ..