Joseph S Tash
Affiliation: University of Kansas Medical Center
Tash J, Chakrasali R, Jakkaraj S, Hughes J, Smith S, Hornbaker K, et al
. Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells. Biol Reprod. 2008;78:1139-52 pubmed publisher
..A current model for gamendazole action posits that this pathway links interaction with HSP90AB1 and EEF1A1 to the loss of spermatids and resulting infertility. ..
Tash J, Johnson D, Enders G. Long-term (6-wk) hindlimb suspension inhibits spermatogenesis in adult male rats. J Appl Physiol (1985). 2002;92:1191-8 pubmed
..These results have significant implications regarding serious effects of long-term exposure to microG on the reproductive capability of scrotal mammals, including humans. ..
Olesen S, Ingles D, Zhu J, Martin M, Betzi S, Georg G, et al
. Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2. Molecules. 2015;20:1643-60 pubmed publisher
..The approach applied herein provides robust assays for a comprehensive biochemical evaluation of potential effectors of the Hsp90-p50Cdc37 complex, such as phosphorylation by a kinase or the interaction with small molecule ligands. ..
Tash J, Attardi B, Hild S, Chakrasali R, Jakkaraj S, Georg G. A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose. Biol Reprod. 2008;78:1127-38 pubmed publisher