Joseph S Tash

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells
    Joseph S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 78:1139-52. 2008
  2. ncbi Identification of phosphoproteins coupled to initiation of motility in live epididymal mouse sperm
    J S Tash
    Department of Molecular and Integrative Physiology and the Center for Reproductive Sciences, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA
    Biochem Biophys Res Commun 251:557-63. 1998
  3. ncbi Microgravity alters protein phosphorylation changes during initiation of sea urchin sperm motility
    J S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160 7401, USA
    FASEB J 13:S43-54. 1999
  4. ncbi Fertilization of sea urchin eggs and sperm motility are negatively impacted under low hypergravitational forces significant to space flight
    J S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 65:1224-31. 2001
  5. ncbi Long-term (6-wk) hindlimb suspension inhibits spermatogenesis in adult male rats
    Joseph S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Appl Physiol 92:1191-8. 2002
  6. ncbi A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose
    Joseph S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 78:1127-38. 2008
  7. ncbi Role of FYN kinase in spermatogenesis: defects characteristic of Fyn-null sperm in mice
    Jinping Luo
    Interdisciplinary Center for Male Contraceptive Research and Drug Development, University of Kansas Medical Center, Kansas City, USA
    Biol Reprod 86:1-8. 2012
  8. ncbi The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility
    Gladis Sanchez
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Mol Hum Reprod 12:565-76. 2006

Research Grants

  1. Interdisciplinary Center for Male Contraceptive Research and Drug Development
    JOSEPH TASH; Fiscal Year: 2007

Collaborators

Detail Information

Publications8

  1. ncbi Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells
    Joseph S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 78:1139-52. 2008
    ..A current model for gamendazole action posits that this pathway links interaction with HSP90AB1 and EEF1A1 to the loss of spermatids and resulting infertility...
  2. ncbi Identification of phosphoproteins coupled to initiation of motility in live epididymal mouse sperm
    J S Tash
    Department of Molecular and Integrative Physiology and the Center for Reproductive Sciences, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA
    Biochem Biophys Res Commun 251:557-63. 1998
    ..Thus it appears that phosphorylation of FP130 and related 120 kDa proteins in mouse, and perhaps human sperm, represent common targets during motility initiation in sperm...
  3. ncbi Microgravity alters protein phosphorylation changes during initiation of sea urchin sperm motility
    J S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160 7401, USA
    FASEB J 13:S43-54. 1999
    ....
  4. ncbi Fertilization of sea urchin eggs and sperm motility are negatively impacted under low hypergravitational forces significant to space flight
    J S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 65:1224-31. 2001
    ..Thus, more detailed studies on the impact of space flight on development should include studies of sperm function and fertilization...
  5. ncbi Long-term (6-wk) hindlimb suspension inhibits spermatogenesis in adult male rats
    Joseph S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Appl Physiol 92:1191-8. 2002
    ..These results have significant implications regarding serious effects of long-term exposure to microG on the reproductive capability of scrotal mammals, including humans...
  6. ncbi A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose
    Joseph S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 78:1127-38. 2008
    ....
  7. ncbi Role of FYN kinase in spermatogenesis: defects characteristic of Fyn-null sperm in mice
    Jinping Luo
    Interdisciplinary Center for Male Contraceptive Research and Drug Development, University of Kansas Medical Center, Kansas City, USA
    Biol Reprod 86:1-8. 2012
    ....
  8. ncbi The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility
    Gladis Sanchez
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Mol Hum Reprod 12:565-76. 2006
    ..Accordingly, we found alpha4 in the sperm tail, predominating in the mid-piece of the flagellum. Therefore, similar to the rat ortholog, human Na,K-ATPase alpha4 isoform has a distinct activity that is essential for sperm function...

Research Grants2

  1. Interdisciplinary Center for Male Contraceptive Research and Drug Development
    JOSEPH TASH; Fiscal Year: 2007
    ....