Affiliation: University of North Carolina
Tarran R, Button B, Boucher R. Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress. Annu Rev Physiol. 2006;68:543-61 pubmed
..We also discuss (a) how derangement of the ADO-CFTR pathway renders CF airways vulnerable to viral infections that deplete ASL volume and produce mucus stasis, and (b) potential shear stress-dependent therapies for CF. ..
Webster M, Reidel B, Tan C, Ghosh A, Alexis N, Donaldson S, et al
. SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration. Eur Respir J. 2018;52: pubmed publisher
..Our data indicate that CF mucosal secretions drive ASL hyperabsorption and that protease-resistant peptides, e.g. SPX-101, can reverse this effect to rehydrate CF ASL. ..
Tan C, Hobbs C, Sameni M, Sloane B, Stutts M, Tarran R. Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures. J Physiol. 2014;592:5251-68 pubmed publisher
..Taken together, our data suggest that CTSB is a pathophysiologically relevant protease that activates ENaC in CF airways. ..
Tarran R, Trout L, Donaldson S, Boucher R. Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia. J Gen Physiol. 2006;127:591-604 pubmed
..Interestingly, the amount of ASL/Cl- secretion elicited by ATP/ADO was influenced by the level of CAP-induced Na+ absorption, suggesting that there are important interactions between the soluble regulators which finely tune ASL volume. ..
Ghosh A, Boucher R, Tarran R. Airway hydration and COPD. Cell Mol Life Sci. 2015;72:3637-52 pubmed publisher
..We shall also discuss existing therapeutic strategies for the treatment of chronic bronchitis and how components of the MCC can be used as biomarkers for the evaluation of tobacco or tobacco-like-product exposure. ..
Rowell T, Tarran R. Will chronic e-cigarette use cause lung disease?. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1398-409 pubmed publisher
..We hope that collating this data will help illustrate gaps in the knowledge of this burgeoning field, directing researchers toward answering whether or not E-Cigs are capable of causing disease. ..
Fellner R, Terryah S, Tarran R. Inhaled protein/peptide-based therapies for respiratory disease. Mol Cell Pediatr. 2016;3:16 pubmed publisher
Kim C, Ahmad S, Wu T, Walton W, Redinbo M, Tarran R. SPLUNC1 is an allosteric modulator of the epithelial sodium channel. FASEB J. 2018;32:2478-2491 pubmed publisher
..These data indicate a novel mode for regulating ENaC at the plasma membrane.-Kim, C. S., Ahmad, S., Wu, T., Walton, W. G., Redinbo, M. R., Tarran, R. SPLUNC1 is an allosteric modulator of the epithelial sodium channel. ..
Tarran R, Sabater J, Clarke T, Tan C, Davies C, Liu J, et al
. Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. Am J Physiol Lung Cell Mol Physiol. 2013;304:L746-56 pubmed publisher
..We conclude that GS-459755 may limit HNE-induced activation of ENaC and may be useful for the treatment of mucus dehydration in CF and COPD without inducing bacterial resistance...