David Tarin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis
    Virginia Urquidi
    University of California, San Diego Cancer Center and Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    Clin Cancer Res 8:61-74. 2002
  2. doi request reprint Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance
    David Tarin
    Department of Pathology and Moores Comprehensive Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0803, La Jolla 92093, United States
    Semin Cancer Biol 21:72-82. 2011
  3. doi request reprint Update on clinical and mechanistic aspects of paraneoplastic syndromes
    David Tarin
    Moores Cancer Center and Department of Pathology, University of California, San Diego, 3855 Health Sciences Drive, MC0803, La Jolla, CA, 92106, USA
    Cancer Metastasis Rev 32:707-21. 2013
  4. doi request reprint Role of the host stroma in cancer and its therapeutic significance
    David Tarin
    Moores UCSD Comprehensive Cancer Center and Department of Pathology, University of California, La Jolla, CA, 92093, USA
    Cancer Metastasis Rev 32:553-66. 2013
  5. pmc Erratum to: Clinical and Biological Implications of the Tumor Microenvironment
    David Tarin
    UCSD Comprehensive Cancer Center and Department of Pathology, La Jolla, San Diego, CA, 92093, USA
    Cancer Microenviron 5:113. 2012
  6. doi request reprint Inappropriate gene expression in human cancer and its far-reaching biological and clinical significance
    David Tarin
    Department of Pathology, University of California, San Diego, La Jolla, CA, USA
    Cancer Metastasis Rev 31:21-39. 2012
  7. ncbi request reprint The fallacy of epithelial mesenchymal transition in neoplasia
    David Tarin
    Rebecca and John Moores Cancer Center and Department of Pathology, University of California, San Diego, San Diego, California, USA
    Cancer Res 65:5996-6000; discussion 6000-1. 2005
  8. doi request reprint Comparisons of metastases in different organs: biological and clinical implications
    David Tarin
    Moores UCSD Comprehensive Cancer Center, University of California, San Diego, La Jolla, California 92093 0803, USA
    Clin Cancer Res 14:1923-5. 2008
  9. ncbi request reprint New insights into the pathogenesis of breast cancer metastasis
    David Tarin
    Department of Pathology and Moores Cancer Center, University of California, San Diego, CA 92093 0803, USA
    Breast Dis 26:13-25. 2006
  10. ncbi request reprint Tumor-stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis
    Valerie Montel
    Rebecca and John Moores Comprehensive Cancer Center and Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0803, USA
    Int J Cancer 119:251-63. 2006

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis
    Virginia Urquidi
    University of California, San Diego Cancer Center and Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    Clin Cancer Res 8:61-74. 2002
    ..Manipulation of candidate genes in these cells will permit evaluation of their functional significance in the geometric progression of breast cancer...
  2. doi request reprint Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance
    David Tarin
    Department of Pathology and Moores Comprehensive Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0803, La Jolla 92093, United States
    Semin Cancer Biol 21:72-82. 2011
    ....
  3. doi request reprint Update on clinical and mechanistic aspects of paraneoplastic syndromes
    David Tarin
    Moores Cancer Center and Department of Pathology, University of California, San Diego, 3855 Health Sciences Drive, MC0803, La Jolla, CA, 92106, USA
    Cancer Metastasis Rev 32:707-21. 2013
    ..It also discusses treatment options and issues relating to conducting randomized clinical trials on these disorders. ..
  4. doi request reprint Role of the host stroma in cancer and its therapeutic significance
    David Tarin
    Moores UCSD Comprehensive Cancer Center and Department of Pathology, University of California, La Jolla, CA, 92093, USA
    Cancer Metastasis Rev 32:553-66. 2013
    ..This dependency is of critical importance for cancer therapy research, and proposed methods for turning this parasitic behaviour of tumours against themselves are suggested below. ..
  5. pmc Erratum to: Clinical and Biological Implications of the Tumor Microenvironment
    David Tarin
    UCSD Comprehensive Cancer Center and Department of Pathology, La Jolla, San Diego, CA, 92093, USA
    Cancer Microenviron 5:113. 2012
    ....
  6. doi request reprint Inappropriate gene expression in human cancer and its far-reaching biological and clinical significance
    David Tarin
    Department of Pathology, University of California, San Diego, La Jolla, CA, USA
    Cancer Metastasis Rev 31:21-39. 2012
    ....
  7. ncbi request reprint The fallacy of epithelial mesenchymal transition in neoplasia
    David Tarin
    Rebecca and John Moores Cancer Center and Department of Pathology, University of California, San Diego, San Diego, California, USA
    Cancer Res 65:5996-6000; discussion 6000-1. 2005
    ....
  8. doi request reprint Comparisons of metastases in different organs: biological and clinical implications
    David Tarin
    Moores UCSD Comprehensive Cancer Center, University of California, San Diego, La Jolla, California 92093 0803, USA
    Clin Cancer Res 14:1923-5. 2008
  9. ncbi request reprint New insights into the pathogenesis of breast cancer metastasis
    David Tarin
    Department of Pathology and Moores Cancer Center, University of California, San Diego, CA 92093 0803, USA
    Breast Dis 26:13-25. 2006
    ..Both of these therapeutic approaches are not yet within our grasp, but we have recognized the nature of the adversary and will eventually be able to design tools to undermine its drive and progress...
  10. ncbi request reprint Tumor-stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis
    Valerie Montel
    Rebecca and John Moores Comprehensive Cancer Center and Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0803, USA
    Int J Cancer 119:251-63. 2006
    ..This dependency on suitable host niches suggests new molecular therapeutic avenues that target genes in the host-support system that is manipulated by the malignant cells...
  11. pmc Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts
    Mika Suzuki
    University of California San Diego Cancer Center, La Jolla, California 92093 0803, USA
    Am J Pathol 171:682-92. 2007
    ..The data indicate that therapeutic targeting of tumor OPN molecules could reset metastatically relevant gene networks, resulting in clinical benefit...
  12. pmc An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression
    Jay S Desgrosellier
    Department of Pathology, Moores University of California San Diego Cancer Center, La Jolla, California, USA
    Nat Med 15:1163-9. 2009
    ....
  13. ncbi request reprint Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein
    Steve Goodison
    University of California San Diego, Cancer Center and Departments of Pathology, La Jolla, California 92093, USA
    Clin Cancer Res 9:3808-14. 2003
    ....
  14. pmc Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model
    Valerie Montel
    Rebecca and John Moores Comprehensive Cancer Center and Department of Pathology, University of California, San Diego, 9500 Gilman Drive, M C 0912 La Jolla, CA 92093 0912, USA
    Am J Pathol 166:1565-79. 2005
    ..The findings also suggest that metastasis to at least two different organs occurs through closely similar genetic mechanisms...
  15. pmc RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia
    David J Shields
    Department of Pathology, Moores Cancer Center, University of California, San Diego, CA 92093 0803, USA
    Proc Natl Acad Sci U S A 107:2189-94. 2010
    ..These data not only define a previously uncharacterized serine hydrolase activity associated with epithelial neoplasia, but also demonstrate the potential benefit of functional proteomics in the identification of new therapeutic targets...
  16. ncbi request reprint Gene expression profiling of human lymph node metastases and matched primary breast carcinomas: clinical implications
    Mika Suzuki
    Rebecca and John Moores UCSD Comprehensive Cancer Center, Department of Pathology, University of California, San Diego, 3855 Health Sciences Drive MC0803, La Jolla, CA 92093 0803, USA
    Mol Oncol 1:172-80. 2007
    ..The important clinical significance of this deduction is that, in most patients, early detection provides time for appropriate therapeutic intervention to be effective in obstructing metastasis...
  17. doi request reprint Expression of melanocyte-related genes in human breast cancer and its implications
    Valerie Montel
    Moores UCSD Cancer Center, University of California, San Diego, USA
    Differentiation 78:283-91. 2009
    ....
  18. pmc Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency
    Mika Suzuki
    Rebecca and John Moores Comprehensive Cancer Center and Department of Pathology, University of California, San Diego, 3855 Health Sciences Dr MC0803, La Jolla, CA 92093 0803, USA
    Am J Pathol 169:673-81. 2006
    ..Specifically, it predicts the existence of natural, nonimmune host mechanisms that stimulate or inactivate tumor growth in different anatomical sites, which may be exploitable for therapeutic benefit...
  19. ncbi request reprint Differential effects of retinoic acid on the growth of isogenic metastatic and non-metastatic breast cancer cell lines and their association with distinct expression of retinoic acid receptor beta isoforms 2 and 4
    Ken Hayashi
    University of California, San Diego Cancer Center and Department of Pathology, MC0912, La Jolla, CA 92093 0912, USA
    Int J Oncol 22:623-9. 2003
    ....
  20. ncbi request reprint Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model
    Dianne Agarwal
    University of California San Diego, Cancer Center and Department of Pathology, La Jolla 92093, USA
    Differentiation 71:114-25. 2003
    ....
  21. ncbi request reprint Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression
    Valerie Montel
    Department of Pathology, University of California, San Diego Cancer Center, La Jolla, California 92093, USA
    Cancer Res 64:1687-94. 2004
    ....
  22. ncbi request reprint Tumor-host interactions contribute to the elevated expression level of alpha1-antichymotrypsin in metastatic breast tumor xenografts
    Valerie Montel
    Department of Pathology and Moores Comprehensive Cancer Center, University of California San Diego, 9500 Gilman Drive MC0912, La Jolla, CA 92093 0912, USA
    Differentiation 73:88-98. 2005
    ..Moreover, because of the xenogeneic nature of our system, we were able to provide evidence of tumor-host reciprocal regulation of ACT production...
  23. ncbi request reprint Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line
    Kanji Kawai
    UCSD Cancer Center and Department of Pathology, University of California San Diego, La Jolla, California 92093 0912, USA
    Genes Chromosomes Cancer 34:1-8. 2002
    ..The excellent resolving power of SKY, coupled with additional information obtained from molecular cytogenetic analyses, will improve our ability to identify genetic lesions characteristic of cancer...
  24. ncbi request reprint Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen
    John D Hooper
    Department of Cell Biology, The Scripps Research Intitute, La Jolla, CA 92037, USA
    Oncogene 22:1783-94. 2003
    ..Thus, specific immunodetection followed by proteomic analysis allows for the identification and partial characterization of a heretofore uncharacterized human cell surface antigen...
  25. pmc Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression
    Kristy K Ward
    Department of Reproductive Medicine, Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    Clin Exp Metastasis 30:579-94. 2013
    ..These results support the continued evaluation of FAK inhibitors as a promising clinical treatment for ovarian cancer...
  26. pmc In silico dissection of cell-type-associated patterns of gene expression in prostate cancer
    Robert O Stuart
    Veterans Affairs San Diego Healthcare System, and Department of Medicine and John and Rebecca Moores UCSD Cancer Center, University of California at San Diego, La Jolla, USA
    Proc Natl Acad Sci U S A 101:615-20. 2004
    ..The results provide patterns of gene expression for these three lineages with relevance to pathogenetic, diagnostic, and therapeutic considerations...
  27. ncbi request reprint Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?
    Erik W Thompson
    Invasion and Metastasis Unit, Department of Surgery, University of Melbourne and Embryology Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Cancer Res 65:5991-5; discussion 5995. 2005
  28. ncbi request reprint Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines
    Nicole Euer
    Roche Diagnostics GmbH, Division Pharma, Penzberg, Germany
    Anticancer Res 22:733-40. 2002
    ..Profound differences in G-protein-mediated signaling and down-regulation of the tumor-suppressor genes DPC4, BARDI and DLC-1 were noted in the metastatic cell line 4A4...