I N Targoff

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Update on myositis-specific and myositis-associated autoantibodies
    I N Targoff
    Veterans Affairs Medical Center, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, 73104, USA
    Curr Opin Rheumatol 12:475-81. 2000
  2. ncbi request reprint Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patients
    Yves Troyanov
    Division of Rheumatology, Department of Medicine, Centre Hospitalier, Universite de Montreal, Faculty of Medicine, Montreal, Quebec, Canada
    Medicine (Baltimore) 84:231-49. 2005
  3. ncbi request reprint Idiopathic inflammatory myopathy: autoantibody update
    Ira N Targoff
    Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Rheumatol Rep 4:434-41. 2002
  4. ncbi request reprint Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies
    Ira N Targoff
    Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Rheum Dis Clin North Am 28:859-90, viii. 2002
  5. ncbi request reprint Autoantibodies and their significance in myositis
    Ira N Targoff
    Department of Medicine, University of Oklahoma Health Sciences Center, Veterans Affairs Medical Center and Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    Curr Rheumatol Rep 10:333-40. 2008
  6. pmc Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes
    Martial Koenig
    University of Montreal School of Medicine, and Laboratory for Research in Autoimmunity, Centre Hospitalier de l Universite de Montreal, M 4243, 1560 East Sherbrooke Street, Montreal, Quebec, Canada H2L 4M1
    Arthritis Res Ther 9:R78. 2007
  7. ncbi request reprint Myositis specific autoantibodies
    Ira N Targoff
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Rheumatol Rep 8:196-203. 2006
  8. ncbi request reprint A novel autoantibody to a 155-kd protein is associated with dermatomyositis
    Ira N Targoff
    Veterans Affairs Medical Center
    Arthritis Rheum 54:3682-9. 2006
  9. ncbi request reprint Antibody to threonyl-transfer RNA synthetase in myositis sera
    I N Targoff
    Department of Medicine, Oklahoma University Health Science Center, Oklahoma City
    Arthritis Rheum 31:515-24. 1988
  10. pmc Anti-KJ: a new antibody associated with the syndrome of polymyositis and interstitial lung disease
    I N Targoff
    Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City
    J Clin Invest 84:162-72. 1989

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Update on myositis-specific and myositis-associated autoantibodies
    I N Targoff
    Veterans Affairs Medical Center, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, 73104, USA
    Curr Opin Rheumatol 12:475-81. 2000
    ..Recent studies have suggested that antigen cleavage during apoptosis, particularly by granzyme B, may be an important factor. Whether the antibodies play a role in tissue injury remains unknown...
  2. ncbi request reprint Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patients
    Yves Troyanov
    Division of Rheumatology, Department of Medicine, Centre Hospitalier, Universite de Montreal, Faculty of Medicine, Montreal, Quebec, Canada
    Medicine (Baltimore) 84:231-49. 2005
    ..Much of IIM is composed of OM. The proposed modified and clinicoserologic classifications have diagnostic, prognostic, and therapeutic value...
  3. ncbi request reprint Idiopathic inflammatory myopathy: autoantibody update
    Ira N Targoff
    Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Rheumatol Rep 4:434-41. 2002
    ..Despite this progress, the reason for production of the autoantibodies and their role in tissue injury remain unknown...
  4. ncbi request reprint Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies
    Ira N Targoff
    Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Rheum Dis Clin North Am 28:859-90, viii. 2002
    ..Recent studies have defined additional myositis autoantibodies that may improve our capacity to diagnose and manage the IIM...
  5. ncbi request reprint Autoantibodies and their significance in myositis
    Ira N Targoff
    Department of Medicine, University of Oklahoma Health Sciences Center, Veterans Affairs Medical Center and Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    Curr Rheumatol Rep 10:333-40. 2008
    ..These findings have significant clinical implications and suggest promising areas of further research...
  6. pmc Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes
    Martial Koenig
    University of Montreal School of Medicine, and Laboratory for Research in Autoimmunity, Centre Hospitalier de l Universite de Montreal, M 4243, 1560 East Sherbrooke Street, Montreal, Quebec, Canada H2L 4M1
    Arthritis Res Ther 9:R78. 2007
    ..These results provide a rationale for patient profiling and its application to therapeutics, because it cannot be assumed that the B-cell response is the same even in the majority of patients in a given diagnostic category...
  7. ncbi request reprint Myositis specific autoantibodies
    Ira N Targoff
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Rheumatol Rep 8:196-203. 2006
    ..The possibility was raised that increased antigen expression in regenerating muscle may help to perpetuate the disease. These antibodies continue to be the subject of active investigation...
  8. ncbi request reprint A novel autoantibody to a 155-kd protein is associated with dermatomyositis
    Ira N Targoff
    Veterans Affairs Medical Center
    Arthritis Rheum 54:3682-9. 2006
    ..This study was undertaken as part of a larger effort to define novel autoantibodies that assist in the clinical evaluation of myositis...
  9. ncbi request reprint Antibody to threonyl-transfer RNA synthetase in myositis sera
    I N Targoff
    Department of Medicine, Oklahoma University Health Science Center, Oklahoma City
    Arthritis Rheum 31:515-24. 1988
    ..Anti-PL-7 is an uncommon myositis-associated antibody that is independent of anti-Jo-1, but is directed at a functionally related enzyme...
  10. pmc Anti-KJ: a new antibody associated with the syndrome of polymyositis and interstitial lung disease
    I N Targoff
    Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City
    J Clin Invest 84:162-72. 1989
    ..This syndrome may be associated with antibodies to translation-related proteins in general, which may have implications for the link of PM and enteroviruses, which are mRNA viruses...
  11. ncbi request reprint The association of anti-Ro52 autoantibodies with myositis and scleroderma autoantibodies
    M B Frank
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Autoimmun 12:137-42. 1999
    ..These data indicate that anti-Ro52 antibodies are produced in particular subsets of myositis patients, and are not limited to sera with anti-Jo-1 antibodies...
  12. ncbi request reprint Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung disease
    I N Targoff
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City
    Arthritis Rheum 35:821-30. 1992
    ..The finding of specific inhibition of gly-tRNA synthetase by all anti-EJ-positive sera strongly supports the identification of EJ antigen as gly-tRNA synthetase...
  13. ncbi request reprint Primary structure and functional expression of human Glycyl-tRNA synthetase, an autoantigen in myositis
    Q Ge
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City
    J Biol Chem 269:28790-7. 1994
    ..Near identity in other regions suggested that they also had important functions. Expression of the cDNA in Escherichia coli yielded a protein of expected size that reacted with the autoantibodies and was active as glycyl-tRNA synthetase...
  14. ncbi request reprint Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase)
    I N Targoff
    Department of Medicine, Oklahoma University Health Science Center, Oklahoma City
    Am J Med 88:241-51. 1990
    ..CONCLUSION: We conclude that anti-PL-12, like anti-Jo-1 and anti-PL-7, was frequently associated with the "Jo-1 syndrome" of myositis with ILD. ILD was a major clinical problem in this group of patients...
  15. ncbi request reprint Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family
    L A Lee
    Department of Medicine, Denver Health Medical Center, Colorado, USA
    J Invest Dermatol 113:146-51. 1999
    ..The p53-like genes, p73 and the several KET splicing variants, are recently described genes of uncertain biologic and pathologic significance. This study provides the first clear association of a p53-like protein with a disease process...
  16. pmc Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen
    Q Ge
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    J Clin Invest 96:1730-7. 1995
    ..These findings indicate that the Mi-2 240 kD is a novel protein that is antigenic for all Mi-2 sera, and strongly suggests that a major common epitope is conformational in nature...
  17. ncbi request reprint Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease
    Satoshi Okada
    Center for Biologics Evaluation and Research, Food and Drug Administration NIH, Bethesda, MD, USA
    Arthritis Rheum 48:2285-93. 2003
    ..To determine if geoclimatic factors may influence the nature and frequency of dermatomyositis (DM), polymyositis, and associated autoantibodies around the world...
  18. ncbi request reprint Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups
    Kakali Sarkar
    National Institute of Environmental Health Sciences, NIH, DHHS, Bethesda, MD 20892, USA
    Arthritis Rheum 52:2433-8. 2005
    ..To assess possible seasonal patterns in the onset of polymyositis (PM) and dermatomyositis (DM)...
  19. pmc Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity
    April Bingham
    From Office of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland 20892 1301, USA
    Medicine (Baltimore) 87:70-86. 2008
    ..Further study is warranted to investigate the pathogenesis of acquired LD in patients with DM...
  20. ncbi request reprint Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase
    Michito Hirakata
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, and Seoul National University Hospital, Korea
    Arthritis Rheum 56:1295-303. 2007
    ....
  21. pmc Seasonal birth patterns in myositis subgroups suggest an etiologic role of early environmental exposures
    Leora J Vegosen
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arthritis Rheum 56:2719-28. 2007
    ..To evaluate whether seasonal early environmental exposures might influence later development of autoimmune disease, by assessing distributions of birth dates in groups of patients with idiopathic inflammatory myopathies (IIMs)...
  22. ncbi request reprint HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Bethesda, Maryland 20892, USA
    Arthritis Rheum 54:3670-81. 2006
    ..To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM...
  23. ncbi request reprint Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:111-27. 2006
    ....
  24. ncbi request reprint Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis
    Ejaz A Shamim
    Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
    Arthritis Rheum 46:1885-93. 2002
    ....