Research Topics
| Alice TarantalSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studiesA F Tarantal
California Regional Primate Research Center, Department of Pediatrics, University of California, Davis 95616 8542, USA
J Acquir Immune Defic Syndr Hum Retrovirol 20:323-33. 1999..These data suggest that although PMPA holds great promise for HIV-infected patients, there is the potential for bone-related toxicity at chronic, high dosages, particularly in infants...- Fetal gene transfer using lentiviral vectors and the potential for germ cell transduction in rhesus monkeys (Macaca mulatta)C Chang I Lee
California National Primate Research Center, University of California, Davis, CA 95616-8542, USA
Hum Gene Ther 16:417-25. 2005.... 
Center for fetal monkey gene transfer for heart, lung, and blood diseases: an NHLBI resource for the gene therapy communityAlice F Tarantal
Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, University of California, Davis, 95616, USA
Hum Gene Ther 23:1130-5. 2012..The Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases successfully aids the gene therapy community in addressing regulatory barriers, and serves as an effective vehicle for advancing the field...
Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeysAlice F Tarantal
California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616 8542, USA
Mol Imaging Biol 14:197-204. 2012....- Fetal rhesus monkey model of obstructive renal dysplasiaA F Tarantal
California Regional Primate Research Center, University of California, Davis, California 95616 8542, USA
Kidney Int 59:446-56. 2001..To understand further the prenatal pathogenesis of obstructive renal dysplasia, a fetal monkey model was developed using ultrasound-guided techniques... - Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta)Alice F Tarantal
Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, CA 95616 8542, USA
Transplantation 88:38-41. 2009.... - Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene deliveryAlice F Tarantal
California National Primate Research Center, University of California, Davis, CA 95616, USA
Mol Ther 12:87-98. 2005.... - Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeysAlice F Tarantal
Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, University of California, Davis, Davis, CA 95616, USA
Hum Gene Ther 17:1254-61. 2006..These investigations have shown that HSV-1-sr39tk and firefly luciferase can be used to safely detect transgene expression at multiple time points in fetal and infant monkeys in vivo and without evidence of adverse effects... - Long-term luciferase expression monitored by bioluminescence imaging after adeno-associated virus-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta)Alice F Tarantal
Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, California National Primate Research Center, Davis, CA 95616, USA
Hum Gene Ther 21:143-8. 2010.... - Administration of recombinant human stem cell factor (rhSCF) and granulocyte-colony stimulating factor (rhG-CSF) to maternal and fetal rhesus monkeys (Macaca mulatta)A F Tarantal
California Regional Primate Research Center and Department of Pediatrics, University of California, Davis, California 95616 8542, USA
Cytokine 11:290-300. 1999.... - Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys (Macaca mulatta)Alice F Tarantal
California Regional Primate Research Center, University of California at Davis, 95616 8542, USA
J Acquir Immune Defic Syndr 29:207-20. 2002..The results of these studies suggest that chronic fetal exposure to tenofovir at the maternal dose of 30 mg/kg throughout gestation can alter select fetal parameters and transiently affect maternal bone biomarkers... - Rhesus monkey model for fetal gene transfer: studies with retroviral- based vector systemsA F Tarantal
California Regional Primate Research Center, University of California at Davis, 95616 8542, USA
Mol Ther 3:128-38. 2001..The rhesus monkey is an important preclinical primate model system for exploring gene transfer approaches for future applications in humans... - Morphological analysis and lentiviral transduction of fetal monkey bone marrow-derived mesenchymal stem cellsChang I Lee
California National Primate Research Center, University of California, Davis, California 95616-8542, USA
Mol Ther 9:112-23. 2004..that the SIN HIV-1-derived lentiviral vectors used in these studies can efficiently transduce rhMSC in vitro (CMV > EF1alpha > PGK) without inhibiting differentiation potential, although the cell cycle was transiently altered at high MOI.. - Strategies for innovation and interdisciplinary translational research: removal of barriers through the CTSA mechanismLars Berglund
Departments of Medicine, Pediatrics, and Cell Biology and Human Anatomy, University of California, Davis, Sacramento, CA, USA
J Investig Med 57:474-6. 2009.... - Nonhuman primate models of intrauterine cytomegalovirus infectionPeter A Barry
Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, CA, USA
ILAR J 47:49-64. 2006.... - Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeysMari S Golub
University of California, Davis, Davis, CA 95616, USA
Am J Clin Nutr 83:647-56. 2006..Iron deficiency anemia (IDA) is relatively common in the third trimester of pregnancy, but causal associations with low birth weight and compromised neonatal iron status are difficult to establish in human populations... - Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivoChristina A Pacak
Center for Fetal Monkey Gene Transfer for Heart, Lung and Blood Diseases, California National Primate Research Center, Davis, USA
Circ Res 99:e3-9. 2006.... - Comparison of growth and differentiation of fetal and adult rhesus monkey mesenchymal stem cellsC Chang I Lee
California National Primate Research Center, University of California, Davis, 95616, USA
Stem Cells Dev 15:209-20. 2006.... - A recombinant rhesus cytomegalovirus expressing enhanced green fluorescent protein retains the wild-type phenotype and pathogenicity in fetal macaquesW L William Chang
Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California 95616, USA
J Virol 76:9493-504. 2002..The pattern of RhCMV infection in the central nervous system may offer an explanation for the severe developmental outcomes associated with congenital human CMV infection early in gestation... - Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta)Alesha B Castillo
Orthopedic Research Laboratories, School of Medicine, University of California at Davis Medical Center, 4635 Second Avenue Suite 2000, Sacramento, CA 95817, USA
J Orthop Res 20:1185-9. 2002..Both defective mineralization of newly formed bone and increased resorption cavity density may result in greater bone fragility... - Immunogenicity and protective efficacy of DNA vaccines expressing rhesus cytomegalovirus glycoprotein B, phosphoprotein 65-2, and viral interleukin-10 in rhesus macaquesYujuan Yue
Center for Comparative Medicine, University of California Davis, County Rd 98 and Hutchison Dr, Davis, CA 95616, USA
J Virol 81:1095-109. 2007..These data demonstrated that DNA vaccines targeting the RhCMV homologues of HCMV gB and pp65 altered the course of acute and persistent RhCMV infection in a primate host... - Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeysMari S Golub
Department of Internal Medicine, California National Primate Research Center, University of California, Davis 95616, USA
Toxicol Sci 74:103-13. 2003..Long-term consequences of this disruption of pubertal development are being studied in this cohort of monkeys as adults... - Simian immunodeficiency virus infection of hematopoietic stem cells and bone marrow stromal cellsChang I Lee
California National Primate Research Center, University of California, Davis, CA 95616-8542, USA
J Acquir Immune Defic Syndr 36:553-61. 2004.... - Adrenocortical cytochrome b5 expression during fetal development of the rhesus macaqueSamantha Mapes
Department of Population Health and Reproduction, University of California, Davis, California 95616, USA
Endocrinology 143:1451-8. 2002..However, the lack of cytochrome b5 and P450c17 expression in the FZ of the developing macaque adrenal cortex for much of the second and third trimesters distinguishes it from the mature zona reticularis seen in adult animals... - Quantitative analysis of male fetal DNA in maternal serum of gravid rhesus monkeys (Macaca mulatta)Daniel F Jimenez
California National Primate Research Center, University of California, Davis, CA 95616-8542, U.S.A
Pediatr Res 53:18-23. 2003.... - Functional and morphological development of lymphoid tissues and immune regulatory and effector function in rhesus monkeys: cytokine-secreting cells, immunoglobulin-secreting cells, and CD5(+) B-1 cells appear early in fetal developmentNorbert Makori
California National Primate Research Center, Center for Comparative Medicine, University of California, Davis, California 95616-8542, USA
Clin Diagn Lab Immunol 10:140-53. 2003..Thus, by the second trimester, the lymphoid tissues of the rhesus monkey fetus have a complete repertoire of properly organized antigen-presenting cells, T cells, and B cells... - Occult pretransplantation systemic inflammation and posttransplantation vascular changes in a primate arterial allograft modelJason T Fitzgerald
Department of Surgery, University of California, Davis Medical Center, Sacramento, USA
Transplantation 78:367-74. 2004..The purpose of this study was to examine the anatomic and physiologic effects of occult pretransplantation systemic inflammation on posttransplantation allograft outcome in a nonhuman primate model... - Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for microPET imagingJoanne Huang
Center of Excellence in Translational Human Stem Cell Research, Department of Biomedical Engineering, College of Engineering, School of Medicine, University of California, Davis, CA 95616 8542, USA
Mol Imaging 7:1-11. 2008..50x10(4) CD34+ cells (1.1 pCi/cell) and 6.25x10(3) rhMSCs (4.4 pCi/cell) could be detected. These studies indicate that CD34+ hematopoietic cells and rhMSCs can be safely radiolabeled with 64Cu-PTSM without adverse cellular effects... - Fetal CD34+ cells in the maternal circulation and long-term microchimerism in rhesus monkeys (Macaca mulatta)Daniel F Jimenez
California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616-8542, USA
Transplantation 79:142-6. 2005..Thus, rhesus monkeys can be used to further our understanding of fetal:maternal microchimerism and the role of fetal cells in maternal health and disease... - Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smokeMari S Golub
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
Brain Res 1151:102-6. 2007..These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link... - Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursorsCynthia A Batchelder
Center of Excellence in Translational Human Stem Cell Research, University of California, Davis, CA, USA
Differentiation 78:45-56. 2009.... - Fetal gender determination in early first trimester pregnancies of rhesus monkeys (Macaca mulatta) by fluorescent PCR analysis of maternal serumDaniel F Jimenez
California National Primate Research Center, University of California, Davis 95616-8542, USA
J Med Primatol 32:315-9. 2003..This study demonstrates that fetal gender can be reliably determined in the early first trimester from maternal serum samples, a non-invasive method for routine gender screening... - Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a nonhuman primate modelClare R Gregory
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616-8745, USA
Transplantation 78:681-5. 2004..On the basis of survival times and degree of calcineurin inhibition, ISATX247 is a more potent immunosuppressive agent than cyclosporine in this nonhuman primate model of renal-allograft transplantation... - Characterization and culture of fetal rhesus monkey renal cortical cellsAlyssa C Leapley
Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, University of California, Davis, California 95616, USA
Pediatr Res 66:448-54. 2009.... - Rhesus brain microvascular endothelial cells are permissive for rhesus cytomegalovirus infectionJames R Carlson
Department of Medical Pathology and Laboratory Medicine, University of California, Davis, CA 95616, USA
J Gen Virol 86:545-9. 2005..These results demonstrate that in vitro infection of rhesus BrMVEC is a dynamic process that is influenced by activation conditions... - Growth, differentiation, and biochemical signatures of rhesus monkey mesenchymal stem cellsBrandon S Kim
California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
Stem Cells Dev 17:185-98. 2008.... - Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineeringKarina H Nakayama
Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, California 95616 8542, USA
Tissue Eng Part A 16:2207-16. 2010..Further, this study provides the initial steps in developing new regenerative medicine strategies for renal tissue engineering and repair... - Effect of age on the frequency, cell cycle, and lineage maturation of rhesus monkey (Macaca mulatta) CD34+ and hematopoietic progenitor cellsC Chang I Lee
California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
Pediatr Res 58:315-22. 2005.... - Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeysDavid H Abbott
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
Biol Reprod 79:154-63. 2008..Thus, in this nonhuman primate model, differential programming of the fetal hypothalamo-pituitary unit with concomitant hyperandrogenism provides evidence to suggest developmental origins of LH and androgen excess in adulthood... - HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaquesJohn C Marecki
Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box C272, Denver, CO 80262, USA
Am J Respir Crit Care Med 174:437-45. 2006.... - Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vectorChristoph A Kahl
Division of Research Immunology/Bone Marrow Transplantation, The Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
Exp Hematol 34:369-81. 2006..CONCLUSIONS: These data indicate that increased gene marking of hematopoietic stem cells can be achieved by escalating busulfan dosages from 40 to 160 mg/m(2) without significant toxicity in infant nonhuman primates... - Beta-defensin 126 on the surface of macaque sperm mediates attachment of sperm to oviductal epitheliaTheodore L Tollner
Center for Health and the Environment, University of California Davis, Bodega Bay, CA 94923, USA
Biol Reprod 78:400-12. 2008..DEFB126 may be directly involved in the formation of a reservoir of sperm in the oviduct of macaques... - Age-related gene expression profiles of rhesus monkey bone marrow-derived mesenchymal stem cellsJoseph G Hacia
Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
J Cell Biochem 103:1198-210. 2008..These data highlight the importance of use of non-human primates to study the properties of stem and progenitor cells, and for future therapies... - Experimental models of fetal obstructive nephropathyDouglas G Matsell
Children s Hospital of Western Ontario, 2230 800 Commissioner s Road East, London, Canada N6C 2V5
Pediatr Nephrol 17:470-6. 2002..Experimental animal models that closely simulate human development and disease will, thus, be essential for exploring these questions, and for assessing novel fetal therapies for future human application... - Altered primate glomerular development due to in utero urinary tract obstructionDouglas G Matsell
Department of Pediatrics, Anatomy and Cell Biology, and Child Health Research Institute, University of Western Ontario, London, Ontario, Canada
Kidney Int 61:1263-9. 2002..A striking feature of this model is the effect of obstruction on normal glomerular development and podocyte survival... - Fetal and infant head circumference sexual dimorphism in primatesTracey H Joffe
Institute of Child Health, MRC Childhood Nutrition Research Center, University College London, London WC1N 1EH, UK
Am J Phys Anthropol 126:97-110. 2005..Finally, some of the problems with ascribing functional significance to brain size sexual dimorphism are discussed, and the energetic implications for brain size sexual dimorphism in infancy are assessed...
Research Grants
- Center for Pediatric Stem/Progenitor Cell Translational ResearchAlice Tarantal; Fiscal Year: 2007..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
- Center for Fetal Gene Transfer for Heart, Lung, and Blood DiseasesAlice Tarantal; Fiscal Year: 2007....
- Annual Gene Therapy Symposium for Heart, Lung, and Blood DiseasesAlice Tarantal; Fiscal Year: 2007..Funding is requested for planning and organizing, travel for speakers and selected students and fellows, and rental of posterboards, equipment, and transport vehicles. Matching funds will be provided by the Institution. ..
- Mesenchymal Stem Cells for Fetal Gene DeliveryAlice Tarantal; Fiscal Year: 2006..abstract_text> ..
- Center for Fetal Gene Transfer for HLB DiseasesAlice Tarantal; Fiscal Year: 2005..abstract_text> ..