Alice Tarantal

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies
    A F Tarantal
    California Regional Primate Research Center, Department of Pediatrics, University of California, Davis 95616 8542, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 20:323-33. 1999
  2. ncbi request reprint Fetal gene transfer using lentiviral vectors and the potential for germ cell transduction in rhesus monkeys (Macaca mulatta)
    C Chang I Lee
    California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
    Hum Gene Ther 16:417-25. 2005
  3. pmc Tissue specificity of decellularized rhesus monkey kidney and lung scaffolds
    Karina H Nakayama
    California National Primate Research Center, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e64134. 2013
  4. pmc Center for fetal monkey gene transfer for heart, lung, and blood diseases: an NHLBI resource for the gene therapy community
    Alice F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, University of California, Davis, 95616, USA
    Hum Gene Ther 23:1130-5. 2012
  5. doi request reprint Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys
    Alice F Tarantal
    California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616 8542, USA
    Mol Imaging Biol 14:197-204. 2012
  6. pmc Long-term luciferase expression monitored by bioluminescence imaging after adeno-associated virus-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta)
    Alice F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, California National Primate Research Center, Davis, CA 95616, USA
    Hum Gene Ther 21:143-8. 2010
  7. ncbi request reprint Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys
    Alice F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, University of California, Davis, Davis, CA 95616, USA
    Hum Gene Ther 17:1254-61. 2006
  8. ncbi request reprint Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery
    Alice F Tarantal
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Mol Ther 12:87-98. 2005
  9. pmc Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta)
    Alice F Tarantal
    Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, CA 95616 8542, USA
    Transplantation 88:38-41. 2009
  10. ncbi request reprint Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys (Macaca mulatta)
    Alice F Tarantal
    California Regional Primate Research Center, University of California at Davis, 95616 8542, USA
    J Acquir Immune Defic Syndr 29:207-20. 2002

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies
    A F Tarantal
    California Regional Primate Research Center, Department of Pediatrics, University of California, Davis 95616 8542, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 20:323-33. 1999
    ..These data suggest that although PMPA holds great promise for HIV-infected patients, there is the potential for bone-related toxicity at chronic, high dosages, particularly in infants...
  2. ncbi request reprint Fetal gene transfer using lentiviral vectors and the potential for germ cell transduction in rhesus monkeys (Macaca mulatta)
    C Chang I Lee
    California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
    Hum Gene Ther 16:417-25. 2005
    ....
  3. pmc Tissue specificity of decellularized rhesus monkey kidney and lung scaffolds
    Karina H Nakayama
    California National Primate Research Center, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e64134. 2013
    ....
  4. pmc Center for fetal monkey gene transfer for heart, lung, and blood diseases: an NHLBI resource for the gene therapy community
    Alice F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, University of California, Davis, 95616, USA
    Hum Gene Ther 23:1130-5. 2012
    ..The Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases successfully aids the gene therapy community in addressing regulatory barriers, and serves as an effective vehicle for advancing the field...
  5. doi request reprint Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys
    Alice F Tarantal
    California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616 8542, USA
    Mol Imaging Biol 14:197-204. 2012
    ....
  6. pmc Long-term luciferase expression monitored by bioluminescence imaging after adeno-associated virus-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta)
    Alice F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, California National Primate Research Center, Davis, CA 95616, USA
    Hum Gene Ther 21:143-8. 2010
    ....
  7. ncbi request reprint Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys
    Alice F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, University of California, Davis, Davis, CA 95616, USA
    Hum Gene Ther 17:1254-61. 2006
    ..These investigations have shown that HSV-1-sr39tk and firefly luciferase can be used to safely detect transgene expression at multiple time points in fetal and infant monkeys in vivo and without evidence of adverse effects...
  8. ncbi request reprint Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery
    Alice F Tarantal
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Mol Ther 12:87-98. 2005
    ....
  9. pmc Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta)
    Alice F Tarantal
    Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, CA 95616 8542, USA
    Transplantation 88:38-41. 2009
    ....
  10. ncbi request reprint Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys (Macaca mulatta)
    Alice F Tarantal
    California Regional Primate Research Center, University of California at Davis, 95616 8542, USA
    J Acquir Immune Defic Syndr 29:207-20. 2002
    ..The results of these studies suggest that chronic fetal exposure to tenofovir at the maternal dose of 30 mg/kg throughout gestation can alter select fetal parameters and transiently affect maternal bone biomarkers...
  11. ncbi request reprint Rhesus monkey model for fetal gene transfer: studies with retroviral- based vector systems
    A F Tarantal
    California Regional Primate Research Center, University of California at Davis, 95616 8542, USA
    Mol Ther 3:128-38. 2001
    ..The rhesus monkey is an important preclinical primate model system for exploring gene transfer approaches for future applications in humans...
  12. ncbi request reprint Fetal rhesus monkey model of obstructive renal dysplasia
    A F Tarantal
    California Regional Primate Research Center, University of California, Davis, California 95616 8542, USA
    Kidney Int 59:446-56. 2001
    ..To understand further the prenatal pathogenesis of obstructive renal dysplasia, a fetal monkey model was developed using ultrasound-guided techniques...
  13. ncbi request reprint Administration of recombinant human stem cell factor (rhSCF) and granulocyte-colony stimulating factor (rhG-CSF) to maternal and fetal rhesus monkeys (Macaca mulatta)
    A F Tarantal
    California Regional Primate Research Center and Department of Pediatrics, University of California, Davis, California 95616 8542, USA
    Cytokine 11:290-300. 1999
    ....
  14. ncbi request reprint Morphological analysis and lentiviral transduction of fetal monkey bone marrow-derived mesenchymal stem cells
    Chang I Lee
    California National Primate Research Center, University of California, Davis, California 95616 8542, USA
    Mol Ther 9:112-23. 2004
    ..that the SIN HIV-1-derived lentiviral vectors used in these studies can efficiently transduce rhMSC in vitro (CMV > EF1alpha > PGK) without inhibiting differentiation potential, although the cell cycle was transiently altered at high MOI..
  15. doi request reprint Strategies for innovation and interdisciplinary translational research: removal of barriers through the CTSA mechanism
    Lars Berglund
    Departments of Medicine, Pediatrics, and Cell Biology and Human Anatomy, University of California, Davis, Sacramento, CA, USA
    J Investig Med 57:474-6. 2009
    ....
  16. ncbi request reprint Comparison of growth and differentiation of fetal and adult rhesus monkey mesenchymal stem cells
    C Chang I Lee
    California National Primate Research Center, University of California, Davis, 95616, USA
    Stem Cells Dev 15:209-20. 2006
    ....
  17. pmc Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys
    Mari S Golub
    University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 83:647-56. 2006
    ..Iron deficiency anemia (IDA) is relatively common in the third trimester of pregnancy, but causal associations with low birth weight and compromised neonatal iron status are difficult to establish in human populations...
  18. ncbi request reprint Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo
    Christina A Pacak
    Center for Fetal Monkey Gene Transfer for Heart, Lung and Blood Diseases, California National Primate Research Center, Davis, USA
    Circ Res 99:e3-9. 2006
    ....
  19. pmc Immunogenicity and protective efficacy of DNA vaccines expressing rhesus cytomegalovirus glycoprotein B, phosphoprotein 65-2, and viral interleukin-10 in rhesus macaques
    Yujuan Yue
    Center for Comparative Medicine, University of California Davis, County Rd 98 and Hutchison Dr, Davis, CA 95616, USA
    J Virol 81:1095-109. 2007
    ..These data demonstrated that DNA vaccines targeting the RhCMV homologues of HCMV gB and pp65 altered the course of acute and persistent RhCMV infection in a primate host...
  20. ncbi request reprint Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeys
    Mari S Golub
    Department of Internal Medicine, California National Primate Research Center, University of California, Davis 95616, USA
    Toxicol Sci 74:103-13. 2003
    ..Long-term consequences of this disruption of pubertal development are being studied in this cohort of monkeys as adults...
  21. ncbi request reprint Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta)
    Alesha B Castillo
    Orthopedic Research Laboratories, School of Medicine, University of California at Davis Medical Center, 4635 Second Avenue Suite 2000, Sacramento, CA 95817, USA
    J Orthop Res 20:1185-9. 2002
    ..Both defective mineralization of newly formed bone and increased resorption cavity density may result in greater bone fragility...
  22. pmc A recombinant rhesus cytomegalovirus expressing enhanced green fluorescent protein retains the wild-type phenotype and pathogenicity in fetal macaques
    W L William Chang
    Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California 95616, USA
    J Virol 76:9493-504. 2002
    ..The pattern of RhCMV infection in the central nervous system may offer an explanation for the severe developmental outcomes associated with congenital human CMV infection early in gestation...
  23. ncbi request reprint Nonhuman primate models of intrauterine cytomegalovirus infection
    Peter A Barry
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, CA, USA
    ILAR J 47:49-64. 2006
    ....
  24. ncbi request reprint Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for microPET imaging
    Joanne Huang
    Center of Excellence in Translational Human Stem Cell Research, Department of Biomedical Engineering, College of Engineering, School of Medicine, University of California, Davis, CA 95616 8542, USA
    Mol Imaging 7:1-11. 2008
    ..50x10(4) CD34+ cells (1.1 pCi/cell) and 6.25x10(3) rhMSCs (4.4 pCi/cell) could be detected. These studies indicate that CD34+ hematopoietic cells and rhMSCs can be safely radiolabeled with 64Cu-PTSM without adverse cellular effects...
  25. ncbi request reprint Adrenocortical cytochrome b5 expression during fetal development of the rhesus macaque
    Samantha Mapes
    Department of Population Health and Reproduction, University of California, Davis, California 95616, USA
    Endocrinology 143:1451-8. 2002
    ..However, the lack of cytochrome b5 and P450c17 expression in the FZ of the developing macaque adrenal cortex for much of the second and third trimesters distinguishes it from the mature zona reticularis seen in adult animals...
  26. ncbi request reprint Occult pretransplantation systemic inflammation and posttransplantation vascular changes in a primate arterial allograft model
    Jason T Fitzgerald
    Department of Surgery, University of California, Davis Medical Center, Sacramento, USA
    Transplantation 78:367-74. 2004
    ..The purpose of this study was to examine the anatomic and physiologic effects of occult pretransplantation systemic inflammation on posttransplantation allograft outcome in a nonhuman primate model...
  27. ncbi request reprint Simian immunodeficiency virus infection of hematopoietic stem cells and bone marrow stromal cells
    Chang I Lee
    California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
    J Acquir Immune Defic Syndr 36:553-61. 2004
    ....
  28. pmc Functional and morphological development of lymphoid tissues and immune regulatory and effector function in rhesus monkeys: cytokine-secreting cells, immunoglobulin-secreting cells, and CD5(+) B-1 cells appear early in fetal development
    Norbert Makori
    California National Primate Research Center, Center for Comparative Medicine, University of California, Davis, California 95616 8542, USA
    Clin Diagn Lab Immunol 10:140-53. 2003
    ..Thus, by the second trimester, the lymphoid tissues of the rhesus monkey fetus have a complete repertoire of properly organized antigen-presenting cells, T cells, and B cells...
  29. ncbi request reprint Fetal CD34+ cells in the maternal circulation and long-term microchimerism in rhesus monkeys (Macaca mulatta)
    Daniel F Jimenez
    California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616 8542, USA
    Transplantation 79:142-6. 2005
    ..In this study, we asked whether fetal CD34 cells can be found in the maternal circulation and if male fetal cells persist in maternal tissues postdelivery...
  30. ncbi request reprint Quantitative analysis of male fetal DNA in maternal serum of gravid rhesus monkeys (Macaca mulatta)
    Daniel F Jimenez
    California National Primate Research Center, University of California, Davis, CA 95616 8542, U S A
    Pediatr Res 53:18-23. 2003
    ....
  31. ncbi request reprint Rhesus brain microvascular endothelial cells are permissive for rhesus cytomegalovirus infection
    James R Carlson
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 86:545-9. 2005
    ..These results demonstrate that in vitro infection of rhesus BrMVEC is a dynamic process that is influenced by activation conditions...
  32. ncbi request reprint Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smoke
    Mari S Golub
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Brain Res 1151:102-6. 2007
    ..These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link...
  33. pmc Characterization and culture of fetal rhesus monkey renal cortical cells
    Alyssa C Leapley
    Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, University of California, Davis, California 95616, USA
    Pediatr Res 66:448-54. 2009
    ....
  34. pmc Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors
    Cynthia A Batchelder
    Center of Excellence in Translational Human Stem Cell Research, University of California, Davis, CA, USA
    Differentiation 78:45-56. 2009
    ....
  35. ncbi request reprint Fetal gender determination in early first trimester pregnancies of rhesus monkeys (Macaca mulatta) by fluorescent PCR analysis of maternal serum
    Daniel F Jimenez
    California National Primate Research Center, University of California, Davis 95616 8542, USA
    J Med Primatol 32:315-9. 2003
    ..This study demonstrates that fetal gender can be reliably determined in the early first trimester from maternal serum samples, a non-invasive method for routine gender screening...
  36. ncbi request reprint Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a nonhuman primate model
    Clare R Gregory
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 8745, USA
    Transplantation 78:681-5. 2004
    ..ISATX247 is a novel calcineurin inhibitor that has shown more potency than cyclosporine in vitro. This is the first study to compare the survival times of renal allografts in nonhuman primates treated with either ISATX247 or cyclosporine...
  37. pmc Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering
    Karina H Nakayama
    Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, California 95616 8542, USA
    Tissue Eng Part A 16:2207-16. 2010
    ..Further, this study provides the initial steps in developing new regenerative medicine strategies for renal tissue engineering and repair...
  38. ncbi request reprint Effect of age on the frequency, cell cycle, and lineage maturation of rhesus monkey (Macaca mulatta) CD34+ and hematopoietic progenitor cells
    C Chang I Lee
    California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
    Pediatr Res 58:315-22. 2005
    ....
  39. doi request reprint Growth, differentiation, and biochemical signatures of rhesus monkey mesenchymal stem cells
    Brandon S Kim
    California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
    Stem Cells Dev 17:185-98. 2008
    ....
  40. ncbi request reprint Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector
    Christoph A Kahl
    Division of Research Immunology Bone Marrow Transplantation, The Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
    Exp Hematol 34:369-81. 2006
    ..We utilized an infant rhesus monkey model to identify an optimal dosage of busulfan that results in efficient long-term gene marking with minimal toxicities...
  41. pmc Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys
    David H Abbott
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 79:154-63. 2008
    ..Thus, in this nonhuman primate model, differential programming of the fetal hypothalamo-pituitary unit with concomitant hyperandrogenism provides evidence to suggest developmental origins of LH and androgen excess in adulthood...
  42. pmc HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques
    John C Marecki
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box C272, Denver, CO 80262, USA
    Am J Respir Crit Care Med 174:437-45. 2006
    ....
  43. ncbi request reprint Age-related gene expression profiles of rhesus monkey bone marrow-derived mesenchymal stem cells
    Joseph G Hacia
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Cell Biochem 103:1198-210. 2008
    ..These data highlight the importance of use of non-human primates to study the properties of stem and progenitor cells, and for future therapies...
  44. ncbi request reprint Fetal and infant head circumference sexual dimorphism in primates
    Tracey H Joffe
    Institute of Child Health, MRC Childhood Nutrition Research Center, University College London, London WC1N 1EH, UK
    Am J Phys Anthropol 126:97-110. 2005
    ..Finally, some of the problems with ascribing functional significance to brain size sexual dimorphism are discussed, and the energetic implications for brain size sexual dimorphism in infancy are assessed...
  45. ncbi request reprint Beta-defensin 126 on the surface of macaque sperm mediates attachment of sperm to oviductal epithelia
    Theodore L Tollner
    Center for Health and the Environment, University of California Davis, Bodega Bay, CA 94923, USA
    Biol Reprod 78:400-12. 2008
    ..DEFB126 may be directly involved in the formation of a reservoir of sperm in the oviduct of macaques...
  46. ncbi request reprint Experimental models of fetal obstructive nephropathy
    Douglas G Matsell
    Children s Hospital of Western Ontario, 2230 800 Commissioner s Road East, London, Canada N6C 2V5
    Pediatr Nephrol 17:470-6. 2002
    ..Experimental animal models that closely simulate human development and disease will, thus, be essential for exploring these questions, and for assessing novel fetal therapies for future human application...
  47. ncbi request reprint Altered primate glomerular development due to in utero urinary tract obstruction
    Douglas G Matsell
    Department of Pediatrics, Anatomy and Cell Biology, and Child Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Kidney Int 61:1263-9. 2002
    ..A striking feature of this model is the effect of obstruction on normal glomerular development and podocyte survival...

Research Grants11

  1. Center for Pediatric Stem/Progenitor Cell Translational Research
    Alice Tarantal; Fiscal Year: 2007
    ..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
  2. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2003
    ..abstract_text> ..
  3. Center for Fetal Gene Transfer for Heart, Lung, and Blood Diseases
    Alice Tarantal; Fiscal Year: 2007
    ....
  4. Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
    Alice Tarantal; Fiscal Year: 2007
    ..Funding is requested for planning and organizing, travel for speakers and selected students and fellows, and rental of posterboards, equipment, and transport vehicles. Matching funds will be provided by the Institution. ..
  5. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2006
    ..abstract_text> ..
  6. Center for Fetal Gene Transfer for HLB Diseases
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  7. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  8. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2004
    ..abstract_text> ..