MALU G TANSEY

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Exp Neurol 208:1-25. 2007
  2. ncbi request reprint Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Front Biosci 13:709-17. 2008
  3. pmc Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response
    Jae Kyung Lee
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    J Neurosci 28:8517-28. 2008
  4. pmc Parkin deficiency increases vulnerability to inflammation-related nigral degeneration
    Tamy C Frank-Cannon
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    J Neurosci 28:10825-34. 2008
  5. pmc Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease
    Ashley S Harms
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Mol Ther 19:46-52. 2011
  6. pmc Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Ther 16:1572-9. 2008
  7. pmc Regulation of microglia effector functions by tumor necrosis factor signaling
    Ashley S Harms
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Glia 60:189-202. 2012
  8. pmc Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e23660. 2011
  9. pmc Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats
    Jae Kyung Lee
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 31:11879-88. 2011
  10. pmc Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
    MALU G TANSEY
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30324, USA
    Neurobiol Dis 37:510-8. 2010

Research Grants

  1. Neurogenic Potential of Progenitor Cells in Adipose
    MALU TANSEY; Fiscal Year: 2006
  2. TNF Signaling in Neurodegeneration
    MALU TANSEY; Fiscal Year: 2007

Collaborators

Detail Information

Publications25

  1. pmc Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Exp Neurol 208:1-25. 2007
    ....
  2. ncbi request reprint Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Front Biosci 13:709-17. 2008
    ..The rationale for current and future use of anti-inflammatory approaches to protect vulnerable neuronal populations in PD is also reviewed...
  3. pmc Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response
    Jae Kyung Lee
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    J Neurosci 28:8517-28. 2008
    ..RGS10 emerges as a novel drug target for prevention of nigrostriatal pathway degeneration, the neuropathological hallmark of PD...
  4. pmc Parkin deficiency increases vulnerability to inflammation-related nigral degeneration
    Tamy C Frank-Cannon
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    J Neurosci 28:10825-34. 2008
    ....
  5. pmc Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease
    Ashley S Harms
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Mol Ther 19:46-52. 2011
    ....
  6. pmc Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Ther 16:1572-9. 2008
    ..This strategy holds the potential for therapeutic application in the treatment of PD...
  7. pmc Regulation of microglia effector functions by tumor necrosis factor signaling
    Ashley S Harms
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Glia 60:189-202. 2012
    ....
  8. pmc Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e23660. 2011
    ....
  9. pmc Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats
    Jae Kyung Lee
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 31:11879-88. 2011
    ....
  10. pmc Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
    MALU G TANSEY
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30324, USA
    Neurobiol Dis 37:510-8. 2010
    ....
  11. pmc RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells
    Jae Kyung Lee
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia, USA Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland, USA
    J Neurochem 122:333-43. 2012
    ....
  12. pmc Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) mice
    Thi A Nguyen
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Neuroinflammation 10:50. 2013
    ....
  13. pmc Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
    Fiona E McAlpine
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Neurobiol Dis 34:163-77. 2009
    ..Targeted inhibition of solTNF in the CNS may slow the appearance of amyloid-associated pathology, cognitive deficits, and potentially the progressive loss of neurons in AD...
  14. pmc The neuro-glial properties of adipose-derived adult stromal (ADAS) cells are not regulated by Notch 1 and are not derived from neural crest lineage
    Philip C Wrage
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 3:e1453. 2008
    ....
  15. pmc Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge
    Christopher J Barnum
    Department of Physiology, School of Medicine, Emory University, 615 Michael Street, Atlanta, GA 30324, USA
    J Neuroinflammation 9:9. 2012
    ..However, long-term outcomes of chronic psychological stressors that elicit a neuroinflammatory response remain unknown...
  16. pmc The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Neuroinflammation 5:14. 2008
    ..Therefore, the aims of our study were to identify specific microglial activities modulated by CDDO-Me in vitro, and to determine the extent to which this modulation affords neuroprotection against inflammatory stimuli...
  17. doi request reprint Modeling neuroinflammatory pathogenesis of Parkinson's disease
    Christopher J Barnum
    Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA
    Prog Brain Res 184:113-32. 2010
    ..In this chapter, we attempt to integrate what is known about the role of neuroinflammation in PD with the factors we feel are critical for understanding how inflammation modulates disease progression...
  18. pmc Neuroinflammation in Parkinson's disease
    Jae Kyung Lee
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Neuroimmune Pharmacol 4:419-29. 2009
    ....
  19. pmc Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Exp Neurol 210:14-29. 2008
    ..ADAS cells may be ideal for ex vivo gene transfer therapies in Parkinson's disease treatment...
  20. doi request reprint Neuroinflammation and non-motor symptoms: the dark passenger of Parkinson's disease?
    Christopher J Barnum
    Department of Physiology, School of Medicine at Emory University, 615 Michael Street, Atlanta, GA 30324, USA
    Curr Neurol Neurosci Rep 12:350-8. 2012
    ..In the current review, we present an argument for this based on the Braak staging and discuss how inflammation might contribute to the development of non-motor PD symptoms...
  21. pmc TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    J Neuroinflammation 5:45. 2008
    ....
  22. ncbi request reprint Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse
    Joyce J Repa
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75390 9151, USA
    J Neurosci 27:14470-80. 2007
    ..Thus, LXR activation resulted in increased cholesterol excretion from the brain, decreased neuroinflammation, and deactivation of microglia to slow neurodegeneration and extend the lifespan of the NPC1 mouse...
  23. pmc Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:9365-75. 2006
    ....
  24. pmc Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
    Terina N Martinez
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX 75390, USA
    Mol Neurodegener 7:45. 2012
    ..Here we investigated the contribution of ceramide sphingolipid signaling in TNF-dependent toxicity...
  25. pmc Does neuroinflammation fan the flame in neurodegenerative diseases?
    Tamy C Frank-Cannon
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Neurodegener 4:47. 2009
    ....

Research Grants3

  1. Neurogenic Potential of Progenitor Cells in Adipose
    MALU TANSEY; Fiscal Year: 2006
    ..Successful completion of these studies should provide new and critical information to evaluate the potential therapeutic value of this novel neural progenitor population in cell replacement strategies. ..
  2. TNF Signaling in Neurodegeneration
    MALU TANSEY; Fiscal Year: 2007
    ....