J J Tanner

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. pmc Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition
    John D Larson
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Protein Sci 15:2630-41. 2006
  2. doi request reprint Structure, mechanism, and dynamics of UDP-galactopyranose mutase
    John J Tanner
    Departments of Chemistry and Biochemistry, University of Missouri, Columbia, MO, United States Electronic address
    Arch Biochem Biophys 544:128-41. 2014
  3. pmc Targeting UDP-galactopyranose mutases from eukaryotic human pathogens
    Karina Kizjakina
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Curr Pharm Des 19:2561-73. 2013
  4. pmc Structural biology of proline catabolism
    John J Tanner
    Departments of Chemistry and Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Amino Acids 35:719-30. 2008
  5. ncbi request reprint Crystal structure of an antigen-binding fragment bound to single-stranded DNA
    J J Tanner
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 314:807-22. 2001
  6. doi request reprint Redox regulation of protein tyrosine phosphatases: structural and chemical aspects
    John J Tanner
    Department of Chemistry, University of Missouri, Columbia, 65211, USA
    Antioxid Redox Signal 15:77-97. 2011
  7. ncbi request reprint Crystal structure of a high-affinity variant of rat alpha-parvalbumin
    Yong Hwan Lee
    Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA
    Biochemistry 43:10008-17. 2004
  8. pmc Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors
    Min Zhang
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Biochemistry 43:12539-48. 2004
  9. ncbi request reprint Desulfovibrio desulfuricans G20 tetraheme cytochrome structure at 1.5 Angstrom and cytochrome interaction with metal complexes
    M V Pattarkine
    Biochemistry Department, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 358:1314-27. 2006
  10. pmc Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein
    Yong Hwan Lee
    Department of Chemistry and Biochemistry, University of Missouri Columbia, 65211, USA
    Nat Struct Biol 10:109-14. 2003

Research Grants

Collaborators

  • M T Henzl
  • Thomas J Reilly
  • Yong-Hwan Lee
  • Anmin Tan
  • Min Zhang
  • CHRISTIAN WHITMAN
  • Leonardo Boechi
  • Christopher Davies
  • Paul E Smith
  • Deborah L Chance
  • David Ballou
  • Elizabeth E Trimmer
  • D F Becker
  • Jonathan P Schuermann
  • Richard L Felts
  • Tommi A White
  • Christopher A Bottoms
  • Harkewal Singh
  • Dhiraj Srivastava
  • Yuzhen Zhou
  • Zhonghui Ou
  • Michael J Calcutt
  • John D Larson
  • Jermaine L Jenkins
  • Karina Kizjakina
  • Moon N Lee
  • Elizabeth L Ostrander
  • William H Johnson
  • Weidong Zhu
  • Navasona Krishnan
  • Dale B Karr
  • Jay C Nix
  • Weimin Zhang
  • Alexander J DiMauro
  • M V Pattarkine
  • Susan L Deutscher
  • Dan Gu
  • Berevan A Baban
  • Pablo Sobrado
  • S Nadaraia
  • Greg L Hura
  • Nikhilesh Sanyal
  • Thomas J Malinski
  • Brady R Still
  • Desire Takawira
  • Melissa K Thorstad
  • Andriana P Nikolova
  • Li Ma
  • Vivek C Furtado
  • Ngoc L Phung
  • Emilia C Arturo
  • Peixuan Guo
  • Dustin Rewinkel
  • Srimevan Wanduragala
  • Songchuan Guo
  • Dawei Lin
  • J D Wall
  • C A Bottoms
  • Season P Prewitt
  • Verena Kallhoff
  • Berevan Baban
  • Sayeh Agah
  • Madhavan P Vinod

Detail Information

Publications49

  1. pmc Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition
    John D Larson
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Protein Sci 15:2630-41. 2006
    ..These results provide new insights into the structural basis of DNA recognition by PutA and reveal three-dimensional structural details of the PutA dimer interface...
  2. doi request reprint Structure, mechanism, and dynamics of UDP-galactopyranose mutase
    John J Tanner
    Departments of Chemistry and Biochemistry, University of Missouri, Columbia, MO, United States Electronic address
    Arch Biochem Biophys 544:128-41. 2014
    ..Here we present a comprehensive review of UGM three-dimensional structure, provide an update on recent developments in understanding the mechanism of the enzyme, and summarize computational studies of active site flexibility. ..
  3. pmc Targeting UDP-galactopyranose mutases from eukaryotic human pathogens
    Karina Kizjakina
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Curr Pharm Des 19:2561-73. 2013
    ..However, the unique role of the flavin cofactor in catalysis is conserved among this enzyme family. In this review, recent findings on eukaryotic UGMs are discussed and presented in comparison with prokaryotic UGMs...
  4. pmc Structural biology of proline catabolism
    John J Tanner
    Departments of Chemistry and Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Amino Acids 35:719-30. 2008
    ....
  5. ncbi request reprint Crystal structure of an antigen-binding fragment bound to single-stranded DNA
    J J Tanner
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 314:807-22. 2001
    ..This result is significant because antibody pathogenicity is thought to be correlated to the Arg content of anti-DNA antibody hypervariable loops...
  6. doi request reprint Redox regulation of protein tyrosine phosphatases: structural and chemical aspects
    John J Tanner
    Department of Chemistry, University of Missouri, Columbia, 65211, USA
    Antioxid Redox Signal 15:77-97. 2011
    ..PTPs with key cysteine residues in structurally similar locations may be expected to share similar mechanisms of oxidative inactivation...
  7. ncbi request reprint Crystal structure of a high-affinity variant of rat alpha-parvalbumin
    Yong Hwan Lee
    Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA
    Biochemistry 43:10008-17. 2004
    ..In 0.15 M KCl and 0.025 M Hepes-KOH (pH 7.4) at 5 degrees C, the macroscopic Ca2+ binding constants are 1.8 x 10(10) and 2.0 x 10(9) M(-1). The corresponding Mg2+ binding constants are 2.7 x 10(6) and 1.2 x 10(5) M(-1)...
  8. pmc Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors
    Min Zhang
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Biochemistry 43:12539-48. 2004
    ..Our results suggest that the molecular basis for increased plasma proline levels in schizophrenic subjects carrying the missense mutation L441P is due to decreased stability of human PRODH2...
  9. ncbi request reprint Desulfovibrio desulfuricans G20 tetraheme cytochrome structure at 1.5 Angstrom and cytochrome interaction with metal complexes
    M V Pattarkine
    Biochemistry Department, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 358:1314-27. 2006
    ....
  10. pmc Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein
    Yong Hwan Lee
    Department of Chemistry and Biochemistry, University of Missouri Columbia, 65211, USA
    Nat Struct Biol 10:109-14. 2003
    ..coli PutA...
  11. ncbi request reprint Structure of recombinant Haemophilus influenzae e (P4) acid phosphatase reveals a new member of the haloacid dehalogenase superfamily
    Richard L Felts
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Biochemistry 46:11110-9. 2007
    ..This observation suggests a structure-based vaccine design strategy in which the dimer interface is disrupted in order to expose epitopes that are buried in dimeric P4...
  12. ncbi request reprint Crystallization and preliminary crystallographic analysis of the proline dehydrogenase domain of the multifunctional PutA flavoprotein from Escherichia coli
    S Nadaraia
    Department of Chemistry, University of Missouri Columbia, 65211, USA
    Acta Crystallogr D Biol Crystallogr 57:1925-7. 2001
    ..Assuming one molecule per asymmetric unit, the Matthews coefficient V(M) is 2.5 A(3) Da(-1), with a solvent content of 50%. The structure of PutA669 will be solved by multiple isomorphous replacement...
  13. pmc Structural basis for the inactivation of Thermus thermophilus proline dehydrogenase by N-propargylglycine
    Tommi A White
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Biochemistry 47:5573-80. 2008
    ..The presumed nonenzymatic hydrolysis of N-propargyliminoglycine and the subsequent rebinding of propynal to the enzyme make the latter mechanism less likely...
  14. ncbi request reprint Structure of Francisella tularensis AcpA: prototype of a unique superfamily of acid phosphatases and phospholipases C
    Richard L Felts
    Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 281:30289-98. 2006
    ..These results imply a phospholipase C catalytic mechanism that is radically different from that of zinc metallophospholipases...
  15. pmc A conserved active site tyrosine residue of proline dehydrogenase helps enforce the preference for proline over hydroxyproline as the substrate
    Elizabeth L Ostrander
    Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA
    Biochemistry 48:951-9. 2009
    ..The kinetic and structural results suggest that Tyr540 is an important determinant of specificity. Structurally, it serves as a negative filter for hydroxyproline by clashing with the 4-hydroxyl group of this potential substrate...
  16. pmc The structure of the proline utilization a proline dehydrogenase domain inactivated by N-propargylglycine provides insight into conformational changes induced by substrate binding and flavin reduction
    Dhiraj Srivastava
    Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA
    Biochemistry 49:560-9. 2010
    ..This analysis suggests that the active site is incompletely assembled in the absence of the substrate, and the binding of proline draws together conserved residues in helix 8 and the beta1-alphal loop to complete the active site...
  17. pmc Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus
    Tommi A White
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Biol Chem 282:14316-27. 2007
    ..This is significant because superoxide production underlies the role of human PRODH in p53-mediated apoptosis, implying commonalities between eukaryotic and bacterial monofunctional PRODHs...
  18. pmc Crystal Structures of the histidine acid phosphatase from Francisella tularensis provide insight into substrate recognition
    Harkewal Singh
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 394:893-904. 2009
    ..The structural data are consistent with a role for FtHAP in scavenging phosphate from small molecules present in host macrophage cells...
  19. pmc Solution structure of Ca2+-free rat beta-parvalbumin (oncomodulin)
    Michael T Henzl
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Protein Sci 16:1914-26. 2007
    ..At 20 degrees C, the majority of amide vectors show no evidence for motion on timescales above 20 ps, and the average order parameter for the entire molecule is 0.92...
  20. pmc A structurally conserved water molecule in Rossmann dinucleotide-binding domains
    Christopher A Bottoms
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Protein Sci 11:2125-37. 2002
    ..Thus, the conserved water molecule appears to be an inherent structural feature of the classic Rossmann dinucleotide-binding domain...
  21. doi request reprint Solution structures of chicken parvalbumin 3 in the Ca(2+)-free and Ca(2+)-bound states
    Michael T Henzl
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    Proteins 79:752-64. 2011
    ..The results lend further support to the idea that Ca(2+) affinity correlates with the structural similarity of the apo- and bound parvalbumin conformations...
  22. pmc Solution structure of Ca2+-free rat alpha-parvalbumin
    Michael T Henzl
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Protein Sci 17:431-8. 2008
    ..This finding implies that the alpha-PV isoform enjoys elevated divalent ion affinity because the metal ion-binding events do not require major structural rearrangement and the concomitant sacrifice of binding energy...
  23. ncbi request reprint Crystal structure of the D94S/G98E variant of rat alpha-parvalbumin. An explanation for the reduced divalent ion affinity
    John J Tanner
    Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA
    Biochemistry 44:10966-76. 2005
    ..The consequent displacement of Phe-57 also produces a close contact with Ser-55. Thus, steric interference may be the source of the enthalpic penalty...
  24. pmc Crystal structure of rat alpha-parvalbumin at 1.05 Angstrom resolution
    Christopher A Bottoms
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Protein Sci 13:1724-34. 2004
    ....
  25. ncbi request reprint Characterization of recombinant Francisella tularensis acid phosphatase A
    Thomas J Reilly
    Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
    Protein Expr Purif 45:132-41. 2006
    ..Such properties include molecular mass, broad substrate specificity, sensitivity and resistance to various inhibitors, pH optimum, and reactivity with rabbit polyclonal antibody to the native enzyme...
  26. pmc Characterization of a unique class C acid phosphatase from Clostridium perfringens
    Thomas J Reilly
    Department of Veterinary Pathobiology, University of Missouri, Columbia, 65211, USA
    Appl Environ Microbiol 75:3745-54. 2009
    ..perfringens isolates tested and found to be cell associated. The described enzyme belongs to nonspecific acid phosphatase class C but is devoid of lipid modification commonly attributed to this class...
  27. pmc Identification and characterization of the DNA-binding domain of the multifunctional PutA flavoenzyme
    Dan Gu
    Department of Chemistry and Biochemistry, University of Missouri, St Louis, Missouri 63121, USA
    J Biol Chem 279:31171-6. 2004
    ..Thus, N-terminal residues 1-47 are critical for DNA-binding and the dimeric structure of PutA. These results are consistent with the ribbon-helix-helix family of transcription factors...
  28. pmc Crystallization of a newly discovered histidine acid phosphatase from Francisella tularensis
    Richard L Felts
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:32-5. 2006
    ..Therefore, the structure of F. tularensis histidine acid phosphatase will be determined by multiwavelength anomalous dispersion phasing using a selenomethionyl derivative...
  29. pmc Detection of L-lactate in polyethylene glycol solutions confirms the identity of the active-site ligand in a proline dehydrogenase structure
    Min Zhang
    Departments of Chemistry and Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Acta Crystallogr D Biol Crystallogr 60:985-6. 2004
    ..These results help to explain why L-lactate was present in the proline dehydrogenase domain crystal structure. This work also has implications for the crystallization of enzymes that bind L-lactate...
  30. pmc Cloning, purification and crystallization of Bacillus anthracis class C acid phosphatase
    Richard L Felts
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:705-8. 2006
    ..9 degrees and the high-resolution limit of usable data increased to 1.6 angstroms. This crystal form is currently being used to determine the structure of B. anthracis class C acid phosphatase with experimental phasing techniques...
  31. ncbi request reprint Crystallization of AcpA, a respiratory burst-inhibiting acid phosphatase from Francisella tularensis
    Richard L Felts
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Biochim Biophys Acta 1752:107-10. 2005
    ..A 1.75-A native data set was recorded at beamline 8.3.1 of the Advanced Light Source. To our knowledge, this is the first report of high-resolution crystals of any F. tularensis protein...
  32. pmc Three crystal forms of the bifunctional enzyme proline utilization A (PutA) from Bradyrhizobium japonicum
    Jonathan P Schuermann
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:949-53. 2008
    ..Centered monoclinic crystals were grown in ammonium sulfate, diffracted to 2.3 A resolution and had two molecules in the asymmetric unit. Removing the histidine tag was important in order to obtain the C2 crystal form...
  33. ncbi request reprint MRSAD: using anomalous dispersion from S atoms collected at Cu Kalpha wavelength in molecular-replacement structure determination
    Jonathan P Schuermann
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Acta Crystallogr D Biol Crystallogr 59:1731-6. 2003
    ..The favorable results obtained from this realistic test case suggest that anomalous differences from S atoms should be routinely collected and used in MR structure determination...
  34. pmc Recognition of nucleoside monophosphate substrates by Haemophilus influenzae class C acid phosphatase
    Harkewal Singh
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 404:639-49. 2010
    ..Finally, the structures suggest that class B acid phosphatases and CCAPs share a common strategy for nucleotide recognition...
  35. pmc Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli
    Moon N Lee
    Department of Chemistry, Grinnell College, Grinnell, Iowa 50112, USA
    Biochemistry 48:7673-85. 2009
    ..Taken together, our results suggest that Leu may be a suitable replacement for Phe223 in the oxidative half-reaction of E. coli MTHFR...
  36. pmc Expression, purification and crystallization of class C acid phosphatases from Francisella tularensis and Pasteurella multocida
    Harkewal Singh
    Department of Chemistry, University of Missouri Columbia, 65211, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:226-31. 2009
    ..Despite this aberrance, autoindexing was robust and the data could be satisfactorily processed to 1.85 A resolution using MOSFLM and SCALA...
  37. pmc Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum
    Dhiraj Srivastava
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 107:2878-83. 2010
    ....
  38. pmc Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase
    Zhonghui Ou
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:464-6. 2006
    ..The space group is P4(2)2(1)2, with unit-cell parameters a = 65.6, c = 101.4 angstroms, one protein molecule per asymmetric unit and 37% solvent content. This is the first report of the crystallization of a class C acid phosphatase...
  39. ncbi request reprint Exploring structurally conserved solvent sites in protein families
    Christopher A Bottoms
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Proteins 64:404-21. 2006
    ..These results suggest that highly conserved solvent sites, by virtue of their proximity to conserved residues, should be considered as one of the defining three-dimensional structural characteristics of protein families and folds...
  40. pmc Cloning, purification and crystallization of Thermus thermophilus proline dehydrogenase
    Tommi A White
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:737-9. 2005
    ..Therefore, the structure of T. thermophilus PRODH will be determined by multiwavelength anomalous dispersion phasing using a selenomethionyl derivative...
  41. ncbi request reprint Structure of an anti-DNA fab complexed with a non-DNA ligand provides insights into cross-reactivity and molecular mimicry
    Jonathan P Schuermann
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Proteins 57:269-78. 2004
    ..The structural and thermodynamic data suggest a molecular mimicry mechanism based on structural plasticity and hydrophobic interactions...
  42. pmc Impact of DNA hairpin folding energetics on antibody-ssDNA association
    Zhonghui Ou
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 374:1029-40. 2007
    ..Rather, it is argued that the stem of the hairpin serves to reduce the degrees of freedom in the free DNA ligand, thereby limiting the entropic cost attendant to complexation with the Fab...
  43. ncbi request reprint Evidence for structural plasticity of heavy chain complementarity-determining region 3 in antibody-ssDNA recognition
    Jonathan P Schuermann
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Mol Biol 347:965-78. 2005
    ..In the context of autoimmune disease, plasticity of the ligand-free antibody could provide a mechanism by which anti-DNA antibodies bind diverse host ligands, and thereby contribute to pathogenicity...
  44. ncbi request reprint High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase
    Jermaine L Jenkins
    Department of Chemistry, University of Missouri Columbia, USA
    Acta Crystallogr D Biol Crystallogr 62:290-301. 2006
    ..These results are discussed in the context of the recently discovered NO-S-nitrosylation-GAPDH-Siah1 apoptosis cascade...
  45. doi request reprint Energetics of OCP1-OCP2 complex formation
    Anmin Tan
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States
    Biophys Chem 134:64-71. 2008
    ..The thermodynamic signature for OCP1/OCP2 complex formation is inconsistent with a rigid-body association and suggests that the reaction is accompanied by a substantial degree of folding...
  46. pmc Redox-induced changes in flavin structure and roles of flavin N(5) and the ribityl 2'-OH group in regulating PutA--membrane binding
    Weimin Zhang
    Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588, USA
    Biochemistry 46:483-91. 2007
    ..We also show that the FAD 2'-OH group acts as a redox-sensitive toggle switch that controls PutA-membrane binding. These results illustrate a new versatility of the ribityl chain in flavoprotein mechanisms...
  47. ncbi request reprint Probing a hydrogen bond pair and the FAD redox properties in the proline dehydrogenase domain of Escherichia coli PutA
    Berevan A Baban
    Department of Chemistry and Biochemistry, University of Missouri St Louis, St Louis, MO 63121, USA
    Biochim Biophys Acta 1701:49-59. 2004
    ..The 40-mV positive shift in E(m) determined for D370A relative to wild-type PutA86-601 (E(m)=-0.066 V, pH 7.0) indicates D370 has a key role in modulating the FAD redox environment...
  48. pmc Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA
    Yuzhen Zhou
    Department of Biochemistry, University of Nebraska Lincoln, Lincoln, NE 68588, USA
    J Mol Biol 381:174-88. 2008
    ..Structural and thermodynamic data suggest that hydrogen bonds between Lys9 and bases adjacent to the GTTGCA motif contribute to transcriptional regulation by fine-tuning the affinity of PutA for put control operators...
  49. ncbi request reprint Crystallization of Phi29 spindle-shaped nano-bar anti-receptor with glycosidase domain
    Alexander J DiMauro
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    J Nanosci Nanotechnol 7:2616-22. 2007
    ..These results suggest a function for gp12 as a cell-wall degrading enzyme in addition to its role in recognition of the host receptor...

Research Grants8

  1. Structural Studies of the Multifunctional PutA Protein
    John Tanner; Fiscal Year: 2005
    ..These studies will contribute pivotal understanding into the regulatory mechanism of PutA and timely knowledge of its structure. ..
  2. Coordination of functions by proline metabolic proteins
    John J Tanner; Fiscal Year: 2010
    ..It is proposed that channeling is a fundamental aspect of the proline oxidation process. ..