Research Topics
Genomes and GenesSpecies | Qizhi TangSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipientsQizhi Tang
Department of Surgery, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Transpl Int 25:1257-67. 2012....- Regulatory T-cell therapy for transplantation: how many cells do we need?Qizhi Tang
Department of Surgery, University of California, San Francisco, California 94143 0780, USA
Curr Opin Organ Transplant 17:349-54. 2012.... - CD4(+)Foxp3(+) regulatory T cell therapy in transplantationQizhi Tang
Division of Transplantation, Department of Surgery, University of California San Francisco, San Francisco, CA 94143 0780, USA
J Mol Cell Biol 4:11-21. 2012.... 
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signalBrian T Fife
UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, California, USA
Nat Immunol 10:1185-92. 2009..Blockade of the immunomodulatory receptor CTLA-4 did not alter T cell motility or abrogate tolerance. Thus, PD-1-PD-L1 interactions maintain peripheral tolerance by mechanisms fundamentally distinct from those of CTLA-4...- Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD miceCraig Meagher
Diabetes Center, University of California, San Francisco, CA 94143, USA
J Immunol 180:7793-803. 2008..CD28KO mice provides an excellent model for the study of disease pathogenesis and development of new therapies for human autoimmune pancreatitis... - Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissuesKristin Melli
Department of Surgery, University of California, San Francisco, CA 94143, USA
J Immunol 182:2590-600. 2009..Therapeutic interventions that intercept this process may be effective at halting the progression of type 1 diabetes... - Central role of defective interleukin-2 production in the triggering of islet autoimmune destructionQizhi Tang
Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, San Francisco, CA 94143 0540, USA
Immunity 28:687-97. 2008..Together, these results suggest intra-islet Treg cell dysfunction secondary to defective IL-2 production is a root cause of the progressive breakdown of self-tolerance and the development of diabetes in nonobese diabetic mice... - Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organsCristina Penaranda
Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Diabetes 59:1461-8. 2010..In this study, we address the role of tertiary lymphoid organs (TLOs) that form in the pancreas of NOD mice during disease progression... - Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hostsTodd V Brennan
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Surg Res 169:e69-75. 2011.... - Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic miceQizhi Tang
Diabetes Center, Department of Medicine, University of California, San Francisco 94143, USA
Nat Immunol 7:83-92. 2006..Such persistent T(reg) cell-dendritic cell contacts preceded the inhibition of T(H) cell activation by dendritic cells, supporting the idea that dendritic cells are central to T(reg) cell function in vivo... - T regulatory cells in autoimmune diabetes: past challenges, future prospectsJeffrey A Bluestone
UCSF Diabetes Center, San Francisco, CA 94143, USA
J Clin Immunol 28:677-84. 2008..The development of type 1 diabetes in the NOD mouse strain it is a complex process that depends on a fine balance between pathogenic and regulatory pathways... - Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathwayBrian T Fife
UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, and Transplantation Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
J Exp Med 203:2737-47. 2006.... 
Regulatory T-cell physiology and application to treat autoimmunityQizhi Tang
UCSF Diabetes Center, Department of Medicine and Department of Pathology, University of California, San Francisco, CA 94143-0540, USA
Immunol Rev 212:217-37. 2006....- Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in miceMark A Travis
Lung Biology Center, Department of Medicine, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA
Nature 449:361-5. 2007.... - B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient micePatrizia Scapini
Department of Laboratory Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 108:E823-32. 2011.... - Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic miceEmma L Masteller
Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143-0540, USA
J Immunol 175:3053-9. 2005..These results provide a direct demonstration of the presence of autoantigen-specific T(reg) in the natural setting that can be applied as therapeutics for organ-specific autoimmunity... - Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell functionQizhi Tang
UCSF Diabetes Center, University of California San Francisco, San Francisco, CA 94143 0540, USA
Eur J Immunol 34:2996-3005. 2004..These results help explain contradictions in the literature and support the existence of functionally distinct Treg... - Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cellsCristina Penaranda
Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
J Immunol 187:2015-22. 2011..Taken together, the results suggest that FNB anti-CD3 therapy promotes tolerance by restoring the balance between pathogenic and regulatory T cells... - Imaging the function of regulatory T cells in vivoQizhi Tang
University of California, San Francisco (UCSF) Diabetes Center, Department of Medicine, 94143-0511, USA
Curr Opin Immunol 18:496-502. 2006..Expansion of such analysis to peripheral tissues together with the development of functional reporter mice will help to further elucidate the mode of operation of Tregs in vivo... - Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cellsKenneth J Scalapino
Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco Veterans Affairs Medical Center, CA 94121, USA
J Immunol 177:1451-9. 2006.... - How do CD4+CD25+ regulatory T cells control autoimmunity?Jeffrey A Bluestone
University of California at San Francisco Diabetes Center, Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0540, USA
Curr Opin Immunol 17:638-42. 2005..Recent in vivo analyses support a model in which Tregs directly or indirectly alter the activation and differentiation of pathogenic T cells through an effect on antigen presenting cells... - The Foxp3+ regulatory T cell: a jack of all trades, master of regulationQizhi Tang
Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Nat Immunol 9:239-44. 2008..Thus, the versatility and adaptability of the Foxp3+ T(reg) cells may in fact be the best argument that these cells are 'multitalented masters of immune regulation'... - Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in miceAmar Nijagal
Eli and Edythe Broad Center of Regeneration Medicine, San Francisco, California, USA
J Clin Invest 121:582-92. 2011..Our study suggests that the clinical success of IUHCTx may be improved by transplanting cells matched to the mother... - Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cellsJeffrey A Bluestone
Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143 0540, USA
Proc Natl Acad Sci U S A 101:14622-6. 2004..Emphasis will be placed on approaches to exploit regulatory T cells either directly or through the use of anti-CD3 immunotherapy...
Research Grants
- "Regulatory 'T' Cell Control of Autoimmune Diabetes".Qizhi Tang; Fiscal Year: 2010..The insight gained from these mechanistic studies will help to improve the design of regulatory T cell-based therapy for patients and to identify new targets for therapeutic intervention of type 1 diabetes. ..