Hua Tang

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi request reprint Selective regulation of hydrogen peroxide signaling by receptor tyrosine phosphatase-alpha
    Qin Hao
    Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Free Radic Biol Med 41:302-10. 2006
  2. ncbi request reprint Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells
    Hua Tang
    Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 277:5441-7. 2002
  3. ncbi request reprint Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cells
    Hua Tang
    Department of Biochemistry, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Blood 105:1977-85. 2005
  4. ncbi request reprint Inactivation of SRC family tyrosine kinases by reactive oxygen species in vivo
    Hua Tang
    Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 280:23918-25. 2005
  5. doi request reprint Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis
    Qin Hao
    Department of Biochemistry, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 284:799-806. 2009
  6. pmc Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells
    Qin Hao
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    Am J Physiol Cell Physiol 303:C548-53. 2012
  7. ncbi request reprint Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells
    Qin Hao
    Department of Biochemistry, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, Texas 75708, USA
    Anticancer Res 33:393-9. 2013
  8. ncbi request reprint Suppression of the phosphorylation of receptor tyrosine phosphatase-alpha on the Src-independent site tyrosine 789 by reactive oxygen species
    Qin Hao
    Department of Biochemistry, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Mol Pharmacol 69:1938-44. 2006
  9. pmc The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-γ production through the p38 mitogen-activated protein kinase pathway
    Hui Peng
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, Texas 75708, USA
    J Biol Chem 286:24508-18. 2011
  10. ncbi request reprint Regulation of urokinase receptor expression by protein tyrosine phosphatases
    Sreerama Shetty
    The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 292:L414-21. 2007

Research Grants

Collaborators

  • Hong Long Ji
  • Buka Samten
  • Hui Peng
  • Lin Zhang
  • Sreerama Shetty
  • S Idell
  • Min Liu
  • Bali Pulendran
  • Yong Xu
  • Ying Huang
  • Tong Zhang
  • MORRIS JAY BIRNBAUM
  • X Cao
  • Qin Hao
  • Z Joe Zhao
  • Dong Yun Han
  • Linping Wang
  • Weiping Cao
  • Zhijuan He
  • Yi Xuan Li
  • Xin Li
  • Cheng Wang
  • Brad Low
  • Stacey A Rutherford
  • Xin Huang
  • Hurng Yi Wang
  • Miri Stolovich
  • Runxiang Zhao
  • Huachen Gan
  • Raymond McKenzie
  • Hong Guang Nie
  • Deepa Bhattarai
  • Xue mei Shi
  • Xue Feng Su
  • Katlin Landers
  • Meimi Zhao
  • Run Zhen Zhao
  • Niren Murthy
  • Ali Pirani
  • Jianhua Zheng
  • Santhakumar Manicassamy
  • Sudhir Pai Kasturi
  • Yixuan Li
  • Qi Wang
  • Jianhua Gao
  • Tanqi Lou
  • Xueqing Yu
  • Xun Liu
  • Zhujiang Chen
  • Chunfang Ruo
  • Minghui Zhang
  • C K James Shen
  • Chung I Wu
  • Eran Hornstein
  • Oded Meyuhas
  • Ruth Cohen
  • Abdelmadjid Guerrah
  • Galit Levy
  • Sun Sik Bae

Detail Information

Publications25

  1. ncbi request reprint Selective regulation of hydrogen peroxide signaling by receptor tyrosine phosphatase-alpha
    Qin Hao
    Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Free Radic Biol Med 41:302-10. 2006
    ..Our findings indicate that H2O2 signaling pathways are selectively regulated by RPTP alpha in cells, which may provide new insights into the functional regulation of ROS signal transduction by PTPs...
  2. ncbi request reprint Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells
    Hua Tang
    Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 277:5441-7. 2002
    ..These results indicate that Pyk2 plays a crucial role in the pulmonary endothelial cell motility such as spreading and migration necessary for angiogenesis...
  3. ncbi request reprint Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cells
    Hua Tang
    Department of Biochemistry, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Blood 105:1977-85. 2005
    ..Since TGF-beta plays a crucial role in the resolution phase of angiogenesis, the down-regulation of TGF-beta signaling by thrombin-PAR1 pathway may provide a new insight into the mechanism of the proangiogenic effect of thrombin...
  4. ncbi request reprint Inactivation of SRC family tyrosine kinases by reactive oxygen species in vivo
    Hua Tang
    Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 280:23918-25. 2005
    ..Because Src family kinases play key roles in cell signaling, the rapid inactivation of Src family kinases by H2O2 may represent a novel mechanism for the protective effects of reactive oxygen species...
  5. doi request reprint Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis
    Qin Hao
    Department of Biochemistry, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 284:799-806. 2009
    ....
  6. pmc Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells
    Qin Hao
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    Am J Physiol Cell Physiol 303:C548-53. 2012
    ..Thus we have indentified VEGFR2 as a PTP-MEG2 substrate, and our findings indicate that PTP-MEG2 is a negative regulator of VEGFR2 signaling and function in ECs...
  7. ncbi request reprint Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells
    Qin Hao
    Department of Biochemistry, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, Texas 75708, USA
    Anticancer Res 33:393-9. 2013
    ..The role of protein kinase D (PKD) in the context of breast cancer cell biology is not clear...
  8. ncbi request reprint Suppression of the phosphorylation of receptor tyrosine phosphatase-alpha on the Src-independent site tyrosine 789 by reactive oxygen species
    Qin Hao
    Department of Biochemistry, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Mol Pharmacol 69:1938-44. 2006
    ..Because Tyr789 plays an important role in RPTPalpha signaling, our findings may provide new insights into the functional regulation of RPTPalpha by oxidative stress in cells...
  9. pmc The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-γ production through the p38 mitogen-activated protein kinase pathway
    Hui Peng
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, Texas 75708, USA
    J Biol Chem 286:24508-18. 2011
    ..Silencing of p38α MAPK with siRNA rendered T cells resistant to ESAT-6 inhibition of IFN-γ production. Taken together, our results demonstrate that ESAT-6 inhibits T cell IFN-γ production in a p38 MAPK-dependent manner...
  10. ncbi request reprint Regulation of urokinase receptor expression by protein tyrosine phosphatases
    Sreerama Shetty
    The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 292:L414-21. 2007
    ....
  11. doi request reprint Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells
    Qin Hao
    Dept of Biochemistry, The Univ of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Am J Physiol Cell Physiol 296:C821-7. 2009
    ....
  12. pmc 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels
    Dong Yun Han
    Department of Biochemistry, University of Texas Health Science Center at Tyler, USA
    Am J Respir Cell Mol Biol 45:1007-14. 2011
    ..Our data suggest that elimination of self-inhibition of αβγ ENaC may be a novel mechanism for CPT-cGMP to stimulate salt reabsorption in human lungs...
  13. pmc Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
    Miri Stolovich
    Department of Biochemistry, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Mol Cell Biol 22:8101-13. 2002
    ..It therefore appears that translation of TOP mRNAs is primarily regulated by growth and mitogenic cues through the PI3-kinase pathway, with a minor role, if any, for the mTOR pathway...
  14. ncbi request reprint Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10
    Hua Tang
    Institute of Immunology, Zhejian University, Hangzhou, PR China
    Blood 108:1189-97. 2006
    ..These results suggest that splenic microenvironment may physiologically induce regulatory DC differentiation in situ...
  15. ncbi request reprint Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling
    Runxiang Zhao
    Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232 6307, USA
    J Biol Chem 277:7882-8. 2002
    ..Together, the data indicate that PZR is a major receptor of ConA and has an important role in cell signaling via c-Src. Considering the various biological activities of ConA, the study of PZR may have major therapeutic implications...
  16. ncbi request reprint Expression and function of NJ-1 surface antigen in megakaryopoiesis
    Hua Tang
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 292:667-74. 2002
    ..We hypothesize that NJ-1(+)MKs are immature MKs and the NJ-1 molecule is involved in MK adhesion to endothelial cells...
  17. ncbi request reprint [Differentially expressed genes in prostate cancer and benign prostatic hyperplasia]
    Tong Zhang
    Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
    Zhonghua Nan Ke Xue 10:897-9. 2004
    ..To detect and analyze the differentially expressed genes in prostate cancer (PCa) and benign prostatic hyperplasia (BPH)...
  18. pmc Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
    Weiping Cao
    Emory Vaccine Center, Atlanta, GA 30329, USA
    Nat Immunol 9:1157-64. 2008
    ..Thus, mTOR signaling is crucial in TLR-mediated IFN-alpha/beta responses by pDCs...
  19. doi request reprint Cellular protein TIA-1 regulates the expression of HBV surface antigen by binding the HBV posttranscriptional regulatory element
    Hua Tang
    Key Laboratory of Molecular Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
    Intervirology 51:203-9. 2008
    ..To identify T-cell intracellular antigen 1 (TIA-1) interacting with the posttranscriptional regulatory element (PRE) of hepatitis B virus (HBV), and reveal TIA-1 function on HBV gene expression...
  20. doi request reprint The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist
    Hua Tang
    Department of Metabolic Disorders, Amgen San Francisco, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA
    Biochem Biophys Res Commun 375:562-5. 2008
    ..Our findings provide evidence that GPR109A is a target for the drug Fumaderm and suggest that niacin should be investigated to treat psoriasis in addition to its role in treating lipid disorders...
  21. ncbi request reprint [The genes associated with geldanamycin inhibiting replication of herpes simplex virus type 1]
    Yi Xuan Li
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin 300070, China
    Bing Du Xue Bao 24:208-12. 2008
    ..It is the first report of gene expression profile in cells infected by virus with GA treatment. The general impact of GA on cellular transcription may help to gain an insight into mechanism of its antiviral effect...
  22. ncbi request reprint S100P contributes to chemosensitivity of human ovarian cancer cell line OVCAR3
    Zhijuan He
    Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, HLJ 150010, People s Republic of China
    Oncol Rep 20:325-32. 2008
    ..Using S100P as a molecular biomarker may increase our ability to predict tumor drug response in ovarian cancer...
  23. ncbi request reprint Serum IgA1 from IgA nephropathy patients induces apoptosis in podocytes through direct and indirect pathways
    Cheng Wang
    Department of Nephrology, the 3rd affiliated hospitalof Sun Yat Sen University, Guangzhou, Guangdong, China
    Clin Invest Med 30:E240-9. 2007
    ..To investigate apoptosis of podocytes induced by IgA1 isolated from IgA nephropathy (IgAN) patients through direct and indirect pathways...
  24. ncbi request reprint Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites
    Hurng Yi Wang
    Department of Biology, National Taiwan Normal University, Taipei, Taiwan
    Mol Biol Evol 20:1795-804. 2003
    ..The support for the evasion hypothesis is still indirect, but, unlike other hypotheses, it can be tested specifically and systematically...
  25. ncbi request reprint Identification and characterization of DEDDL, a human-specific isoform of DEDD
    Xin Huang
    Institute of Immunology, Second Military Medical University, Shanghai, 200433, PR China
    Gene Expr 13:141-53. 2006
    ..Finally, why DEDD and DEDDL are unstable in the overexpression and other studies may be explained by the finding that they are potential substrates of active caspases...

Research Grants5

  1. Tyrosine Phosphatases and Endothelial Dysfunction
    Hua Tang; Fiscal Year: 2004
    ..abstract_text> ..