Research Topics
Genomes and Genes | Fusheng TangSummaryAffiliation: University of Arkansas at Little Rock Country: USA Publications
| Collaborators
|
Detail Information
Publications
Regulated degradation of a class V myosin receptor directs movement of the yeast vacuoleFusheng Tang
Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
Nature 422:87-92. 2003..Thus the regulated disruption of this transport complex places the vacuole in its proper location. This may be a general mechanism whereby organelles are deposited at their terminal destination...
Identification of an organelle-specific myosin V receptorKuniko Ishikawa
Dept of Biochemistry, The University of Iowa, Iowa City, IA 52242, USA
J Cell Biol 160:887-97. 2003..Organelle-specific receptors such as Vac17p provide a mechanism whereby a single type of myosin V can move diverse cargoes to distinct destinations at different times...
The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnoverJason E Duex
Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
J Cell Biol 172:693-704. 2006..These findings suggest that the dynamic changes in PI3,5P2 are controlled through a tight coupling of synthesis and turnover...
A life-span extending form of autophagy employs the vacuole-vacuole fusion machineryFusheng Tang
Department of Biology, University of Arkansas, Little Rock, Arkansas 72204 1099, USA
Autophagy 4:874-86. 2008..Pending future biochemical studies, the concept of secretophagy may provide a mechanism for autophagy in life-span extension...
An age-dependent feedback control model of calcium dynamics in yeast cellsFusheng Tang
Department of Biology, FH 406, University of Arkansas at Little Rock, 2801 S University Ave, Little Rock, AR 72204 1099, USA
J Math Biol 60:849-79. 2010..1 microM while a very small fraction (1%) of aged wild type cells (>50 generations) can tolerate a high cytosolic calcium concentration of 0.5 microM...
Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processesFusheng Tang
Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Traffic 7:1368-77. 2006..These findings suggest that a major role of Vac8p is to spatially separate multiple functions thereby enabling vacuole inheritance to occur concurrently with other vacuolar processes...
Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusionSenetibeb Gebre
Department of Biology, University of Arkansas, Little Rock, AR, USA
Cell Cycle 11:2176-88. 2012..Since active TORC1 stimulates vacuole scission and CR downregulates TORC1, Osh6 may link these two pathways by adjusting vacuolar membrane organization to extend lifespan...
A structural approach for finding functional modules from large biological networksMutlu Mete
Department of Applied Science, University of Arkansas at Little Rock, Little Rock, Arkansas, USA
BMC Bioinformatics 9:S19. 2008..Unfortunately, existing computer-based clustering methods developed to find those modules are either not so accurate or too slow...
Identification of longevity genes with systems biology approachesYuanyou Tan
Department of Biology, University of Arkansas, Little Rock, AR, USA
Adv Appl Bioinform Chem 2:49-56. 2009..A combination of hypothesis from data-mining, in silico experimentation from simulations, and wet laboratory validation will make the systematic identification of all longevity genes possible...
Palmitoylation plays a role in targeting Vac8p to specific membrane subdomainsYutian Peng
Department of Cell and Developmental Biology, Life Sciences Institute, 210 Washtenaw Avenue, Room 6437, University of Michigan, Ann Arbor, MI 48109 2216, USA
Traffic 7:1378-87. 2006..In addition, our studies provide evidence that palmitoylation targets Vac8p to specific membrane subdomains...
