Daolin Tang

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Endogenous HMGB1 regulates autophagy
    Daolin Tang
    Damage Associated Molecular Pattern Molecule Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Cell Biol 190:881-92. 2010
  2. doi Apoptosis promotes early tumorigenesis
    D Tang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Oncogene 30:1851-4. 2011
  3. pmc High-mobility group box 1 is essential for mitochondrial quality control
    Daolin Tang
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Cell Metab 13:701-11. 2011
  4. pmc Strange attractors: DAMPs and autophagy link tumor cell death and immunity
    W Hou
    Department of Surgery DAMP Laboratory, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh 15213, PA, USA
    Cell Death Dis 4:e966. 2013
  5. pmc A Janus tale of two active high mobility group box 1 (HMGB1) redox states
    Daolin Tang
    Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States of America
    Mol Med 18:1360-2. 2012
  6. pmc High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
    Daolin Tang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2185-95. 2011
  7. pmc HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
    D Tang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Oncogene 29:5299-310. 2010
  8. doi The redox protein HMGB1 regulates cell death and survival in cancer treatment
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 6:1181-3. 2010
  9. pmc Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice
    Rui Kang
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    Gastroenterology 146:1097-107. 2014
  10. pmc The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Proc Natl Acad Sci U S A 109:7031-6. 2012

Collaborators

Detail Information

Publications36

  1. pmc Endogenous HMGB1 regulates autophagy
    Daolin Tang
    Damage Associated Molecular Pattern Molecule Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Cell Biol 190:881-92. 2010
    ..Thus, endogenous HMGB1 is a critical pro-autophagic protein that enhances cell survival and limits programmed apoptotic cell death...
  2. doi Apoptosis promotes early tumorigenesis
    D Tang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Oncogene 30:1851-4. 2011
    ..These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis...
  3. pmc High-mobility group box 1 is essential for mitochondrial quality control
    Daolin Tang
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Cell Metab 13:701-11. 2011
    ..Our findings reveal an essential role for HMGB1 in autophagic surveillance with important effects on mitochondrial quality control...
  4. pmc Strange attractors: DAMPs and autophagy link tumor cell death and immunity
    W Hou
    Department of Surgery DAMP Laboratory, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh 15213, PA, USA
    Cell Death Dis 4:e966. 2013
    ..Thus, DAMPs and autophagy are suitable emergent targets for cancer therapy, considering their more nuanced role in tumor progression. ..
  5. pmc A Janus tale of two active high mobility group box 1 (HMGB1) redox states
    Daolin Tang
    Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States of America
    Mol Med 18:1360-2. 2012
    ..Reduced HMGB1 protein promotes autophagy, whereas oxidized HMGB1 promotes apoptosis. Thus, the differential activity of HMGB1 in immunity, inflammation and cell death depends on the cellular redox status within tissues...
  6. pmc High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
    Daolin Tang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2185-95. 2011
    ..Autophagy, the process by which cells break down spent biochemical and damaged components, plays an important role in cell survival following stress. High mobility group box 1 (HMGB1) regulates autophagy in response to oxidative stress...
  7. pmc HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
    D Tang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Oncogene 29:5299-310. 2010
    ..HMGB1 release, as well as its redox state, thus links autophagy and apoptosis, representing a suitable target when coupled with conventional tumor treatments...
  8. doi The redox protein HMGB1 regulates cell death and survival in cancer treatment
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 6:1181-3. 2010
    ..This suggests a new function for HMGB1 within the tumor microenvironment, regulating cell death and survival and suggests that it plays an important functional role in cross-regulating apoptosis and autophagy...
  9. pmc Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice
    Rui Kang
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    Gastroenterology 146:1097-107. 2014
    ..Little is known about its intracellular roles in response to tissue injury or during subsequent local and systemic inflammatory responses. We investigated the function of Hmgb1 in mice after induction of acute pancreatitis...
  10. pmc The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Proc Natl Acad Sci U S A 109:7031-6. 2012
    ..Our results suggest a critical role for RAGE expression in the earliest stages of pancreatic carcinogenesis, potentially acting as the "autophagic switch," regulating mitochondrial STAT3 signaling...
  11. doi Metabolic regulation by HMGB1-mediated autophagy and mitophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Autophagy 7:1256-8. 2011
    ..These findings reveal a novel pathway coupling autophagy and cellular energy metabolism...
  12. pmc HMGB1 in cancer: good, bad, or both?
    Rui Kang
    Department of Surgery, University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 19:4046-57. 2013
    ..Here, we review the current knowledge of both HMGB1's oncogenic and tumor-suppressive roles and the potential strategies that target HMGB1 for the prevention and treatment of cancer...
  13. pmc Autophagy is required for IL-2-mediated fibroblast growth
    Rui Kang
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Exp Cell Res 319:556-65. 2013
    ..These findings suggest that autophagy is an important pro-survival regulator for IL-2-induced cell growth in fibroblasts...
  14. pmc The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2175-84. 2011
    ..Taken together, these results suggest that RAGE is an important regulator of oxidative injury...
  15. pmc The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells
    Philip J Vernon
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    J Immunol 190:1372-9. 2013
    ..KCR mice also maintained a significantly less suppressive milieu evidenced by marked decreases in CCL22 in relation to CXCL10 and diminished serum levels of IL-6...
  16. pmc High-mobility group box 1, oxidative stress, and disease
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, G 27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Antioxid Redox Signal 14:1315-35. 2011
    ....
  17. pmc Direct molecular interactions between HMGB1 and TP53 in colorectal cancer
    Kristen M Livesey
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Autophagy 8:846-8. 2012
    ..Thus, HMGB1 and TP53 are critical in the cross-regulation of apoptosis and autophagy and central to colon cancer biology...
  18. ncbi RAGE regulates autophagy and apoptosis following oxidative injury
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 7:442-4. 2011
    ..These findings provide insight into how crosstalk between apoptosis and autophagy is mediated via ROS signaling with a process involving RAGE...
  19. pmc AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 8:989-91. 2012
    ..Thus, AGER is an important inflammatory mediator that modulates crosstalk between prosurvival pathways, IL6-pSTAT3 and autophagy, in PDA tumor cells, and contributes to early PanIN formation...
  20. ncbi HMGB1: a novel Beclin 1-binding protein active in autophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 6:1209-11. 2010
    ..Taken together, these findings indicate that endogenous HMGB1 functions as an autophagy effector by regulation of autophagosome formation...
  21. ncbi HMGB1 as an autophagy sensor in oxidative stress
    Rui Kang
    DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Autophagy 7:904-6. 2011
    ..These findings provide insight into how HMGB1, a damage associated molecular pattern (DAMP), triggers autophagy as defense mechanism under conditions of cellular stress...
  22. pmc Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer
    Siuwah Tang
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreas 42:740-59. 2013
    ..These miRNAs are involved in DNA repair, cell cycle, and cell invasion and also play important roles in promoting metastases...
  23. pmc p53/HMGB1 complexes regulate autophagy and apoptosis
    Kristen M Livesey
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 72:1996-2005. 2012
    ..These insights provide a novel link between HMGB1 and p53 in the cross-regulation of apoptosis and autophagy in the setting of cell stress, providing insights into their reciprocal roles in carcinogenesis...
  24. pmc High-mobility group box 1 and cancer
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, G 27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    Biochim Biophys Acta 1799:131-40. 2010
    ..Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1...
  25. ncbi Autophagy inhibition in combination cancer treatment
    Kristen M Livesey
    University of Pittsburgh, G 27A Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Curr Opin Investig Drugs 10:1269-79. 2009
    ..Screening for new agents is ongoing, which, coupled with conventional chemotherapeutic compounds, may usher in a new generation of autophagy-inhibiting agents...
  26. pmc Eat-me: autophagy, phagocytosis, and reactive oxygen species signaling
    Philip J Vernon
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Antioxid Redox Signal 18:677-91. 2013
    ....
  27. pmc PAMPs and DAMPs: signal 0s that spur autophagy and immunity
    Daolin Tang
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Immunol Rev 249:158-75. 2012
    ..Here, we review recent advances in our understanding of autophagic molecular mechanisms and functions in emergent immunity...
  28. pmc DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death
    Qiuhong Zhang
    Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 9:451-8. 2013
    ..Since both autophagy and DAMPs are important for pathogenesis of human disease, it is crucial to understand how they interplay to sustain homeostasis in stressful or dangerous environments...
  29. pmc PKR-dependent inflammatory signals
    Rui Kang
    Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sci Signal 5:pe47. 2012
    ..Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases...
  30. pmc Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) in human peripheral blood mononuclear cells
    Sebnem Unlu
    Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e38899. 2012
    ..Our findings demonstrate that a specific microRNA expression signature is associated with the inflammatory response to damaged/injured cells and carries implications for many acute and chronic inflammatory disorders...
  31. doi Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE)
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 7:91-3. 2011
    ..These findings provide insight into how autophagy- and apoptosis-crossregulatory molecules interact in response to cellular stress including tumor therapy...
  32. pmc Emerging role of high-mobility group box 1 (HMGB1) in liver diseases
    Ruochan Chen
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Infectious Diseases and State Key Lab of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Mol Med 19:357-66. 2013
    ..The importance of HMGB1 activation in various forms of liver disease in relation to liver damage, steatosis, inflammation, fibrosis, tumorigenesis and regeneration is discussed in this review. ..
  33. pmc RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
    Louis J Sparvero
    Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, Pittsburgh, USA
    J Transl Med 7:17. 2009
    ..Understanding the molecular structure and function of it and its ligands in the setting of inflammation is critically important in understanding the role of this receptor in tumor biology...
  34. pmc Life after death: targeting high mobility group box 1 in emergent cancer therapies
    Z Sheng Guo
    The University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15213, USA Departments of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA 15213, USA
    Am J Cancer Res 3:1-20. 2013
    ..This has significant implications for developing novel cancer therapeutics...
  35. doi HMGB1 promotes drug resistance in osteosarcoma
    Jun Huang
    Departments of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    Cancer Res 72:230-8. 2012
    ..Therefore, through its role as a regulator of autophagy, HMGB1 is a critical factor in the development of chemoresistance, and it offers a novel target for improving osteosarcoma therapy...
  36. pmc The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
    R Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Cell Death Differ 17:666-76. 2010
    ..Our data suggest that targeted inhibition of RAGE or its ligands may serve as novel targets to enhance current cancer therapies...