Chongren Tang

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, Washington 98195 8055, USA
    Biochim Biophys Acta 1791:563-72. 2009
  2. doi request reprint Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice
    Chongren Tang
    Diabetes Obesity Center for Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109
    J Lipid Res 57:100-8. 2016
  3. pmc Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 51:1719-28. 2010
  4. pmc An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux
    John F Oram
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 283:11541-9. 2008
  5. pmc ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation
    Ashley M Vaughan
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 50:285-92. 2009
  6. pmc The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor
    Chongren Tang
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 284:32336-43. 2009
  7. ncbi request reprint Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 279:7622-8. 2004
  8. ncbi request reprint Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1
    Chongren Tang
    Division of Metabolism, Endocrinology, and Nutrition, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    J Lipid Res 47:107-14. 2006
  9. pmc Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice
    Kimberly A Edgel
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, and the Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98109, USA
    Biochim Biophys Acta 1821:425-34. 2012
  10. pmc Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export
    Baohai Shao
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 51:1849-58. 2010

Collaborators

Detail Information

Publications25

  1. doi request reprint The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, Washington 98195 8055, USA
    Biochim Biophys Acta 1791:563-72. 2009
    ..The ABCA1 pathway has therefore become a promising new therapeutic target for treating cardiovascular disease and diabetes...
  2. doi request reprint Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice
    Chongren Tang
    Diabetes Obesity Center for Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109
    J Lipid Res 57:100-8. 2016
    ....
  3. pmc Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 51:1719-28. 2010
    ..Impaired ABCA1-mediated cholesterol export could therefore contribute to the increased atherosclerosis and nephropathy associated with diabetes...
  4. pmc An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux
    John F Oram
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 283:11541-9. 2008
    ..Direct interactions with ABCA1 and activation of signaling pathways likely involve other structural determinants of PLTP...
  5. pmc ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation
    Ashley M Vaughan
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 50:285-92. 2009
    ....
  6. pmc The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor
    Chongren Tang
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 284:32336-43. 2009
    ..These findings implicate ABCA1 as a direct molecular link between the cardioprotective effects of cholesterol export from arterial macrophages and suppressed inflammation...
  7. ncbi request reprint Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 279:7622-8. 2004
    ..These results suggest that the interaction of apolipoproteins with ABCA1-expressing cells activates JAK2, which in turn activates a process that enhances apolipoprotein interactions with ABCA1 and lipid removal from cells...
  8. ncbi request reprint Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1
    Chongren Tang
    Division of Metabolism, Endocrinology, and Nutrition, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    J Lipid Res 47:107-14. 2006
    ..These findings show that amphipathic helices coordinate the activity of ABCA1 by several distinct mechanisms that are likely to involve different cell surface binding sites...
  9. pmc Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice
    Kimberly A Edgel
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, and the Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98109, USA
    Biochim Biophys Acta 1821:425-34. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  10. pmc Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export
    Baohai Shao
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 51:1849-58. 2010
    ..Therefore, oxidation of apoA-I in the artery wall by MPO-generated chlorinating intermediates may contribute to atherogenesis by impairing cholesterol efflux from macrophages...
  11. ncbi request reprint Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells
    Marisa Passarelli
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Diabetes 54:2198-205. 2005
    ....
  12. pmc Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages
    Jenny E Kanter
    Department of Pathology, Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109, USA
    Biochim Biophys Acta 1821:358-64. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  13. pmc Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1
    Tomio Umemoto
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98195, USA
    Circ Res 112:1345-54. 2013
    ..However, little is known concerning anti-inflammatory effects of HDL and apoAI on adipocytes...
  14. pmc The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice
    Michelle M Averill
    Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 9:e109252. 2014
    ....
  15. pmc Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity
    Katya B Rubinow
    Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    J Lipid Res 53:1376-83. 2012
    ..These effects appear independent of testosterone conversion to dihydrotestosterone. Further research is needed to determine how changes in HDL protein content affect CVD risk in men...
  16. pmc Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase
    Baohai Shao
    From the Department of Medicine, University of Washington, Seattle B S, C T, A s, P S M, G D D, X Q Z, J W H Diabetes and Obesity Center of Excellence, University of Washington, Seattle B S, C T, P S M, J W H Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY N B Center for Molecular Biology and Biotechnology, Florida Atlantic University, Jupiter N B and Children s Hospital Oakland Research Institute, CA M N O
    Circ Res 114:1733-42. 2014
    ..However, the mechanisms that contribute to impaired sterol efflux capacity remain poorly understood...
  17. pmc Regulation of ABCA1 functions by signaling pathways
    Yuhua Liu
    Deparment of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195 8055, USA
    Biochim Biophys Acta 1821:522-9. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  18. ncbi request reprint Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells
    John F Oram
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 278:52379-85. 2003
    ..Thus, PLTP mimics apolipoproteins in removing cellular lipids by the ABCA1 pathway, except that PLTP acts more as an intermediary in the transfer of cellular lipids to lipoprotein particles...
  19. doi request reprint A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects
    Baohai Shao
    Diabetes and Obesity Center of Excellence and Kidney Research Institute, Department of Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98195, United States
    J Proteome Res 14:2792-806. 2015
    ..Quantifying proteins in HDL may be useful in the assessment of cardiovascular risk in patients with ESRD and in assessing response to therapeutic interventions. ..
  20. doi request reprint ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction
    Hao Wei
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98109 8050 Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98109 8050
    J Lipid Res 56:2337-47. 2015
    ..Overall, ABCG1 modulates ATM cholesterol content in obesity and weight loss regimes leading to an alteration in M1 to M2 ratio that we suggest is due to the extent of macrophage egress from adipose tissue. ..
  21. pmc Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men
    Katya B Rubinow
    Center for Research in Reproduction and Contraception, Division of Metabolism, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98109, United States
    Steroids 77:454-60. 2012
    ..Further investigation of the effects of sex steroids on HDL composition and function may help resolve the apparently conflicting data regarding testosterone, HDL-C, and CVD risk...
  22. pmc Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 97:1598-605. 2012
    ....
  23. doi request reprint Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity
    Tomas Vaisar
    Department of Medicine, University of Washington, Seattle, WA 98105
    J Lipid Res 56:1519-30. 2015
    ..Our observations indicate that the inflammatory impairment of HDL-C efflux capacity is due in part to SAA-mediated remodeling of HDL's protein cargo. ..
  24. pmc Expression of apolipoprotein A-I in rabbit carotid endothelium protects against atherosclerosis
    Rowan Flynn
    Department of Medicine, University of Washington, Seattle, Washington 98195 7710, USA
    Mol Ther 19:1833-41. 2011
    ..Expression of apoA-I in arterial endothelium significantly retards atherosclerosis. HDAd provides prolonged, stable expression of a therapeutic transgene in the artery wall...
  25. pmc Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts
    Andrew M Cheng
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e33917. 2012
    ..Thus, apoA-I overexpression might be a useful therapeutic tool against vascular inflammation...