Yuichiro Tanaka

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer
    Yuichiro Tanaka
    Department of Surgery Urology 112F, Veterans Affairs Medical Center, University of California, 4150 Clement St, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 383:440-4. 2009
  2. doi request reprint Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
    Nobuyuki Kikuno
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Int J Cancer 123:552-60. 2008
  3. ncbi request reprint Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA
    Shinji Urakami
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Clin Cancer Res 12:6989-97. 2006
  4. doi request reprint DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines
    Ken Kawamoto
    Department of Urology, Veterans Affairs Medical Center and University of California School of Medicine, San Francisco, CA 94121, USA
    Int J Cancer 123:535-42. 2008
  5. ncbi request reprint Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection
    Shinji Urakami
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California, USA
    Clin Cancer Res 12:2109-16. 2006
  6. doi request reprint Functional significance of Wnt inhibitory factor-1 gene in kidney cancer
    Kazumori Kawakami
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Cancer Res 69:8603-10. 2009
  7. pmc BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Carcinogenesis 30:662-70. 2009
  8. pmc miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, CA 94121, USA
    Clin Cancer Res 19:73-84. 2013
  9. ncbi request reprint Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer
    Yuichiro Tanaka
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Cancer Epidemiol Biomarkers Prev 16:92-7. 2007
  10. doi request reprint Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, CA, USA
    Cancer Res 70:2809-18. 2010

Collaborators

Detail Information

Publications68

  1. doi request reprint Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer
    Yuichiro Tanaka
    Department of Surgery Urology 112F, Veterans Affairs Medical Center, University of California, 4150 Clement St, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 383:440-4. 2009
    ..056) of cancer. This is the first report that demonstrates a protective effect for the race-related MLH1 polymorphism at codon 384 against prostate cancer and these results are important in understanding their role in this disease...
  2. doi request reprint Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
    Nobuyuki Kikuno
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Int J Cancer 123:552-60. 2008
    ..These findings strengthen the understanding of how genistein may be chemoprotective in prostate cancer...
  3. ncbi request reprint Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA
    Shinji Urakami
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Clin Cancer Res 12:6989-97. 2006
    ..We hypothesized that combined methylation analysis of Wnt antagonist genes could serve as a panel of biomarkers for diagnosis, staging, and prognosis in renal cell carcinoma (RCC)...
  4. doi request reprint DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines
    Ken Kawamoto
    Department of Urology, Veterans Affairs Medical Center and University of California School of Medicine, San Francisco, CA 94121, USA
    Int J Cancer 123:535-42. 2008
    ..This is the first report indicating that aberrant DNA methylation and histone modifications work together to silence the sFRP2 gene in RCC cells...
  5. ncbi request reprint Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection
    Shinji Urakami
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California, USA
    Clin Cancer Res 12:2109-16. 2006
    ..We hypothesized that combined methylation analysis of Wnt-antagonist genes could improve their use as a panel of biomarkers for diagnosing and staging of bladder cancers...
  6. doi request reprint Functional significance of Wnt inhibitory factor-1 gene in kidney cancer
    Kazumori Kawakami
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Cancer Res 69:8603-10. 2009
    ..In conclusion, this is the first report documenting that the WIF-1 is downregulated by promoter methylation and functions as a tumor suppressor gene by inducing apoptosis in RCC cells...
  7. pmc BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Carcinogenesis 30:662-70. 2009
    ..Genistein being a natural, non-toxic, dietary isoflavone is effective in retarding the growth of RCC cells, making it a promising candidate for epigenetic therapy in renal carcinoma...
  8. pmc miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, CA 94121, USA
    Clin Cancer Res 19:73-84. 2013
    ..miRNAs can act as oncomirs or tumor-suppressor miRs in cancer. This study was undertaken to investigate the status and role of miR-34b in prostate cancer...
  9. ncbi request reprint Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer
    Yuichiro Tanaka
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Cancer Epidemiol Biomarkers Prev 16:92-7. 2007
    ..This study is the first to report COMT polymorphism to be associated with RCC. These results are important in understanding the role of COMT polymorphisms in the pathogenesis of RCC...
  10. doi request reprint Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, CA, USA
    Cancer Res 70:2809-18. 2010
    ..The specific downregulation of oncogenes by miR may contribute to novel therapeutic approaches in the treatment of prostate cancer...
  11. pmc Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e43812. 2012
    ..This study suggests that genistein mediated suppression of oncogenic miRNAs can be an important dietary therapeutic strategy for the treatment of PCa...
  12. ncbi request reprint Polymorphisms of DNA repair genes are risk factors for prostate cancer
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, United States
    Eur J Cancer 43:231-7. 2007
    ..This is the first report on the studies of XPC and XRCC1 Arg194Trp polymorphisms in PC, and our present data suggest that XPC Lys939Gln and the T-A haplotype of XRCC1 Arg194Trp and Arg399Gln may be risk factors for PC in Japanese...
  13. pmc Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    J Urol 179:2020-4. 2008
    ..We hypothesized that mismatch repair gene polymorphism could be a risk factor for prostate cancer and p53 Pro/Pro genotype carriers could influence MSH3 and MSH6 polymorphisms...
  14. pmc Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e70372. 2013
    ..At present there are no reports about the relationship between gensitein, miRNAs and lncRNAs. In this study, we focused on miRNAs, lncRNA that are regulated by genistein and investigated their functional role in PCa...
  15. ncbi request reprint Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer
    Takashi Tokizane
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Clin Cancer Res 11:5793-801. 2005
    ..We hypothesized that promoter/enhancer CpG methylation contributes to the regulation of CYP1B1 expression in human prostate tissue...
  16. ncbi request reprint Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer
    Masahiro Sasaki
    Department of Urology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Clin Cancer Res 10:2015-9. 2004
    ..To test this hypothesis, we investigated the genotypic distributions of six different loci on the CYP1B1 gene and their association with renal cell cancer...
  17. pmc Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer
    Mohd Saif Zaman
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e50203. 2012
    ..miR-23b is located on chromosome number 9 and plays different roles in different organs especially with regards to cancer development. However, the functional significance of miR-23b-3p in renal cell carcinoma (RCC) has not been reported...
  18. doi request reprint miRNA-708 control of CD44(+) prostate cancer-initiating cells
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Cancer Res 72:3618-30. 2012
    ..miR-708 therefore may represent a novel therapeutic target or diagnostic and prognostic biomarker in prostate cancer...
  19. ncbi request reprint Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Clin Cancer Res 17:5287-98. 2011
    ..The main objective of the present study was to identify microRNA (miRNA) genes that regulate metastatic PCa...
  20. pmc Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Cancer 116:66-76. 2010
    ..We report here that B-cell translocation gene 3 (BTG3) is transcriptionally down-regulated in prostate cancer and the mechanism of inactivation is through promoter hypermethylation...
  21. pmc MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, California, USA
    PLoS ONE 8:e67686. 2013
    ..Furthermore, re-expression of miR-23b may be a beneficial therapeutic strategy for the treatment of human bladder cancer. ..
  22. pmc Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e58929. 2013
    ..Our results show that genistein up-regulates tumor suppressor miR-574-3p expression targeting several cell signaling pathways. These findings enhance understanding of how genistein regulates with miRNA in PCa...
  23. ncbi request reprint Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway
    Shinji Urakami
    Department of Urology 112F, Veterans Affairs Medical Center, and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Cancer Res 12:383-91. 2006
    ..Wnt inhibitory factor-1 (Wif-1) was identified as one of the secreted antagonists that can bind Wnt protein. We hypothesize that Wif-1 plays an important role in bladder cancer pathogenesis...
  24. ncbi request reprint WT1 and WT1-AS genes are inactivated by promoter methylation in ovarian clear cell adenocarcinoma
    Masanori Kaneuchi
    Department of Urology, University of California San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Cancer 104:1924-30. 2005
    ..The authors hypothesized that Wilms tumor suppressor 1 gene (WT1) sense and antisense (WT1-AS) expression and their promoter methylation status could characterize ovarian clear cell adenocarcinoma from ovarian serous adenocarcinoma...
  25. ncbi request reprint CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor alpha and estrogen receptor beta expressions
    Masahiro Sasaki
    Department of Urology, University of California San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Cancer Res 63:3913-8. 2003
    ..This is the first report that demonstrates that the rare polymorphisms at codons 119 and 432 of CYP1B1 gene have higher risk for endometrial cancer, and positive correlations with ERalpha and ERbeta expressions in endometrial cancer...
  26. pmc MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer
    Seong O Suh
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Carcinogenesis 32:772-8. 2011
    ..The apoptotic cells are increased after WT p53 transfection. In summary, this is the first report documenting that downregulation of miR-145 is through DNA methylation and p53 mutation pathways in prostate cancer...
  27. pmc Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancer
    Kazumori Kawakami
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Int J Cancer 128:541-50. 2011
    ..In conclusion, this is the first report documenting that the sFRP-5 is downregulated by promoter methylation and histone acetylation and functions as a tumor suppressor gene by inducing apoptosis in RCC cells...
  28. pmc miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, California 94121, USA
    Cancer Res 72:6435-46. 2012
    ..Loss of miR-23b may confer proliferative advantage and promote prostate cancer migration and invasion, and reexpression of miR-23b may contribute to the epigenetic therapy for prostate cancer...
  29. ncbi request reprint Polymorphisms of DNA repair genes are associated with renal cell carcinoma
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 342:1058-62. 2006
    ..Our present data suggest that the XRCC1 399Gln allele may be linked to susceptibility for RCC...
  30. ncbi request reprint CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility
    Hiroshi Hirata
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Clin Cancer Res 13:5056-62. 2007
    ..Currently, there are no reports investigating the role of CXCL12 G801A polymorphism in prostate cancer (PC)...
  31. ncbi request reprint Alleles of polymorphic sites that correspond to hyperactive variants of CYP1B1 protein are significantly less frequent in Japanese as compared to American and German populations
    Masahiro Sasaki
    Department of Urology, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Hum Mutat 21:652. 2003
    ..This report clearly demonstrates rare variants that correspond to hyper-activity of CYP1B1 protein are significantly 1ess frequent in the Japanese population...
  32. doi request reprint Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Cancer Res 68:2736-44. 2008
    ..Altogether, our data provide new insights into the epigenetic mechanism of the action of genistein that may contribute to the chemopreventive activity of this dietary isoflavone and have important implications for epigenetic therapy...
  33. doi request reprint Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells
    Inik Chang
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Cancer Ther 12:1049-59. 2013
    ..Together, our findings suggest that induction of the BH3-only protein Hrk is a critical step in 2-ME activation of the JNK-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak...
  34. pmc Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer
    Hiroshi Hirata
    Department of Urology, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA
    PLoS ONE 7:e51056. 2012
    ..In conclusion, our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4, resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer...
  35. ncbi request reprint MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma
    Hiroshi Hirata
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Clin Cancer Res 13:4123-9. 2007
    ..There is currently no information about the role of MDM2 polymorphism in renal cell carcinoma (RCC). We investigated polymorphisms in p53-related genes, including MDM2, and their interactions in renal cancer...
  36. pmc MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer
    Yi Chen
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Cancer Prev Res (Phila) 4:76-86. 2011
    ..Genistein, a potential nontoxic chemopreventive agent, restores expression of ARHI and may be an important dietary therapeutic agent for treating prostate cancer...
  37. pmc MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
    PLoS ONE 7:e46743. 2012
    ..Various compounds are currently being used as ROCK1 inhibitors; therefore restoration of tumor suppressor miR-1280 might be therapeutically useful either alone or in combination with these compounds in the treatment of bladder cancer...
  38. pmc MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer
    Shahana Majid
    Department of Urology, VA Medical Center and University of California San Francisco, USA
    Cancer Res 71:2611-21. 2011
    ..miR-205 also inhibited tumor cell growth in vivo. This is the first study showing that miR-205 inhibits proto-oncogenic SFKs, indicating a therapeutic potential of miR-205 in the treatment of renal cancer...
  39. ncbi request reprint Polymorphisms of estrogen receptor alpha in prostate cancer
    Yuichiro Tanaka
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 37:202-8. 2003
    ..The present study suggests that polymorphism in codon 10 of ERalpha may be a risk factor for prostate cancer. These results are important in understanding the role of ERalpha polymorphism in the pathogenesis of prostate cancer...
  40. doi request reprint Catechol-O-methyltransferase-mediated metabolism of 4-hydroxyestradiol inhibits the growth of human renal cancer cells through the apoptotic pathway
    Inik Chang
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Carcinogenesis 33:420-6. 2012
    ..Together, these findings show that COMT in the presence of 4-OHE(2) prevents RCC cell proliferation by enhancing apoptosis and that GADD45α plays a critical role in the COMT-mediated inhibition of RCC...
  41. pmc MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Cancer Res 71:6208-19. 2011
    ..Taken together, our findings define a major tumor suppressive role for miR-708, which may offer an attractive new target for prognostic and therapeutic intervention in RCC...
  42. ncbi request reprint Estrogen receptor alpha polymorphisms and renal cell carcinoma--a possible risk
    Yuichiro Tanaka
    Department of Urology, University of California at San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 202:109-16. 2003
    ..These polymorphisms of ERalpha have been shown to be associated with various cancers. Based on the evidence, it is hypothesized that polymorphisms of the ERalpha gene are associated with renal cell carcinoma...
  43. ncbi request reprint CYP1B1 gene in endometrial cancer
    Masahiro Sasaki
    Department of Urology 112F, University of California San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 202:171-6. 2003
    ....
  44. ncbi request reprint Epigenetic modifications of RASSF1A gene through chromatin remodeling in prostate cancer
    Ken Kawamoto
    Department of Urology, Veterans Affairs Medical Center and University of California School of Medicine, San Francisco, California 94121, USA
    Clin Cancer Res 13:2541-8. 2007
    ..The present study was designed to investigate the mechanisms of inactivation of the RASSF1A gene through the analysis of CpG methylation and histone acetylation and H3 methylation associated with the RASSF1A promoter region...
  45. pmc Up-regulation of microRNA-21 correlates with lower kidney cancer survival
    Mohd Saif Zaman
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e31060. 2012
    ..MicroRNA-21 is up-regulated in a variety of cancers like, breast, colorectal, lung, head and neck etc. However, the regulation of miR-21 in renal cell carcinoma (RCC) has not yet been studied systematically...
  46. ncbi request reprint Transforming growth factor-beta(s) and their receptors in aging rat prostate
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 294:464-9. 2002
    ..These findings are important in understanding the mechanisms of UGM mediated prostatic growth...
  47. ncbi request reprint Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer
    Yuichiro Tanaka
    Department of Urology 112F, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, California 94121, USA
    Cancer Epidemiol Biomarkers Prev 15:238-44. 2006
    ..This is the first report that shows the polymorphisms of COMT to be associated with sporadic prostatic carcinogenesis. These results are important in understanding the role of COMT polymorphisms in the pathogenesis of prostate cancer...
  48. ncbi request reprint Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura
    Masaki Yamanaka
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Urol 173:318-23. 2005
    ..We hypothesized that intracavernous administration of VEGF would recover erectile dysfunction due to diabetes by protection from apoptosis in the penile cavernosum...
  49. ncbi request reprint Polymorphisms of estrogen receptor alpha gene in endometrial cancer
    Masahiro Sasaki
    Department of Urology, Urology Research Center 112F, University of California, San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 297:558-64. 2002
    ..Thus, inherited alterations in ERalpha may be associated with changes in estrogen metabolism and thereby may possibly explain inter-individual differences in disease incidences of endometrial cancer...
  50. ncbi request reprint Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer
    Masanori Kaneuchi
    Department of Urology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, CA, USA
    Biochem Biophys Res Commun 316:1156-62. 2004
    ..This is the first report suggesting that 14-3-3 sigma gene expression and methylation status can characterize histological features of different types of ovarian cancer...
  51. ncbi request reprint Six polymorphisms on estrogen receptor 1 gene in Japanese, American and German populations
    Masahiro Sasaki
    Department of Urology, Urology Research Center, University of California, San Francisco, CA 94121, USA
    Eur J Clin Pharmacol 59:389-93. 2003
    ..We hypothesize that polymorphisms in exon 1 of the ESR1 gene are associated with a lower incidence of estrogen-related diseases in the Japanese population...
  52. pmc Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells
    Takeshi Chiyomaru
    From the Department of Urology, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121
    J Biol Chem 289:12550-65. 2014
    ..These results demonstrate that HOTAIR is suppressed by miR-141 in an Ago2-dependent manner. ..
  53. pmc MicroRNA-4723 inhibits prostate cancer growth through inactivation of the Abelson family of nonreceptor protein tyrosine kinases
    Sumit Arora
    Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e78023. 2013
    ..In conclusion, we have identified a novel microRNA that mediates regulation of Abl kinases in prostate cancer. This study suggests that miR-4723 may be an attractive target for therapeutic intervention in prostate cancer. ..
  54. pmc MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma
    Soichiro Yamamura
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Carcinogenesis 33:294-300. 2012
    ..Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription, indicating a novel role of miR-34a in the regulation of transcription by c-Myc...
  55. ncbi request reprint Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers
    Masahiro Sasaki
    Department of Urology 112F, University of California San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 202:201-7. 2003
    ..These reports clearly demonstrate that selective hypermethylation can selectively silence multiple promoters of steroid receptors in carcinogenesis...
  56. ncbi request reprint Regulation of SRC Kinases by microRNA-3607 Located in a Frequently Deleted Locus in Prostate Cancer
    Sharanjot Saini
    Authors Affiliation Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, California
    Mol Cancer Ther 13:1952-63. 2014
    ..Mol Cancer Ther; 13(7); 1952-63. ©2014 AACR. ..
  57. ncbi request reprint Resveratrol suppresses growth of Ishikawa cells through down-regulation of EGF
    Masanori Kaneuchi
    Department of Urology, San Francisco and Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Int J Oncol 23:1167-72. 2003
    ..The present study suggests that resveratrol can suppress proliferation of Ishikawa cells through down-regulation of EGF...
  58. ncbi request reprint CpG methylation at promoter site -140 inactivates TGFbeta2 receptor gene in prostate cancer
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California 94121, USA
    Cancer 104:44-52. 2005
    ..The authors of the current study hypothesized that CpG methylation of the TbetaRII promoter at the Sp1 binding site -140 mediates this loss of TbetaRII expression in prostate cancer...
  59. pmc MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California, USA
    Cancer 116:5637-49. 2010
    ..In this study, the authors demonstrated that miRNA-205 (miR-205) induced the expression the interleukin (IL) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters...
  60. ncbi request reprint The E-cadherin -160 C/A polymorphism and prostate cancer risk in white and black American men
    Deepa Pookot
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, 94121, USA
    J Urol 176:793-6. 2006
    ..We hypothesized that allelic variation at this site may be associated with racial differences in the incidence and severity of prostate cancer...
  61. ncbi request reprint Quercetin regulates growth of Ishikawa cells through the suppression of EGF and cyclin D1
    Masanori Kaneuchi
    Department of Urology, University of California, and Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Oncol 22:159-64. 2003
    ..The present study suggests that quercetin can suppress proliferation of Ishikawa cells through down-regulation of EGF and cyclin D1...
  62. pmc MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer
    Hiroshi Hirata
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e55502. 2013
    ..Also knock down of miR-182-5p in order to increase expression of tumor suppressor genes FOXF2, RECK and MTSS1 may be of therapeutic benefit in prostate cancer treatment...
  63. ncbi request reprint Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats
    Masaki Yamanaka
    Department of Urology, Veterans Affairs Medical Center, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Urol 170:291-7. 2003
    ..Molecular and immunohistochemical analyses for apoptosis were then performed in rat crura to assess their role in diabetes induced erectile dysfunction and insulin treatment...
  64. ncbi request reprint Single nucleotide polymorphisms of estrogen receptor alpha in human renal cell carcinoma
    Yuichiro Tanaka
    Department of Urology, Veterans Affairs Medical Center, University of California at San Francisco, 4150 Clement Street, 94121 1545, San Francisco, CA, USA
    Biochem Biophys Res Commun 296:1200-6. 2002
    ..The present study demonstrates for the first time that codon 10 polymorphism on exon 1 of ERalpha may be involved in renal cancer risk...
  65. ncbi request reprint Loss of anti-apoptotic genes in aging rat crura
    Masaki Yamanaka
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    J Urol 168:2296-300. 2002
    ..Gene and protein expression of pro-apoptotic and anti-apoptotic factors was then analyzed in aging rat crura to assess its role in aging erectile dysfunction...
  66. ncbi request reprint Polymorphisms of the CYP1B1 gene have higher risk for prostate cancer
    Yuichiro Tanaka
    Department of Urology, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 296:820-6. 2002
    ..These results are important in understanding the role of CYP1B1 polymorphisms in the pathogenesis of prostate cancer...
  67. ncbi request reprint Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Biochem Biophys Res Commun 292:482-91. 2002
    ..This is the first report to demonstrate differential gene and protein expression of growth factors in dorsal and ventral lobes is associated with aging rat prostate, suggesting their role in pathogenesis of prostatic diseases with aging...