Tsunenobu Tamura

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint The form of folate affects the mechanisms of methotrexate resistance in Enterococcus hirae [corrected]
    T Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham 35294, USA
    Microbiology 143:2639-46. 1997
  2. ncbi request reprint Maternal plasma pyridoxal-5'-phosphate concentrations and risk of isolated oral clefts in the Philippines
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Birth Defects Res A Clin Mol Teratol 79:276-80. 2007
  3. ncbi request reprint Folate and human reproduction
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Am J Clin Nutr 83:993-1016. 2006
  4. ncbi request reprint Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama, Birmingham, AL 35294, USA
    Pediatrics 116:703-8. 2005
  5. ncbi request reprint Plasma zinc concentrations of mothers and the risk of nonsyndromic oral clefts in their children: a case-control study in the Philippines
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Birth Defects Res A Clin Mol Teratol 73:612-6. 2005
  6. ncbi request reprint Effect of long-term, high-copper intake on the concentrations of plasma homocysteine and B vitamins in young men
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
    Nutrition 20:757-9. 2004
  7. ncbi request reprint Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL, USA
    Br J Nutr 91:773-7. 2004
  8. ncbi request reprint Effect of zinc supplementation of pregnant women on the mental and psychomotor development of their children at 5 y of age
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
    Am J Clin Nutr 77:1512-6. 2003
  9. ncbi request reprint Homocysteine, B vitamins, and vascular-access thrombosis in patients treated with hemodialysis
    T Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
    Am J Kidney Dis 32:475-81. 1998
  10. ncbi request reprint Maternal plasma zinc concentrations and pregnancy outcome
    T Tamura
    Departments of Nutrition Sciences and Obstetrics and Gynecology, University of Alabama at Birmingham, 35294 3360, USA
    Am J Clin Nutr 71:109-13. 2000

Research Grants

Detail Information

Publications34

  1. ncbi request reprint The form of folate affects the mechanisms of methotrexate resistance in Enterococcus hirae [corrected]
    T Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham 35294, USA
    Microbiology 143:2639-46. 1997
    ....
  2. ncbi request reprint Maternal plasma pyridoxal-5'-phosphate concentrations and risk of isolated oral clefts in the Philippines
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Birth Defects Res A Clin Mol Teratol 79:276-80. 2007
    ..Its association with the status assessed by plasma pyridoxal-5'-phosphate (PLP) concentrations is unknown...
  3. ncbi request reprint Folate and human reproduction
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Am J Clin Nutr 83:993-1016. 2006
    ....
  4. ncbi request reprint Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama, Birmingham, AL 35294, USA
    Pediatrics 116:703-8. 2005
    ....
  5. ncbi request reprint Plasma zinc concentrations of mothers and the risk of nonsyndromic oral clefts in their children: a case-control study in the Philippines
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Birth Defects Res A Clin Mol Teratol 73:612-6. 2005
    ..Findings from animal experiments suggest a link between poor maternal zinc status and increased risk of oral clefts in offspring; however, there are few human studies on this issue...
  6. ncbi request reprint Effect of long-term, high-copper intake on the concentrations of plasma homocysteine and B vitamins in young men
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
    Nutrition 20:757-9. 2004
    ..We evaluated the effect of a long-term, high-copper intake on plasma total homocysteine, folate, vitamin B12, and pyridoxal-5'-phosphate concentrations in humans...
  7. ncbi request reprint Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL, USA
    Br J Nutr 91:773-7. 2004
    ....
  8. ncbi request reprint Effect of zinc supplementation of pregnant women on the mental and psychomotor development of their children at 5 y of age
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
    Am J Clin Nutr 77:1512-6. 2003
    ..A negative effect of prenatal zinc deficiency on brain function has been well established in experimental animals, but this association in humans is controversial...
  9. ncbi request reprint Homocysteine, B vitamins, and vascular-access thrombosis in patients treated with hemodialysis
    T Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
    Am J Kidney Dis 32:475-81. 1998
    ..All three white patients had Ala/Ala genotype, and 3 in 45 black patients (6.7%) were heterozygotes (Val/Ala)...
  10. ncbi request reprint Maternal plasma zinc concentrations and pregnancy outcome
    T Tamura
    Departments of Nutrition Sciences and Obstetrics and Gynecology, University of Alabama at Birmingham, 35294 3360, USA
    Am J Clin Nutr 71:109-13. 2000
    ..There is no consensus in the literature as to whether maternal zinc nutriture is associated with pregnancy outcome or fetal growth...
  11. ncbi request reprint Folate and homocysteine metabolism in copper-deficient rats
    T Tamura
    Department of Nutrition Sciences, 218 Webb Bldg, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biochim Biophys Acta 1427:351-6. 1999
    ..These data support the concept that copper deficiency can be a risk factor for cardiovascular disease...
  12. ncbi request reprint Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapy
    T Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Epilepsy Res 40:7-15. 2000
    ..Our data suggest that hyperhomocysteinemia is not a serious clinical concern in epileptic patients when folate nutriture is adequate...
  13. ncbi request reprint Serum leptin concentrations during pregnancy and their relationship to fetal growth
    T Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
    Obstet Gynecol 91:389-95. 1998
    ..To test the hypothesis that maternal and cord serum leptin concentrations correlate with birth weight of infants...
  14. ncbi request reprint Gender difference in cord serum ferritin concentrations
    T Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
    Biol Neonate 75:343-9. 1999
    ..09, p > 0.41). Although the mechanism of the gender difference is unknown, it may be important to consider the sex of neonates when evaluating their iron nutriture immediately after birth...
  15. pmc 13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man
    Joseph E Baggott
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem Biophys Res Commun 361:307-10. 2007
    ..10-HCO-H(2)folate may function in vivo as the predominant substrate for AICAR transformylase in humans...
  16. doi request reprint Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase
    Joseph E Baggott
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
    Exp Biol Med (Maywood) 235:271-7. 2010
    ..In vitro exchange reactions of purine C(2) using H(4)folate coenzymes are not duplicated in vivo and is consistent with H(2)folate coenzymes being used in vivo by AICAR transformylase...
  17. ncbi request reprint Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age
    Tsunenobu Tamura
    Department of Nutrition Sciences, Civitan International Research Center, University of Alabama at Birmingham 35294 3360, USA
    J Pediatr 140:165-70. 2002
    ..Our purpose was to evaluate the association between fetal iron status and mental and psychomotor development at 5 years of age...
  18. pmc 13C enrichment of carbons 2 and 8 of purine by folate-dependent reactions after [13C]formate and [2-13C]glycine dosing in adult humans
    Joseph E Baggott
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Metabolism 56:708-15. 2007
    ..Possible mechanisms explaining our findings are discussed. Oral [(13)C]formate or [2-(13)C]glycine dosing and urine collection can be used to study purine biosynthesis in humans...
  19. ncbi request reprint Metabolism of 10-formyldihydrofolate in humans
    J E Baggott
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
    Biomed Pharmacother 55:454-7. 2001
    ..We believe that a new folate metabolic map is needed which incorporates the oxidation of 10-formyltetrahydrofolate and the utilization of 10-formyldihydrofolate by AICAR transformylase...
  20. ncbi request reprint Maternal serum ferritin and fetal growth
    J Hou
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35294, USA
    Obstet Gynecol 95:447-52. 2000
    ..To determine the relationship between maternal serum ferritin and concentrations and specific types of fetal growth restriction (FGR)...
  21. doi request reprint Meta-analysis of cancer risk in folic acid supplementation trials
    Joseph E Baggott
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Epidemiol 36:78-81. 2012
    ..Solid monitoring systems to detect side effects, including increase in cancer risk, should be established before the initiation of folic acid supplementation trials...
  22. ncbi request reprint Folate content in commercial white and whole wheat sandwich breads
    Kelley E Johnston
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Agric Food Chem 52:6338-40. 2004
    ..These percentages were markedly higher than those in 2001. Our data suggest that folic acid in breads containing enriched flour declined after 2001 and monitoring of fortification may be necessary...
  23. ncbi request reprint Zinc status of women with low bone mineral density who receive calcium supplements
    Sarah L Morgan
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biol Trace Elem Res 110:211-22. 2006
    ..Although limited by the small sample size and short study duration, our data suggest that a daily calcium dose of 1200 mg had no effect on the zinc status of our subjects...
  24. ncbi request reprint Plasma extracellular superoxide dismutase activity in healthy pregnant women is not influenced by zinc supplementation
    T Tamura
    Departments of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
    Biol Trace Elem Res 80:107-13. 2001
    ..Plasma EC-SOD activities did not prove to be a better indicator of zinc nutriture of pregnant women than either plasma zinc or plasma alkaline phosphatase activities...
  25. ncbi request reprint Mass spectrometric method for detecting carbon 13 enrichment introduced by folate coenzymes in uric acid
    Gregory S Gorman
    Southern Research Institute, Birmingham, AL, USA
    Anal Biochem 321:188-91. 2003
    ..This method could replace radiochemical methods and could trace the incorporation of carbon fragments into the purine ring from 13C-labeled metabolites in humans...
  26. ncbi request reprint Effect of smoking on serum concentrations of total homocysteine and B vitamins in mid-pregnancy
    K Pagan
    Department of Nutrition Sciences, 218 Webb Building, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Clin Chim Acta 306:103-9. 2001
    ..We suggest that it is essential to consider the nutritional status of folate, vitamin B-12 and vitamin B-6 in evaluating the effect of smoking on homocysteine metabolism...
  27. ncbi request reprint Re-evaluation of the metabolism of oral doses of racemic carbon-6 isomers of formyltetrahydrofolate in human subjects
    J E Baggott
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Br J Nutr 85:653-7. 2001
    ..This discovery unveils new folate metabolism in human subjects...
  28. ncbi request reprint Iron-dependent formation of homocysteine from methionine and other thioethers
    J E Baggott
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Clin Nutr 61:1359-63. 2007
    ..We tested whether homocysteine is formed from methionine and other thioethers in vitro and in vivo, because methionine can be chemically demethylated to homocysteine...
  29. ncbi request reprint Elevated amniotic fluid ferritin levels are associated with inflammation-related pregnancy loss following mid-trimester amniocentesis
    P S Ramsey
    Department of Obstetrics and Gynecology, Center for Research in Women s Health, University of Alabama at Birmingham, 35249 7333, USA
    J Matern Fetal Neonatal Med 11:302-6. 2002
    ..We determined the association between amniotic fluid (AF) ferritin levels and post-amniocentesis pregnancy loss...
  30. ncbi request reprint Effect of cow milk on food folate bioavailability in young women
    Mary Frances Picciano
    Department of Nutrition, Pennsylvania State University, University Park, USA
    Am J Clin Nutr 80:1565-9. 2004
    ..The findings of animal and human studies suggest that a certain component in milk enhances food folate bioavailability...
  31. ncbi request reprint Folate determination in human milk
    Tsunenobu Tamura
    J Nutr Sci Vitaminol (Tokyo) 52:161. 2006
  32. ncbi request reprint The preterm prediction study: elevated cervical ferritin levels at 22 to 24 weeks of gestation are associated with spontaneous preterm delivery in asymptomatic women
    Patrick S Ramsey
    National Institute of Child Health and Human Development, Maternal Fetal Medicine Units Network, USA
    Am J Obstet Gynecol 186:458-63. 2002
    ..Our objective was to determine whether elevated levels of ferritin in the genital tract may be a potent marker to identify patients at risk for spontaneous preterm delivery...
  33. doi request reprint In vitro formation of homocysteine in whole blood in the presence of anticoagulants
    Tsunenobu Tamura
    Clin Chem 54:1402-3. 2008
  34. ncbi request reprint Trienzyme extraction in combination with microbiologic assay in food folate analysis: an updated review
    Taisun H Hyun
    Department of Food and Nutrition, Chungbuk National University, Gaeshin dong, Cheongju, 361 763, Korea
    Exp Biol Med (Maywood) 230:444-54. 2005
    ....

Research Grants1

  1. Role of 10-formyldihydrofolate in purine biosynthesis
    Tsunenobu Tamura; Fiscal Year: 2004
    ..If this pathway is proven, derivatives of 10-HCO-H2folate could be used to inhibit de novo purine biosynthesis for developing new anticancer drugs. ..