Carol A Tamminga

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint The potential for viral gene therapy in psychiatry
    Scott J Russo
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Am J Psychiatry 165:675. 2008
  2. doi request reprint Schizophrenia: treatment targets beyond monoamine systems
    Hisham M Ibrahim
    Department of Psychiatry, University of Texas Southwestern, Dallas, 75390 9086, USA
    Annu Rev Pharmacol Toxicol 51:189-209. 2011
  3. pmc Bipolar and schizophrenia network for intermediate phenotypes: outcomes across the psychosis continuum
    Carol A Tamminga
    To whom correspondence should be addressed Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, US tel 214 648 4924, fax 214 648 4948
    Schizophr Bull 40:S131-7. 2014
  4. pmc Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Schizophr Bull 38:927-35. 2012
  5. ncbi request reprint Hippocampal novelty activations in schizophrenia: disease and medication effects
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United States
    Schizophr Res 138:157-63. 2012
  6. ncbi request reprint Cell death
    Michael W Vogel
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1503. 2005
  7. ncbi request reprint Hippocampus, VI. Depression and the Hippocampus
    Alexander Neumeister
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1057. 2005
  8. ncbi request reprint Hippocampus, IV: relational memory
    Stephan Heckers
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:663. 2005
  9. ncbi request reprint The hippocampus
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:25. 2005
  10. ncbi request reprint Frontal cortex function
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:2178. 2004

Detail Information

Publications80

  1. doi request reprint The potential for viral gene therapy in psychiatry
    Scott J Russo
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Am J Psychiatry 165:675. 2008
  2. doi request reprint Schizophrenia: treatment targets beyond monoamine systems
    Hisham M Ibrahim
    Department of Psychiatry, University of Texas Southwestern, Dallas, 75390 9086, USA
    Annu Rev Pharmacol Toxicol 51:189-209. 2011
    ..Animal models, some with genetic characteristics, can be more easily and directly developed to match an individual component than to match an illness definition as broad as schizophrenia...
  3. pmc Bipolar and schizophrenia network for intermediate phenotypes: outcomes across the psychosis continuum
    Carol A Tamminga
    To whom correspondence should be addressed Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, US tel 214 648 4924, fax 214 648 4948
    Schizophr Bull 40:S131-7. 2014
    ..In future, we will use this biomarker information to establish a pathway to biomarker-based classification in psychoses. ..
  4. pmc Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Schizophr Bull 38:927-35. 2012
    ....
  5. ncbi request reprint Hippocampal novelty activations in schizophrenia: disease and medication effects
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United States
    Schizophr Res 138:157-63. 2012
    ....
  6. ncbi request reprint Cell death
    Michael W Vogel
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1503. 2005
  7. ncbi request reprint Hippocampus, VI. Depression and the Hippocampus
    Alexander Neumeister
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1057. 2005
  8. ncbi request reprint Hippocampus, IV: relational memory
    Stephan Heckers
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:663. 2005
  9. ncbi request reprint The hippocampus
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:25. 2005
  10. ncbi request reprint Frontal cortex function
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:2178. 2004
  11. ncbi request reprint Prefrontal cortex, structural analysis: segmenting the prefrontal cortex
    Robert W Buchanan
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1978. 2004
  12. ncbi request reprint Substance P: a neuropeptide
    Tomas Hokfelt
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 163:578. 2006
  13. ncbi request reprint The anatomy of fear extinction
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 163:961. 2006
  14. ncbi request reprint HIV and AIDS
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 163:1322. 2006
  15. ncbi request reprint Central mechanisms for thyroid hormone regulation
    Ronald M Lechan
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Am J Psychiatry 163:1492. 2006
  16. ncbi request reprint The neurobiology of cognition in schizophrenia
    Carol A Tamminga
    Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas 75390 9070, USA
    J Clin Psychiatry 67:9-13; discussion 36-42. 2006
    ..Once developed and tested, the effective compounds will be valuable for the treatment of the symptom domains of cognitive dysfunction and negative symptoms...
  17. pmc The neuropharmacology of psychosis
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, NE5 110F, Dallas, TX 75390 9127, USA
    Schizophr Bull 33:937-46. 2007
    ..We discuss the kinds of data necessary to further support the dimensional aspects of psychosis...
  18. ncbi request reprint Intramyocyte lipids may impair insulin signaling
    Craig Malloy
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 164:1475. 2007
  19. doi request reprint The hippocampal formation in schizophrenia
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, NE5 110F, 2201 Inwood Rd, Dallas, TX 75235, USA
    Am J Psychiatry 167:1178-93. 2010
    ..Tests of this model could result in novel approaches to the treatment of psychosis and declarative memory alterations and in novel animal preparations for basic schizophrenia research...
  20. ncbi request reprint Phenotype of schizophrenia: a review and formulation
    C A Tamminga
    Department of Psychiatry, UT Southwestern Medical School, Dallas, TX 75390, USA
    Mol Psychiatry 10:27-39. 2005
    ..This paper reviews the status of general knowledge in this area and proposes an approach to discovery, including identifying brain regions of dysfunction and subsequent localized, hypothesis-driven molecular screening...
  21. ncbi request reprint Structure of the human prefrontal cortex
    David A Lewis
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1366. 2004
  22. ncbi request reprint Schizophrenia, VIII: pharmacologic models
    Adrienne C Lahti
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 160:2091. 2003
  23. ncbi request reprint GABA neurons in the human prefrontal cortex
    Carol Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1764. 2004
  24. ncbi request reprint The human brain
    Carol A Tamminga
    University of Texas Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Boulevard, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1169. 2004
  25. ncbi request reprint Schizophrenia, I
    Carol A Tamminga
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Am J Psychiatry 160:846. 2003
  26. ncbi request reprint Similarities and differences among antipsychotics
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Clin Psychiatry 64:7-10. 2003
    ..The treating physician must carefully match the diverse needs of schizophrenic patients with the varied characteristics of the second-generation antipsychotics...
  27. pmc Cognitive endophenotypes of psychosis within dimension and diagnosis
    Elena I Ivleva
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Psychiatry Res 196:38-44. 2012
    ..These data support the notion that schizophrenia and psychotic bipolar disorder present a clinical continuum with overlapping cognitive features defining the psychosis phenotype...
  28. ncbi request reprint Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ....
  29. ncbi request reprint Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:273-82. 2003
    ....
  30. pmc AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli
    Vaishnav Krishnan
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 64:691-700. 2008
    ..Recent evidence suggests that dopaminergic neurons of the ventral tegmental area (VTA) play a key role in the manifestation of stress vulnerability...
  31. ncbi request reprint Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Biol Psychiatry 55:234-43. 2004
    ..Here we examined the molecular basis of these alterations and whether these findings can be replicated in another cohort...
  32. ncbi request reprint The neurobiology of cognition in schizophrenia
    Carol A Tamminga
    Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, USA
    J Clin Psychiatry 67:e11. 2006
    ..Domain treatment of schizophrenia is a new method of treating schizophrenia that involves treating a single domain of dysfunction at a time...
  33. pmc Predictive pursuit association with deficits in working memory in psychosis
    Amanda F Moates
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 72:752-7. 2012
    ..Because predictive pursuit might depend on the working memory system, we have hypothesized a relationship between the two in healthy control subjects (HC) and SZ and here examine whether it extends to psychotic bipolar disorder (BDP)...
  34. pmc Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia
    Adrienne C Lahti
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 34:2675-90. 2009
    ..After 1 week of treatment, greater rCBF increase in the ventral striatum and greater decrease in the hippocampus were associated with good response...
  35. ncbi request reprint Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex
    Max A Castillo
    Department of Neurology, The University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 67:208-16. 2010
    ..This in turn could affect the binding of Stx 1 to its protein partners and result in abnormal neurotransmitter release and synaptic transmission...
  36. pmc Are structural brain abnormalities associated with suicidal behavior in patients with psychotic disorders?
    Christoforos I Giakoumatos
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Psychiatr Res 47:1389-95. 2013
    ..Regions in which differences were observed are part of neural circuitries that mediate inhibition, impulsivity and emotion, visceral, visual and auditory perception. ..
  37. ncbi request reprint mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, 60612, USA
    Neuropsychopharmacology 27:499-517. 2002
    ..Our results suggest that there are defects in the expression of selective G protein alpha subunits in prefrontal cortex of adult and teenage suicide subjects, which appear to be related to mental disorders...
  38. pmc Neurobiology of self-awareness in schizophrenia: an fMRI study
    Mujeeb U Shad
    The University of Texas Health Science Center, Houston, TX, United States
    Schizophr Res 138:113-9. 2012
    ..These findings support results from earlier studies and demonstrate selective alteration in the activation of cortical midline structures associated with evaluations of self-reference in schizophrenia as compared to controls...
  39. pmc Comparing genes and phenomenology in the major psychoses: schizophrenia and bipolar 1 disorder
    Elena Ivleva
    Department of Psychiatry, University of Texas Southwestern Medical School, 5352 Harry Hines Boulevard, Dallas, TX 75235, USA
    Schizophr Bull 34:734-42. 2008
  40. pmc Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?
    Subroto Ghose
    University of Texas Southwestern Medical Center, NE5 110C, Dallas, TX 75390 9127, USA
    Am J Psychiatry 166:812-20. 2009
    ..GCP II is an enzyme that metabolizes N-acetyl-aspartyl-glutamate (NAAG), which is the only known specific endogenous agonist of mGluR3 in the mammalian brain...
  41. ncbi request reprint Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Am J Psychiatry 159:419-29. 2002
    ..The authors examined whether 5-HT(2A) receptor subtypes are altered in the postmortem brains of teenage suicide victims...
  42. pmc Brain gray matter phenotypes across the psychosis dimension
    Elena I Ivleva
    Department of Psychiatry, UT Southwestern Medical Center, 6363 Forest Park Road, Suite 6 633, Dallas, TX 75235, USA
    Psychiatry Res 204:13-24. 2012
    ....
  43. pmc Memory generalization is selectively altered in the psychosis dimension
    Elena I Ivleva
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Schizophr Res 138:74-80. 2012
    ..These results suggest that the two disorders present a clinical continuum with overlapping hippocampus-mediated memory generalization dysfunction underlying the psychosis phenotype...
  44. pmc Human postmortem tissue: what quality markers matter?
    Ana D Stan
    University of Texas Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110F, Dallas, TX 75390 9127, USA
    Brain Res 1123:1-11. 2006
    ..g., thawed tissue, surgical tissue), that yielded unexpected quality indicators. These data also suggest that cases whose source was a Medical Examiner's office represent high tissue quality...
  45. pmc Social memory in mice: disruption with an NMDA antagonist and attenuation with antipsychotic drugs
    Xue Min Gao
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9127, United States
    Pharmacol Biochem Behav 92:236-42. 2009
    ..The neural mechanisms of these actions are not known, although medial temporal lobe memory systems have been implicated...
  46. ncbi request reprint Multidose risperidone treatment evaluated in a rodent model of tardive dyskinesia
    Xue Min Gao
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 31:1864-8. 2006
    ..If this animal model predicts TD risk in humans, the TD liability with low-dose risperidone is at a placebo level, whereas higher doses show haloperidol-like TD risk, as predicted from the acute motor effects...
  47. ncbi request reprint Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
    Thomas A Green
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2025-32. 2008
    ....
  48. ncbi request reprint Evaluating glutamatergic transmission in schizophrenia
    Carol A Tamminga
    University of Texas Southwestern Medical School, Dallas, Texas, 75390, USA
    Ann N Y Acad Sci 1003:113-8. 2003
    ..What I will report in this paper has been individually reported elsewhere but brought together here in a new synthesis...
  49. doi request reprint Animal models of schizophrenia emphasizing construct validity
    Masaya Yanagi
    Department of Psychiatry, UT Southwestern Medical School, Dallas, Texas, USA
    Prog Mol Biol Transl Sci 105:411-44. 2012
    ..This chapter emphasizes the crucial need for construct validity and of modeling discrete elements of schizophrenia's illness presentation as the way to successful advances...
  50. pmc The interactive effects of ketamine and nicotine on human cerebral blood flow
    Laura M Rowland
    Department of Psychiatry, Functional Neuroimaging Laboratory, Maryland Psychiatric Research Center, University of Maryland School of Medicine, 55 Wade Avenue, Baltimore, MD 21228 0247, USA
    Psychopharmacology (Berl) 208:575-84. 2010
    ..The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF)...
  51. ncbi request reprint Muscarinic agonists for the treatment of cognition in schizophrenia
    Angela K Sellin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    CNS Spectr 13:985-96. 2008
    ..We present an overview of likely side effects of muscarinic agonists. We outline the anticholinergic activity of several available antipsychotics and review the available M1 muscarinic agonists...
  52. ncbi request reprint Neurobiological underpinnings of insight deficits in schizophrenia
    Mujeeb U Shad
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 6363 Forest Park Road, Dallas, TX 75390, USA
    Int Rev Psychiatry 19:437-46. 2007
    ..Using published and preliminary data, we propose a hypothetical model of insight that may help initiate neurobiological investigations in this complex area...
  53. pmc The GABAβ receptor as a target for antidepressant drug action
    Subroto Ghose
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Br J Pharmacol 162:1-17. 2011
    ..Together with the earlier preclinical studies, these new data point to a role for the GABA(B) system in major depression and support the antidepressant potential of GABA(B) receptor antagonists...
  54. ncbi request reprint Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary
    Elena I Ivleva
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75235, USA
    Neurosci Biobehav Rev 34:897-921. 2010
    ..Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed...
  55. pmc In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:1042-6. 2009
    ..03-ppm peaks, assuming identical T(1) and T(2) between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 +/- 0.2 (mean +/- SD; N = 6)...
  56. pmc A framework on surface-based connectivity quantification for the human brain
    Hao Huang
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, United States
    J Neurosci Methods 197:324-32. 2011
    ....
  57. pmc Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T
    Abhishek Banerjee
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 68:325-31. 2012
    ..The Gly concentrations in pure GM and white matter were estimated to be 1.1 and 0.1 mM, with 95% confidence intervals 1.0-1.2 and 0.0-0.2, respectively...
  58. pmc Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia
    Subroto Ghose
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9127, USA
    Schizophr Res 111:131-7. 2009
    ..These data suggest that NAAG-mediated signaling is disrupted in the AH in schizophrenia and localize the defect to the CA1 and CA3 regions...
  59. ncbi request reprint The science of antipsychotics: mechanistic insight
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    CNS Spectr 8:5-9. 2003
    ..Understanding the differences in mechanisms of action of new antipsychotics will allow physicians to better choose treatment that meets the needs of each individual patient...
  60. ncbi request reprint Insight and frontal cortical function in schizophrenia: a review
    Mujeeb U Shad
    University of Texas Southwestern Medical Center at Dallas, TX, USA
    Schizophr Res 86:54-70. 2006
    ..This review will discuss the implications of these findings and directions for future research...
  61. ncbi request reprint Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cell 131:391-404. 2007
    ....
  62. doi request reprint Neural correlates of successful response inhibition in unmedicated patients with late-life depression
    David S Bobb
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Geriatr Psychiatry 20:1057-69. 2012
    ..In this study, we compared brain activation between a group of unmedicated participants with LLD and an unmedicated healthy cohort during SST performance...
  63. pmc Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder
    Aybala Saricicek
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Am J Psychiatry 169:851-9. 2012
    ..To understand its molecular basis, the authors also studied β2*-nAChR binding in postmortem brain samples from depressed subjects...
  64. pmc Brief report: Insight into illness and social attributional style in Asperger's syndrome
    Nyaz Didehbani
    Center for BrainHealth, The University of Texas at Dallas, 2200 W Mockingbird Lane, Dallas, TX 75235, USA
    J Autism Dev Disord 42:2754-60. 2012
    ..Results revealed that EB was negatively correlated with insight as assessed with the clinician-administered but not the self-administered measure of insight...
  65. pmc A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8849, USA
    J Affect Disord 150:551-8. 2013
    ..We examined whether phenytoin attenuated the effects of hydrocortisone on declarative memory. Functional magnetic resonance imaging (fMRI) assessed task-related hippocampal activation...
  66. ncbi request reprint Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression
    Ghanshyam N Pandey
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    J Psychiatr Res 37:421-32. 2003
    ....
  67. ncbi request reprint [(3)H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Am J Psychiatry 159:66-73. 2002
    ..To examine the role of this enzyme in suicidal behavior, the authors examined the catalytic and regulatory activities of protein kinase A in the postmortem brain of suicide victims...
  68. ncbi request reprint Regional expression of RGS4 mRNA in human brain
    Holly A Erdely
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Eur J Neurosci 19:3125-8. 2004
    ..In conclusion, RGS4 mRNA distribution in human postmortem tissue from normal persons was very dense in most cortical layers examined, with lower density in the basal ganglia and thalamus...
  69. ncbi request reprint Cerebellar Purkinje cell loss in aging Hu-Bcl-2 transgenic mice
    Hadi Zanjani
    Lab Développement et Vieillissement du Système Nerveux DVSN, UMR NPA 7102 Centre National de la Recherche Scientifique and Université Pierre and Marie Curie, 75005 Paris, France
    J Comp Neurol 475:481-92. 2004
    ....
  70. ncbi request reprint The Lurcher mouse: fresh insights from an old mutant
    Michael W Vogel
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Brain Res 1140:4-18. 2007
    ....
  71. ncbi request reprint Regional alterations in RGS4 protein in schizophrenia
    Holly A Erdely
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Synapse 59:472-9. 2006
    ..Measurement of protein levels using Western blot demonstrated that RGS4 protein is decreased in the frontal cortex of schizophrenia cases...
  72. pmc Desire, disease, and the origins of the dopaminergic system
    Roy V Sillitoe
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Schizophr Bull 34:212-9. 2008
    ....
  73. ncbi request reprint Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments
    Mikhail V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:108-23. 2002
    ..The present data provide new insights into the pathogenic events that lead to differential responses to pharmacological treatments in genetically different animals following exposure to the same environmental challenge...
  74. ncbi request reprint Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits
    Mikhail V Pletnikov
    Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:97-107. 2002
    ..The present data demonstrate that the same environmental insult can produce differential neuroanatomical and behavioral abnormalities in genetically different inbred rat strains...
  75. ncbi request reprint Oxidative stress, nitric oxide, and the mechanisms of cell death in Lurcher Purkinje cells
    Rebecca McFarland
    Department of Biology, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Dev Neurobiol 67:1032-46. 2007
    ....
  76. ncbi request reprint Survival of interneurons and parallel fiber synapses in a cerebellar cortex deprived of Purkinje cells: studies in the double mutant mouse Grid2Lc/+;Bax(-/-)
    S Hadi Zanjani
    Equipe Développement et Vieillissement du Système Nerveux, UMR NPA 7102 CNRS et Univ P and M Curie, 75005 Paris, France
    J Comp Neurol 497:622-35. 2006
    ....
  77. ncbi request reprint Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum
    Mikhail V Ovanesov
    Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 13:185-94. 2007
    ..The present data are the first in vivo evidence that GLU excitotoxicity might contribute to BDV-associated neuronal injury in the striatum...
  78. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  79. pmc Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:16. 2008
    ..The data demonstrate for the first time that a non-lytic persistent virus infection of neurons activates microglia long before any measurable neuronal loss...
  80. ncbi request reprint Cell death, Bcl-2, Bax, and the cerebellum
    Michael W Vogel
    Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA
    Cerebellum 1:277-87. 2002
    ....

Research Grants30

  1. PARTIAL DOPAMINE AGONISTS IN TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 1992
    ....
  2. Examination of the Limbic Cortex in Schizophrenia
    Carol Tamminga; Fiscal Year: 2006
    ..These data will have implications for understanding the mechanisms of the illness and for directing future new drug discovery for schizophrenia therapeutics. ..
  3. Comparitive Antipsychotic Drug Actions on Brain Neuroche
    Carol Tamminga; Fiscal Year: 2006
    ..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
  4. Psychiatric Research Education Program(PREP)
    Carol Tamminga; Fiscal Year: 2007
    ..Together, these features place the UTSWMC Department of Psychiatry in an ideal position to stimulate and train the next generation of basic and clinical psychiatric researchers. ..
  5. Comparitive Antipsychotic Drug Actions on Brain Neurochemistry
    Carol Tamminga; Fiscal Year: 2007
    ..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
  6. Treating Cognition in Schizophrenia
    Carol Tamminga; Fiscal Year: 2007
    ....
  7. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Carol Tamminga; Fiscal Year: 2007
    ....
  8. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Carol Tamminga; Fiscal Year: 2009
    ....
  9. Antipsychotic Influence on Altered MTL Neuronal Activity in Schizophrenia
    Carol Tamminga; Fiscal Year: 2009
    ..We propose to test the elements of this model with in vivo brain imaging using measures of basal activity and relational memory probes, correlating alterations in neural activity with characteristics of the illness. ..
  10. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Carol A Tamminga; Fiscal Year: 2010
    ....
  11. Comparitive Antipsychotic Drug Actions on Brain Neuroche
    Carol Tamminga; Fiscal Year: 2005
    ..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
  12. Examination of the Limbic Cortex in Schizophrenia
    Carol Tamminga; Fiscal Year: 2005
    ..These data will have implications for understanding the mechanisms of the illness and for directing future new drug discovery for schizophrenia therapeutics. ..
  13. PARTIAL DOPAMINE AGONISTS IN TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 1993
    ....
  14. PARTIAL DOPAMINE AGONIST TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 2000
    ..These data will predict and later help us to select optimal agonist intrinsic activity ior clinical testing for antipsychotic actvity, duration of therapeutic action, and side effects. ..
  15. PARTIAL DOPAMINEAGONIST TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 2001
    ..These data will predict and later help us to select optimal agonist intrinsic activity ior clinical testing for antipsychotic actvity, duration of therapeutic action, and side effects. ..
  16. Examination of the Limbic Cortex in Schizophrenia
    Carol Tamminga; Fiscal Year: 2002
    ..These data will have implications for understanding the mechanisms of the illness and for directing future new drug discovery for schizophrenia therapeutics. ..
  17. PARTIAL DOPAMINEAGONIST TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 2002
    ..These data will predict and later help us to select optimal agonist intrinsic activity ior clinical testing for antipsychotic actvity, duration of therapeutic action, and side effects. ..
  18. Examination of the Limbic Cortex in Schizophrenia
    Carol Tamminga; Fiscal Year: 2004
    ..These data will have implications for understanding the mechanisms of the illness and for directing future new drug discovery for schizophrenia therapeutics. ..
  19. Antipsychotic Drug Actions on Brain Neurochemistry
    Carol Tamminga; Fiscal Year: 2003
    ..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
  20. Examination of the Limbic Cortex in Schizophrenia
    Carol Tamminga; Fiscal Year: 2003
    ..These data will have implications for understanding the mechanisms of the illness and for directing future new drug discovery for schizophrenia therapeutics. ..
  21. Comparitive Antipsychotic Drug Actions on Brain Neuroche
    Carol Tamminga; Fiscal Year: 2004
    ..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
  22. Antipsychotic Influence on Altered MTL Neuronal Activity in Schizophrenia
    Carol A Tamminga; Fiscal Year: 2010
    ..We propose to test the elements of this model with in vivo brain imaging using measures of basal activity and relational memory probes, correlating alterations in neural activity with characteristics of the illness. ..