WILLIAM contact TALMAN

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles
    Jennifer A Hobin
    Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA
    J Transl Med 10:72. 2012
  2. doi request reprint Sudden death following selective neuronal lesions in the rat nucleus tractus solitarii
    William T Talman
    Department of Neurology, Carver College of Medicine University of Iowa and Veterans Affairs Healthcare System, Iowa City, IA, United States Electronic address
    Auton Neurosci 175:9-16. 2013
  3. ncbi request reprint Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat
    William T Talman
    Department of Neurology, Carver College of Medicine, University of Iowa and Department of Veterans Affairs Medical Center, Iowa, IA 52242, USA
    Cell Mol Neurobiol 32:1119-26. 2012
  4. doi request reprint Views of translational research from a somewhat translational scientist
    William T Talman
    Laboratory of Neurobiology, Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Investig Med 60:863-8. 2012
  5. pmc Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat
    Li Hsien Lin
    Laboratory of Neurobiology, Department of Neurology, Roy and Lucille Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Physiol 590:3545-59. 2012
  6. ncbi request reprint Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase
    William T Talman
    Department of Neurology, Laboratory of Neurobiology, VAMC and University of Iowa, Iowa City, IA 52242, USA
    Hypertension 43:820-4. 2004
  7. pmc Parasympathetic stimulation elicits cerebral vasodilatation in rat
    William T Talman
    Laboratory of Neurobiology, Department of Neurology, VAMC and Carver College of Medicine, University of Iowa, Iowa City, IA 52246, USA
    Auton Neurosci 133:153-7. 2007
  8. pmc Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension
    William T Talman
    Laboratory of Neurobiology, Department of Neurology, VAHCS, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Brain Res 1139:126-32. 2007
  9. ncbi request reprint Glutamatergic transmission in the nucleus tractus solitarii: from server to peripherals in the cardiovascular information superhighway
    W T Talman
    Department of Neurology, Veterans Affairs Medical Center, University of Iowa, Iowa City 52242, USA
    Braz J Med Biol Res 30:1-7. 1997
  10. ncbi request reprint Inhibiting the nucleus tractus solitarii extends cerebrovascular autoregulation during hypertension
    William T Talman
    Laboratory of Neurobiology, Department of Neurology and Neuroscience, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    Brain Res 931:92-5. 2002

Research Grants

  1. Neurogenic Cardiac Damage and Sudden Death
    WILLIAM TALMAN; Fiscal Year: 2009
  2. Cardiovascular Response to Glutamate Nitric Oxide
    WILLIAM TALMAN; Fiscal Year: 2006
  3. CARDIOVASCULAR RESPONSE TO GLUTAMATE NITRIC OXIDE
    WILLIAM TALMAN; Fiscal Year: 2002
  4. Neurogenic Cardiac Damage and Sudden Death
    WILLIAM contact TALMAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications35

  1. pmc Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles
    Jennifer A Hobin
    Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA
    J Transl Med 10:72. 2012
    ....
  2. doi request reprint Sudden death following selective neuronal lesions in the rat nucleus tractus solitarii
    William T Talman
    Department of Neurology, Carver College of Medicine University of Iowa and Veterans Affairs Healthcare System, Iowa City, IA, United States Electronic address
    Auton Neurosci 175:9-16. 2013
    ..Thus, the effect of the toxins may depend on an action of SAP independent of the effects of the SAP conjugates on targeted neuronal types...
  3. ncbi request reprint Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat
    William T Talman
    Department of Neurology, Carver College of Medicine, University of Iowa and Department of Veterans Affairs Medical Center, Iowa, IA 52242, USA
    Cell Mol Neurobiol 32:1119-26. 2012
    ..Thus, cardiac and cardiovascular effects of lesions directed toward catecholamine neurons of the NTS are similar to those following damage directed toward NK1 receptor-containing neurons...
  4. doi request reprint Views of translational research from a somewhat translational scientist
    William T Talman
    Laboratory of Neurobiology, Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Investig Med 60:863-8. 2012
    ..Finding treatments, while always an aim of biomedical research, may arise as a result of basic studies that were not originally aimed at a target of translational research...
  5. pmc Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat
    Li Hsien Lin
    Laboratory of Neurobiology, Department of Neurology, Roy and Lucille Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Physiol 590:3545-59. 2012
    ..We suggest that, at the basal state, nNOS is maximally engaged. Thus, its upregulation does not augment the baroreflex...
  6. ncbi request reprint Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase
    William T Talman
    Department of Neurology, Laboratory of Neurobiology, VAMC and University of Iowa, Iowa City, IA 52242, USA
    Hypertension 43:820-4. 2004
    ..These data support the hypothesis and suggest that neuronal nitric oxide synthase is critical to transmission of baroreflex signals through the nucleus tractus solitarii...
  7. pmc Parasympathetic stimulation elicits cerebral vasodilatation in rat
    William T Talman
    Laboratory of Neurobiology, Department of Neurology, VAMC and Carver College of Medicine, University of Iowa, Iowa City, IA 52246, USA
    Auton Neurosci 133:153-7. 2007
    ..In the current study approaching the ganglion through an incision over the zygomatic arch provided clear exposure of the ganglion and stimulation of the ganglion with that approach led to vasodilatation...
  8. pmc Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension
    William T Talman
    Laboratory of Neurobiology, Department of Neurology, VAHCS, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Brain Res 1139:126-32. 2007
    ..These findings further support the hypothesis that NO released from parasympathetic fibers contributes to cerebral vasodilatation during acute hypertension...
  9. ncbi request reprint Glutamatergic transmission in the nucleus tractus solitarii: from server to peripherals in the cardiovascular information superhighway
    W T Talman
    Department of Neurology, Veterans Affairs Medical Center, University of Iowa, Iowa City 52242, USA
    Braz J Med Biol Res 30:1-7. 1997
    ..Work continues concerning GLU signal transduction and mechanisms that modulate that transduction both at the NTS and at other cardiovascular nuclei...
  10. ncbi request reprint Inhibiting the nucleus tractus solitarii extends cerebrovascular autoregulation during hypertension
    William T Talman
    Laboratory of Neurobiology, Department of Neurology and Neuroscience, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    Brain Res 931:92-5. 2002
    ..In treated rats, injections of lidocaine into the nucleus tractus solitarii blocked breakthrough and the baroreflex. Therefore, central, like peripheral, baroreflex interruption extends autoregulation during hypertension...
  11. ncbi request reprint Parasympathetic nerves influence cerebral blood flow during hypertension in rat
    W T Talman
    Department of Neurology, University of Iowa and Department of Veterans Affairs Medical Center, Iowa City 52242, USA
    Brain Res 873:145-8. 2000
    ..Acutely hypertensive denervated animals developed significantly less cerebral vasodilatation than did control animals with intact nerves. Thus, parasympathetic vasodilator nerves contribute to vasodilatation seen with acute hypertension...
  12. ncbi request reprint Nitroxidergic influences on cardiovascular control by NTS: a link with glutamate
    W T Talman
    Laboratory of Neurobiology, Department of Neurology and Neuroscience Program, University of Iowa, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Ann N Y Acad Sci 940:169-78. 2001
    ..These studies support a role for nitroxidergic neurons in mediating cardiovascular and other visceral reflex responses that result from release of GLU into the NTS...
  13. ncbi request reprint The myth of nitric oxide in central cardiovascular control by the nucleus tractus solitarii
    W T Talman
    Department of Veterans Affairs Medical Center, Iowa City, IA, USA
    Braz J Med Biol Res 30:515-20. 1997
    ..The studies suggest that S-nitrosocysteine, not nitric oxide, may be an interneuronal messenger for cardiovascular neurons in the NTS...
  14. ncbi request reprint Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii
    L H Lin
    Department of Neurology, University of Iowa, Iowa City, IA 52246, USA
    J Chem Neuroanat 29:127-36. 2005
    ..These data support our hypothesis and provide anatomical support for the suggestion that nitroxidergic activation of the NTS involves sGC...
  15. ncbi request reprint Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons
    L H Lin
    Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    J Chem Neuroanat 32:54-64. 2006
    ..These results support our hypothesis and suggest prominent roles of VGLUT2-IR containing neurons and VGLUT3-IR containing neurons in transmitting cardiovascular signals via the ADN to the brain stem...
  16. ncbi request reprint Localization of vesicular glutamate transporters and neuronal nitric oxide synthase in rat nucleus tractus solitarii
    L H Lin
    Department of Neurology, University of Iowa, VAMC 3 278, MS 151, Iowa City, IA 52246, USA
    Neuroscience 123:247-55. 2004
    ..VGluT2-IR positive fibers were also apposed to nNOS-IR positive fibers throughout the NTS. These data support our hypothesis and confirm that glutamatergic fibers in the NTS contain nNOS...
  17. ncbi request reprint Colocalization of GluR1 and neuronal nitric oxide synthase in rat nucleus tractus solitarii neurons
    L H Lin
    Department of Neurology, University of Iowa and Veterans Affairs Medical Center, MS 151, Iowa City, IA 52246, USA
    Neuroscience 106:801-9. 2001
    ....
  18. pmc Identification and localization of cell types that express endothelial and neuronal nitric oxide synthase in the rat nucleus tractus solitarii
    L H Lin
    Department of Neurology, University of Iowa, VAMC 1 10W19, MS 151, Iowa City, IA 52242, USA
    Brain Res 1171:42-51. 2007
    ....
  19. pmc Colocalization of neurokinin-1, N-methyl-D-aspartate, and AMPA receptors on neurons of the rat nucleus tractus solitarii
    L H Lin
    Department of Neurology, University of Iowa, 1191 Medical Laboratories, Iowa City, IA 52242, USA
    Neuroscience 154:690-700. 2008
    ..The data support our hypothesis, provide an anatomical framework for glutamate and SP interactions, and may explain the loss of baroreflexes when NTS neurons, which could respond to glutamate as well as SP, are killed...
  20. pmc Feline immunodeficiency virus as a gene transfer vector in the rat nucleus tractus solitarii
    L H Lin
    Department of Neurology, 1191 ML, University of Iowa, Iowa City, IA 52242, USA
    Cell Mol Neurobiol 30:339-46. 2010
    ..The cell-type specificity of FIV in the NTS may provide a molecular method to study local physiological functions mediated by potential neurotransmitters in the NTS...
  21. ncbi request reprint N-methyl-D-aspartate receptors on neurons that synthesize nitric oxide in rat nucleus tractus solitarii
    L H Lin
    Department of Neurology, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    Neuroscience 100:581-8. 2000
    ....
  22. ncbi request reprint Nitroxidergic neurons in rat nucleus tractus solitarii express vesicular glutamate transporter 3
    L H Lin
    Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    J Chem Neuroanat 29:179-91. 2005
    ..These findings support our hypothesis that neurons and fibers containing VGLUT3 lie in close proximity to those containing nNOS and that both proteins colocalize in some neurons and fibers in the NTS...
  23. ncbi request reprint Hemodynamic effects of L-glutamate in NTS of conscious rats: a possible role of vascular nitrosyl factors
    E Colombari
    Cardiovascular Center, University of Iowa College of Medicine, Iowa City, USA
    Am J Physiol 274:H1066-74. 1998
    ....
  24. ncbi request reprint Neural control of the heart. Central and peripheral
    W T Talman
    Department of Neurology, University of Iowa, Iowa City
    Neurol Clin 11:239-56. 1993
    ..Rapid recognition and appropriate treatment of the cardiac complications as well as the underlying condition are critical for effective management of many such patients...
  25. ncbi request reprint Hemodynamic effects elicited by stimulation of the nucleus tractus solitarii
    M Yin
    Department of Neurology, University of Iowa College of Medicine, Iowa City 52242
    Hypertension 23:I73-7. 1994
    ..This study suggests that NTS neurons exert differential effects on renal, mesenteric, and hindquarter vascular beds and that glutamate-induced regional hemodynamic changes are mediated predominantly through autonomic pathways...
  26. ncbi request reprint NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase
    Deoclecio A Chianca
    Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 286:H1521-7. 2004
    ..This study links sGC with NMDA, but not AMPA or metabotropic, receptors in cardiovascular signal transduction through NTS...
  27. ncbi request reprint Direct projections from the cardiovascular nucleus tractus solitarii to pontine preganglionic parasympathetic neurons: a link to cerebrovascular regulation
    Khristofor Agassandian
    Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Comp Neurol 452:242-54. 2002
    ..Finally, it demonstrates differential innervation of medullary and pontine preganglionic parasympathetic neurons by different regions of the nucleus tractus solitarii...
  28. ncbi request reprint Effect of substance P injection into the nucleus tractus solitarius of rats on cricothyroid and thyroarytenoid motor activity and cardiovascular and respiratory systems
    Nancy M Bauman
    Department of Otolaryngology Head and Neck Surgery, University of Iowa College of Medicine, Iowa City 52242, USA
    Ann Otol Rhinol Laryngol 111:875-83. 2002
    ..This model may prove useful in evaluating pharmacological targets of central reflex activity to manage life-threatening laryngeal reflex activity...
  29. ncbi request reprint Coexistence of NMDA and AMPA receptor subunits with nNOS in the nucleus tractus solitarii of rat
    Li Hsien Lin
    Veterans Affairs Medical Center, Department of Neurology, University of Iowa, 3 278, MS 151, Iowa City 52246, USA
    J Chem Neuroanat 24:287-96. 2002
    ..In addition, these data provide support for an anatomical link between ionotropic glutamate receptors and nitric oxide in the NTS...
  30. ncbi request reprint Ablation of NK1 receptors in rat nucleus tractus solitarii blocks baroreflexes
    Jeffrey Riley
    Laboratory of Neurobiology, Department of Neurology, University of Iowa and Veterans Affairs Medical Center, Iowa City 52242, USA
    Hypertension 40:823-6. 2002
    ..When the toxin had been injected bilaterally, the baroreflex gain was significantly reduced. Therefore, neurons that express SP receptors play a critical role in mediating baroreflexes through the nucleus tractus solitarii of rat...
  31. ncbi request reprint Evidence for a glutamatergic input to pontine preganglionic neurons of the superior salivatory nucleus in rat
    Li Hsien Lin
    Department of Neurology, University of Iowa and Veterans Affairs Medical Center, VAMC 3 278, MS 151, Iowa City, IA 52242, USA
    J Chem Neuroanat 25:261-8. 2003
    ..They further provide support for the suggestion that there are glutamatergic inputs to SSN neurons and would be consistent with an excitatory input that could regulate cerebrovascular tone...
  32. ncbi request reprint A novel central pathway links arterial baroreceptors and pontine parasympathetic neurons in cerebrovascular control
    Khristofor Agassandian
    Laboratory of Neurobiology, Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    Cell Mol Neurobiol 23:463-78. 2003
    ..Further study is needed to clarify the role this pathway plays in integrative physiology...
  33. ncbi request reprint Glutamate and blood pressure in multiple system atrophy
    William T Talman
    Clin Auton Res 13:239-41. 2003
  34. ncbi request reprint Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotension
    Ronald G Victor
    Donald W Reynolds Clinical Cardiovascular Research Center, Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235 8586, USA
    Am J Med 112:361-8. 2002
    ....
  35. ncbi request reprint NO and central cardiovascular control: a simple molecule with a complex story
    William T Talman
    Hypertension 48:552-4. 2006

Research Grants11

  1. Neurogenic Cardiac Damage and Sudden Death
    WILLIAM TALMAN; Fiscal Year: 2009
    ..Therefore, the studies could lead to translational clinical studies of treatments aimed at those mechanisms and thus at a major source of morbidity and mortality in affected humans. ..
  2. Cardiovascular Response to Glutamate Nitric Oxide
    WILLIAM TALMAN; Fiscal Year: 2006
    ..e. on nNOS immunoreactive dendrites or neurons in NTS. ..
  3. CARDIOVASCULAR RESPONSE TO GLUTAMATE NITRIC OXIDE
    WILLIAM TALMAN; Fiscal Year: 2002
    ....
  4. Neurogenic Cardiac Damage and Sudden Death
    WILLIAM contact TALMAN; Fiscal Year: 2010
    ..Therefore, the studies could lead to translational clinical studies of treatments aimed at those mechanisms and thus at a major source of morbidity and mortality in affected humans. ..