J E Talmadge

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint American Society of Hematology--48th Annual Meeting and Exposition. Treatments for leukemia and lymphoma. 9-12 December 2006 Orlando, FL, USA
    James E Talmadge
    University of Nebraska Medical Center, Laboratory of Transplantation Immunology Department of Pathology and Microbiology 985660, Omaha, NE 68198 5660, USA
    IDrugs 10:87-9. 2007
  2. ncbi request reprint Inflammatory cell infiltration of tumors: Jekyll or Hyde
    James E Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Cancer Metastasis Rev 26:373-400. 2007
  3. ncbi request reprint Lymphocyte subset recovery following allogeneic bone marrow transplantation: CD4(+)-cell count and transplant-related mortality
    J E Talmadge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Bone Marrow Transplant 41:19-21. 2008
  4. ncbi request reprint Clonal selection of metastasis within the life history of a tumor
    James E Talmadge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7660, USA
    Cancer Res 67:11471-5. 2007
  5. ncbi request reprint Gene therapy of cancer - 12th International Conference
    James E Talmadge
    University of Nebraska Medical Center, Laboratory of Transplantation Immunology, Department of Pathology and Microbiology 985660, Omaha, NE 68198 5660, USA
    IDrugs 7:100-4. 2004
  6. doi request reprint Follistatin as an inhibitor of experimental metastasis
    James E Talmadge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7660, USA
    Clin Cancer Res 14:624-6. 2008
  7. ncbi request reprint Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity
    James Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, South 42nd Street, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 4:1757-73. 2004
  8. ncbi request reprint Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy
    James E Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7660, USA
    Clin Cancer Res 13:5243-8. 2007
  9. ncbi request reprint Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion
    James E Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, 987660, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 7:140-51. 2007
  10. pmc Murine models to evaluate novel and conventional therapeutic strategies for cancer
    James E Talmadge
    University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Am J Pathol 170:793-804. 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint American Society of Hematology--48th Annual Meeting and Exposition. Treatments for leukemia and lymphoma. 9-12 December 2006 Orlando, FL, USA
    James E Talmadge
    University of Nebraska Medical Center, Laboratory of Transplantation Immunology Department of Pathology and Microbiology 985660, Omaha, NE 68198 5660, USA
    IDrugs 10:87-9. 2007
  2. ncbi request reprint Inflammatory cell infiltration of tumors: Jekyll or Hyde
    James E Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Cancer Metastasis Rev 26:373-400. 2007
    ..Within this review, we discuss the role of tumor infiltrating, myeloid-monocytic cells, and T lymphocytes, as well as their potential for tumor control, immunosuppression, and facilitation of metastasis...
  3. ncbi request reprint Lymphocyte subset recovery following allogeneic bone marrow transplantation: CD4(+)-cell count and transplant-related mortality
    J E Talmadge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Bone Marrow Transplant 41:19-21. 2008
  4. ncbi request reprint Clonal selection of metastasis within the life history of a tumor
    James E Talmadge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7660, USA
    Cancer Res 67:11471-5. 2007
  5. ncbi request reprint Gene therapy of cancer - 12th International Conference
    James E Talmadge
    University of Nebraska Medical Center, Laboratory of Transplantation Immunology, Department of Pathology and Microbiology 985660, Omaha, NE 68198 5660, USA
    IDrugs 7:100-4. 2004
    ..Adenoviruses were the predominating viral vector, although pox viral, herpes simplex viral, retroviral and lentiviral vectors were also used...
  6. doi request reprint Follistatin as an inhibitor of experimental metastasis
    James E Talmadge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7660, USA
    Clin Cancer Res 14:624-6. 2008
  7. ncbi request reprint Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity
    James Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, South 42nd Street, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 4:1757-73. 2004
    ..In summary, these studies revealed significant hematopoietic activity by both pharmacologic and molecular analysis using a >99% pure carbohydrate fraction from Aloe vera gels...
  8. ncbi request reprint Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy
    James E Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7660, USA
    Clin Cancer Res 13:5243-8. 2007
    ..We also focus on the relationship between MDSCs, tumor growth, therapeutic responses, and the mechanisms of cellular expansion, activation, and immunosuppression...
  9. ncbi request reprint Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion
    James E Talmadge
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, 987660, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 7:140-51. 2007
    ..In summary, our results suggest that celecoxib chemoprevention of autochthonous intestinal tumors can regulate IMSCs and CD4(+) T cell numbers...
  10. pmc Murine models to evaluate novel and conventional therapeutic strategies for cancer
    James E Talmadge
    University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Am J Pathol 170:793-804. 2007
    ....
  11. ncbi request reprint Potential for cytokine and product manipulation to improve the results of autologous stem cell transplantation for rheumatoid arthritis
    J E Talmadge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 7660, USA
    J Rheumatol Suppl 64:32-8. 2001
    ..These observations suggest the potential for immune regulation using stem cell manipulation or posttransplant cytokine administration as therapeutic strategies for autoimmune/inflammatory diseases...
  12. ncbi request reprint Mechanisms of immune dysfunction in stem cell transplantation
    J E Talmadge
    Department of Pathology and Microbiology, University of Nebraska, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Int J Immunopharmacol 22:1041-56. 2000
    ..Therefore, there is the potential to regulate immune recovery by stem cell product manipulation or post-transplantation cytokine administration...
  13. ncbi request reprint Hematopoietic stem cell graft manipulation as a mechanism of immunotherapy
    James E Talmadge
    Nebraska Medical Center, University of Nebraska Medical Center 987660, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 3:1121-43. 2003
    ....
  14. ncbi request reprint Spleen but not tumor infiltration by dendritic and T cells is increased by intravenous adenovirus-Flt3 ligand injection
    J C Solheim
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cancer Gene Ther 14:364-71. 2007
    ..In addition, we noted tumor and Adv-Flt3L expansion of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs), which may inhibit the therapeutic efficacy of Adv-Flt3L-expanded DCs...
  15. ncbi request reprint Immune dysfunction despite high levels of immunoregulatory cytokine gene expression in autologous peripheral blood stem cell transplanted non-Hodgkin's lymphoma patients
    R K Singh
    Department of Pathology and Microbiology, and, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Exp Hematol 28:499-507. 2000
    ..In the present studies, we examined the role of immunoregulatory cytokine gene expression in immune reconstitution following high-dose chemotherapy and peripheral stem cell transplantation...
  16. doi request reprint Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells
    Moses K Donkor
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 9:937-48. 2009
    ..MDSCs are also directly associated with VEGF-A and G-CSF transcript levels suggesting multiple mechanisms for MDSC regulation and COX-2, NOS-2 and ARG-1 supporting multiple mechanisms of T-cell suppression...
  17. ncbi request reprint Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation
    Jehad H Edwan
    Department of Medical Microbiology and Immunology, and Center for Allergy, Asthma, and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Immunol 172:5016-23. 2004
    ..These data suggest that Flt3-L can reverse allergic airway inflammation and associated changes in pulmonary functions in murine asthma model...
  18. ncbi request reprint Treatment with Flt3 ligand plasmid reverses allergic airway inflammation in ovalbumin-sensitized and -challenged mice
    Jehad H Edwan
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, CRISS I Room 131, 2500 California Plaza, Omaha, NE 68178, USA
    Int Immunopharmacol 5:345-57. 2005
    ..05). Total BALF cellularity, eosinophiles counts and BALF IL-5 levels were also reduced (P<0.01). pUMVC3-hFLex treatment can reverse established experimental asthma and might provide a novel approach for treating asthma...
  19. ncbi request reprint Flt3 ligand bioactivity and pharmacology in neoplasia
    A J Reber
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Curr Drug Targets Immune Endocr Metabol Disord 4:149-56. 2004
    ..This review focuses on the effects of Flt3L on DCs and other effector populations, and on its potential activity as a therapeutic agent for cancer, alone and in combination with vaccines...
  20. ncbi request reprint Use of matrix metalloproteinase (MMP)-9 knockout mice demonstrates that MMP-9 activity is not absolutely required for G-CSF or Flt-3 ligand-induced hematopoietic progenitor cell mobilization or engraftment
    Simon N Robinson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    Stem Cells 21:417-27. 2003
    ....
  21. doi request reprint Models of metastasis in drug discovery
    James E Talmadge
    University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Biol 602:215-33. 2010
    ..In this chapter, we provide protocols for models of metastasis that can be used in translational and drug discovery studies...
  22. ncbi request reprint Flt3 ligand and conjugation to IL-1beta peptide as adjuvants for a type 1, T-cell response to an HIV p17 gag vaccine
    Vladimir M Pisarev
    Laboratory of Transplantation Immunology, Department of Pathology Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Vaccine 20:2358-68. 2002
    ..This suggests that a combination adjuvant strategy using Flt3L and conjugation to a biologically active IL-1beta fragment may be used to preferentially increase type 1 T-cell and CTL responses to HIV-1 gag antigenic epitopes...
  23. pmc Immune reconstitution after autologous hematopoietic transplantation with Lin-, CD34+, Thy-1lo selected or intact stem cell products
    Rakesh K Singh
    Department of Pathology and Microbiology, University of Nebraska Medical Center 987660, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 7:1033-43. 2007
    ....
  24. ncbi request reprint Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells
    R Lee Mosley
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 7660, USA
    Int Immunopharmacol 2:925-40. 2002
    ....
  25. ncbi request reprint Monocyte/macrophage recruitment, activation and differentiation modulate interleukin-8 production: a paracrine role of tumor-associated macrophages in tumor angiogenesis
    Michelle L Varney
    Department of Pathology and Microbiology, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    In Vivo 16:471-7. 2002
    ....
  26. ncbi request reprint Sustained release of growth factors
    Simon N Robinson
    Department of Genetics, Cell Biology and Anatomy, 986395 University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
    In Vivo 16:535-40. 2002
    ..In addition to improving the pharmacokinetic and pharmacodynamic profile of recombinant molecules, sustained release may also increase the biological activity of the molecules...
  27. ncbi request reprint Lymphodepleting effects and safety of pentostatin for nonmyeloablative allogeneic stem-cell transplantation
    Steven Z Pavletic
    Department of Internal Medicine, Section of Oncology Hematology, University of Nebraska Medical Center, Omaha, NE, USA
    Transplantation 76:877-81. 2003
    ..5% donor CD3 lymphocytes. PT demonstrated lymphodepleting effects and promising safety, supporting alloNST as early as 7 days after initiation of PT...
  28. ncbi request reprint Delivery of Flt3 ligand (Flt3L) using a poloxamer-based formulation increases biological activity in mice
    S N Robinson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6395, USA
    Bone Marrow Transplant 31:361-9. 2003
    ..The observation of increased bioactivity by PG-Flt3L in rodents suggests the potential for improved clinical efficacy of Flt3L by reducing the time required for HPC mobilization...
  29. ncbi request reprint CCL21 is an effective surgical neoadjuvant for treatment of mammary tumors
    Abdelkader E Ashour
    Eppley Institute, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cancer Biol Ther 6:1206-10. 2007
    ..Overall, our indings suggest that intratumoral administration of CCL21 has potential as a neoadjuvant mmunotherapy for breast cancer...
  30. doi request reprint Closing the manufacturing process of dendritic cell vaccines transduced with adenovirus vectors
    Dumrul Gulen
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States
    Int Immunopharmacol 8:1728-36. 2008
    ..4+3.8%. We conclude that it is possible to efficiently manufacture Adv transduced DCs using a functionally closed system...
  31. ncbi request reprint Activity of acetyl-Ser-Asp-Lys-Pro (AcSDKP) on human hematopoietic progenitor cells in short-term and long-term bone marrow cultures
    J D Jackson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 6495, USA
    J Hematother Stem Cell Res 9:489-96. 2000
    ..These results will aid in determining kinetic properties of AcSDKP for the development of clinical protocols to protect normal human hematopoietic stem and progenitor cells following cycle-specific chemotherapy agents...
  32. ncbi request reprint Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model
    D K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int Immunopharmacol 1:2081-9. 2001
    ..However, there was no change in BAL fluid IL-4 and serum IgE levels. These data suggest that FL treatment prevents ovalbumin-induced asthma in the mouse and may provide a useful adjuvant in the treatment of human asthma...
  33. ncbi request reprint CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity
    Heth R Turnquist
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int J Oncol 30:631-9. 2007
    ....
  34. ncbi request reprint Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival
    Zhengtang Chen
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5845, USA
    Cancer Res 65:9004-11. 2005
    ..In summary, our data show that inhibition of VEGF-C expression using siRNA-mediated gene silencing vectors reduces lymphangiogenesis and lymph node and spontaneous lung metastasis, and enhances survival...
  35. ncbi request reprint Flt3 ligand delivered in a pluronic formulation prolongs the survival of mice with orthotopic pancreatic adenocarcinoma
    Abdelkader E Ashour
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Cancer Biother Radiopharm 22:235-8. 2007
    ..Overall, these observations suggest that Flt3L formulated in ProGelz may have potential clinical utility as a treatment for pancreatic cancer...
  36. doi request reprint Therapeutic activity of sunitinib for Her2/neu induced mammary cancer in FVB mice
    Fuminori Abe
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 10:140-5. 2010
    ..Based on these results, we suggest that sunitinib reduction of immune suppressive cells is a critical part of its adjuvant immune therapeutic activity...
  37. doi request reprint Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice
    Fuminori Abe
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Cancer Immunol Immunother 59:47-62. 2010
    ..Together our results support a role for MDSCs in tumor initiation and progressive, T-cell depression and loss of function provide evidence which support multiple mechanisms of MDSC expansion in a site-dependent manner...
  38. ncbi request reprint CCL21-induced immune cell infiltration
    Abdelkader E Ashour
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int Immunopharmacol 7:272-6. 2007
    ..Furthermore, at 4 days small lymphoid-like structures were visible in the injection areas. These results provide guidance for the optimal timing of CCL21 use in combination with vaccines...
  39. pmc AACR centennial series: the biology of cancer metastasis: historical perspective
    James E Talmadge
    The University of Nebraska Medical Center, Transplantation Immunology Laboratory, Omaha, Nebraska, USA
    Cancer Res 70:5649-69. 2010
    ....
  40. ncbi request reprint Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency
    Richard K Gilroy
    Department of Pediatric Hematology Oncology, University of Nebraska Medical Center, 982168 Nebraska Medical Center, Omaha, NE 68198 2168, USA
    Blood 103:1171-4. 2004
    ..We postulate that he has engrafted a donor intestine-derived immune system and is incapable of rejecting his engrafted organs...
  41. ncbi request reprint Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice
    Yasushi Sawanobori
    Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Blood 111:5457-66. 2008
    ..Overall, our data established the identity and dynamics of MDSCs in a tumor-bearing host mediated by chemokines and elucidated unexpected effects of the paucity of macrophages on tumor development...
  42. ncbi request reprint Effect of granulocyte colony-stimulating factor on bone metabolism during peripheral blood stem cell mobilization
    Tsutomu Watanabe
    Department of Pediatrics, University of Tokushima School of Medicine, Tokushima, Japan
    Int J Hematol 77:75-81. 2003
    ..This result suggests that bone resorption is either directly or indirectly related to the mobilization of PBSC by G-CSF...
  43. ncbi request reprint Regional, but not systemic recruitment/expansion of dendritic cells by a pluronic-formulated Flt3-ligand plasmid with vaccine adjuvant activity
    Hongxun Sang
    International Joint Cancer Institute of Shanghai, Xijing Hospital, Xi an 710032, PR China
    Vaccine 21:3019-29. 2003
    ....
  44. ncbi request reprint Murine mammary adenocarcinoma cells transfected with p53 and/or Flt3L induce antitumor immune responses
    Hongxun Sang
    International Joint Cancer Institute of Shanghai and Institute of Orthopaedics, Xijing Hospital, Xi an 710032, PR China
    Cancer Gene Ther 12:427-37. 2005
    ..We suggest that immunization with DCs transfected with the Flt3L transgene and a tumor Ag may potentially heighten T-cell responses and therapeutic activity...
  45. ncbi request reprint Pharmacokinetics and biodistribution of RGD-targeted doxorubicin-loaded nanoparticles in tumor-bearing mice
    David C Bibby
    Alnis BioSciences Inc, 5764 Shellmound St, Emeryville, CA 94608, USA
    Int J Pharm 293:281-90. 2005
    ..5 and 1.8% of the administered dose at t=48 h, respectively. In contrast to all of the organs studied, the tumors contained high levels of a doxorubicin metabolite...
  46. ncbi request reprint Hematopoietic progenitor cell mobilization in mice by sustained delivery of granulocyte colony-stimulating factor
    Simon N Robinson
    MD Anderson, Texas Medical Center, Houston, TX 77030, USA
    J Interferon Cytokine Res 25:490-500. 2005
    ..In addition, we observed a more rapid trafficking of the PG G-CSF to the marrow, which could also facilitate mobilization...