Research Topics
| J E TalmadgeSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Detail Information
Publications
American Society of Hematology--48th Annual Meeting and Exposition. Treatments for leukemia and lymphoma. 9-12 December 2006 Orlando, FL, USAJames E Talmadge
University of Nebraska Medical Center, Laboratory of Transplantation Immunology Department of Pathology and Microbiology 985660, Omaha, NE 68198-5660, USA
IDrugs 10:87-9. 2007- Lymphocyte subset recovery following allogeneic bone marrow transplantation: CD4(+)-cell count and transplant-related mortalityJ E Talmadge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
Bone Marrow Transplant 41:19-21. 2008 - Clonal selection of metastasis within the life history of a tumorJames E Talmadge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-7660, USA
Cancer Res 67:11471-5. 2007 - Gene therapy of cancer - 12th International ConferenceJames E Talmadge
University of Nebraska Medical Center, Laboratory of Transplantation Immunology, Department of Pathology and Microbiology 985660, Omaha, NE 68198 5660, USA
IDrugs 7:100-4. 2004..Adenoviruses were the predominating viral vector, although pox viral, herpes simplex viral, retroviral and lentiviral vectors were also used... - Follistatin as an inhibitor of experimental metastasisJames E Talmadge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-7660, USA
Clin Cancer Res 14:624-6. 2008 - Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activityJames Talmadge
Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, South 42nd Street, Omaha, NE 68198 7660, USA
Int Immunopharmacol 4:1757-73. 2004..In summary, these studies revealed significant hematopoietic activity by both pharmacologic and molecular analysis using a >99% pure carbohydrate fraction from Aloe vera gels... - Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapyJames E Talmadge
Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7660, USA
Clin Cancer Res 13:5243-8. 2007..We also focus on the relationship between MDSCs, tumor growth, therapeutic responses, and the mechanisms of cellular expansion, activation, and immunosuppression... - Inflammatory cell infiltration of tumors: Jekyll or HydeJames E Talmadge
Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
Cancer Metastasis Rev 26:373-400. 2007..Within this review, we discuss the role of tumor infiltrating, myeloid-monocytic cells, and T lymphocytes, as well as their potential for tumor control, immunosuppression, and facilitation of metastasis... - Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansionJames E Talmadge
Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, 987660, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
Int Immunopharmacol 7:140-51. 2007..In summary, our results suggest that celecoxib chemoprevention of autochthonous intestinal tumors can regulate IMSCs and CD4(+) T cell numbers... 
Murine models to evaluate novel and conventional therapeutic strategies for cancerJames E Talmadge
University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
Am J Pathol 170:793-804. 2007....- Potential for cytokine and product manipulation to improve the results of autologous stem cell transplantation for rheumatoid arthritisJ E Talmadge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 7660, USA
J Rheumatol Suppl 64:32-8. 2001..These observations suggest the potential for immune regulation using stem cell manipulation or posttransplant cytokine administration as therapeutic strategies for autoimmune/inflammatory diseases... - Mechanisms of immune dysfunction in stem cell transplantationJ E Talmadge
Department of Pathology and Microbiology, University of Nebraska, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
Int J Immunopharmacol 22:1041-56. 2000..Therefore, there is the potential to regulate immune recovery by stem cell product manipulation or post-transplantation cytokine administration... - Hematopoietic stem cell graft manipulation as a mechanism of immunotherapyJames E Talmadge
Nebraska Medical Center, University of Nebraska Medical Center 987660, Omaha, NE 68198 7660, USA
Int Immunopharmacol 3:1121-43. 2003.... - Spleen but not tumor infiltration by dendritic and T cells is increased by intravenous adenovirus-Flt3 ligand injectionJ C Solheim
Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
Cancer Gene Ther 14:364-71. 2007..In addition, we noted tumor and Adv-Flt3L expansion of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs), which may inhibit the therapeutic efficacy of Adv-Flt3L-expanded DCs... - Immune dysfunction despite high levels of immunoregulatory cytokine gene expression in autologous peripheral blood stem cell transplanted non-Hodgkin's lymphoma patientsR K Singh
Department of Pathology and Microbiology, and, University of Nebraska Medical Center, Omaha, Nebraska, USA
Exp Hematol 28:499-507. 2000..In the present studies, we examined the role of immunoregulatory cytokine gene expression in immune reconstitution following high-dose chemotherapy and peripheral stem cell transplantation... 
Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cellsMoses K Donkor
Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
Int Immunopharmacol 9:937-48. 2009..MDSCs are also directly associated with VEGF-A and G-CSF transcript levels suggesting multiple mechanisms for MDSC regulation and COX-2, NOS-2 and ARG-1 supporting multiple mechanisms of T-cell suppression...- Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammationJehad H Edwan
Department of Medical Microbiology and Immunology, and Center for Allergy, Asthma, and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
J Immunol 172:5016-23. 2004..These data suggest that Flt3-L can reverse allergic airway inflammation and associated changes in pulmonary functions in murine asthma model... - Treatment with Flt3 ligand plasmid reverses allergic airway inflammation in ovalbumin-sensitized and -challenged miceJehad H Edwan
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, CRISS I Room 131, 2500 California Plaza, Omaha, NE 68178, USA
Int Immunopharmacol 5:345-57. 2005..05). Total BALF cellularity, eosinophiles counts and BALF IL-5 levels were also reduced (P<0.01). pUMVC3-hFLex treatment can reverse established experimental asthma and might provide a novel approach for treating asthma... - Flt3 ligand bioactivity and pharmacology in neoplasiaA J Reber
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
Curr Drug Targets Immune Endocr Metabol Disord 4:149-56. 2004..This review focuses on the effects of Flt3L on DCs and other effector populations, and on its potential activity as a therapeutic agent for cancer, alone and in combination with vaccines... - Use of matrix metalloproteinase (MMP)-9 knockout mice demonstrates that MMP-9 activity is not absolutely required for G-CSF or Flt-3 ligand-induced hematopoietic progenitor cell mobilization or engraftmentSimon N Robinson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
Stem Cells 21:417-27. 2003.... - Models of metastasis in drug discoveryJames E Talmadge
University of Nebraska Medical Center, Omaha, NE, USA
Methods Mol Biol 602:215-33. 2010..In this chapter, we provide protocols for models of metastasis that can be used in translational and drug discovery studies... - Flt3 ligand and conjugation to IL-1beta peptide as adjuvants for a type 1, T-cell response to an HIV p17 gag vaccineVladimir M Pisarev
Laboratory of Transplantation Immunology, Department of Pathology Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
Vaccine 20:2358-68. 2002..This suggests that a combination adjuvant strategy using Flt3L and conjugation to a biologically active IL-1beta fragment may be used to preferentially increase type 1 T-cell and CTL responses to HIV-1 gag antigenic epitopes... - Immune reconstitution after autologous hematopoietic transplantation with Lin-, CD34+, Thy-1lo selected or intact stem cell productsRakesh K Singh
Department of Pathology and Microbiology, University of Nebraska Medical Center 987660, Omaha, NE 68198 7660, USA
Int Immunopharmacol 7:1033-43. 2007.... - Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cellsR Lee Mosley
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 7660, USA
Int Immunopharmacol 2:925-40. 2002.... - Monocyte/macrophage recruitment, activation and differentiation modulate interleukin-8 production: a paracrine role of tumor-associated macrophages in tumor angiogenesisMichelle L Varney
Department of Pathology and Microbiology, 987660 Nebraska Medical Center, Omaha, NE 68198-7660, USA
In Vivo 16:471-7. 2002.... - Sustained release of growth factorsSimon N Robinson
Department of Genetics, Cell Biology and Anatomy, 986395 University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
In Vivo 16:535-40. 2002..In addition to improving the pharmacokinetic and pharmacodynamic profile of recombinant molecules, sustained release may also increase the biological activity of the molecules... - Lymphodepleting effects and safety of pentostatin for nonmyeloablative allogeneic stem-cell transplantationSteven Z Pavletic
Department of Internal Medicine, Section of Oncology Hematology, University of Nebraska Medical Center, Omaha, NE, USA
Transplantation 76:877-81. 2003..5% donor CD3 lymphocytes. PT demonstrated lymphodepleting effects and promising safety, supporting alloNST as early as 7 days after initiation of PT... - Delivery of Flt3 ligand (Flt3L) using a poloxamer-based formulation increases biological activity in miceS N Robinson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-6395, USA
Bone Marrow Transplant 31:361-9. 2003..The observation of increased bioactivity by PG-Flt3L in rodents suggests the potential for improved clinical efficacy of Flt3L by reducing the time required for HPC mobilization... - CCL21 is an effective surgical neoadjuvant for treatment of mammary tumorsAbdelkader E Ashour
Eppley Institute, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
Cancer Biol Ther 6:1206-10. 2007..Overall, our indings suggest that intratumoral administration of CCL21 has potential as a neoadjuvant mmunotherapy for breast cancer... - Closing the manufacturing process of dendritic cell vaccines transduced with adenovirus vectorsDumrul Gulen
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States
Int Immunopharmacol 8:1728-36. 2008..4+3.8%. We conclude that it is possible to efficiently manufacture Adv transduced DCs using a functionally closed system... - Activity of acetyl-Ser-Asp-Lys-Pro (AcSDKP) on human hematopoietic progenitor cells in short-term and long-term bone marrow culturesJ D Jackson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 6495, USA
J Hematother Stem Cell Res 9:489-96. 2000..These results will aid in determining kinetic properties of AcSDKP for the development of clinical protocols to protect normal human hematopoietic stem and progenitor cells following cycle-specific chemotherapy agents... - Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse modelD K Agrawal
Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
Int Immunopharmacol 1:2081-9. 2001..However, there was no change in BAL fluid IL-4 and serum IgE levels. These data suggest that FL treatment prevents ovalbumin-induced asthma in the mouse and may provide a useful adjuvant in the treatment of human asthma... - CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunityHeth R Turnquist
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
Int J Oncol 30:631-9. 2007.... - Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survivalZhengtang Chen
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5845, USA
Cancer Res 65:9004-11. 2005..In summary, our data show that inhibition of VEGF-C expression using siRNA-mediated gene silencing vectors reduces lymphangiogenesis and lymph node and spontaneous lung metastasis, and enhances survival... - Flt3 ligand delivered in a pluronic formulation prolongs the survival of mice with orthotopic pancreatic adenocarcinomaAbdelkader E Ashour
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Cancer Biother Radiopharm 22:235-8. 2007..Overall, these observations suggest that Flt3L formulated in ProGelz may have potential clinical utility as a treatment for pancreatic cancer... - Therapeutic activity of sunitinib for Her2/neu induced mammary cancer in FVB miceFuminori Abe
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
Int Immunopharmacol 10:140-5. 2010..Based on these results, we suggest that sunitinib reduction of immune suppressive cells is a critical part of its adjuvant immune therapeutic activity... - Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic miceFuminori Abe
Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7660, USA
Cancer Immunol Immunother 59:47-62. 2010..Together our results support a role for MDSCs in tumor initiation and progressive, T-cell depression and loss of function provide evidence which support multiple mechanisms of MDSC expansion in a site-dependent manner... - CCL21-induced immune cell infiltrationAbdelkader E Ashour
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Int Immunopharmacol 7:272-6. 2007..Furthermore, at 4 days small lymphoid-like structures were visible in the injection areas. These results provide guidance for the optimal timing of CCL21 use in combination with vaccines... - AACR centennial series: the biology of cancer metastasis: historical perspectiveJames E Talmadge
The University of Nebraska Medical Center, Transplantation Immunology Laboratory, Omaha, Nebraska, USA
Cancer Res 70:5649-69. 2010.... - Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiencyRichard K Gilroy
Department of Pediatric Hematology/Oncology, University of Nebraska Medical Center, 982168 Nebraska Medical Center, Omaha, NE 68198-2168, USA
Blood 103:1171-4. 2004..We postulate that he has engrafted a donor intestine-derived immune system and is incapable of rejecting his engrafted organs... - Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing miceYasushi Sawanobori
Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Blood 111:5457-66. 2008..Overall, our data established the identity and dynamics of MDSCs in a tumor-bearing host mediated by chemokines and elucidated unexpected effects of the paucity of macrophages on tumor development... - Effect of granulocyte colony-stimulating factor on bone metabolism during peripheral blood stem cell mobilizationTsutomu Watanabe
Department of Pediatrics, University of Tokushima School of Medicine, Tokushima, Japan
Int J Hematol 77:75-81. 2003..This result suggests that bone resorption is either directly or indirectly related to the mobilization of PBSC by G-CSF... - Regional, but not systemic recruitment/expansion of dendritic cells by a pluronic-formulated Flt3-ligand plasmid with vaccine adjuvant activityHongxun Sang
International Joint Cancer Institute of Shanghai, Xijing Hospital, Xi'an 710032, PR China
Vaccine 21:3019-29. 2003.... - Murine mammary adenocarcinoma cells transfected with p53 and/or Flt3L induce antitumor immune responsesHongxun Sang
International Joint Cancer Institute of Shanghai and Institute of Orthopaedics, Xijing Hospital, Xi'an 710032, PR China
Cancer Gene Ther 12:427-37. 2005..We suggest that immunization with DCs transfected with the Flt3L transgene and a tumor Ag may potentially heighten T-cell responses and therapeutic activity... - Pharmacokinetics and biodistribution of RGD-targeted doxorubicin-loaded nanoparticles in tumor-bearing miceDavid C Bibby
Alnis BioSciences Inc, 5764 Shellmound St, Emeryville, CA 94608, USA
Int J Pharm 293:281-90. 2005..5 and 1.8% of the administered dose at t=48 h, respectively. In contrast to all of the organs studied, the tumors contained high levels of a doxorubicin metabolite... - Hematopoietic progenitor cell mobilization in mice by sustained delivery of granulocyte colony-stimulating factorSimon N Robinson
MD Anderson, Texas Medical Center, Houston, TX 77030, USA
J Interferon Cytokine Res 25:490-500. 2005..In addition, we observed a more rapid trafficking of the PG G-CSF to the marrow, which could also facilitate mobilization...