Research Topics
Species | P TalkeSummaryAffiliation: University of California Country: USA Publications
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Publications
A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgeryPekka Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143, USA
Anesth Analg 95:430-5, table of contents. 2002....- Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humansPekka Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, 94143, USA
Anesthesiology 99:65-70. 2003..The goal of this study was to profile the peripheral vasoconstrictive effects of a selective alpha(2)-adrenoceptor agonist in isolation from the sympatholytic effects it also induces... - Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in ratsP Talke
Departments of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
Acta Anaesthesiol Scand 47:347-54. 2003..This investigation the compared EMG effects of intrathecally administered dexmedetomidine, MPV-2426 (fadolmidine), and tizanidine in Sprague-Dawley rats, which has not been previously described... - Alpha-2B adrenoceptor polymorphism and peripheral vasoconstrictionPekka Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143 0648, USA
Pharmacogenet Genomics 15:357-63. 2005..This study tested the hypothesis that alpha-2 AR activation will induce enhanced vasoconstriction in carriers of the alpha-2B AR DD genotype, compared to carriers of the II or the DI genotypes... - Effect of peripheral vasoconstriction on pulse oximetryPekka Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
J Clin Monit Comput 20:305-9. 2006..We tested the hypothesis that peripheral vasodilation has an effect on arterial oxygen saturation measurements by pulse oximetry, independent of temperature... - Clonidine-induced vasoconstriction in awake volunteersP O Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
Anesth Analg 93:271-6, 1st contents page. 2001..These data suggest that an alpha-2 agonist with a high alpha-2a/alpha-2b selectivity should provide more profound sedative and analgesic effects with less undesirable vasoconstrictive effects... - The effects of clonidine on human digital vasculatureP O Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143 0648, USA
Anesth Analg 91:793-7. 2000..Our findings suggest that the lower threshold for clonidine-induced vasoconstriction in human digital vasculature is 1.0 ng/mL... - The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheepP O Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
Anesth Analg 90:1060-6. 2000..In conclusion, medetomidine decreased and redistributed organ blood flow in sheep. Atipamezole reversed the medetomidine-induced hemodynamic changes, but redistributed blood flow from the brain, heart, and kidney to the skeletal muscle... - The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgeryP Talke
Departments of Anesthesia, University of California, San Francisco, CA 94143 0648, USA
Anesth Analg 90:834-9. 2000..IMPLICATIONS: The alpha(2) agonist, dexmedetomidine, attenuates increases in heart rate and plasma norepinephrine concentrations during emergence from anesthesia in vascular surgery patients... - Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsyPekka Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 048, USA
J Neurosurg Anesthesiol 19:195-9. 2007..Dexmedetomidine did not reduce seizure focus activity and thus may be a suitable anesthetic adjunct during seizure surgery... - Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteersPekka Talke
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143 0648, USA
Anesthesiology 102:536-42. 2005..The goal of this study was to test the hypothesis that alpha2B-adrenoceptor activation induces enhanced vasoconstriction in carriers of the DD genotype, compared with carriers of the insertion/insertion (II) genotype... - Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humansP Talke
Department of Anesthesia, University of California, San Francisco 94143 0648, USA
Anesth Analg 85:358-64. 1997..Dexmedetomidine had no effect on lumbar cerebrospinal fluid pressure. We will continue to investigate the potential utility of dexmedetomidine for neurosurgical anesthesia... - Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidineP Talke
Department of Anesthesia, University of California, San Francisco 94143 0648, USA
Anesth Analg 85:1136-42. 1997..We also found that heart rate, blood pressure, and plasma catecholamine concentrations decrease during dexmedetomidine infusion... - Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholdsP Talke
Department of Anesthesia, University of California, San Francisco 94143 0648, USA
Anesthesiology 87:835-41. 1997..They also measured the effects of dexmedetomidine on heart rate, blood pressures, and plasma catecholamine concentrations... - Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomyP Talke
Department of Anesthesia, UCSF 94143 0648, USA
Anesthesiology 85:999-1004. 1996..However, the data on the effect of desflurane on intracranial pressure in humans are still limited and inconclusive. The authors hypothesized that isoflurane and desflurane increase intracranial pressure compared with propofol... - Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imagingAlastair J Martin
Department of Radiology, University of California, San Francisco, California 94143, USA
Magn Reson Med 54:1107-14. 2005..0 +/- 0.8 mm (range = 0.1-1.9 mm). All procedures were considered technical successes and there were no intraoperative complications; however, one patient did develop a postoperative infection... - Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracyPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
J Neurosurg 112:479-90. 2010.... - Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomyP Talke
Department of Anesthesia, University of California, San Francisco, 94143 0648, USA
Anesthesiology 91:127-30. 1999..0 MAC end-tidal) of sevoflurane for 10 min each. The authors continuously monitored lumbar cerebrospinal fluid (CSF) pressure, blood pressure, heart rate, and anesthetic concentrations... - Autonomic nervous system responses during sedative infusions of dexmedetomidineCharles W Hogue
Department of Anesthesiology and Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
Anesthesiology 97:592-8. 2002..The purpose of this study was to determine the effects of dexmedetomidine on systemic and cardiac autonomic reflex responses during rest and during thermal stress...