P Talke

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143, USA
    Anesth Analg 95:430-5, table of contents. 2002
  2. ncbi request reprint Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, 94143, USA
    Anesthesiology 99:65-70. 2003
  3. ncbi request reprint Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats
    P Talke
    Departments of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    Acta Anaesthesiol Scand 47:347-54. 2003
  4. ncbi request reprint Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143 0648, USA
    Pharmacogenet Genomics 15:357-63. 2005
  5. ncbi request reprint Effect of peripheral vasoconstriction on pulse oximetry
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    J Clin Monit Comput 20:305-9. 2006
  6. ncbi request reprint Clonidine-induced vasoconstriction in awake volunteers
    P O Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 93:271-6, 1st contents page. 2001
  7. ncbi request reprint The effects of clonidine on human digital vasculature
    P O Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143 0648, USA
    Anesth Analg 91:793-7. 2000
  8. ncbi request reprint The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep
    P O Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 90:1060-6. 2000
  9. ncbi request reprint The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery
    P Talke
    Departments of Anesthesia, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 90:834-9. 2000
  10. ncbi request reprint Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 048, USA
    J Neurosurg Anesthesiol 19:195-9. 2007

Detail Information

Publications19

  1. ncbi request reprint A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143, USA
    Anesth Analg 95:430-5, table of contents. 2002
    ..We conclude that the sequential administration of isoflurane and propofol did not provide earlier recovery and cognition than the intraoperative use of isoflurane alone...
  2. ncbi request reprint Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, 94143, USA
    Anesthesiology 99:65-70. 2003
    ..The goal of this study was to profile the peripheral vasoconstrictive effects of a selective alpha(2)-adrenoceptor agonist in isolation from the sympatholytic effects it also induces...
  3. ncbi request reprint Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats
    P Talke
    Departments of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    Acta Anaesthesiol Scand 47:347-54. 2003
    ..This investigation the compared EMG effects of intrathecally administered dexmedetomidine, MPV-2426 (fadolmidine), and tizanidine in Sprague-Dawley rats, which has not been previously described...
  4. ncbi request reprint Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143 0648, USA
    Pharmacogenet Genomics 15:357-63. 2005
    ..This study tested the hypothesis that alpha-2 AR activation will induce enhanced vasoconstriction in carriers of the alpha-2B AR DD genotype, compared to carriers of the II or the DI genotypes...
  5. ncbi request reprint Effect of peripheral vasoconstriction on pulse oximetry
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    J Clin Monit Comput 20:305-9. 2006
    ..We tested the hypothesis that peripheral vasodilation has an effect on arterial oxygen saturation measurements by pulse oximetry, independent of temperature...
  6. ncbi request reprint Clonidine-induced vasoconstriction in awake volunteers
    P O Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 93:271-6, 1st contents page. 2001
    ..These data suggest that an alpha-2 agonist with a high alpha-2a/alpha-2b selectivity should provide more profound sedative and analgesic effects with less undesirable vasoconstrictive effects...
  7. ncbi request reprint The effects of clonidine on human digital vasculature
    P O Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143 0648, USA
    Anesth Analg 91:793-7. 2000
    ..Our findings suggest that the lower threshold for clonidine-induced vasoconstriction in human digital vasculature is 1.0 ng/mL...
  8. ncbi request reprint The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep
    P O Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 90:1060-6. 2000
    ..In conclusion, medetomidine decreased and redistributed organ blood flow in sheep. Atipamezole reversed the medetomidine-induced hemodynamic changes, but redistributed blood flow from the brain, heart, and kidney to the skeletal muscle...
  9. ncbi request reprint The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery
    P Talke
    Departments of Anesthesia, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 90:834-9. 2000
    ..0002). We conclude that dexmedetomidine attenuates increases in heart rate and plasma norepinephrine concentrations during emergence from anesthesia...
  10. ncbi request reprint Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143 048, USA
    J Neurosurg Anesthesiol 19:195-9. 2007
    ..Dexmedetomidine did not reduce seizure focus activity and thus may be a suitable anesthetic adjunct during seizure surgery...
  11. ncbi request reprint Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers
    Pekka Talke
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143 0648, USA
    Anesthesiology 102:536-42. 2005
    ..The goal of this study was to test the hypothesis that alpha2B-adrenoceptor activation induces enhanced vasoconstriction in carriers of the DD genotype, compared with carriers of the insertion/insertion (II) genotype...
  12. ncbi request reprint Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans
    P Talke
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesth Analg 85:358-64. 1997
    ..We conclude that dexmedetomidine does not have an effect on lumbar CSF pressure in patients with normal intracranial pressure who have undergone transphenoidal pituitary hypophysectomy...
  13. ncbi request reprint Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine
    P Talke
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesth Analg 85:1136-42. 1997
    ..Hemodynamic and catecholamine results suggest that dexmedetomidine attenuates sympathetic activity during the immediate postoperative period...
  14. ncbi request reprint Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds
    P Talke
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesthesiology 87:835-41. 1997
    ..They also measured the effects of dexmedetomidine on heart rate, blood pressures, and plasma catecholamine concentrations...
  15. ncbi request reprint Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy
    P Talke
    Department of Anesthesia, UCSF 94143 0648, USA
    Anesthesiology 85:999-1004. 1996
    ..However, the data on the effect of desflurane on intracranial pressure in humans are still limited and inconclusive. The authors hypothesized that isoflurane and desflurane increase intracranial pressure compared with propofol...
  16. ncbi request reprint Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging
    Alastair J Martin
    Department of Radiology, University of California, San Francisco, California 94143, USA
    Magn Reson Med 54:1107-14. 2005
    ..0 +/- 0.8 mm (range = 0.1-1.9 mm). All procedures were considered technical successes and there were no intraoperative complications; however, one patient did develop a postoperative infection...
  17. pmc Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 112:479-90. 2010
    ....
  18. ncbi request reprint Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy
    P Talke
    Department of Anesthesia, University of California, San Francisco, 94143 0648, USA
    Anesthesiology 91:127-30. 1999
    ..0 MAC end-tidal) of sevoflurane for 10 min each. The authors continuously monitored lumbar cerebrospinal fluid (CSF) pressure, blood pressure, heart rate, and anesthetic concentrations...
  19. ncbi request reprint Autonomic nervous system responses during sedative infusions of dexmedetomidine
    Charles W Hogue
    Department of Anesthesiology and Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anesthesiology 97:592-8. 2002
    ..The purpose of this study was to determine the effects of dexmedetomidine on systemic and cardiac autonomic reflex responses during rest and during thermal stress...