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Genomes and Genes | Konrad TalbotSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
The sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia researchKonrad Talbot
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Prog Brain Res 179:87-94. 2009..These effects and those on prepulse inhibition, social interaction, and diverse aspects of spatial memory suggest that homozygous sdy mice may model various features of schizophrenia...
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineKonrad Talbot
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
J Clin Invest 122:1316-38. 2012....- Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic locationKonrad Talbot
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e16886. 2011..DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases. This study determined whether such synaptic reductions are isoform-specific... - Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expressionJunxia Tang
Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
Hum Mol Genet 18:3851-63. 2009.... - Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's diseaseNatalia Louneva
Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Pathol 173:1488-95. 2008..These data demonstrate for the first time the preferential localization and increase of caspase-3 in the PSD fractions in AD and suggest an important role for caspase 3 in synapse degeneration during disease progression... 
Dysbindin-1 is a synaptic and microtubular protein that binds brain snapinKonrad Talbot
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Hum Mol Genet 15:3041-54. 2006..The function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin...- Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophreniaGregory C Carlson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
Proc Natl Acad Sci U S A 108:E962-70. 2011..Furthermore, these data implicate reduced fast-phasic inhibition as a common underlying mechanism of schizophrenia-associated intermediate phenotypes... - Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and functionDarrick T Balu
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hippocampus 22:230-40. 2012..Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia... - Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humansAinie Soetanto
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Arch Gen Psychiatry 67:448-57. 2010..In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines... - Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaChang Gyu Hahn
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Med 12:824-8. 2006..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia... - Neurodevelopment, neuroplasticity, and new genes for schizophreniaSteven E Arnold
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Prog Brain Res 147:319-45. 2005..Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity... - Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophreniaKonrad Talbot
Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
J Clin Invest 113:1353-63. 2004..Such changes may contribute to the cognitive deficits common in schizophrenia... - Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strainAndrew H Fairless
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
Brain Res 1230:211-7. 2008..Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system...