Konrad Talbot

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint The sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia research
    Konrad Talbot
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Prog Brain Res 179:87-94. 2009
  2. pmc Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    J Clin Invest 122:1316-38. 2012
  3. pmc Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location
    Konrad Talbot
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e16886. 2011
  4. pmc Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
    Junxia Tang
    Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
    Hum Mol Genet 18:3851-63. 2009
  5. pmc Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease
    Natalia Louneva
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Pathol 173:1488-95. 2008
  6. ncbi request reprint Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 15:3041-54. 2006
  7. pmc Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
    Gregory C Carlson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Proc Natl Acad Sci U S A 108:E962-70. 2011
  8. pmc Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function
    Darrick T Balu
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hippocampus 22:230-40. 2012
  9. pmc Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans
    Ainie Soetanto
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Arch Gen Psychiatry 67:448-57. 2010
  10. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006

Collaborators

Detail Information

Publications13

  1. doi request reprint The sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia research
    Konrad Talbot
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Prog Brain Res 179:87-94. 2009
    ..These effects and those on prepulse inhibition, social interaction, and diverse aspects of spatial memory suggest that homozygous sdy mice may model various features of schizophrenia...
  2. pmc Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    J Clin Invest 122:1316-38. 2012
    ....
  3. pmc Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location
    Konrad Talbot
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e16886. 2011
    ..DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases. This study determined whether such synaptic reductions are isoform-specific...
  4. pmc Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
    Junxia Tang
    Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
    Hum Mol Genet 18:3851-63. 2009
    ....
  5. pmc Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease
    Natalia Louneva
    Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Pathol 173:1488-95. 2008
    ..These data demonstrate for the first time the preferential localization and increase of caspase-3 in the PSD fractions in AD and suggest an important role for caspase 3 in synapse degeneration during disease progression...
  6. ncbi request reprint Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 15:3041-54. 2006
    ..The function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin...
  7. pmc Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
    Gregory C Carlson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Proc Natl Acad Sci U S A 108:E962-70. 2011
    ..Furthermore, these data implicate reduced fast-phasic inhibition as a common underlying mechanism of schizophrenia-associated intermediate phenotypes...
  8. pmc Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function
    Darrick T Balu
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hippocampus 22:230-40. 2012
    ..Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia...
  9. pmc Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans
    Ainie Soetanto
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Arch Gen Psychiatry 67:448-57. 2010
    ..In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines...
  10. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  11. ncbi request reprint Neurodevelopment, neuroplasticity, and new genes for schizophrenia
    Steven E Arnold
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Prog Brain Res 147:319-45. 2005
    ..Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity...
  12. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
    ..Such changes may contribute to the cognitive deficits common in schizophrenia...
  13. pmc Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain
    Andrew H Fairless
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104 3403, USA
    Brain Res 1230:211-7. 2008
    ..Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system...