Takahiro Takano

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Traditional acupuncture triggers a local increase in adenosine in human subjects
    Takahiro Takano
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA
    J Pain 13:1215-23. 2012
  2. ncbi request reprint Cortical spreading depression causes and coincides with tissue hypoxia
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
    Nat Neurosci 10:754-62. 2007
  3. ncbi request reprint Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease
    Takahiro Takano
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1097:40-50. 2007
  4. ncbi request reprint Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
  5. pmc Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+
    Fushun Wang
    Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14640, USA
    Sci Signal 5:ra26. 2012
  6. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
  7. pmc Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia
    Arnulfo Torres
    Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Sci Signal 5:ra8. 2012
  8. doi request reprint Loss of astrocytic domain organization in the epileptic brain
    Nancy Ann Oberheim
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:3264-76. 2008
  9. pmc Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
    Xiaoning Han
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 12:342-53. 2013
  10. pmc Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release
    Fushun Wang
    Center for Translational Neuromedicine, Division of Glia Disease and Therapeutics, University of Rochester Medical School, Rochester, New York 14642
    J Neurosci 33:17404-12. 2013

Collaborators

Detail Information

Publications40

  1. pmc Traditional acupuncture triggers a local increase in adenosine in human subjects
    Takahiro Takano
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA
    J Pain 13:1215-23. 2012
    ..This study strengthens the role of adenosine in acupuncture-mediated antinociception by directly providing such evidence in humans...
  2. ncbi request reprint Cortical spreading depression causes and coincides with tissue hypoxia
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
    Nat Neurosci 10:754-62. 2007
    ..Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply...
  3. ncbi request reprint Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease
    Takahiro Takano
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1097:40-50. 2007
    ....
  4. ncbi request reprint Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity...
  5. pmc Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+
    Fushun Wang
    Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14640, USA
    Sci Signal 5:ra26. 2012
    ..Active control of the extracellular K+ concentration thus provides astrocytes with a simple yet powerful mechanism to rapidly modulate network activity...
  6. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
    ..This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity...
  7. pmc Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia
    Arnulfo Torres
    Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Sci Signal 5:ra8. 2012
    ..Thus, astrocytic ATP release evoked by an activity-associated decrease in [Ca(2+)](e) may provide a negative feedback mechanism that potentiates inhibitory transmission in response to local hyperexcitability...
  8. doi request reprint Loss of astrocytic domain organization in the epileptic brain
    Nancy Ann Oberheim
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:3264-76. 2008
    ..Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain...
  9. pmc Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
    Xiaoning Han
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 12:342-53. 2013
    ..Mice allografted with murine GPCs showed no enhancement of either LTP or learning. These findings indicate that human glia differentially enhance both activity-dependent plasticity and learning in mice...
  10. pmc Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release
    Fushun Wang
    Center for Translational Neuromedicine, Division of Glia Disease and Therapeutics, University of Rochester Medical School, Rochester, New York 14642
    J Neurosci 33:17404-12. 2013
    ..Combined, these studies show that photolysis but not by agonists induced astrocytic Ca(2+) signaling triggers glutamate release. ..
  11. ncbi request reprint Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...
  12. ncbi request reprint Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor
    Lane Bekar
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    Nat Med 14:75-80. 2008
    ....
  13. pmc Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
    Weiguo Peng
    Department of Neurosurgery, Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:12489-93. 2009
    ..1), which crosses the blood-brain barrier. Systemic administration of BBG may thus comprise a readily feasible approach by which to treat traumatic SCI in humans...
  14. pmc In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression
    Alexander S Thrane
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cereb Blood Flow Metab 33:996-9. 2013
    ....
  15. pmc Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
    Nanna Goldman
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
    Nat Neurosci 13:883-8. 2010
    ..These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture...
  16. pmc Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake
    Fushun Wang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:7911-6. 2012
    ..Thus, Bergmann glia play a previously unappreciated role in controlling the membrane potential and thereby the activity of adjacent Purkinje cells...
  17. pmc Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury
    Chunlan Huang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 32:3333-8. 2012
    ..Connexins may thereby constitute a new therapeutic target in spinal cord injury...
  18. pmc Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema
    Alexander S Thrane
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:846-51. 2011
    ....
  19. pmc An astrocytic basis of epilepsy
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:973-81. 2005
    ..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders...
  20. pmc Purinergic signaling regulates neural progenitor cell expansion and neurogenesis
    Jane H C Lin
    Department of Cell Biology, New York Medical College, Valhalla, NY, USA
    Dev Biol 302:356-66. 2007
    ..As a result, progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof...
  21. pmc Receptor-mediated glutamate release from volume sensitive channels in astrocytes
    Takahiro Takano
    Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:16466-71. 2005
    ..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions...
  22. pmc Cultured astrocytes do not release adenosine during hypoxic conditions
    Takumi Fujita
    Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    J Cereb Blood Flow Metab 32:e1-7. 2012
    ..These results show that cultured astrocytes do not release adenosine during mild hypoxia, an observation consistent with their high resistance to hypoxia...
  23. doi request reprint Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices
    Takahiro Takano
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York
    Glia 62:78-95. 2014
    ..These observations suggest that the functional properties and the fine structure of astrocytes in slices may be reflective of early stages of reactive gliosis and should be confirmed in vivo when possible...
  24. ncbi request reprint The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
    Ditte Lovatt
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 27:12255-66. 2007
    ....
  25. pmc Astrocytes and ischemic injury
    Takahiro Takano
    Divison of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Stroke 40:S8-12. 2009
    ..Neuroprotective efforts targeting the functional integrity of astrocytes may constitute a superior strategy for future neuroprotection...
  26. ncbi request reprint Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Drug Deliv Rev 58:773-87. 2006
    ....
  27. ncbi request reprint P2X7 receptor inhibition improves recovery after spinal cord injury
    Xiaohai Wang
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Med 10:821-7. 2004
    ..P2X7R antagonists inhibit this process, reducing both the histological extent and functional sequelae of acute SCI...
  28. pmc Uniquely hominid features of adult human astrocytes
    Nancy Ann Oberheim
    Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 29:3276-87. 2009
    ..On this basis, we posit that this astrocytic complexity has permitted the increased functional competence of the adult human brain...
  29. ncbi request reprint Signaling at the gliovascular interface
    Marie Simard
    Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
    J Neurosci 23:9254-62. 2003
    ..It is speculated that calcium signaling may play a role in astrocytic functions related to the blood-brain barrier, including blood flow regulation, metabolic trafficking, and water homeostasis...
  30. pmc Sleep drives metabolite clearance from the adult brain
    Lulu Xie
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 342:373-7. 2013
    ..Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system. ..
  31. pmc Astrocytic calcium signaling: mechanism and implications for functional brain imaging
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Biol 489:93-109. 2009
    ....
  32. pmc Deciphering migraine
    Takahiro Takano
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    J Clin Invest 119:16-9. 2009
    ....
  33. pmc Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts
    Nanna Goldman
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, United States
    Cell Calcium 53:297-301. 2013
    ..These observations indicate that purine signaling induces transient changes in fibroblast cytoarchitecture that could be related to the beneficial effects of acupuncture...
  34. pmc Intercellular calcium signaling mediated by point-source burst release of ATP
    Gregory Arcuino
    Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:9840-5. 2002
    ....
  35. ncbi request reprint DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+
    Takahiro Takano
    Cell Calcium 41:503-4. 2007
  36. doi request reprint A central role of connexin 43 in hypoxic preconditioning
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:681-95. 2008
    ..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance...
  37. pmc Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes
    Jyoti K Jaiswal
    The Rockefeller University, 1230 York Avenue, Box 304, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 104:14151-6. 2007
    ..We have used this approach to demonstrate that lysosomes undergo calcium-triggered exocytosis in astrocytes...
  38. ncbi request reprint Connexin mediates gap junction-independent resistance to cellular injury
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 23:430-41. 2003
    ..Moreover, cells expressing nonfunctional mutant connexins also acquired a high resistance to injury. These observations identify Cx proteins as active players in cell survival...
  39. ncbi request reprint Beyond the role of glutamate as a neurotransmitter
    Maiken Nedergaard
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Nat Rev Neurosci 3:748-55. 2002
    ..Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes...
  40. ncbi request reprint Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells
    Jane H C Lin
    Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 22:4302-11. 2002
    ....