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Genomes and Genes | Takahiro TakanoSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Traditional acupuncture triggers a local increase in adenosine in human subjectsTakahiro Takano
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA
J Pain 13:1215-23. 2012....
Cortical spreading depression causes and coincides with tissue hypoxiaTakahiro Takano
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
Nat Neurosci 10:754-62. 2007..Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply...- Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's diseaseTakahiro Takano
Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
Ann N Y Acad Sci 1097:40-50. 2007.... - Astrocyte-mediated control of cerebral blood flowTakahiro Takano
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Neurosci 9:260-7. 2006..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity... - Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+Fushun Wang
Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14640, USA
Sci Signal 5:ra26. 2012..Active control of the extracellular K+ concentration thus provides astrocytes with a simple yet powerful mechanism to rapidly modulate network activity... - Extracellular Ca²⁺ acts as a mediator of communication from neurons to gliaArnulfo Torres
Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
Sci Signal 5:ra8. 2012..Thus, astrocytic ATP release evoked by an activity-associated decrease in [Ca(2+)](e) may provide a negative feedback mechanism that potentiates inhibitory transmission in response to local hyperexcitability... 
Loss of astrocytic domain organization in the epileptic brainNancy Ann Oberheim
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 28:3264-76. 2008..Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain...- Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activityDitte Lovatt
Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 109:6265-70. 2012..This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity... - Astrocytic Ca2+ signaling evoked by sensory stimulation in vivoXiaohai Wang
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Neurosci 9:816-23. 2006..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity... - Adenosine is crucial for deep brain stimulation-mediated attenuation of tremorLane Bekar
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
Nat Med 14:75-80. 2008.... - Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injuryWeiguo Peng
Department of Neurosurgery, Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 106:12489-93. 2009..1), which crosses the blood-brain barrier. Systemic administration of BBG may thus comprise a readily feasible approach by which to treat traumatic SCI in humans... - Adenosine A1 receptors mediate local anti-nociceptive effects of acupunctureNanna Goldman
Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
Nat Neurosci 13:883-8. 2010..These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture... - Receptor-mediated glutamate release from volume sensitive channels in astrocytesTakahiro Takano
Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:16466-71. 2005..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions... - Purinergic signaling regulates neural progenitor cell expansion and neurogenesisJane H C Lin
Department of Cell Biology, New York Medical College, Valhalla, NY, USA
Dev Biol 302:356-66. 2007..As a result, progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof... - Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptakeFushun Wang
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 109:7911-6. 2012..Thus, Bergmann glia play a previously unappreciated role in controlling the membrane potential and thereby the activity of adjacent Purkinje cells... - Critical role of connexin 43 in secondary expansion of traumatic spinal cord injuryChunlan Huang
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
J Neurosci 32:3333-8. 2012..Connexins may thereby constitute a new therapeutic target in spinal cord injury... - Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edemaAlexander S Thrane
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 108:846-51. 2011.... - An astrocytic basis of epilepsyGuo-Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Med 11:973-81. 2005..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders... - Cultured astrocytes do not release adenosine during hypoxic conditionsTakumi Fujita
Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
J Cereb Blood Flow Metab 32:e1-7. 2012..These results show that cultured astrocytes do not release adenosine during mild hypoxia, an observation consistent with their high resistance to hypoxia... - The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortexDitte Lovatt
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 27:12255-66. 2007.... - Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brainGuo Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Adv Drug Deliv Rev 58:773-87. 2006.... - Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult miceXiaoning Han
Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Cell Stem Cell 12:342-53. 2013..Mice allografted with murine GPCs showed no enhancement of either LTP or learning. These findings indicate that human glia differentially enhance both activity-dependent plasticity and learning in mice... - P2X7 receptor inhibition improves recovery after spinal cord injuryXiaohai Wang
Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
Nat Med 10:821-7. 2004..P2X7R antagonists inhibit this process, reducing both the histological extent and functional sequelae of acute SCI... - Uniquely hominid features of adult human astrocytesNancy Ann Oberheim
Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 29:3276-87. 2009..On this basis, we posit that this astrocytic complexity has permitted the increased functional competence of the adult human brain... - Astrocytes and ischemic injuryTakahiro Takano
Divison of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Stroke 40:S8-12. 2009..Neuroprotective efforts targeting the functional integrity of astrocytes may constitute a superior strategy for future neuroprotection... - Signaling at the gliovascular interfaceMarie Simard
Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
J Neurosci 23:9254-62. 2003..It is speculated that calcium signaling may play a role in astrocytic functions related to the blood-brain barrier, including blood flow regulation, metabolic trafficking, and water homeostasis... - Astrocytic calcium signaling: mechanism and implications for functional brain imagingXiaohai Wang
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA
Methods Mol Biol 489:93-109. 2009.... - Deciphering migraineTakahiro Takano
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
J Clin Invest 119:16-9. 2009.... - Purine receptor mediated actin cytoskeleton remodeling of human fibroblastsNanna Goldman
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, United States
Cell Calcium 53:297-301. 2013..These observations indicate that purine signaling induces transient changes in fibroblast cytoarchitecture that could be related to the beneficial effects of acupuncture... - A central role of connexin 43 in hypoxic preconditioningJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:681-95. 2008..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance... - DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+Takahiro Takano
Cell Calcium 41:503-4. 2007 - Intercellular calcium signaling mediated by point-source burst release of ATPGregory Arcuino
Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 99:9840-5. 2002.... - Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytesJyoti K Jaiswal
The Rockefeller University, 1230 York Avenue, Box 304, New York, NY 10065, USA
Proc Natl Acad Sci U S A 104:14151-6. 2007..We have used this approach to demonstrate that lysosomes undergo calcium-triggered exocytosis in astrocytes... - Connexin mediates gap junction-independent resistance to cellular injuryJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 23:430-41. 2003..Moreover, cells expressing nonfunctional mutant connexins also acquired a high resistance to injury. These observations identify Cx proteins as active players in cell survival... - Beyond the role of glutamate as a neurotransmitterMaiken Nedergaard
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
Nat Rev Neurosci 3:748-55. 2002..Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes... - Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cellsJane H C Lin
Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 22:4302-11. 2002....