Shannon Takala-Harrison

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc An elaborated feeding cycle model for reductions in vectorial capacity of night-biting mosquitoes by insecticide-treated nets
    Arnaud Le Menach
    Universite Pierre et Marie Curie Paris 6, UMR S 707, Paris, France
    Malar J 6:10. 2007
  2. pmc Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
    Amed Ouattara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, Bamako, Mali
    Malar J 9:175. 2010
  3. pmc Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism
    S L Takala
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, GA, USA
    Infect Genet Evol 6:417-24. 2006
  4. pmc A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 5:31. 2006
  5. pmc Short report: rare Plasmodium falciparum merozoite surface protein 1 19-kda (msp-1(19)) haplotypes identified in Mali using high-throughput genotyping methods
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 76:855-9. 2007
  6. pmc Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS Med 4:e93. 2007
  7. pmc Variation in the Circumsporozoite Protein of Plasmodium falciparum: Vaccine Development Implications
    Kavita Gandhi
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e101783. 2014
  8. pmc Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein
    Kavita Gandhi
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 86:775-81. 2012
  9. pmc Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development
    Shannon L Takala
    Howard Hughes Medical Institute and Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Sci Transl Med 1:2ra5. 2009
  10. pmc Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial
    Matthew B Laurens
    Malaria Group, Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e79323. 2013

Collaborators

Detail Information

Publications16

  1. pmc An elaborated feeding cycle model for reductions in vectorial capacity of night-biting mosquitoes by insecticide-treated nets
    Arnaud Le Menach
    Universite Pierre et Marie Curie Paris 6, UMR S 707, Paris, France
    Malar J 6:10. 2007
    ..Insecticide Treated Nets (ITNs) are an important tool for malaria control. ITNs are effective because they work on several parts of the mosquito feeding cycle, including both adult killing and repelling effects...
  2. pmc Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
    Amed Ouattara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, Bamako, Mali
    Malar J 9:175. 2010
    ....
  3. pmc Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism
    S L Takala
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, GA, USA
    Infect Genet Evol 6:417-24. 2006
    ....
  4. pmc A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 5:31. 2006
    ..Methods are needed to monitor genetic diversity in polymorphic vaccine antigens, but determining which genetic variants of such antigens are present in infected individuals is complicated by the frequent occurrence of mixed infections...
  5. pmc Short report: rare Plasmodium falciparum merozoite surface protein 1 19-kda (msp-1(19)) haplotypes identified in Mali using high-throughput genotyping methods
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 76:855-9. 2007
    ....
  6. pmc Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS Med 4:e93. 2007
    ....
  7. pmc Variation in the Circumsporozoite Protein of Plasmodium falciparum: Vaccine Development Implications
    Kavita Gandhi
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e101783. 2014
    ..The lack of association between sequence variation and hazard of infection or clinical malaria suggests that naturally acquired immunity to CSP may not be allele-specific. ..
  8. pmc Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein
    Kavita Gandhi
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 86:775-81. 2012
    ....
  9. pmc Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development
    Shannon L Takala
    Howard Hughes Medical Institute and Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Sci Transl Med 1:2ra5. 2009
    ..This extreme diversity may pose a serious obstacle to an effective polyvalent recombinant subunit apical membrane antigen-1 vaccine...
  10. pmc Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial
    Matthew B Laurens
    Malaria Group, Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e79323. 2013
    ..Extended follow-up was conducted to evaluate extended safety, immunogenicity and efficacy...
  11. pmc Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    J Infect Dis 202:801-8. 2010
    ..Chloroquine-susceptible parasites that predominate in Malawi likely represent a reexpansion of the susceptible parasites that survived in the population despite widespread drug pressure in the region...
  12. pmc Autosome-wide linkage analysis of hip structural phenotypes in the Old Order Amish
    E A Streeten
    University of Maryland School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, Baltimore, MD, USA
    Bone 43:607-12. 2008
    ..We derived hip structural phenotypes using the Hip Structural Analysis program (HSA) and performed autosome-wide linkage analysis of hip geometric structural phenotypes...
  13. pmc Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia
    Shannon Takala-Harrison
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 110:240-5. 2013
    ....
  14. pmc Seroreactivity to Plasmodium falciparum erythrocyte membrane protein 1 intracellular domain in malaria-exposed children and adults
    Mark A Travassos
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore
    J Infect Dis 208:1514-9. 2013
    ..This approach has the potential to identify conserved, seroreactive extracellular PfEMP1 domains critical for protective immunity to malaria. ..
  15. ncbi request reprint Return of chloroquine antimalarial efficacy in Malawi
    Miriam K Laufer
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    N Engl J Med 355:1959-66. 2006
    ..The molecular marker of chloroquine-resistant falciparum malaria subsequently declined in prevalence and was undetectable by 2001, suggesting that chloroquine might once again be effective in Malawi...
  16. pmc Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial
    Mahamadou A Thera
    Malaria Research and Training Center, University of Bamako, Bamako, Mali
    PLoS ONE 3:e1465. 2008
    ..The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria...