Nobuyuki Takahashi

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Gene targeting approaches to analyzing hypertension
    N Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599 7525, USA
    J Am Soc Nephrol 10:1598-605. 1999
  2. ncbi request reprint Human genetics, animal models and computer simulations for studying hypertension
    Nobuyuki Takahashi
    Department of Pathology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Trends Genet 20:136-45. 2004
  3. pmc Uncompensated polyuria in a mouse model of Bartter's syndrome
    N Takahashi
    Department of Pathology and Laboratory Medicine and Division of Nephrology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 97:5434-9. 2000
  4. ncbi request reprint Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Endocrinology 144:2184-90. 2003
  5. pmc Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Metab 6:506-12. 2007
  6. ncbi request reprint Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate
    N Takahashi
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Kidney Int 71:266-71. 2007
  7. ncbi request reprint Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Am Soc Nephrol 16:125-32. 2005
  8. ncbi request reprint Kidney function in mice lacking aldosterone
    Natalia Makhanova
    Dept of Pathology and Laboratory Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Am J Physiol Renal Physiol 290:F61-9. 2006
  9. pmc Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    J Clin Invest 116:1302-9. 2006
  10. pmc Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma
    Yau Sheng Tsai
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 114:240-9. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Gene targeting approaches to analyzing hypertension
    N Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599 7525, USA
    J Am Soc Nephrol 10:1598-605. 1999
    ..These various gene targeting experiments help identify genes regulating BP, promote a better understanding of the pathophysiology of the condition, and help identify potential targets for therapies...
  2. ncbi request reprint Human genetics, animal models and computer simulations for studying hypertension
    Nobuyuki Takahashi
    Department of Pathology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Trends Genet 20:136-45. 2004
    ..We have chosen the rennin-angiotensin system as our main example. Future directions of hypertension research using gene targeting are also discussed...
  3. pmc Uncompensated polyuria in a mouse model of Bartter's syndrome
    N Takahashi
    Department of Pathology and Laboratory Medicine and Division of Nephrology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 97:5434-9. 2000
    ..The NKCC2 mutant animals should be valuable for uncovering new pathophysiologic and therapeutic aspects of genetic disturbances in water and electrolyte recovery by the kidney...
  4. ncbi request reprint Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Endocrinology 144:2184-90. 2003
    ..This emphasizes that the value of these types of simulation lies in the thoughts that they provoke rather than in their ability to replicate experimental data...
  5. pmc Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Metab 6:506-12. 2007
    ..Most of the metabolic changes in Ren1c(-/-) mice were reversed by angiotensin II administration. These results support a role for angiotensin II in the pathogenesis of diet-induced obesity and insulin resistance...
  6. ncbi request reprint Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate
    N Takahashi
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Kidney Int 71:266-71. 2007
    ..As it allows repeated measurements in the same animals, it facilitates detection of subtle differences or changes in renal function...
  7. ncbi request reprint Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Am Soc Nephrol 16:125-32. 2005
    ..These results demonstrate that renin is the only enzyme capable of maintaining plasma angiotensins and that renin expression in the kidney is very tightly regulated at the mRNA level...
  8. ncbi request reprint Kidney function in mice lacking aldosterone
    Natalia Makhanova
    Dept of Pathology and Laboratory Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Am J Physiol Renal Physiol 290:F61-9. 2006
    ..Our data show the substantial correction of these abnormalities, except the low blood pressure, by high dietary salt does not depend on aldosterone...
  9. pmc Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    J Clin Invest 116:1302-9. 2006
    ..Thus, absence of the bradykinin B2 receptor increases the oxidative stress, mitochondrial DNA damage, and many senescence-associated phenotypes already present in untreated Akita diabetic mice...
  10. pmc Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma
    Yau Sheng Tsai
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 114:240-9. 2004
    ..These results provide genetic evidence for a critical role for PPARgamma in blood pressure regulation that is not dependent on altered insulin sensitivity...
  11. ncbi request reprint Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene
    Toshio Nishikimi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Cardiovasc Res 66:94-103. 2005
    ..Contribution of the natriuretic peptide system to the development of heart failure (HF) in vivo was examined using mice lacking or having decreased natriuretic peptide receptor-A (NPRA), a guanylyl cyclase-linked receptor...
  12. pmc A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy
    Chih Hong Wang
    Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 108:2070-5. 2011
    ..Our data demonstrate that a modest decrease in eNOS, comparable to that associated with human NOS3 variants, is sufficient to enhance diabetic nephropathy independently of its effects on BP...
  13. pmc eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype
    Feng Li
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Am Soc Nephrol 23:652-60. 2012
    ..In conclusion, reduced maternal eNOS/nitric oxide exacerbates the sFlt1-related pre-eclampsia-like phenotype through activation of the endothelin system...
  14. ncbi request reprint Protein inhibitor of activated STAT3 inhibits adipogenic gene expression
    Jianbei Deng
    Department of Nutrition, CB 7461, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem Biophys Res Commun 339:923-31. 2006
    ..Increased PIAS3 expression in adipose tissue may play a role in the metabolic disturbances of obesity...
  15. pmc Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 101:13302-5. 2004
    ..The importance of bradykinin demonstrated here bears strongly on how current drugs reduce diabetic nephropathy and suggests that B2 receptor-specific agonists merit consideration in this context...
  16. ncbi request reprint Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    J Am Soc Nephrol 13:604-10. 2002
    ..One possible factor is a regulated increase in the movement of cytoplasmic protein to the luminal membrane leading to a restoration of functional transporter to an essentially wild type level...
  17. pmc Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel
    Naohiro Yamaguchi
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Clin Invest 117:1344-53. 2007
    ..Taken together, the data indicate that impaired CaM inhibition of RyR2, associated with defective sarcoplasmic reticulum Ca(2+) release and altered gene expression, leads to cardiac hypertrophy and early death...
  18. ncbi request reprint Altering the expression in mice of genes by modifying their 3' regions
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Cell 6:597-606. 2004
    ..In mice having two functionally different native genes with modified 3'UTRs, the desired expression was obtained...
  19. pmc The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
    N Matsukawa
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 96:7403-8. 1999
    ..We conclude that NPRC modulates the availability of the natriuretic peptides at their target organs, thereby allowing the activity of the natriuretic peptide system to be tailored to specific local needs...
  20. ncbi request reprint Nitric oxide-mediated vasodilatory effect of atrial natriuretic peptide in forearm vessels of healthy humans
    Takashi Sugamori
    The Fourth Department of Internal Medicine, Shimane Medical University, Izumo, Japan
    Clin Exp Pharmacol Physiol 29:92-7. 2002
    ..05). 4. These results suggest that the forearm vasodilative response to ANP is modulated, in part, by an endothelium-derived NO-mediated mechanism associated with a decrease in AngII caused by ANP...
  21. doi request reprint Oxytocin receptor-deficient mice developed late-onset obesity
    Yuki Takayanagi
    Department of Physiology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Neuroreport 19:951-5. 2008
    ..In contrast, brown adipose tissue in Oxtr-/- mice contained large lipid droplets and cold-induced thermogenesis was impaired. This study demonstrates that oxytocin receptor plays essential roles in the regulation of energy homeostasis...
  22. ncbi request reprint Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma
    Nobuyuki Takahashi
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 277:16906-12. 2002
    ..These data suggest that both CBP and p300 are indispensable for the full activation of PPARgamma and adipocyte differentiation and that CBP and p300 do not mutually complement in the process...
  23. ncbi request reprint Dietary regulation of nuclear receptors in obesity-related metabolic syndrome
    Teruo Kawada
    Kyoto University, Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Uji, Kyoto 611 0011, Japan
    Asia Pac J Clin Nutr 17:126-30. 2008
    ..These findings indicate that dietary factor acts as an agonist of PPARs and is a valuable medical and food component for the gradual improvement of metabolic syndrome...
  24. ncbi request reprint Pulmonary-renal syndrome in systemic sclerosis: a report of three cases and review of the literature
    Taio Naniwa
    Division of Rheumatology, Nagoya City University Hospital, Department of Internal Medicine and Molecular Sciences, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Nagoya 467 8601, Japan
    Mod Rheumatol 17:37-44. 2007
    ..Clinical courses of the patients with PRS with thrombotic microangiopathy suggest that high-dose corticosteroid therapy is a trigger of diffuse alveolar hemorrhage in patients with diffuse SSc with signs of thrombotic microangiopathy...
  25. ncbi request reprint The importance of subjectivity in perceptual errors on the emergence of indirect reciprocity
    Nobuyuki Takahashi
    Department of Behavioral Science, Graduate School of Letters, Hokkaido University, Sapporo 060 0810, Japan
    J Theor Biol 243:418-36. 2006
    ..Since we believe that there is no guarantee that perceptual errors are shared among all individuals in a society, we argue that the latter moral principle may play a more important role in human interactions...
  26. ncbi request reprint ACT domain repeat protein 7, ACR7, interacts with a chaperone HSP18.0-CII in rice nuclei
    Toshihiko Hayakawa
    Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, 981 8555 Japan
    Plant Cell Physiol 47:891-904. 2006
    ..0-CII in vivo. The potential ability of nuclear protein ACR7 to bind Gln and the possibility of the protein acting as a Gln sensor in rice leaves is discussed...
  27. ncbi request reprint Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea
    Toshihiro Mita
    Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    Acta Trop 98:137-44. 2006
    ....
  28. ncbi request reprint Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats
    Ikuo Ikeda
    Laboratory of Food and Biomolecular Science, Department of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amemiyamachi, Aoba ku, Sendai 981 8555, Japan
    Biochim Biophys Acta 1760:800-7. 2006
    ..These observations suggest a possibility that campestenone has an ability to prevent coronary heart disease by improving obesity and abnormality of lipid metabolism...
  29. ncbi request reprint Two novel spliced presenilin 2 transcripts in human lymphocyte with oxidant stress and brain
    Nobuyuki Takahashi
    Department of Neurology, Nara Medical University, Kashihara, Japan
    Mol Cell Biochem 252:279-83. 2003
    ....
  30. pmc PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity
    Yasutomi Kamei
    Department of Molecular Medical Science, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 100:12378-83. 2003
    ..These results demonstrate that PGC-1beta/ERRL1 can function as a protein ligand of ERR, and that its level contributes to the control of energy balance in vivo, and provide a strategy for developing novel antiobesity drugs...
  31. ncbi request reprint Periplasmic secretion of native ovalbumin without signal cleavage in Escherichia coli
    Yasuhiro Arii
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biosci Biotechnol Biochem 67:368-71. 2003
    ..We concluded that a process resembling the secretion of ovalbumin process in the oviduct occurs also in bacteria...
  32. ncbi request reprint A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle
    Yasutomi Kamei
    PRESTO, Japan Science and Technology Corporation, National Institute of Health and Nutrition, 1 23 1, Toyama Shinjuku ku, Tokyo 162 863, Japan
    FEBS Lett 536:232-6. 2003
    ..Ectopic expression of FKHR enhanced LPL gene expression in C2C12 muscle cells in culture. These results implicate FKHR as an important modulator of lipid metabolism in skeletal muscle...
  33. ncbi request reprint Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes
    Yasushi Okamura
    Section of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    Physiol Genomics 22:269-82. 2005
    ..Such genome-wide information of ion channel genes in basal chordates enables us to begin correlating the innovation and remodeling of genes with the adaptation of more recent chordates to their physical environment...
  34. ncbi request reprint Hydrotropism in abscisic acid, wavy, and gravitropic mutants of Arabidopsis thaliana
    Nobuyuki Takahashi
    Graduate School of Life Sciences, Tohoku University, Katahira, Aoba ku, Sendai 980 8577, Japan
    Planta 216:203-11. 2002
    ..Furthermore, hydrotropism and the wavy response may share part of a common molecular pathway controlling the directional growth of roots...
  35. ncbi request reprint Increased vulnerability to L-DOPA toxicity in dopaminergic neurons From VMAT2 heterozygote knockout mice
    Shingo Kariya
    Department of Neurology, Nara Medical University, Nara, Japan
    J Mol Neurosci 27:277-79. 2005
    ..Our results suggest that reduction of VMAT2 activity might attenuate the efficacy of L-DOPA therapy for patients with PD...
  36. ncbi request reprint Short duration of reactive hyperemia in the forearm of subjects with multiple cardiovascular risk factors
    Yutaka Ishibashi
    Division of Cardiovascular Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan
    Circ J 70:115-23. 2006
    ..In the present study reactive hyperemia was measured using plethysmography in healthy subjects with multiple cardiovascular risk factors...
  37. ncbi request reprint High plasma brain natriuretic polypeptide level as a marker of risk for thromboembolism in patients with nonvalvular atrial fibrillation
    Hiromi Shimizu
    Fourth Department of Internal Medicine, Shimane Medical University, Shimane, Japan
    Stroke 33:1005-10. 2002
    ..The purpose of this study was to assess a possible relationship between LAA function and plasma BNP levels in nonvalvular AF...
  38. ncbi request reprint Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia
    Andrew Masta
    School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea
    Pharmacogenetics 13:697-700. 2003
    ..This study highlights the medical consequences of population origins and the need for a better understanding of the genetic diversity of our global species...