Hsin Hsiung Tai

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase
    Hoon Cho
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Arch Biochem Biophys 433:447-53. 2005
  2. doi Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs)
    Hsin Hsiung Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Prostaglandins Other Lipid Mediat 96:37-40. 2011
  3. doi Prostaglandin catabolic enzymes as tumor suppressors
    Hsin Hsiung Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Cancer Metastasis Rev 30:409-17. 2011
  4. ncbi NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions
    H H Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, 40536 0082, USA
    Curr Pharm Des 12:955-62. 2006
  5. pmc 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer
    Hsin Hsiung Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Prostaglandins Other Lipid Mediat 83:203-8. 2007
  6. ncbi Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells
    Jingyan Wei
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Lung Cancer 69:26-32. 2010
  7. ncbi Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
    Hoon Cho
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Arch Biochem Biophys 419:139-46. 2003
  8. pmc Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation
    Daquan Gao
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, KY 40536, USA
    Angew Chem Int Ed Engl 45:653-7. 2006
  9. pmc Computational redesign of human butyrylcholinesterase for anticocaine medication
    Yongmei Pan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 102:16656-61. 2005
  10. ncbi Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis
    Xiaoqin Huang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, KY 40536, USA
    Bioorg Med Chem 14:3553-62. 2006

Collaborators

  • Chang Guo Zhan
  • Hoon Cho
  • Fang Zheng
  • Mei Chuan Ko
  • Wen Chang Chang
  • Shuichi Yamamoto
  • Mohamed Diwan M Abdulhameed
  • Kotha Subbaramaiah
  • LEE WARREN SLICE
  • D H Johnson
  • John Rg Challis
  • Ido Wolf
  • Sudhansu K Dey
  • Kikuko Watanabe
  • Tadayuki Akagi
  • Min Tong
  • Xiuling Li
  • Adel Hamza
  • Weili Yan
  • Jingyan Wei
  • Yunfei Ding
  • Liu Xue
  • Xiuling Chi
  • Daquan Gao
  • Yuhua Zhao
  • Wenchao Yang
  • Yongmei Pan
  • Lei Fang
  • Shurong Hou
  • Shuqian Liu
  • Junjun Liu
  • Naoki Wakimoto
  • Hung Pham
  • Jeffrey D Roizen
  • Rose M Rizek
  • Li Yang
  • Taisuke Otani
  • Xiaoqin Huang
  • Guangfu Yang
  • Michael G Backlund
  • Louis J Muglia
  • Jeffrey A Moscow
  • Min Yan
  • Feng Xiang Yan
  • Sandra K Winchester
  • Xiabin Chen
  • Zhenyu Jin
  • Xinyun Zhao
  • James H Woods
  • Alan C Goren
  • Chu Chun Weng
  • Brittany Morgan Freeman
  • Dong Yin
  • James O'Kelly
  • Benny Chong
  • Keith L Black
  • Guido Eibl
  • Minoru Asada
  • Lilach Abramovitz
  • H Phillip Koeffler
  • Romina Vincenti
  • Sarah Keating
  • Kyung Ho Park
  • Carole S Watson
  • Takefumi Kikuchi
  • Carlos L Arteaga
  • Joseph M Amann
  • Raymond DuBois
  • David P Carbone
  • Marta Guix
  • Dean Billheimer
  • Rut Porta
  • Alan D Bocking
  • Adriana Gonzalez
  • Baoheng Du
  • Takiko Daikoku
  • Lydia Petrovic
  • Ellen Scherl
  • Andrew J Dannenberg
  • Melanie Greifer
  • Kentaro Yamaguchi
  • Vijaykumar R Holla
  • Sharada Katkuri
  • Jason R Mann
  • Ginger L Milne
  • Erik S Musiek
  • Raymond N DuBois
  • F Gregory Buchanan
  • Earl Lawrence
  • Dawn Dawson

Detail Information

Publications49

  1. ncbi Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase
    Hoon Cho
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Arch Biochem Biophys 433:447-53. 2005
    ..These results suggest that Ile-17, Asn-91, and Val-186 are involved in the interaction with NAD(+) and contribute to the full catalytic activity of 15-PGDH...
  2. doi Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs)
    Hsin Hsiung Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Prostaglandins Other Lipid Mediat 96:37-40. 2011
    ..Taken together, NSAIDs may up-regulate 15-PGDH by increasing the protein expression as well as decreasing the turnover of 15-PGDH in cancer cells...
  3. doi Prostaglandin catabolic enzymes as tumor suppressors
    Hsin Hsiung Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Cancer Metastasis Rev 30:409-17. 2011
    ..Future directions of research on these prostaglandin catabolic enzymes as tumor suppressors are also discussed...
  4. ncbi NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions
    H H Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, 40536 0082, USA
    Curr Pharm Des 12:955-62. 2006
    ..Future investigations in these areas are warranted...
  5. pmc 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer
    Hsin Hsiung Tai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Prostaglandins Other Lipid Mediat 83:203-8. 2007
    ..These results suggest that tumor suppressive action of these agents may, in part, be related to their ability to induce 15-PGDH expression...
  6. ncbi Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells
    Jingyan Wei
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Lung Cancer 69:26-32. 2010
    ..However, PI 3-kinase and protein kinase C had minimal contribution. These results indicate that activation of the TPalpha induces the expression of VEGF through multiple signaling pathways...
  7. ncbi Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
    Hoon Cho
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Arch Biochem Biophys 419:139-46. 2003
    ..These results indicate that the coenzyme specificity of 15-PGDH can be altered from NAD+ to NADP+ by changing a few critical residues near the N-terminal end...
  8. pmc Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation
    Daquan Gao
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, KY 40536, USA
    Angew Chem Int Ed Engl 45:653-7. 2006
  9. pmc Computational redesign of human butyrylcholinesterase for anticocaine medication
    Yongmei Pan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 102:16656-61. 2005
    ....
  10. ncbi Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis
    Xiaoqin Huang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, KY 40536, USA
    Bioorg Med Chem 14:3553-62. 2006
    ....
  11. ncbi NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer
    Yunfei Ding
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Carcinogenesis 26:65-72. 2005
    ..Furthermore, the expression of 15-PGDH was found to be stimulated by hyaluronidase. These results suggest that 15-PGDH may decrease the level of proliferative PGE2, induce apoptosis and function like a tumor suppressor...
  12. ncbi Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells
    Min Tong
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Endocrinology 145:2141-7. 2004
    ..These results indicate that the induction of 15-PGDH by DHT, IL-6, and forskolin in LNCaP cells may involve a functional androgen receptor and phosphorylation-dependent multiple signaling pathways...
  13. ncbi Glycogen synthase kinase-3 phosphorylation, T-cell factor signaling activation, and cell morphology change following stimulation of thromboxane receptor alpha
    Weili Yan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, 40536 0082, USA
    J Pharmacol Exp Ther 317:267-74. 2006
    ..Together, our results showed for the first time TP agonist-induced phosphorylation of GSK-3 and activation of Tcf/Lef signaling leading to cell proliferation and transformation...
  14. pmc Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo
    Yuhua Zhao
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, United States
    Lung Cancer 68:161-9. 2010
    ..This study indicates that restoration of LTBDH/PGR expression is effective in preventing lung cancer growth in vitro and in vivo...
  15. pmc Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis
    Adel Hamza
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536, USA
    J Phys Chem B 114:5605-16. 2010
    ..Our mPGES-1 trimer model represents a reasonable open conformation of the enzyme and is therefore promising for studying mPGES-1 binding with ligands in future structure-based drug design targeting mPGES-1...
  16. doi Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine
    Liu Xue
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, USA
    Biochem J 453:447-54. 2013
    ....
  17. ncbi Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells
    Min Tong
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Biochem Pharmacol 72:701-9. 2006
    ..Together, our results indicate that 15-PGDH is one of the target genes that HDAC inhibitors and TGF-beta may induce to exhibit tumor suppressive effects...
  18. pmc Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine
    Liu Xue
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street Lexington, KY 40536, USA
    Mol Pharmacol 79:290-7. 2011
    ..e., the relative catalytic efficiency), determining the efficacy in practical protection of mice from the acute cocaine toxicity and future direction for further improving the efficacy of the enzyme in the cocaine overdose treatment...
  19. ncbi Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells
    Xiuling Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Arch Biochem Biophys 467:20-30. 2007
    ..Our results suggest that increased expression of thromboxane synthase as seen in prostate tumor may stimulate tumorigenesis as a consequence of concurrent increased synthesis of two fatty acids capable of activating ERKs...
  20. pmc Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells
    Xiuling Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    PLoS ONE 8:e54073. 2013
    ..7 macrophages induced expression of MMPs, VEGF and MCP-1 genes, and increased the invasive potential in A549 cells. These findings suggest that TXA(2) may stimulate invasion of cancer cells through MCP-1-mediated macrophage recruitment...
  21. ncbi Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells
    Min Tong
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Lexington, KY 40536 0082, USA
    Carcinogenesis 27:2170-9. 2006
    ..The levels of IL-1beta-induced COX-2 expression appeared to correlate inversely with those of 15-PGDH expression in the cells. These results support the contention that COX-2 and 15-PGDH are regulated reciprocally in A549 cells...
  22. ncbi Structure and function of human NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase
    Hsin Hsiung Tai
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Adv Exp Med Biol 507:245-50. 2002
  23. ncbi 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells
    Min Tong
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Arch Biochem Biophys 435:50-5. 2005
    ..The induction of 15-PGDH expression by dexamethasone and other glucocorticoids at the therapeutic level provides an additional biochemical mechanism for the anti-inflammatory action of these glucocorticoids...
  24. ncbi Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD+ and PGE2 by homology modeling, docking and molecular dynamics simulation
    Adel Hamza
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Bioorg Med Chem 13:4544-51. 2005
    ..The reported 3D model of 15-PGDH-NAD+-PGE2 complex might be valuable for future rational design of novel inhibitors of 15-PGDH...
  25. ncbi Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells
    Shuqian Liu
    Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    Mol Cancer Res 2:477-87. 2004
    ..In summary, these studies show unexpected relationships between thiamine metabolism and genes that may be involved in the oncogenesis of breast and lung cancer...
  26. pmc Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants
    Adel Hamza
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
    J Phys Chem B 109:4776-82. 2005
    ....
  27. pmc Novel human mPGES-1 inhibitors identified through structure-based virtual screening
    Adel Hamza
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States
    Bioorg Med Chem 19:6077-86. 2011
    ..The positive experimental results suggest that our recently modeled trimeric structure of mPGES-1 in its open state is ready for the structure-based drug design and discovery...
  28. ncbi Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells
    Xiuling Chi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Exp Cell Res 316:2251-9. 2010
    ..Our results indicate that IL-4 up-regulates 15-PGDH by increased gene transcription and decreased protein turnover and the up-regulation can be mediated by JAK-STAT6 as well as MAPKs, PI-3K/Akt and PKC pathways...
  29. ncbi Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
    Hoon Cho
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Arch Biochem Biophys 405:247-51. 2002
    ..This regulatory site appears to overlap with the activator site occupied by imipramine since activation of the enzyme by this activator is competitively inhibited by compound CT-8...
  30. pmc Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells
    Jingyan Wei
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, United States
    Biochem Pharmacol 74:787-800. 2007
    ..These results indicate that I-BOP-induced COX-2 expression through multiple signaling pathways...
  31. ncbi 14-3-3zeta interacts with human thromboxane receptors and is involved in the agonist-induced activation of the extracellular-signal-regulated kinase
    Weili Yan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Biochem Pharmacol 71:624-33. 2006
    ....
  32. ncbi Increased expression of matrix metalloproteinases mediates thromboxane A2-induced invasion in lung cancer cells
    Xiuling Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, 40536 0596, USA
    Curr Cancer Drug Targets 12:703-15. 2012
    ..Our studies establish the relationship between TP and MMPs in cancer cell invasion and suggest that the thromboxane A(2) (TXA(2))-TP signaling is a potential therapeutic target for cancer invasion and metastasis...
  33. ncbi Prostaglandin catabolizing enzymes
    Hsin Hsiung Tai
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Prostaglandins Other Lipid Mediat 68:483-93. 2002
    ..Future investigation may shed more light on the roles of these enzymes in health and diseases...
  34. doi 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells
    Xiuling Chi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, United States
    Arch Biochem Biophys 487:139-45. 2009
    ..Taken together, these results indicate that flurbiprofen up-regulates 15-PGDH by increasing the expression and decreasing the degradation of 15-PGDH in HT29 cells...
  35. ncbi Agents that elevate cyclic AMP induce receptor phosphorylation primarily at serine 331 in HEK 293 cells overexpressing human thromboxane receptor alpha
    Shuichi Yamamoto
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Biochem Pharmacol 64:375-83. 2002
    ..These results indicate that Ser-331 is the primary site responsible for the phosphorylation and desensitization of the human TPalpha induced by agents that activate PKA...
  36. doi Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells
    Xiuling Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Carcinogenesis 30:1606-13. 2009
    ..These results provide strong evidence that Nurr1 plays a significant role in cell proliferation and may mediate TP agonist-induced proliferation in lung cancer cells...
  37. pmc Most efficient cocaine hydrolase designed by virtual screening of transition states
    Fang Zheng
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536, USA
    J Am Chem Soc 130:12148-55. 2008
    ....
  38. ncbi Coordinate regulation of prostaglandin metabolism for induction of parturition in mice
    Sandra K Winchester
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 143:2593-8. 2002
    ....
  39. ncbi Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha
    Taisuke Otani
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 290:G361-8. 2006
    ..The decrease in amounts of 15-PGDH in inflamed mucosa can be explained at least, in part, by TNF-alpha-mediated suppression of 15-PGDH transcription...
  40. ncbi Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2
    Hoon Cho
    Polymer Science Engineering, Chosun University, Gwangju 501 579, Republic of Korea
    Bioorg Med Chem 14:6486-91. 2006
    ..This indicates that the side-chain oxygen or nitrogen atom at position 148 of 15-PGDH plays an important role in anchoring C-15 hydroxyl group of PGE2 through hydrogen bonding for catalytic reaction...
  41. ncbi 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer
    Ido Wolf
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    Cancer Res 66:7818-23. 2006
    ..Our results indicate for the first time that 15-PGDH may be a novel tumor suppressor gene in breast cancer, and suggest that this enzyme can modulate the ER pathway...
  42. ncbi Serine 331 is major site of phosphorylation and desensitization induced by protein kinase C in thromboxane receptor alpha
    Feng Xiang Yan
    Institute of Pharmacy and Pharmacology, Nanhua University, Hengyang 421001, China
    Acta Pharmacol Sin 23:952-60. 2002
    ....
  43. ncbi Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer
    Li Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 67:5587-93. 2007
    ..This effect is reversible in a subset of NSCLC upon treatment with an EGFR TKI...
  44. ncbi 15-Hydroxyprostaglandin dehydrogenase protein expression in human fetal membranes with and without subclinical inflammation
    Rose M Rizek
    Department of Obstetrics and Gynecology, University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada
    Reprod Sci 14:260-9. 2007
    ..The differential expression of 55-kDa ir-PGDH in preterm amnion with and without PPROM supports the need for a better understanding of the different forms of PGDH...
  45. pmc Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice
    Jeffrey D Roizen
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 22:105-12. 2008
    ..Thus, endocrine control of labor has the capacity to plastically adapt to changes in genetically determined prostaglandin signals...
  46. pmc 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers
    Min Yan
    Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 101:17468-73. 2004
    ..These findings thus delineate an enzymatic pathway that induces colon cancer suppression, a pathway that is activated by TGF-beta and mediated by 15-PGDH...
  47. pmc 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
    Michael G Backlund
    Department of Medicine, Cell and Developmental Biology, Vanderbilt University Medical Center and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232 6838, USA
    J Biol Chem 280:3217-23. 2005
    ..In summary, these results suggest a novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression...
  48. doi Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase
    Naoki Wakimoto
    Division of Hematology Oncology, Cedars Sinai Medical Center University of California at Los Angeles School of Medicine, USA
    Cancer Res 68:6978-86. 2008
    ..Our studies provide evidence that the up-regulation of 15-PGDH induced by NSAIDs has the potential to inhibit growth of GBM, in part, by up-regulation of p21 possibly independent from COX-2 enzymatic function...
  49. ncbi 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice
    Hung Pham
    Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, California, USA
    Mol Carcinog 47:466-77. 2008
    ..Based on these data, we conclude that PGDH expression suppresses K-Ras(V12)-mediated tumorigenesis in intestinal epithelial cells...