Tahir Tahirov

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA
    Nigar D Babayeva
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e33698. 2012
  2. doi request reprint Structure and function of eukaryotic DNA polymerase δ
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198 7696, USA
    Subcell Biochem 62:217-36. 2012
  3. pmc Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis
    Javier Sanchez Garcia
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK
    BMC Mol Biol 10:82. 2009
  4. pmc Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Biol Direct 4:11. 2009
  5. pmc Crystal structure of HIV-1 Tat complexed with human P-TEFb
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Nature 465:747-51. 2010
  6. pmc Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA
    Vinod B Agarkar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Mol Biol 397:278-89. 2010
  7. pmc Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA
    Vinod B Agarkar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:1261-3. 2009
  8. doi request reprint Three-dimensional structures of DNA-bound transcriptional regulators
    Tripti Shrivastava
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Biol 674:43-55. 2010
  9. pmc Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA
    Nigar D Babayeva
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA
    Cell Cycle 9:3054-62. 2010
  10. pmc X-ray structure of the complex of regulatory subunits of human DNA polymerase delta
    Andrey G Baranovskiy
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Cell Cycle 7:3026-36. 2008

Collaborators

Detail Information

Publications11

  1. pmc Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA
    Nigar D Babayeva
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e33698. 2012
    ..DNA binding by Ets1 dimer resulted in formation of additional intermolecular protein•DNA interactions, implying that the complex formation is cooperative...
  2. doi request reprint Structure and function of eukaryotic DNA polymerase δ
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198 7696, USA
    Subcell Biochem 62:217-36. 2012
    ..In this chapter we review the current state of the Pol δ structure-function relationship with an emphasis on the role of its accessory subunits...
  3. pmc Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis
    Javier Sanchez Garcia
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK
    BMC Mol Biol 10:82. 2009
    ..Human Pol delta comprises the same four subunits, and the crystal structure was recently reported of a complex of human p50 and the N-terminal domain of p66, the human orthologues of Cdc1 and Cdc27, respectively...
  4. pmc Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Biol Direct 4:11. 2009
    ..However, the details of the evolutionary relationships between DNA polymerases of archaea and eukaryotes remain unresolved...
  5. pmc Crystal structure of HIV-1 Tat complexed with human P-TEFb
    Tahir H Tahirov
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Nature 465:747-51. 2010
    ..Importantly, Tat induces significant conformational changes in P-TEFb. This finding lays a foundation for the design of compounds that would specifically inhibit the Tat.P-TEFb complex and block HIV replication...
  6. pmc Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA
    Vinod B Agarkar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Mol Biol 397:278-89. 2010
    ..In this study, we determined that Elf3 amino acid residues within this flanking region, including Trp361, are important for the structural integrity of the protein as well as for the Efl3 DNA binding and transactivation activity...
  7. pmc Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA
    Vinod B Agarkar
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:1261-3. 2009
    ..The crystals belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 42.66, b = 52, c = 99.78 A, and diffracted to a resolution of 2.2 A...
  8. doi request reprint Three-dimensional structures of DNA-bound transcriptional regulators
    Tripti Shrivastava
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Biol 674:43-55. 2010
    ....
  9. pmc Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA
    Nigar D Babayeva
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA
    Cell Cycle 9:3054-62. 2010
    ..The proposed mechanism was verified both in vitro by surface plasmon resonance and in vivo by transcription-based assays...
  10. pmc X-ray structure of the complex of regulatory subunits of human DNA polymerase delta
    Andrey G Baranovskiy
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Cell Cycle 7:3026-36. 2008
    ....
  11. pmc Crystallization and preliminary crystallographic analysis of the complex of the second and third regulatory subunits of human Pol delta
    Andrey G Baranovskiy
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:822-4. 2008
    ..The crystal had unit-cell parameters a = 95.13, b = 248.54, c = 103.46 A, beta = 106.94 degrees and diffracted to a resolution of 3 A. Four molecules of p50-p66(N) in an asymmetric unit corresponded to a crystal solvent content of 72.2%...

Research Grants4

  1. Structural Basis for Synergistic Gene Expression by Runx1 and Ets1 Proteins
    Tahir H Tahirov; Fiscal Year: 2010
    ..Success with the proposed structural studies ultimately will lead to the discovery of novel therapies for the prevention and treatment of leukemia and other cancers. ..
  2. Structural Basis for Synergistic Gene Expression by Runx1 and Ets1 Proteins
    Tahir Tahirov; Fiscal Year: 2009
    ..Success with the proposed structural studies ultimately will lead to the discovery of novel therapies for the prevention and treatment of leukemia and other cancers. ..
  3. Structural Basis for Synergistic Gene Expression by Runx1 and Ets1 Proteins
    Tahir Tahirov; Fiscal Year: 2009
    ..Success with the proposed structural studies ultimately will lead to the discovery of novel therapies for the prevention and treatment of leukemia and other cancers. ..