C O Tacket

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Infect Dis 45:S20-3. 2007
  2. ncbi request reprint Immune responses to an oral typhoid vaccine strain that is modified to constitutively express Vi capsular polysaccharide
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 190:565-70. 2004
  3. ncbi request reprint Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Immunol 108:241-7. 2003
  4. ncbi request reprint Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes
    C O Tacket
    Center for Vaccine Development, Baltimore, MD 21201, USA
    J Infect Dis 182:302-5. 2000
  5. ncbi request reprint Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
    Clin Immunol 97:146-53. 2000
  6. doi request reprint Plant-based oral vaccines: results of human trials
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA
    Curr Top Microbiol Immunol 332:103-17. 2009
  7. pmc Plant-based vaccines against diarrheal diseases
    Carol O Tacket
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Trans Am Clin Climatol Assoc 118:79-87. 2007
  8. ncbi request reprint Plant-derived vaccines against diarrheal diseases
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA
    Vaccine 23:1866-9. 2005
  9. ncbi request reprint Garden-variety vaccines: antigens derived from transgenic plants
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, MD, USA
    Expert Rev Vaccines 3:529-31. 2004
  10. pmc Role of EspB in experimental human enteropathogenic Escherichia coli infection
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 68:3689-95. 2000

Collaborators

Detail Information

Publications30

  1. ncbi request reprint CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Infect Dis 45:S20-3. 2007
    ..This review summarizes the clinical data that directed the logical progression of this vaccine development strategy...
  2. ncbi request reprint Immune responses to an oral typhoid vaccine strain that is modified to constitutively express Vi capsular polysaccharide
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 190:565-70. 2004
    ..Although many of the volunteers generated antibody-secreting cell responses to Vi, only 2 of the 32 volunteers generated anti-Vi IgG antibody in serum...
  3. ncbi request reprint Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Immunol 108:241-7. 2003
    ..Lymphoproliferative responses and IFN-gamma production were observed transiently among those who received 250 microg or 500 microg but not 2000 microg of VLP. Studies to increase immunogenicity using a mucosal adjuvant are planned...
  4. ncbi request reprint Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes
    C O Tacket
    Center for Vaccine Development, Baltimore, MD 21201, USA
    J Infect Dis 182:302-5. 2000
    ..Overall, 19 of 20 volunteers developed an immune response of some kind, although the level of serum antibody increases was modest...
  5. ncbi request reprint Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
    Clin Immunol 97:146-53. 2000
    ..This study demonstrates that fragment C of tetanus toxin delivered orally to volunteers in an S. Typhi vector can elicit protective levels of serum antitoxin...
  6. doi request reprint Plant-based oral vaccines: results of human trials
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA
    Curr Top Microbiol Immunol 332:103-17. 2009
    ..This chapter examines some early human studies of oral transgenic plant-derived vaccines against enterotoxigenic Escherichia coli infection, norovirus, and hepatitis B...
  7. pmc Plant-based vaccines against diarrheal diseases
    Carol O Tacket
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Trans Am Clin Climatol Assoc 118:79-87. 2007
    ..This paper describes early clinical studies evaluating oral transgenic plant vaccines against enteric infections such as enterotoxigenic E. coli infection and norovirus...
  8. ncbi request reprint Plant-derived vaccines against diarrheal diseases
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA
    Vaccine 23:1866-9. 2005
    ..New oral vaccines based on other transgenic plants will soon be evaluated in humans...
  9. ncbi request reprint Garden-variety vaccines: antigens derived from transgenic plants
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, MD, USA
    Expert Rev Vaccines 3:529-31. 2004
    ..This factor will inhibit the development and distribution of safe and effective new vaccines against high priority pathogens...
  10. pmc Role of EspB in experimental human enteropathogenic Escherichia coli infection
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 68:3689-95. 2000
    ..These results demonstrate that EspB is a critical virulence determinant of EPEC infections and suggest that EspB contributes to an immune response...
  11. pmc Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 68:1196-201. 2000
    ..This phase 2 study supports the further development of CVD 908-htrA as a single-dose vaccine against typhoid fever and as a possible live vector for oral delivery of other vaccine antigens...
  12. ncbi request reprint Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 22:4385-9. 2004
    ..Four (44%) of nine volunteers also developed stool IgA. Transgenic plants represent a new vector for oral vaccine antigens...
  13. ncbi request reprint Lack of prophylactic efficacy of an enteric-coated bovine hyperimmune milk product against enterotoxigenic Escherichia coli challenge administered during a standard meal
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Infect Dis 180:2056-9. 1999
    ..Either the specificity or titer of anti-colonization factor antibodies or the formulation of antibodies in this product was not adequate to provide passive protection against ETEC challenge...
  14. pmc Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challenge with Vibrio cholerae O1 El tor inaba three months after vaccination
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 67:6341-5. 1999
    ..Peak stool V. cholerae excretion among placebo recipients was 1.1 x 10(7) CFU/g and among vaccinees was 4.9 x 10(2) CFU/g (P < 0.001). This vaccine could therefore be a safe and effective tool to prevent cholera in travelers...
  15. pmc Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans
    C O Tacket
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 65:452-6. 1997
    ..typhi flagellar and particulate antigens after the higher doses. These studies demonstrate the potential of CVD 908-htrA as a live vector for the delivery of heterologous genes, and a clinical trial of such a construct is planned...
  16. ncbi request reprint Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Nat Med 4:607-9. 1998
    ..The present study was conducted as a proof of principle to determine if humans would also develop a serum and/or mucosal immune response to an antigen delivered in an uncooked foodstuff...
  17. pmc Effect of prior experimental human enteropathogenic Escherichia coli infection on illness following homologous and heterologous rechallenge
    M S Donnenberg
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 66:52-8. 1998
    ..These studies indicate that prior EPEC infection can reduce disease severity upon homologous challenge. Further studies may require the development of new model systems...
  18. pmc Investigation of the roles of toxin-coregulated pili and mannose-sensitive hemagglutinin pili in the pathogenesis of Vibrio cholerae O139 infection
    C O Tacket
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 66:692-5. 1998
    ..01). We conclude that TCP are an important colonization factor of V. cholerae O139 and probably of El Tor V. cholerae O1. In contrast, MSHA does not appear to promote intestinal colonization in humans...
  19. pmc Validation of a volunteer model of cholera with frozen bacteria as the challenge
    D A Sack
    Department of International Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Infect Immun 66:1968-72. 1998
    ..Use of this model should minimize differences in attack rates or severity when groups are challenged at different times and in different institutions...
  20. pmc Safety and immunogenicity in humans of an attenuated Salmonella typhi vaccine vector strain expressing plasmid-encoded hepatitis B antigens stabilized by the Asd-balanced lethal vector system
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 65:3381-5. 1997
    ....
  21. pmc Safety, immunogenicity, and efficacy against cholera challenge in humans of a typhoid-cholera hybrid vaccine derived from Salmonella typhi Ty21a
    C O Tacket
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201
    Infect Immun 58:1620-7. 1990
    ..cholerae O antigen in ameliorating clinical illness and illustrates the use of an S. typhi carrier vaccine strain expressing a foreign antigen...
  22. ncbi request reprint Concomitant induction of CD4+ and CD8+ T cell responses in volunteers immunized with Salmonella enterica serovar typhi strain CVD 908-htrA
    Rosângela Salerno-Goncalves
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 170:2734-41. 2003
    ....
  23. pmc Cell-mediated immune responses in humans after immunization with one or two doses of oral live attenuated typhoid vaccine CVD 909
    Rezwanul Wahid
    Center for Vaccine Development, Department of Pediatrics, University of Maryland, Baltimore, MD 21201, USA
    Vaccine 25:1416-25. 2007
    ..These observations add impetus for the continuing evaluation of CVD 909 as a typhoid vaccine candidate...
  24. ncbi request reprint Host-Salmonella interaction: human trials
    M M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
    Microbes Infect 3:1271-9. 2001
    ....
  25. pmc Generation of specific effector and memory T cells with gut- and secondary lymphoid tissue- homing potential by oral attenuated CVD 909 typhoid vaccine in humans
    R Wahid
    Department of Pediatrics, Center for Vaccine Development, University of Maryland, Baltimore, Maryland, USA
    Mucosal Immunol 1:389-98. 2008
    ..This is the first demonstration that oral immunization of humans with S. Typhi elicits diverse IFN-gamma-secreting CD4(+) and CD8(+) T(CM) and T(EM) subsets able to migrate to the gut and other lymphoid tissues...
  26. pmc Vaginal microbiome of reproductive-age women
    Jacques Ravel
    Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 108:4680-7. 2011
    ....
  27. ncbi request reprint Plant-derived vaccines against diarrhoeal diseases
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    Expert Opin Biol Ther 4:719-28. 2004
    ..This review examines some early attempts to develop oral transgenic plant vaccines against enteric infections such as enterotoxigenic Escherichia coli infection, cholera and norovirus infection...
  28. pmc Phase 1 safety and pharmacokinetic study of chimeric murine-human monoclonal antibody c alpha Stx2 administered intravenously to healthy adult volunteers
    Thomas C Dowling
    Pharmacy Practice and Science Department, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Antimicrob Agents Chemother 49:1808-12. 2005
    ..0-mg/kg dose (206.4 +/- 12.4 h). Future studies are needed to confirm the safety of this c alpha Stx2, and innovative clinical trials will be required to measure its efficacy in preventing or treating HUS...
  29. pmc Adjuvanted intranasal Norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues
    Samer S El-Kamary
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 202:1649-58. 2010
    ..Noroviruses cause significant morbidity and mortality from acute gastroenteritis in all age groups worldwide...
  30. ncbi request reprint Dose-dependent neutralizing-antibody responses to vaccinia
    Robert B Belshe
    Center for Vaccine Development, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Infect Dis 189:493-7. 2004
    ..Larger lesion size and fever after vaccination were associated with significantly higher neutralizing-antibody titers after vaccination...