YVETTE TACHE

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes
    Andreas Stengel
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Curr Pharm Des 19:98-105. 2013
  2. pmc Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents
    Y Tache
    CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Curr Med Chem 19:35-42. 2012
  3. pmc A role for corticotropin-releasing factor in functional gastrointestinal disorders
    YVETTE TACHE
    Center for Ulcer Research and Education CURE Digestive Diseases Research Center, Building 115, Room 117, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 11:270-7. 2009
  4. pmc From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases
    YVETTE TACHE
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Ann N Y Acad Sci 1148:29-41. 2008
  5. ncbi request reprint Role of corticotropin-releasing factor pathways in stress-related alterations of colonic motor function and viscerosensibility in female rodents
    YVETTE TACHE
    Center for Neurovisceral Sciences and Women s Health, and CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Gend Med 2:146-54. 2005
  6. pmc Corticotropin-releasing factor receptors and stress-related alterations of gut motor function
    YVETTE TACHE
    CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, UCLA, Los Angeles, California 90073, USA
    J Clin Invest 117:33-40. 2007
  7. pmc Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways
    Muriel Larauche
    CURE Digestive Diseases Research Center, Diseases Research Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 297:G215-27. 2009
  8. pmc Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice
    Lixin Wang
    CURE Digestive Diseases Research Center, and Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 298:G45-56. 2010
  9. doi request reprint Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008
  10. pmc Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice
    Vicente Martinez
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences, VA Greater Los Angeles Healthcare System, Bldg 115, Rm 117, 11301 Whilshire Blvd, Los Angeles CA 90073, USA
    J Physiol 556:221-34. 2004

Research Grants

Detail Information

Publications90

  1. pmc Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes
    Andreas Stengel
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Curr Pharm Des 19:98-105. 2013
    ....
  2. pmc Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents
    Y Tache
    CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Curr Med Chem 19:35-42. 2012
    ..A better understanding of brain circuitries through which these peptides are released will provide new strategies to recruit integrated and multifaceted gastroprotective mechanisms...
  3. pmc A role for corticotropin-releasing factor in functional gastrointestinal disorders
    YVETTE TACHE
    Center for Ulcer Research and Education CURE Digestive Diseases Research Center, Building 115, Room 117, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 11:270-7. 2009
    ..Yet to be ascertained is whether CRF1 receptor antagonists hold promise as a new therapy in IBS treatment...
  4. pmc From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases
    YVETTE TACHE
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Ann N Y Acad Sci 1148:29-41. 2008
    ....
  5. ncbi request reprint Role of corticotropin-releasing factor pathways in stress-related alterations of colonic motor function and viscerosensibility in female rodents
    YVETTE TACHE
    Center for Neurovisceral Sciences and Women s Health, and CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Gend Med 2:146-54. 2005
    ..The activation of brain corticotropin-releasing factor (CRF) pathways has a key role in the behavioral and visceral responses to stress...
  6. pmc Corticotropin-releasing factor receptors and stress-related alterations of gut motor function
    YVETTE TACHE
    CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, UCLA, Los Angeles, California 90073, USA
    J Clin Invest 117:33-40. 2007
    ..We also examine how these mechanisms translate into the development of new approaches for irritable bowel syndrome, a multifactorial disorder for which stress has been implicated in the pathophysiology...
  7. pmc Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways
    Muriel Larauche
    CURE Digestive Diseases Research Center, Diseases Research Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 297:G215-27. 2009
    ..Stresslike colonic alterations induced by ip cortagine in rats and mice through restricted activation of peripheral CRF(1) receptors support a role for peripheral CRF(1) signaling as the local arm of the colonic response to stress...
  8. pmc Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice
    Lixin Wang
    CURE Digestive Diseases Research Center, and Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 298:G45-56. 2010
    ..These data established that PYY/PYY(3-36) potently inhibits basal and stress/serotonin/cholinergic-stimulated propulsive colonic motor function in conscious mice, likely via Y(2) receptors...
  9. doi request reprint Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008
    ..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms...
  10. pmc Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice
    Vicente Martinez
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences, VA Greater Los Angeles Healthcare System, Bldg 115, Rm 117, 11301 Whilshire Blvd, Los Angeles CA 90073, USA
    J Physiol 556:221-34. 2004
    ....
  11. pmc Chronic injection of pansomatostatin agonist ODT8-SST differentially modulates food intake and decreases body weight gain in lean and diet-induced obese rats
    Andreas Stengel
    Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Regul Pept 167:201-8. 2011
    ..In DIO rats, ODT8-SST reduces lean mass but promotes food intake and fat mass, indicating differential responsiveness to somatostatin under obese conditions...
  12. pmc Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in rats
    Andreas Stengel
    Department of Medicine, Center for Ulcer Research and Education, Digestive Diseases Division, University of California Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Endocrinology 151:4224-35. 2010
    ....
  13. pmc Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor
    Andreas Stengel
    Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 150:4911-9. 2009
    ..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect...
  14. pmc CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats
    Miriam Goebel-Stengel
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles 90073, USA
    Am J Physiol Regul Integr Comp Physiol 303:R850-60. 2012
    ..These data highlight the importance of studying the molecular forms of peptides that exist in vivo in tissue and circulation of the animal being studied...
  15. ncbi request reprint Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2
    Vicente Martinez
    Center for Ulcer Research and Education Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine, University of California at Los Angeles, USA
    J Pharmacol Exp Ther 301:611-7. 2002
    ....
  16. pmc Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2
    Andreas Stengel
    Department of Medicine, CURE Digestive Diseases Research Center, Digestive Diseases Division at University of California Los Angeles, USA
    Am J Physiol Gastrointest Liver Physiol 301:G239-48. 2011
    ....
  17. pmc Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgery
    Lixin Wang
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VAGLAHS, Los Angeles, CA 90073, USA
    Brain Res 1415:34-46. 2011
    ..Abdominal surgery activates CRF-ir neurons selectively in the PVN of rats without colchicine treatment...
  18. pmc Repeated psychological stress-induced alterations of visceral sensitivity and colonic motor functions in mice: influence of surgery and postoperative single housing on visceromotor responses
    Muriel Larauche
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA and CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Los Angeles, CA, 90073, USA
    Stress 13:343-54. 2010
    ..NS-GH and NS-SH mice, respectively. These data indicate that the combination of S-SH required for VMR monitoring with EMG is an important component of repeated WAS-induced post-stress visceral hypersensitivity and defecation in mice...
  19. pmc Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting
    Andreas Stengel
    Center for Ulcer Research and Education, Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90073, USA
    Endocrinology 150:153-60. 2009
    ..These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response...
  20. doi request reprint Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOAT
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Peptides 31:1689-96. 2010
    ..These data indicate that LPS induces a long-lasting reduction of AG and DG levels that may have a bearing with the decrease in food intake. The faster drop in AG than DG within 2 h is associated with reduced circulating GOAT...
  21. ncbi request reprint Intraperitoneal corticotropin-releasing factor and urocortin induce Fos expression in brain and spinal autonomic nuclei and long lasting stimulation of colonic motility in rats
    Celine Maillot
    Digestive Diseases Research Center, Department of Medicine, Digestive Diseases Division, Los Angeles, CA, USA
    Brain Res 974:70-81. 2003
    ..These results indicate that i.p. CRF and urocortin induce a peptide specific activation of brain nuclei receiving viscerosensory inputs and involved in autonomic circuitries whose effector limbs may impact on visceral function...
  22. pmc Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats
    Miriam Goebel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Brain Res 1300:114-24. 2009
    ..These data demonstrate that nesfatin-1 neurons are part of the hypothalamic and hindbrain neuronal cell groups activated by restraint suggesting a possible role of nesfatin-1 in the response to stress...
  23. pmc Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, California, USA
    Endocrinology 150:232-8. 2009
    ..NUCB2 gene expression is significantly regulated by nutritional status, suggesting a regulatory role of peripheral nesfatin-1 in energy homeostasis...
  24. pmc Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implications
    Andreas Stengel
    CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States
    Peptides 32:2208-17. 2011
    ..A better understanding of these mechanisms will allow targeting components of ghrelin signaling that may improve food intake and gastric motility alterations induced by stress...
  25. pmc Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents
    Guillaume Gourcerol
    Center for Ulcer Research and Education Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Gastroenterology 140:1586-96.e6. 2011
    ..Corticotropin-releasing factor receptor-1 (CRF(1)) mediates the stress-induced colonic motor activity. Less is known about the role of CRF(2) in the colonic response to stress...
  26. pmc Activation of brain somatostatin 2 receptors stimulates feeding in mice: analysis of food intake microstructure
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
    Physiol Behav 101:614-22. 2010
    ..The shortened inter-meal interval suggests an inhibitory effect of the sst(2) agonist on "satiety", whereas "satiation" is not altered as indicated by normal meal size...
  27. ncbi request reprint Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats
    Mulugeta Million
    Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 26:1188-95. 2005
    ..5+/-23.3% and 63.5+/-7.2%, respectively in Fisher rats. These data suggest that peripheral CRF2 receptor activation exerts antinociceptive effects on CRD-induced visceral pain, whereas CRF1 contributes to visceral sensitization...
  28. ncbi request reprint Proximal colon distension induces Fos expression in the brain and inhibits gastric emptying through capsaicin-sensitive pathways in conscious rats
    Vicente Martinez
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, 90073, USA
    Brain Res 1086:168-80. 2006
    ..Capsaicin-sensitive afferent pathways are involved in mediating brain neuronal activation and functional changes associated with noxious visceral stimulation...
  29. pmc Urocortins and CRF type 2 receptor isoforms expression in the rat stomach are regulated by endotoxin: role in the modulation of delayed gastric emptying
    Pu Qing Yuan
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine and Brain Research Institute UCLA, 1301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 303:G20-31. 2012
    ..The CRF(2) signaling system may act to counteract the early gastric motor alterations to endotoxemia...
  30. pmc Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in rats
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 31:263-70. 2010
    ....
  31. ncbi request reprint Water avoidance stress activates colonic myenteric neurons in female rats
    Marcel Miampamba
    Department of Medicine, Center for Neurovisceral Sciences and Women s Health and CURE Digestive Diseases Research Center and Brain Research Institute, University of California, Los Angeles, California, USA
    Neuroreport 18:679-82. 2007
    ..Atropine blocked fecal pellet output but not Fos expression in myenteric ganglia. These results indicate that psychological stress stimulates the activity of colonic cholinergic myenteric neurons...
  32. ncbi request reprint Peripheral CRF activates myenteric neurons in the proximal colon through CRF(1) receptor in conscious rats
    Marcel Miampamba
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 282:G857-65. 2002
    ..These results indicate that peripheral CRF activates myenteric cholinergic neurons in the proximal colon through CRF(1) receptor...
  33. pmc Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in rats
    Lixin Wang
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 39:164-70. 2013
    ....
  34. doi request reprint Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in rats
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division, University of California Los Angeles, VA Greater Los Angeles Health Care System, CA 90073, USA
    Peptides 32:1942-7. 2011
    ..These changes are opposite to those of ghrelin in response to LPS supporting a differential gastric regulation of NUCB2/nesfatin-1 and ghrelin expression derived from the same cell by immune challenge...
  35. pmc Localization of nesfatin-1 neurons in the mouse brain and functional implication
    Miriam Goebel-Stengel
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Brain Res 1396:20-34. 2011
    ....
  36. pmc Mice overexpressing corticotropin-releasing factor show brain atrophy and motor dysfunctions
    Miriam Goebel
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, UCLA and VA GLA Healthcare System, Los Angeles, CA, USA
    Neurosci Lett 473:11-5. 2010
    ....
  37. pmc Expression of corticotropin releasing factor receptor type 1 (CRF1) in the human gastrointestinal tract and upregulation in the colonic mucosa in patients with ulcerative colitis
    Pu Qing Yuan
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, CA 90073, USA
    Peptides 38:62-9. 2012
    ..The increase of CRF(1) IR cells prominently in macrophages of the sigmoid colonic mucosa of UC patients provides anatomical support for a role of CRF(1) signaling in modulating the immune-inflammatory process of UC...
  38. pmc Stress-induced visceral analgesia assessed non-invasively in rats is enhanced by prebiotic diet
    Muriel Larauche
    VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    World J Gastroenterol 18:225-36. 2012
    ....
  39. pmc Modulation of gastric motility by brain-gut peptides using a novel non-invasive miniaturized pressure transducer method in anesthetized rodents
    Guillaume Gourcerol
    CURE Digestive Diseases Research Center, and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 32:737-46. 2011
    ..Using this method we established in mice that the gastric motility response to central vagal activation is impaired under chronic expression of CRF...
  40. pmc Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa
    Andreas Stengel
    Center for Neurobiology of Stress, CURE Digestive Diseases Research Center, USA
    Biochem Biophys Res Commun 392:67-71. 2010
    ..Detection of GOAT in the plasma raises the possibility that ghrelin octanoylation may occur in the circulation and the fasting-induced increase in GOAT may contribute to the increase of acylated ghrelin after fasting...
  41. pmc Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA
    Peptides 31:2229-35. 2010
    ..The restoration of circulating AG levels inhibited by abdominal surgery may contribute to alleviate postoperative gastric ileus...
  42. pmc Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in rats
    Miriam Goebel
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Brain Res 1351:150-64. 2010
    ....
  43. pmc Peripheral activation of corticotropin-releasing factor receptor 2 inhibits food intake and alters meal structures in mice
    Lixin Wang
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine Digestive Diseases Division, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Peptides 32:51-9. 2011
    ..These data indicate that Ucns, through peripheral CRF(2) receptor-mediated induction of satiation, inhibit the eating response to a fast more potently than the physiological nocturnal feeding in mice...
  44. ncbi request reprint Identification and characterization of multiple corticotropin-releasing factor type 2 receptor isoforms in the rat esophagus
    S Vincent Wu
    Center for Ulcer Research and Education, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90073, USA, and Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
    Endocrinology 148:1675-87. 2007
    ....
  45. pmc Nesfatin-1(30-59) but not the N- and C-terminal fragments, nesfatin-1(1-29) and nesfatin-1(60-82) injected intracerebroventricularly decreases dark phase food intake by increasing inter-meal intervals in mice
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 35:143-8. 2012
    ..The delayed onset may be indicative of time required to modulate other hypothalamic and medullary networks regulating nocturnal feeding as established for nesfatin-1...
  46. pmc CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice
    Lixin Wang
    Division of Digestive Diseases, Department of Medicine, CURE and Center for Neurobiological Stress, David Geffen School of Medicine at University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
    PLoS ONE 6:e16377. 2011
    ..These data support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress...
  47. ncbi request reprint Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats
    Pu Qing Yuan
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 26:653-64. 2005
    ..These results indicate that increased central vagal outflow activates cholinergic neurons in the stomach while in the duodenum, VIP neurons are preferentially stimulated...
  48. pmc Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brain
    Lixin Wang
    CURE Digestive Diseases Research Center and Center for Neurobiological Stress, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Brain Res 1247:79-91. 2009
    ..Activation of medullary catecholaminergic centers might reflect the afferent and efferent limbs of the functional responses associated to visceral pain...
  49. ncbi request reprint Gastric vagal efferent inhibition evoked by intravenous CRF is unrelated to simultaneously recorded vagal afferent activity in urethane-anesthetized rats
    David W Adelson
    Center for Ulcer Research and Education, Digestive Diseases Research Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, California 90073, USA
    J Neurophysiol 97:3004-14. 2007
    ..The data demonstrate a predominantly inhibitory influence of iv CRF on VE outflow to the hindstomach, not driven by gastric vagovagal reflex activity...
  50. pmc Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein
    Lixin Wang
    CURE Digestive Diseases Center and Center for Neurobiology of Stress, David Geffen School of Medicine, University of California at Los Angeles and VAGLAHS, Los Angeles, California, USA
    Neuroreport 19:873-6. 2008
    ..These results indicate that Thy1-alphaSyn mice display altered basal and stress-stimulated propulsive colonic motility and will be a useful model to study gut dysfunction associated with Parkinson's disease...
  51. ncbi request reprint A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health CNS, West Los Angeles VA Medical Center, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 985:32-42. 2003
    ....
  52. pmc Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals
    Miriam Goebel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
    Peptides 32:36-43. 2011
    ..The lack of nesfatin-1 effect when injected peripherally at a 23-times higher dose indicates a primarily central site of the anorexigenic action for nesfatin-1 in mice...
  53. pmc Lipopolysaccharide increases plasma levels of corticotropin-releasing hormone in rats
    Miriam Goebel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, UCLA, and VA Greater Los Angeles Healthcare System, CA, USA
    Neuroendocrinology 93:165-73. 2011
    ..Whether these changes are reflected by increased circulating levels of CRH and adrenocorticotropic hormone (ACTH) is unknown...
  54. ncbi request reprint LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications
    Lixin Wang
    CURE Bldg 115, Rm 117B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G611-20. 2006
    ..These data showed that IL-1 and PG pathways are part of the early mechanisms by which LPS suppresses fasted plasma ghrelin and that exogenous ghrelin can normalize LPS-induced-altered digestive functions...
  55. ncbi request reprint Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus
    Lixin Wang
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Department of Medicine, University of California at Los Angeles, Building 115, Room 203, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neurosci Lett 325:47-51. 2002
    ..About 90% of the Fos-positive neurons in the Arc expressed neuropeptide Y (NPY) messenger RNA. These data indicate that NPY neurons in the Arc are likely the primary target mediating i.p. ghrelin induced orexigenic effect...
  56. ncbi request reprint Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats
    Ines Schwetz
    Center for Neurovisceral Sciences and Women s Health, University of California Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 289:G704-12. 2005
    ..Both acute and delayed stress-induced visceral hypersensitivity in MS rats are mediated by the CRF/CRF(1)R system...
  57. pmc Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight
    Andreas Stengel
    CURE Digestive Diseases Research Center and Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 31:357-69. 2010
    ....
  58. ncbi request reprint Cephalic phase of acid secretion involves activation of medullary TRH receptor subtype 1 in rats
    Vicente Martinez
    CURE Digestive Diseases Research Center, Veteran s Affairs Greater Los Angeles Healthcare System, Department of Medicine, Division of Digestive Diseases and Brain Research Institute, School of Medicine, University of California at Los Angeles, 90073, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1310-9. 2002
    ..These results indicate that the cholinergic-dependent acid response to sham feeding is mediated by brain medullary TRH(1) receptors in rats...
  59. ncbi request reprint Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents
    Guillaume Gourcerol
    Center for Ulcer Research and Education CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, USA
    Obesity (Silver Spring) 15:2643-52. 2007
    ..We aimed to investigate the effects of peripheral and intracisternal (IC) injection of obestatin on feeding, gastric motility, and blood glucose in rats as well as in diet-induced obese (DIO) mice...
  60. ncbi request reprint Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats
    Jozsef Czimmer
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 290:G511-8. 2006
    ....
  61. pmc Brain-gut interactions between central vagal activation and abdominal surgery to influence gastric myenteric ganglia Fos expression in rats
    Marcel Miampamba
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA
    Peptides 32:1078-82. 2011
    ..The modulation of gastric vagus-myenteric neuron activity could play an important role in the recovery phase of postoperative gastric ileus...
  62. pmc Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model
    S Vincent Wu
    CURE, Building 115, Room 217, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 152:126-37. 2011
    ....
  63. ncbi request reprint Ghrelin: new insight to mechanisms and treatment of postoperative gastric ileus
    Andreas Stengel
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Curr Pharm Des 17:1587-93. 2011
    ....
  64. pmc Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors
    Cornelia Kiank
    David Geffen School of Medicine at UCLA, CURE Digestive Diseases Research Center Animal Core, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Brain Behav Immun 24:41-8. 2010
    ....
  65. pmc Corticotropin-releasing factor signaling and visceral response to stress
    Andreas Stengel
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Exp Biol Med (Maywood) 235:1168-78. 2010
    ....
  66. pmc Minireview: nesfatin-1--an emerging new player in the brain-gut, endocrine, and metabolic axis
    Andreas Stengel
    Department of Medicine, CURE Digestive Diseases Research Center, University of California, Los Angeles, Building 115, Room 117, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 152:4033-8. 2011
    ..However, the cellular mechanisms of nesfatin-1's action remain poorly understood, partly because the receptor through which nesfatin-1 exerts its pleiotropic actions is yet to be identified...
  67. ncbi request reprint Urocortins and the regulation of gastrointestinal motor function and visceral pain
    Vicente Martinez
    Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurovisceral Sciences and Women s Health, University of California, Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 25:1733-44. 2004
    ..These observations suggest that, acting centrally and peripherally, Ucns might play a significant role in the modulation of gastrointestinal motor and pain responses during stress and stress-related pathophysiological conditions...
  68. ncbi request reprint The CRF(1) receptor antagonist, NBI-35965, abolished the activation of locus coeruleus neurons induced by colorectal distension and intracisternal CRF in rats
    Hovsep P Kosoyan
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Veterans Affairs Medical Center, Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Brain Res 1056:85-96. 2005
    ..This activation may have relevance to irritable bowel syndrome characterized by lower pain threshold to CRD and hypervigilance to colonic input...
  69. pmc Serum and colonic mucosal immune markers in irritable bowel syndrome
    Lin Chang
    Center for Neurobiology of Stress, University of California, Los Angeles, California 90095 7378, USA
    Am J Gastroenterol 107:262-72. 2012
    ....
  70. pmc Nesfatin-1--role as possible new potent regulator of food intake
    Andreas Stengel
    Department of Medicine, CURE Digestive Diseases Research Center, Digestive Diseases Division UCLA, Los Angeles, CA 90073, USA
    Regul Pept 163:18-23. 2010
    ..Lastly, potential clinical implications of targeting NUCB2/nesfatin-1 signaling and existing gaps in knowledge to ascertain the role and mechanisms of action of nesfatin-1 are presented...
  71. pmc Regulation of food intake: the gastric X/A-like endocrine cell in the spotlight
    Andreas Stengel
    Center for Ulcer Research and Education, Digestive Diseases Research Center, Center for Neurobiology of Stress, Building 115, Room 117, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 11:448-54. 2009
    ..Importantly, synergistic interactions between ghrelin and intestinal peptides seem to orchestrate food intake and body weight regulation, which may have implications for understanding mechanisms leading to the treatment of obesity...
  72. pmc Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlight
    Andreas Stengel
    Department of Medicine and CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Annu Rev Physiol 71:219-39. 2009
    ..Here, we review how various stressors affect the gut, with special emphasis on the central and peripheral CRF signaling systems...
  73. pmc Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei
    Miriam Goebel
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Neurosci Lett 452:241-6. 2009
    ..The features and distributions of nesfatin-1 IR and mRNA expression in the brain and spinal cord suggest that NUCB2/nesfatin-1 could play a wider role in autonomic regulation of visceral-endocrine functions besides food intake...
  74. pmc Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage
    Andreas Stengel
    Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, Los Angeles, CA, USA
    Curr Protein Pept Sci 12:293-304. 2011
    ....
  75. pmc Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, VA Greater Los Angeles Health Care System, California, USA
    Neuroreport 22:253-7. 2011
    ..The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety...
  76. ncbi request reprint Peripheral corticotropin-releasing factor induces diarrhea in rats: role of CRF1 receptor in fecal watery excretion
    Paul R Saunders
    Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, CURE, Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California, Los Angeles, CA 90073, USA
    Eur J Pharmacol 435:231-5. 2002
    ..These results demonstrate that peripheral CRF induces watery diarrhea, primarily through the activation of CRF1 receptor suggesting a possible role for these pathways in colonic responses to stress...
  77. ncbi request reprint Bacterial lipopolysaccharide shifts fasted plasma ghrelin to postprandial levels in rats
    Nicole R Basa
    CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine and Brain Research Institute, University of California at Los Angeles, Building 115, Room 203, 11301 Wilshire Boulevard, 90073, USA
    Neurosci Lett 343:25-8. 2003
    ..Re-feeding decreased plasma ghrelin levels by 58+/-3% compared with pre-feeding fasting values in i.p. vehicle group. These data provide the first evidence that LPS shifts fasting ghrelin levels to those observed postprandially...
  78. ncbi request reprint Activation of raphe pallidus neurons increases insulin through medullary thyrotropin-releasing hormone (TRH)-vagal pathways
    Hong Yang
    Center for Ulcer Research and Education, Veterans Affairs Greater Los Angeles Healthcare System, UCLA Department of Medicine, and Brain Research Institute, Los Angeles, California 90073, USA
    Pancreas 25:301-7. 2002
    ....
  79. pmc Electrophysiological evidence for distinct vagal pathways mediating CCK-evoked motor effects in the proximal versus distal stomach
    Shiho Okano-Matsumoto
    Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, Osaka, Japan
    J Physiol 589:371-93. 2011
    ....
  80. ncbi request reprint Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats
    Keishi Kawakubo
    CURE Digestive Diseases Research Center, Veteran s Affairs Greater Los Angeles Healthcare System, Department of Medicine, and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1035-41. 2002
    ..These data indicate that PYY-infused intravenously at doses reported to mimic postprandial peak blood levels prevents ethanol-induced gastric injury through vagal independent pathways and PYY-preferring receptors...
  81. ncbi request reprint Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons
    Marcel Miampamba
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Department of Medicine, University of California, Los Angeles, 90073, USA
    Regul Pept 105:145-54. 2002
    ..5 (PGP 9.5) revealed the neuronal identity of myenteric cells bearing PAC1. The neuronal localization of PACAP and PAC1 receptors supports their role in the neural regulation of gastric acid secretion and gastrointestinal motor function...
  82. pmc Stress and visceral pain: from animal models to clinical therapies
    Muriel Larauche
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Exp Neurol 233:49-67. 2012
    ....
  83. ncbi request reprint Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles 90073, USA
    Am J Physiol Gastrointest Liver Physiol 282:G34-40. 2002
    ..The distinct profile of hUcn II, only on gastric transit, is linked to its CRF(2) selectivity...
  84. ncbi request reprint Coordinated gastric and sphincter motility evoked by intravenous CCK-8 as monitored by ultrasonomicrometry in rats
    David W Adelson
    Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 286:G321-32. 2004
    ..These data revealed CCK-8-induced gastric and sphincter activity consistent with retropulsion of gastric content...
  85. ncbi request reprint Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats
    Keishi Kawakubo
    Digestive Diseases Division, CURE Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles, CA 90073, USA
    Peptides 26:1580-9. 2005
    ..Mast cells mediate RX-induced gastric hyperemia via 5-HT3, 5-HT4, and H2 receptors; initial increase depends upon CTMC whereas MMC contributes to the later response...
  86. ncbi request reprint Intravenous urocortin II decreases blood pressure through CRF(2) receptor in rats
    Chih Yen Chen
    Department of Medicine and Brain Research Institute, University of California, Building 115 Room No 117, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Regul Pept 113:125-30. 2003
    ..These data show that iv hUcn II induces hypotension through peripheral CRF(2) receptor while not altering the responsiveness to sympathetic nervous system-mediated rise in MAP...
  87. pmc The RAPID method for blood processing yields new insight in plasma concentrations and molecular forms of circulating gut peptides
    Andreas Stengel
    University of California and CURE Digestive Disease Research Center, Building 115, Room 117, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 150:5113-8. 2009
    ..Therefore, the RAPID method represents an efficacious means to detect circulating variations in peptide concentrations and form relevant to the understanding of physiological function of endocrine peptides...
  88. pmc Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis
    Eunok Im
    Section of Inflammatory Bowel Disease and Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    Gastroenterology 138:2457-67, 2467.e1-5. 2010
    ..We investigated the functions of CRHR1 and CRHR2 signaling during intestinal inflammation and angiogenesis...
  89. pmc Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study
    Muriel Larauche
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    J Neurogastroenterol Motil 17:213-34. 2011
    ....
  90. ncbi request reprint Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileus
    Andrew Luckey
    Department of Veternas Affairs, Greater Los Angeles Healthcare System, La Jolla, California 90073, USA
    Gastroenterology 125:654-9. 2003
    ..Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus...

Research Grants29

  1. STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
    YVETTE TACHE; Fiscal Year: 2007
    ..In addition, it will anchor the gut CRF signaling system as part of the physiological effector limb in stress-related gut motor alterations. This could underpin novel strategies for management of functional bowel disorders. ..
  2. CORTICOTROPIN-RELEASING FACTOR-ACTION ON GI FUNCTION
    YVETTE TACHE; Fiscal Year: 2007
    ..abstract_text> ..
  3. Corticotropin-Releasing Factor Action on GI Function
    YVETTE FRANCE TACHE; Fiscal Year: 2010
    ..These studies have the potential to underpin molecular mechanisms of stress-related gut diseases leading to new treatment targeting these stress pathways. ..
  4. Stress-Induced Activition of Colonic Motor Function
    YVETTE TACHE; Fiscal Year: 2009
    ..This could underpin novel strategies for management of functional bowel disorders. ..
  5. STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
    YVETTE TACHE; Fiscal Year: 2004
    ..abstract_text> ..
  6. CORTICOTROPIN-RELEASING FACTOR--ACTION ON GI FUNCTION
    YVETTE TACHE; Fiscal Year: 1993
    ....
  7. Stress-Induced Activition of Colonic Motor Function
    YVETTE FRANCE TACHE; Fiscal Year: 2010
    ..In addition, it will anchor the gut CRF signaling system as part of the physiological effector limb in stress-related gut motor alterations. This could underpin novel strategies for management of functional bowel disorders. ..