Research Topics
Genomes and Genes
| YVETTE TACHESummaryAffiliation: University of California Country: USA Publications
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Publications
Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypesAndreas Stengel
CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Curr Pharm Des 19:98-105. 2013....- Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferentsY Tache
CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Curr Med Chem 19:35-42. 2012..A better understanding of brain circuitries through which these peptides are released will provide new strategies to recruit integrated and multifaceted gastroprotective mechanisms... - Role of corticotropin-releasing factor pathways in stress-related alterations of colonic motor function and viscerosensibility in female rodentsYVETTE TACHE
Center for Neurovisceral Sciences and Women s Health, and CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Gend Med 2:146-54. 2005..The activation of brain corticotropin-releasing factor (CRF) pathways has a key role in the behavioral and visceral responses to stress... 
Corticotropin-releasing factor receptors and stress-related alterations of gut motor functionYVETTE TACHE
CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, UCLA, Los Angeles, California 90073, USA
J Clin Invest 117:33-40. 2007..We also examine how these mechanisms translate into the development of new approaches for irritable bowel syndrome, a multifactorial disorder for which stress has been implicated in the pathophysiology...- A role for corticotropin-releasing factor in functional gastrointestinal disordersYVETTE TACHE
Center for Ulcer Research and Education CURE Digestive Diseases Research Center, Building 115, Room 117, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 11:270-7. 2009..Yet to be ascertained is whether CRF1 receptor antagonists hold promise as a new therapy in IBS treatment... - From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseasesYVETTE TACHE
Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Ann N Y Acad Sci 1148:29-41. 2008.... - Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathwaysMuriel Larauche
CURE Digestive Diseases Research Center, Diseases Research Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 297:G215-27. 2009..Stresslike colonic alterations induced by ip cortagine in rats and mice through restricted activation of peripheral CRF(1) receptors support a role for peripheral CRF(1) signaling as the local arm of the colonic response to stress... - Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious miceLixin Wang
CURE Digestive Diseases Research Center, and Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Am J Physiol Gastrointest Liver Physiol 298:G45-56. 2010..These data established that PYY/PYY(3-36) potently inhibits basal and stress/serotonin/cholinergic-stimulated propulsive colonic motor function in conscious mice, likely via Y(2) receptors... 
Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in ratsMuriel Larauche
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms...- Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in miceVicente Martinez
CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences, VA Greater Los Angeles Healthcare System, Bldg 115, Rm 117, 11301 Whilshire Blvd, Los Angeles CA 90073, USA
J Physiol 556:221-34. 2004.... - Chronic injection of pansomatostatin agonist ODT8-SST differentially modulates food intake and decreases body weight gain in lean and diet-induced obese ratsAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Regul Pept 167:201-8. 2011..In DIO rats, ODT8-SST reduces lean mass but promotes food intake and fat mass, indicating differential responsiveness to somatostatin under obese conditions... - Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptorAndreas Stengel
Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 150:4911-9. 2009..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect... - Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in ratsAndreas Stengel
Department of Medicine, Center for Ulcer Research and Education, Digestive Diseases Division, University of California Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Endocrinology 151:4224-35. 2010.... - CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed ratsMiriam Goebel-Stengel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles 90073, USA
Am J Physiol Regul Integr Comp Physiol 303:R850-60. 2012..These data highlight the importance of studying the molecular forms of peptides that exist in vivo in tissue and circulation of the animal being studied... - Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2Vicente Martinez
Center for Ulcer Research and Education Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine, University of California at Los Angeles, USA
J Pharmacol Exp Ther 301:611-7. 2002.... - Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2Andreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Digestive Diseases Division at University of California Los Angeles, USA
Am J Physiol Gastrointest Liver Physiol 301:G239-48. 2011.... - Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgeryLixin Wang
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VAGLAHS, Los Angeles, CA 90073, USA
Brain Res 1415:34-46. 2011..Abdominal surgery activates CRF-ir neurons selectively in the PVN of rats without colchicine treatment... - Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOATAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
Peptides 31:1689-96. 2010..These data indicate that LPS induces a long-lasting reduction of AG and DG levels that may have a bearing with the decrease in food intake. The faster drop in AG than DG within 2 h is associated with reduced circulating GOAT... - Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fastingAndreas Stengel
Center for Ulcer Research and Education, Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90073, USA
Endocrinology 150:153-60. 2009..These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response... - Repeated psychological stress-induced alterations of visceral sensitivity and colonic motor functions in mice: influence of surgery and postoperative single housing on visceromotor responsesMuriel Larauche
Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA and CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Los Angeles, CA, 90073, USA
Stress 13:343-54. 2010..NS-GH and NS-SH mice, respectively. These data indicate that the combination of S-SH required for VMR monitoring with EMG is an important component of repeated WAS-induced post-stress visceral hypersensitivity and defecation in mice... - Intraperitoneal corticotropin-releasing factor and urocortin induce Fos expression in brain and spinal autonomic nuclei and long lasting stimulation of colonic motility in ratsCeline Maillot
Digestive Diseases Research Center, Department of Medicine, Digestive Diseases Division, Los Angeles, CA, USA
Brain Res 974:70-81. 2003..These results indicate that i.p. CRF and urocortin induce a peptide specific activation of brain nuclei receiving viscerosensory inputs and involved in autonomic circuitries whose effector limbs may impact on visceral function... - Restraint stress activates nesfatin-1-immunoreactive brain nuclei in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
Brain Res 1300:114-24. 2009..These data demonstrate that nesfatin-1 neurons are part of the hypothalamic and hindbrain neuronal cell groups activated by restraint suggesting a possible role of nesfatin-1 in the response to stress... - Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosaAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, California, USA
Endocrinology 150:232-8. 2009..NUCB2 gene expression is significantly regulated by nutritional status, suggesting a regulatory role of peripheral nesfatin-1 in energy homeostasis... - Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implicationsAndreas Stengel
CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States
Peptides 32:2208-17. 2011..A better understanding of these mechanisms will allow targeting components of ghrelin signaling that may improve food intake and gastric motility alterations induced by stress... - Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodentsGuillaume Gourcerol
Center for Ulcer Research and Education Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Gastroenterology 140:1586-96.e6. 2011..Corticotropin-releasing factor receptor-1 (CRF(1)) mediates the stress-induced colonic motor activity. Less is known about the role of CRF(2) in the colonic response to stress... - Activation of brain somatostatin 2 receptors stimulates feeding in mice: analysis of food intake microstructureAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
Physiol Behav 101:614-22. 2010..The shortened inter-meal interval suggests an inhibitory effect of the sst(2) agonist on "satiety", whereas "satiation" is not altered as indicated by normal meal size... - Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female ratsMulugeta Million
Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 26:1188-95. 2005..5+/-23.3% and 63.5+/-7.2%, respectively in Fisher rats. These data suggest that peripheral CRF2 receptor activation exerts antinociceptive effects on CRD-induced visceral pain, whereas CRF1 contributes to visceral sensitization... - Proximal colon distension induces Fos expression in the brain and inhibits gastric emptying through capsaicin-sensitive pathways in conscious ratsVicente Martinez
CURE Digestive Diseases Research Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, 90073, USA
Brain Res 1086:168-80. 2006..Capsaicin-sensitive afferent pathways are involved in mediating brain neuronal activation and functional changes associated with noxious visceral stimulation... - Urocortins and CRF type 2 receptor isoforms expression in the rat stomach are regulated by endotoxin: role in the modulation of delayed gastric emptyingPu Qing Yuan
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine and Brain Research Institute UCLA, 1301 Wilshire Blvd, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 303:G20-31. 2012..The CRF(2) signaling system may act to counteract the early gastric motor alterations to endotoxemia... - Peripheral CRF activates myenteric neurons in the proximal colon through CRF(1) receptor in conscious ratsMarcel Miampamba
CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 282:G857-65. 2002..These results indicate that peripheral CRF activates myenteric cholinergic neurons in the proximal colon through CRF(1) receptor... - Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 31:263-70. 2010.... - Water avoidance stress activates colonic myenteric neurons in female ratsMarcel Miampamba
Department of Medicine, Center for Neurovisceral Sciences and Women s Health and CURE Digestive Diseases Research Center and Brain Research Institute, University of California, Los Angeles, California, USA
Neuroreport 18:679-82. 2007..Atropine blocked fecal pellet output but not Fos expression in myenteric ganglia. These results indicate that psychological stress stimulates the activity of colonic cholinergic myenteric neurons... - Localization of nesfatin-1 neurons in the mouse brain and functional implicationMiriam Goebel-Stengel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Brain Res 1396:20-34. 2011.... - Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division, University of California Los Angeles, VA Greater Los Angeles Health Care System, CA 90073, USA
Peptides 32:1942-7. 2011..These changes are opposite to those of ghrelin in response to LPS supporting a differential gastric regulation of NUCB2/nesfatin-1 and ghrelin expression derived from the same cell by immune challenge... - Mice overexpressing corticotropin-releasing factor show brain atrophy and motor dysfunctionsMiriam Goebel
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, UCLA and VA GLA Healthcare System, Los Angeles, CA, USA
Neurosci Lett 473:11-5. 2010.... - Stress-induced visceral analgesia assessed non-invasively in rats is enhanced by prebiotic dietMuriel Larauche
VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
World J Gastroenterol 18:225-36. 2012.... - Identification and characterization of multiple corticotropin-releasing factor type 2 receptor isoforms in the rat esophagusS Vincent Wu
Center for Ulcer Research and Education, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90073, USA, and Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
Endocrinology 148:1675-87. 2007.... - Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosaAndreas Stengel
Center for Neurobiology of Stress, CURE Digestive Diseases Research Center, USA
Biochem Biophys Res Commun 392:67-71. 2010..Detection of GOAT in the plasma raises the possibility that ghrelin octanoylation may occur in the circulation and the fasting-induced increase in GOAT may contribute to the increase of acylated ghrelin after fasting... - Modulation of gastric motility by brain-gut peptides using a novel non-invasive miniaturized pressure transducer method in anesthetized rodentsGuillaume Gourcerol
CURE Digestive Diseases Research Center, and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 32:737-46. 2011..Using this method we established in mice that the gastric motility response to central vagal activation is impaired under chronic expression of CRF... - Peripheral activation of corticotropin-releasing factor receptor 2 inhibits food intake and alters meal structures in miceLixin Wang
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine Digestive Diseases Division, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Peptides 32:51-9. 2011..These data indicate that Ucns, through peripheral CRF(2) receptor-mediated induction of satiation, inhibit the eating response to a fast more potently than the physiological nocturnal feeding in mice... - Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Brain Res 1351:150-64. 2010.... - Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA
Peptides 31:2229-35. 2010..The restoration of circulating AG levels inhibited by abdominal surgery may contribute to alleviate postoperative gastric ileus... - Nesfatin-1(30-59) but not the N- and C-terminal fragments, nesfatin-1(1-29) and nesfatin-1(60-82) injected intracerebroventricularly decreases dark phase food intake by increasing inter-meal intervals in miceAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
Peptides 35:143-8. 2012..The delayed onset may be indicative of time required to modulate other hypothalamic and medullary networks regulating nocturnal feeding as established for nesfatin-1... - Lipopolysaccharide increases plasma levels of corticotropin-releasing hormone in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, UCLA, and VA Greater Los Angeles Healthcare System, CA, USA
Neuroendocrinology 93:165-73. 2011..Whether these changes are reflected by increased circulating levels of CRH and adrenocorticotropic hormone (ACTH) is unknown... - Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious ratsPu Qing Yuan
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
Peptides 26:653-64. 2005..These results indicate that increased central vagal outflow activates cholinergic neurons in the stomach while in the duodenum, VIP neurons are preferentially stimulated... - A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in ratsMulugeta Million
CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health CNS, West Los Angeles VA Medical Center, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
Brain Res 985:32-42. 2003.... - Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervalsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
Peptides 32:36-43. 2011..The lack of nesfatin-1 effect when injected peripherally at a 23-times higher dose indicates a primarily central site of the anorexigenic action for nesfatin-1 in mice... - CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing miceLixin Wang
Division of Digestive Diseases, Department of Medicine, CURE and Center for Neurobiological Stress, David Geffen School of Medicine at University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
PLoS ONE 6:e16377. 2011..These data support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress... - Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brainLixin Wang
CURE Digestive Diseases Research Center and Center for Neurobiological Stress, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
Brain Res 1247:79-91. 2009..Activation of medullary catecholaminergic centers might reflect the afferent and efferent limbs of the functional responses associated to visceral pain... - Gastric vagal efferent inhibition evoked by intravenous CRF is unrelated to simultaneously recorded vagal afferent activity in urethane-anesthetized ratsDavid W Adelson
Center for Ulcer Research and Education, Digestive Diseases Research Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, California 90073, USA
J Neurophysiol 97:3004-14. 2007..The data demonstrate a predominantly inhibitory influence of iv CRF on VE outflow to the hindstomach, not driven by gastric vagovagal reflex activity... - Abnormal colonic motility in mice overexpressing human wild-type alpha-synucleinLixin Wang
CURE Digestive Diseases Center and Center for Neurobiology of Stress, David Geffen School of Medicine, University of California at Los Angeles and VAGLAHS, Los Angeles, California, USA
Neuroreport 19:873-6. 2008..These results indicate that Thy1-alphaSyn mice display altered basal and stress-stimulated propulsive colonic motility and will be a useful model to study gut dysfunction associated with Parkinson's disease... - LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implicationsLixin Wang
CURE Bldg. 115, Rm. 117B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 291:G611-20. 2006..These data showed that IL-1 and PG pathways are part of the early mechanisms by which LPS suppresses fasted plasma ghrelin and that exogenous ghrelin can normalize LPS-induced-altered digestive functions... - Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans ratsInes Schwetz
Center for Neurovisceral Sciences and Women's Health, University of California Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 289:G704-12. 2005..Both acute and delayed stress-induced visceral hypersensitivity in MS rats are mediated by the CRF/CRF(1)R system... - Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleusLixin Wang
CURE: Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Department of Medicine, University of California at Los Angeles, Building 115, Room 203, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Neurosci Lett 325:47-51. 2002..About 90% of the Fos-positive neurons in the Arc expressed neuropeptide Y (NPY) messenger RNA. These data indicate that NPY neurons in the Arc are likely the primary target mediating i.p. ghrelin induced orexigenic effect... - Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weightAndreas Stengel
CURE Digestive Diseases Research Center and Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 31:357-69. 2010.... - Cephalic phase of acid secretion involves activation of medullary TRH receptor subtype 1 in ratsVicente Martinez
CURE Digestive Diseases Research Center, Veteran s Affairs Greater Los Angeles Healthcare System, Department of Medicine, Division of Digestive Diseases and Brain Research Institute, School of Medicine, University of California at Los Angeles, 90073, USA
Am J Physiol Gastrointest Liver Physiol 283:G1310-9. 2002..These results indicate that the cholinergic-dependent acid response to sham feeding is mediated by brain medullary TRH(1) receptors in rats... - Brain-gut interactions between central vagal activation and abdominal surgery to influence gastric myenteric ganglia Fos expression in ratsMarcel Miampamba
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA
Peptides 32:1078-82. 2011..The modulation of gastric vagus-myenteric neuron activity could play an important role in the recovery phase of postoperative gastric ileus... - Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodentsGuillaume Gourcerol
Center for Ulcer Research and Education CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, USA
Obesity (Silver Spring) 15:2643-52. 2007..We aimed to investigate the effects of peripheral and intracisternal (IC) injection of obestatin on feeding, gastric motility, and blood glucose in rats as well as in diet-induced obese (DIO) mice... - Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in ratsJozsef Czimmer
CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 290:G511-8. 2006.... - Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell modelS Vincent Wu
CURE, Building 115, Room 217, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 152:126-37. 2011.... - Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in ratsLixin Wang
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at University of California Los Angeles, Los Angeles, CA 90073, USA
Peptides 39:164-70. 2013.... - Corticotropin-releasing factor signaling and visceral response to stressAndreas Stengel
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Exp Biol Med (Maywood) 235:1168-78. 2010.... - Minireview: nesfatin-1--an emerging new player in the brain-gut, endocrine, and metabolic axisAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, University of California, Los Angeles, Building 115, Room 117, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 152:4033-8. 2011..However, the cellular mechanisms of nesfatin-1's action remain poorly understood, partly because the receptor through which nesfatin-1 exerts its pleiotropic actions is yet to be identified... - Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptorsCornelia Kiank
David Geffen School of Medicine at UCLA, CURE Digestive Diseases Research Center Animal Core, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Brain Behav Immun 24:41-8. 2010.... - Ghrelin: new insight to mechanisms and treatment of postoperative gastric ileusAndreas Stengel
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Curr Pharm Des 17:1587-93. 2011.... - The CRF(1) receptor antagonist, NBI-35965, abolished the activation of locus coeruleus neurons induced by colorectal distension and intracisternal CRF in ratsHovsep P Kosoyan
CURE: Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women's Health, Veterans Affairs Medical Center, Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Brain Res 1056:85-96. 2005..This activation may have relevance to irritable bowel syndrome characterized by lower pain threshold to CRD and hypervigilance to colonic input... - Urocortins and the regulation of gastrointestinal motor function and visceral painVicente Martinez
Department of Medicine, CURE/Digestive Diseases Research Center, Center for Neurovisceral Sciences and Women's Health, University of California, Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 25:1733-44. 2004..These observations suggest that, acting centrally and peripherally, Ucns might play a significant role in the modulation of gastrointestinal motor and pain responses during stress and stress-related pathophysiological conditions... - Serum and colonic mucosal immune markers in irritable bowel syndromeLin Chang
Center for Neurobiology of Stress, University of California, Los Angeles, California 90095 7378, USA
Am J Gastroenterol 107:262-72. 2012.... - Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlightAndreas Stengel
Department of Medicine and CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Annu Rev Physiol 71:219-39. 2009..Here, we review how various stressors affect the gut, with special emphasis on the central and peripheral CRF signaling systems... - Peripheral corticotropin-releasing factor induces diarrhea in rats: role of CRF1 receptor in fecal watery excretionPaul R Saunders
Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, CURE, Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California, Los Angeles, CA 90073, USA
Eur J Pharmacol 435:231-5. 2002..These results demonstrate that peripheral CRF induces watery diarrhea, primarily through the activation of CRF1 receptor suggesting a possible role for these pathways in colonic responses to stress... - Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stageAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, Los Angeles, CA, USA
Curr Protein Pept Sci 12:293-304. 2011.... - Centrally injected kisspeptin reduces food intake by increasing meal intervals in miceAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, VA Greater Los Angeles Health Care System, California, USA
Neuroreport 22:253-7. 2011..The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety... - Nesfatin-1--role as possible new potent regulator of food intakeAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Digestive Diseases Division UCLA, Los Angeles, CA 90073, USA
Regul Pept 163:18-23. 2010..Lastly, potential clinical implications of targeting NUCB2/nesfatin-1 signaling and existing gaps in knowledge to ascertain the role and mechanisms of action of nesfatin-1 are presented... - Regulation of food intake: the gastric X/A-like endocrine cell in the spotlightAndreas Stengel
Center for Ulcer Research and Education, Digestive Diseases Research Center, Center for Neurobiology of Stress, Building 115, Room 117, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 11:448-54. 2009..Importantly, synergistic interactions between ghrelin and intestinal peptides seem to orchestrate food intake and body weight regulation, which may have implications for understanding mechanisms leading to the treatment of obesity... - Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nucleiMiriam Goebel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
Neurosci Lett 452:241-6. 2009..The features and distributions of nesfatin-1 IR and mRNA expression in the brain and spinal cord suggest that NUCB2/nesfatin-1 could play a wider role in autonomic regulation of visceral-endocrine functions besides food intake... - Activation of raphe pallidus neurons increases insulin through medullary thyrotropin-releasing hormone (TRH)-vagal pathwaysHong Yang
Center for Ulcer Research and Education, Veterans Affairs Greater Los Angeles Healthcare System, UCLA Department of Medicine, and Brain Research Institute, Los Angeles, California 90073, USA
Pancreas 25:301-7. 2002.... - Bacterial lipopolysaccharide shifts fasted plasma ghrelin to postprandial levels in ratsNicole R Basa
CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine and Brain Research Institute, University of California at Los Angeles, Building 115, Room 203, 11301 Wilshire Boulevard, 90073, USA
Neurosci Lett 343:25-8. 2003..Re-feeding decreased plasma ghrelin levels by 58+/-3% compared with pre-feeding fasting values in i.p. vehicle group. These data provide the first evidence that LPS shifts fasting ghrelin levels to those observed postprandially... - Electrophysiological evidence for distinct vagal pathways mediating CCK-evoked motor effects in the proximal versus distal stomachShiho Okano-Matsumoto
Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, Osaka, Japan
J Physiol 589:371-93. 2011.... - Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized ratsKeishi Kawakubo
CURE: Digestive Diseases Research Center, Veteran's Affairs Greater Los Angeles Healthcare System, Department of Medicine, and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 283:G1035-41. 2002..These data indicate that PYY-infused intravenously at doses reported to mimic postprandial peak blood levels prevents ethanol-induced gastric injury through vagal independent pathways and PYY-preferring receptors... - Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neuronsMarcel Miampamba
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Department of Medicine, University of California, Los Angeles, 90073, USA
Regul Pept 105:145-54. 2002..5 (PGP 9.5) revealed the neuronal identity of myenteric cells bearing PAC1. The neuronal localization of PACAP and PAC1 receptors supports their role in the neural regulation of gastric acid secretion and gastrointestinal motor function... - Stress and visceral pain: from animal models to clinical therapiesMuriel Larauche
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
Exp Neurol 233:49-67. 2012.... - Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in ratsMulugeta Million
CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles 90073, USA
Am J Physiol Gastrointest Liver Physiol 282:G34-40. 2002..The distinct profile of hUcn II, only on gastric transit, is linked to its CRF(2) selectivity... - Coordinated gastric and sphincter motility evoked by intravenous CCK-8 as monitored by ultrasonomicrometry in ratsDavid W Adelson
Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 286:G321-32. 2004..These data revealed CCK-8-induced gastric and sphincter activity consistent with retropulsion of gastric content... - Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in ratsKeishi Kawakubo
Digestive Diseases Division, CURE: Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles, CA 90073, USA
Peptides 26:1580-9. 2005..Mast cells mediate RX-induced gastric hyperemia via 5-HT3, 5-HT4, and H2 receptors; initial increase depends upon CTMC whereas MMC contributes to the later response... - Intravenous urocortin II decreases blood pressure through CRF(2) receptor in ratsChih-Yen Chen
Department of Medicine and Brain Research Institute, University of California, Building 115 Room No 117, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Regul Pept 113:125-30. 2003..These data show that iv hUcn II induces hypotension through peripheral CRF(2) receptor while not altering the responsiveness to sympathetic nervous system-mediated rise in MAP... - Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesisEunok Im
Section of Inflammatory Bowel Disease and Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
Gastroenterology 138:2457-67, 2467.e1-5. 2010..We investigated the functions of CRHR1 and CRHR2 signaling during intestinal inflammation and angiogenesis... - The RAPID method for blood processing yields new insight in plasma concentrations and molecular forms of circulating gut peptidesAndreas Stengel
University of California and CURE Digestive Disease Research Center, Building 115, Room 117, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 150:5113-8. 2009..Therefore, the RAPID method represents an efficacious means to detect circulating variations in peptide concentrations and form relevant to the understanding of physiological function of endocrine peptides... - Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome studyMuriel Larauche
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
J Neurogastroenterol Motil 17:213-34. 2011.... - Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileusAndrew Luckey
Department of Veternas Affairs, Greater Los Angeles Healthcare System, La Jolla, California 90073, USA
Gastroenterology 125:654-9. 2003..CONCLUSIONS: These data show that CRF(1) activation plays an important role in mediating the early phase of gastric ileus...
Research Grants
- STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTIONYVETTE TACHE; Fiscal Year: 2007..In addition, it will anchor the gut CRF signaling system as part of the physiological effector limb in stress-related gut motor alterations. This could underpin novel strategies for management of functional bowel disorders. ..
- CORTICOTROPIN-RELEASING FACTOR-ACTION ON GI FUNCTIONYVETTE TACHE; Fiscal Year: 2007..abstract_text> ..
- Corticotropin-Releasing Factor Action on GI FunctionYVETTE FRANCE TACHE; Fiscal Year: 2010..These studies have the potential to underpin molecular mechanisms of stress-related gut diseases leading to new treatment targeting these stress pathways. ..
- Stress-Induced Activition of Colonic Motor FunctionYVETTE TACHE; Fiscal Year: 2009..This could underpin novel strategies for management of functional bowel disorders. ..
- STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTIONYVETTE TACHE; Fiscal Year: 2004..abstract_text> ..
- CORTICOTROPIN-RELEASING FACTOR--ACTION ON GI FUNCTIONYVETTE TACHE; Fiscal Year: 1993....
- Stress-Induced Activition of Colonic Motor FunctionYVETTE FRANCE TACHE; Fiscal Year: 2010..In addition, it will anchor the gut CRF signaling system as part of the physiological effector limb in stress-related gut motor alterations. This could underpin novel strategies for management of functional bowel disorders. ..