Y Tache

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Proximal colon distention increases Fos expression in the lumbosacral spinal cord and activates sacral parasympathetic NADPHd-positive neurons in rats
    V Martinez
    Department of Medicine, CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, California 90073, USA
    J Comp Neurol 390:311-21. 1998
  2. ncbi request reprint Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats
    C Maillot
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 119:1569-79. 2000
  3. ncbi request reprint Corticotropin-releasing factor and the brain-gut motor response to stress
    Y Tache
    CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Los Angeles 90073, USA
    Can J Gastroenterol 13:18A-25A. 1999
  4. ncbi request reprint Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors
    Y Tache
    CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, Bldg 115, Rm 203, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 280:G173-7. 2001
  5. pmc Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors
    G Gourcerol
    CURE Digestive Diseases Research Center and Center for Stress Neurobiology, UCLA, VA Greater Los Angeles Healthcare System, CURE Bldg 115, Rm 118B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 296:G992-G1002. 2009
  6. ncbi request reprint Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents
    G Gourcerol
    CURE Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Peptides 27:2811-9. 2006
  7. ncbi request reprint Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats
    M Million
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Digestive Diseases Division, Department of Medicine, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 877:345-53. 2000
  8. ncbi request reprint Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathways
    H Yang
    CURE Digestive Diseases Research Center, West Los Angeles Veterans Affairs Medical Center, and Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California, Los Angeles, California 90073, USA
    Am J Physiol 277:G555-62. 1999
  9. ncbi request reprint Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats
    M Miampamba
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Bldg 115, Rm 203, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 280:G979-91. 2001
  10. pmc Corticotropin releasing factor in the rat colon: expression, localization and upregulation by endotoxin
    P Q Yuan
    Center for Neurobiology of Stress, VA Greater Los Angeles Healthcare System, and Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 31:322-31. 2010

Detail Information

Publications52

  1. ncbi request reprint Proximal colon distention increases Fos expression in the lumbosacral spinal cord and activates sacral parasympathetic NADPHd-positive neurons in rats
    V Martinez
    Department of Medicine, CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, California 90073, USA
    J Comp Neurol 390:311-21. 1998
    ..The marked activation of NADPHd-positive neurons in the sacral parasympathetic nucleus suggests a possible role of nitric oxide in the visceroautonomic reflexes induced by distention of the proximal colon...
  2. ncbi request reprint Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats
    C Maillot
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 119:1569-79. 2000
    ..CRF has preferential affinity for CRF-R1, whereas urocortin displays high affinity for both. We investigated changes in colonic motor function after intraperitoneal (IP) injection of CRF-related peptides...
  3. ncbi request reprint Corticotropin-releasing factor and the brain-gut motor response to stress
    Y Tache
    CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Los Angeles 90073, USA
    Can J Gastroenterol 13:18A-25A. 1999
    ..Hypersecretion of CRF in the brain may contribute to the pathophysiology of stress-related exacerbation of irritable bowel syndrome...
  4. ncbi request reprint Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors
    Y Tache
    CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, Bldg 115, Rm 203, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 280:G173-7. 2001
    ..CRF subtype 1 receptors are involved in the colonic and anxiogenic responses to stress and may have clinical relevance in the comorbidity of anxiety/depression and irritable bowel syndrome...
  5. pmc Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors
    G Gourcerol
    CURE Digestive Diseases Research Center and Center for Stress Neurobiology, UCLA, VA Greater Los Angeles Healthcare System, CURE Bldg 115, Rm 118B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 296:G992-G1002. 2009
    ..Noninvasive colonic manometry opens new venues to investigate colonic motor function in genetically modified mice relevant to diseases that involve colonic motility alterations...
  6. ncbi request reprint Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents
    G Gourcerol
    CURE Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Peptides 27:2811-9. 2006
    ..These data show that obestatin neither influences cumulative food intake, gastric motility or vagal afferent activity nor CCK-induced satiety signaling...
  7. ncbi request reprint Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats
    M Million
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Digestive Diseases Division, Department of Medicine, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 877:345-53. 2000
    ....
  8. ncbi request reprint Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathways
    H Yang
    CURE Digestive Diseases Research Center, West Los Angeles Veterans Affairs Medical Center, and Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California, Los Angeles, California 90073, USA
    Am J Physiol 277:G555-62. 1999
    ..These results suggest that intracisternal PYY acts independently of medullary TRH to decrease ethanol-induced gastric lesions. The PYY action involves vagal cholinergic-mediated CGRP/NO protective mechanisms...
  9. ncbi request reprint Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats
    M Miampamba
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Bldg 115, Rm 203, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 280:G979-91. 2001
    ..These results indicated that central vagal efferent stimulation by intracisternal RX-77368 activates gastric myenteric neurons as well as glial cells mainly through nicotinic ACh receptors in conscious rats...
  10. pmc Corticotropin releasing factor in the rat colon: expression, localization and upregulation by endotoxin
    P Q Yuan
    Center for Neurobiology of Stress, VA Greater Los Angeles Healthcare System, and Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 31:322-31. 2010
    ..These data suggests that colonic CRF may be part of the local effector limb of the CRF(1) receptor mediated colonic alterations induced by acute stress...
  11. pmc Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2)
    C Y Chen
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
    Br J Pharmacol 136:237-47. 2002
    ..rUcn action was antagonized by astressin(2)-B. 7. These data show that i.c. rUcn acts through CRF(2) receptors to inhibit central vagal gastric contractile response and postoprandial emptying...
  12. ncbi request reprint Peripheral corticotropin releasing factor (CRF) and a novel CRF1 receptor agonist, stressin1-A activate CRF1 receptor expressing cholinergic and nitrergic myenteric neurons selectively in the colon of conscious rats
    P Q Yuan
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles 90073, USA
    Neurogastroenterol Motil 19:923-36. 2007
    ..These data support that one mechanism through which peripherally injected CRF ligands stimulate colonic function involves a direct action on colonic cholinergic and nitrergic myenteric neurons expressing CRF(1) receptor...
  13. pmc CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats
    M Million
    CURE Digestive Diseases Research Center, Department of Medicine, University of California Los Angeles, CA 90073, USA
    Gut 55:172-81. 2006
    ..We hypothesised that CRF2 receptor activation may influence visceral pain induced by colorectal distension (CRD) in conscious rats, and assessed the possible sites and mechanisms of action...
  14. ncbi request reprint Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats
    V Martinez
    CURE Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Department of Medicine, Digestive Disease Division and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 893:29-35. 2001
    ....
  15. ncbi request reprint Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious rats
    P Q Yuan
    CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, and Digestive Diseases Division, University of California, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 281:G560-8. 2001
    ..These results indicate that acute cold exposure activates cholinergic as well as nitrergic neurons in the gastric myenteric ganglia through vagal nicotinic pathways in conscious rats...
  16. ncbi request reprint Enhanced pelvic responses to stressors in female CRF-overexpressing mice
    M Million
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, CA 90073, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1429-38. 2007
    ....
  17. pmc Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice
    A Stengel
    Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division at the University of California Los Angeles, USA
    Neurogastroenterol Motil 23:e223-36. 2011
    ..We investigated whether ODT8-SST acts in the brain to influence stress-related alterations of gastric and colonic motor function and sst receptor subtype(s) involved...
  18. ncbi request reprint Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding
    Y Tache
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Auton Neurosci 125:42-52. 2006
    ....
  19. ncbi request reprint Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway
    G Gourcerol
    Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Endocrinology 148:6115-23. 2007
    ..Such synergy is lost in DIO mice, suggesting a resistance to the satiety signaling that may contribute to maintain obesity...
  20. ncbi request reprint Intracisternal sauvagine is more potent than corticotropin-releasing factor to decrease gastric vagal efferent activity in rats
    H P Kosoyan
    CURE, Digestive Diseases Research Center, West Los Angeles Veterans Administration Medical Center, California 90073, USA
    Peptides 20:851-8. 1999
    ....
  21. ncbi request reprint Intracisternal injection of somatostatin receptor 5-preferring agonists induces a vagal cholinergic stimulation of gastric emptying in rats
    V Martinez
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    J Pharmacol Exp Ther 293:1099-105. 2000
    ..c. at 0.8 nmol/rat. These results show that BIM-23056 injected i.c. acts in the brain independently from medullary TRH to induce a vagal cholinergic stimulation of gastric emptying through the sst(5) receptor subtype...
  22. ncbi request reprint Central action of adrenomedullin to inhibit gastric emptying in rats
    V Martinez
    CURE Digestive Diseases Research Center, West Los Angeles Veterans Administration Medical Center, Department of Medicine and Brain Research Institute, University of California School of Medicine, 90073, USA
    Endocrinology 138:3749-55. 1997
    ..The central AM action is mediated through adrenal-dependent, beta-adrenergic pathways independently from activation of central CRF receptors...
  23. ncbi request reprint Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in rats
    H Yang
    CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Department of Medicine, UCLA, CA 90073, USA
    Neuroscience 95:773-9. 2000
    ....
  24. ncbi request reprint Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF
    M Million
    CURE Digestive Diseases Research Center, West Los Angeles Department of Veterans Affairs Medical Center, Los Angeles, USA
    Am J Physiol 276:G1027-36. 1999
    ..These data show that central CRF restrains the proinflammatory action of stress in experimental colitis...
  25. pmc Central administration of pan-somatostatin agonist ODT8-SST prevents abdominal surgery-induced inhibition of circulating ghrelin, food intake and gastric emptying in rats
    A Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 23:e294-308. 2011
    ..We investigated whether activation of brain sst signaling pathways modulates surgical stress-induced inhibition of gastric emptying and food intake...
  26. ncbi request reprint Peripheral urocortin inhibits gastric emptying and food intake in mice: differential role of CRF receptor 2
    L Wang
    Center for Ulcer Research and Education, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine, Division of Digestive Diseases and Brain Research Institute, University of California at Los Angeles, Los Angeles 90073, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1401-10. 2001
    ..These data indicate that intraperitoneal urocortin-induced decrease in feeding is only partly mediated by CRF-R2, whereas urocortin action to delay gastric emptying of a meal involves primarily CRF-R2...
  27. pmc Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation
    L Wang
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles and Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, USA
    Neurogastroenterol Motil 24:e425-36. 2012
    ..We investigated functional gut alterations at earlier ages and histological correlates...
  28. ncbi request reprint Esophageal distension induced gastric relaxation is mediated in part by vagal peripheral reflex mechanism in rats
    J Y Wei
    CURE Digestive Diseases Research Center, Department of Medicine and Brain Research Institute, UCLA School of Medicine 90095, USA
    J Auton Nerv Syst 63:12-8. 1997
    ..The other 40% can be maintained without central and enteric nervous systems involvement, probably via a proposed gastric vagal afferent-esophageal collateral reflex...
  29. ncbi request reprint 5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4 receptors in conscious mice
    L Wang
    Digestive Diseases Research Center and Center for Neurovisceral Sciences and Woman s Health, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Am J Physiol Gastrointest Liver Physiol 292:G419-28. 2007
    ..These findings suggest an important role of activation of colonic myenteric neurons in the 5-HT4 receptor-mediated colonic propulsive motor response...
  30. ncbi request reprint Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in rats
    A E Kresse
    CURE: Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1203-13. 2001
    ..These data show that colitis upregulates CRF gene synthesis in magnocellular hypothalamic neurons but dampens CRF gene transcription in the pPVN and plasma corticosterone responses to environmental acute stressors...
  31. ncbi request reprint Peripheral PYY inhibits intracisternal TRH-induced gastric acid secretion by acting in the brain
    H Yang
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine and Brain Research Institute, School of Medicine, University of California, 90073, USA
    Am J Physiol Gastrointest Liver Physiol 279:G575-81. 2000
    ..5%, respectively. These results provide supporting evidence that peripheral PYY inhibits central vagal stimulation of gastric acid secretion through an action in the brain...
  32. pmc Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats
    L Wang
    Department of Medicine, CURE Digestive Diseases Center and Center for Neurobiology of Stress, Digestive Diseases Division, University of California at Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Neurogastroenterol Motil 24:e235-45. 2012
    ..However, L-dopa delays gastric emptying, which dampens its absorption. We investigated whether ghrelin prevents L-dopa action on gastric emptying and enhances circulating L-dopa in rats...
  33. pmc Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents
    Y Tache
    CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Curr Med Chem 19:35-42. 2012
    ..A better understanding of brain circuitries through which these peptides are released will provide new strategies to recruit integrated and multifaceted gastroprotective mechanisms...
  34. pmc Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats
    A Stengel
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    J Physiol Pharmacol 61:399-407. 2010
    ..The food intake reduction following sst(2) receptor blockade suggests a role of this receptor in the orexigenic drive during the dark phase...
  35. ncbi request reprint TRH stimulation and L-glutamic acid inhibition of proximal gastric motor activity in the rat dorsal vagal complex
    H E Raybould
    Center for Ulcer Research and Education, VA Wadsworth Medical Center, Los Angeles, CA 90073
    Brain Res 495:319-28. 1989
    ..Subpopulations of neurons in the DVC may, therefore, be activated by specific neurotransmitters having opposite effects on gastric motor activity...
  36. pmc Nesfatin-1: a novel inhibitory regulator of food intake and body weight
    A Stengel
    Department of Medicine, CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Obes Rev 12:261-71. 2011
    ....
  37. pmc SMS 201-995-induced stimulation of gastric acid secretion via the dorsal vagal complex and inhibition via the hypothalamus in anaesthetized rats
    M Yoneda
    CURE Gastroenteric Biology Center, West Los Angeles VA Medical Center, CA 90073, USA
    Br J Pharmacol 116:2303-9. 1995
    ..The site specific pattern of acid responses to SMS 201-995 may be linked to the distribution of receptor subtypes at these sites that convey the different biological actions of somatostatin...
  38. ncbi request reprint Central TRH receptor 1 antisense blocks cold-induced gastric emptying but not brain c-Fos induction
    V Martinez
    CURE Digestive Diseases Research Center, VA Wadsworth Greater Los Angeles Health Care System, Department of Medicine, Digestive Disease Division and Brain Research Institute, University of California, Los Angeles, USA
    Peptides 22:81-90. 2001
    ..These data indicate that central activation of TRH-R1 mediates cold-induced stimulation of gastric emptying but does not influence the induction of c-Fos expression in the brain...
  39. pmc Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications
    M Larauche
    CURE, Digestive Diseases Research Center and Center for Neurobiology of Stress Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine UCLA and VA Greater Los Angeles Healthcare System, Angeles, California, USA
    J Physiol Pharmacol 60:33-46. 2009
    ....
  40. ncbi request reprint Microinjection of bombesin into the ventrolateral reticular formation inhibits peripherally stimulated gastric acid secretion through spinal pathways in rats
    T Ishikawa
    CURE: Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 918:1-9. 2001
    ....
  41. pmc Visceral analgesia induced by acute and repeated water avoidance stress in rats: sex difference in opioid involvement
    M Larauche
    Department of Medicine, CURE Digestive Diseases Research Center and Oppenheimer Family Center for Neurobiology of Stress, Digestive Diseases Division at the University of California Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 24:1031-e547. 2012
    ....
  42. ncbi request reprint Capsaicin-sensitive vagal afferent fibers and stimulation of gastric acid secretion in anesthetized rats
    H E Raybould
    CURE VA Wadsworth Medical Center, Los Angeles, CA 90073
    Eur J Pharmacol 167:237-43. 1989
    ..These results indicate that capsaicin-sensitive vagal afferent fibers mediate the vagal portion of the secretory response to gastric distension; in addition these afferents play a role in the gastric acid secretory response to histamine...
  43. pmc CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome
    Y Tache
    CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Woman s Health, West Los Angeles VA Medical Center, University of California Los Angeles, 1130 Wilshire Boulevard, Los Angeles, CA 90073, U S A
    Br J Pharmacol 141:1321-30. 2004
    ..Targeting CRF(1)-dependent pathways may have potential benefit against stress or anxiety-/depression-related functional bowel disorders...
  44. ncbi request reprint Peripheral adrenomedullin inhibits gastric emptying through CGRP8-37 -sensitive receptors and prostaglandins pathways in rats
    V Martinez
    CURE Digestive Diseases Research Center, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 27:1376-82. 2006
    ..These data indicate that peripheral AM inhibits gastric emptying through the interaction with CGRP8-37 -sensitive receptors, likely CGRP1 receptors, and the recruitment of prostaglandin-dependent mechanisms...
  45. ncbi request reprint Synergistic interaction between CCK and leptin to regulate food intake
    L Wang
    CURE, Digestive Diseases Research Center, University of California at Los Angeles, USA
    Regul Pept 92:79-85. 2000
    ..These observations provide a mean through which leptin and CCK integrate short- and mid-term meal-related input signals into long-term control of energy balance...
  46. pmc Central neuropeptide Y and the sigma ligand, JO 1784, reverse corticotropin-releasing factor-induced inhibition of gastric acid secretion in rats
    M Gue
    CURE VA Wadsworth Medical Center, Department of Medicine, Los Angeles, CA
    Br J Pharmacol 107:642-7. 1992
    ..7 +/- 4.7 episodes per dog).6. It is concluded from these studies that the generation of nitric oxide contributes to the marked antiarrhythmic effects of preconditioning in the canine myocardium, probably through elevation of cyclic GMP...
  47. ncbi request reprint Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique
    Y H Wang
    Department of Medicine, Division of Digestive Diseases, CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences, Los Angeles, CA 90073, USA
    Allergy 60:117-24. 2005
    ..Desloratadine inhibits the release of allergic inflammatory mediators in vitro. We studied the impact of desloratadine on mast cell degranulation due to activation and re-activation by the secretagogue, compound 48/80...
  48. pmc Corticotropin releasing factor receptor antagonists: potential future therapy in gastroenterology?
    Y Tache
    CURE Digestive Diseases Research Center, Bldg 115, Room 117, VA Greater Los Angeles Health Care System, 1130 Wilshire Blvd, Los Angeles, CA 90073, USA
    Gut 53:919-21. 2004
    ..New corticotropin releasing factor (CRF) antagonists in irritable bowel disease (IBS) warrant testing, and CRF1 receptors may be a promising target for the treatment of IBS...
  49. ncbi request reprint Feedback regulation of thyrotropin-releasing hormone gene expression by thyroid hormone in the caudal raphe nuclei in rats
    H Yang
    CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Department of Medicine and Brain Research Institute, UCLA, California 90073, USA
    Endocrinology 140:43-9. 1999
    ..These findings may have important relevance to understanding autonomic-related visceral alterations induced by hypothyroidism...
  50. ncbi request reprint High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice
    V Martinez
    CURE Digestive Diseases Research Center, Veterans Administration Medical Center West Los Angeles, USA
    Gastroenterology 114:1125-32. 1998
    ..Somatostatin receptor subtype 2 (sst2) agonists inhibit gastric secretion. The role of sst2 in the regulation of acid secretion was assessed using sst2 knockout mice and urethane to induce somatostatin release...
  51. ncbi request reprint Peripheral secretin-induced Fos expression in the rat brain is largely vagal dependent
    H Yang
    CURE, Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 128:131-41. 2004
    ..Secretin injected i.p. may signal to the brain by interacting with secretin receptors on vagal afferent as well as on AP neurons outside the blood-brain barrier...
  52. ncbi request reprint Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?
    G Gourcerol
    CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Division of Digestive Diseases, University of California, Los Angeles, USA
    Regul Pept 141:1-7. 2007
    ..Those relate not only to redefining the biological action of obestatin that should be renamed GAP, but also the identification of the native ligand for GPR39...