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Genomes and Genes | Y TacheSummaryAffiliation: University of California Country: USA Publications
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Proximal colon distention increases Fos expression in the lumbosacral spinal cord and activates sacral parasympathetic NADPHd-positive neurons in ratsV Martinez
Department of Medicine, CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, California 90073, USA
J Comp Neurol 390:311-21. 1998..The marked activation of NADPHd-positive neurons in the sacral parasympathetic nucleus suggests a possible role of nitric oxide in the visceroautonomic reflexes induced by distention of the proximal colon...- Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in ratsC Maillot
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Gastroenterology 119:1569-79. 2000..CRF has preferential affinity for CRF-R1, whereas urocortin displays high affinity for both. We investigated changes in colonic motor function after intraperitoneal (IP) injection of CRF-related peptides... - Corticotropin-releasing factor and the brain-gut motor response to stressY Tache
CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Los Angeles 90073, USA
Can J Gastroenterol 13:18A-25A. 1999..Hypersecretion of CRF in the brain may contribute to the pathophysiology of stress-related exacerbation of irritable bowel syndrome... - Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptorsY Tache
CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, Bldg 115, Rm 203, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 280:G173-7. 2001..CRF subtype 1 receptors are involved in the colonic and anxiogenic responses to stress and may have clinical relevance in the comorbidity of anxiety/depression and irritable bowel syndrome... 
Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressorsG Gourcerol
CURE Digestive Diseases Research Center and Center for Stress Neurobiology, UCLA, VA Greater Los Angeles Healthcare System, CURE Bldg 115, Rm 118B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 296:G992-G1002. 2009..Noninvasive colonic manometry opens new venues to investigate colonic motor function in genetically modified mice relevant to diseases that involve colonic motility alterations...- Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis ratsM Million
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Digestive Diseases Division, Department of Medicine, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
Brain Res 877:345-53. 2000.... - Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathwaysH Yang
CURE Digestive Diseases Research Center, West Los Angeles Veterans Affairs Medical Center, and Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California, Los Angeles, California 90073, USA
Am J Physiol 277:G555-62. 1999..These results suggest that intracisternal PYY acts independently of medullary TRH to decrease ethanol-induced gastric lesions. The PYY action involves vagal cholinergic-mediated CGRP/NO protective mechanisms... - Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious ratsM Miampamba
CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Bldg 115, Rm 203, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 280:G979-91. 2001..These results indicated that central vagal efferent stimulation by intracisternal RX-77368 activates gastric myenteric neurons as well as glial cells mainly through nicotinic ACh receptors in conscious rats... - Peripheral corticotropin releasing factor (CRF) and a novel CRF1 receptor agonist, stressin1-A activate CRF1 receptor expressing cholinergic and nitrergic myenteric neurons selectively in the colon of conscious ratsP Q Yuan
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles 90073, USA
Neurogastroenterol Motil 19:923-36. 2007..These data support that one mechanism through which peripherally injected CRF ligands stimulate colonic function involves a direct action on colonic cholinergic and nitrergic myenteric neurons expressing CRF(1) receptor... - Corticotropin releasing factor in the rat colon: expression, localization and upregulation by endotoxinP Q Yuan
Center for Neurobiology of Stress, VA Greater Los Angeles Healthcare System, and Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
Peptides 31:322-31. 2010..These data suggests that colonic CRF may be part of the local effector limb of the CRF(1) receptor mediated colonic alterations induced by acute stress... - CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in ratsM Million
CURE Digestive Diseases Research Center, Department of Medicine, University of California Los Angeles, CA 90073, USA
Gut 55:172-81. 2006..We hypothesised that CRF2 receptor activation may influence visceral pain induced by colorectal distension (CRD) in conscious rats, and assessed the possible sites and mechanisms of action... - Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in ratsV Martinez
CURE Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Department of Medicine, Digestive Disease Division and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90073, USA
Brain Res 893:29-35. 2001.... - Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feedingY Tache
CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Auton Neurosci 125:42-52. 2006.... - Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious ratsP Q Yuan
CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, and Digestive Diseases Division, University of California, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 281:G560-8. 2001..These results indicate that acute cold exposure activates cholinergic as well as nitrergic neurons in the gastric myenteric ganglia through vagal nicotinic pathways in conscious rats... - Enhanced pelvic responses to stressors in female CRF-overexpressing miceM Million
CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, CA 90073, USA
Am J Physiol Regul Integr Comp Physiol 292:R1429-38. 2007.... 
Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in miceA Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division at the University of California Los Angeles, USA
Neurogastroenterol Motil 23:e223-36. 2011..We investigated whether ODT8-SST acts in the brain to influence stress-related alterations of gastric and colonic motor function and sst receptor subtype(s) involved...- Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathwayG Gourcerol
Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Endocrinology 148:6115-23. 2007..Such synergy is lost in DIO mice, suggesting a resistance to the satiety signaling that may contribute to maintain obesity... - Intracisternal injection of somatostatin receptor 5-preferring agonists induces a vagal cholinergic stimulation of gastric emptying in ratsV Martinez
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
J Pharmacol Exp Ther 293:1099-105. 2000..c. at 0.8 nmol/rat. These results show that BIM-23056 injected i.c. acts in the brain independently from medullary TRH to induce a vagal cholinergic stimulation of gastric emptying through the sst(5) receptor subtype... - Central administration of pan-somatostatin agonist ODT8-SST prevents abdominal surgery-induced inhibition of circulating ghrelin, food intake and gastric emptying in ratsA Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
Neurogastroenterol Motil 23:e294-308. 2011..We investigated whether activation of brain sst signaling pathways modulates surgical stress-induced inhibition of gastric emptying and food intake... - Central action of adrenomedullin to inhibit gastric emptying in ratsV Martinez
CURE Digestive Diseases Research Center, West Los Angeles Veterans Administration Medical Center, Department of Medicine and Brain Research Institute, University of California School of Medicine, 90073, USA
Endocrinology 138:3749-55. 1997..The central AM action is mediated through adrenal-dependent, beta-adrenergic pathways independently from activation of central CRF receptors... - Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRFM Million
CURE Digestive Diseases Research Center, West Los Angeles Department of Veterans Affairs Medical Center, Los Angeles, USA
Am J Physiol 276:G1027-36. 1999..These data show that central CRF restrains the proinflammatory action of stress in experimental colitis... - Intracisternal sauvagine is more potent than corticotropin-releasing factor to decrease gastric vagal efferent activity in ratsH P Kosoyan
CURE, Digestive Diseases Research Center, West Los Angeles Veterans Administration Medical Center, California 90073, USA
Peptides 20:851-8. 1999.... - Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in ratsH Yang
CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Department of Medicine, UCLA, CA 90073, USA
Neuroscience 95:773-9. 2000.... - Peripheral urocortin inhibits gastric emptying and food intake in mice: differential role of CRF receptor 2L Wang
Center for Ulcer Research and Education, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine, Division of Digestive Diseases and Brain Research Institute, University of California at Los Angeles, Los Angeles 90073, USA
Am J Physiol Regul Integr Comp Physiol 281:R1401-10. 2001..These data indicate that intraperitoneal urocortin-induced decrease in feeding is only partly mediated by CRF-R2, whereas urocortin action to delay gastric emptying of a meal involves primarily CRF-R2... - Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecationL Wang
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles and Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, USA
Neurogastroenterol Motil 24:e425-36. 2012..We investigated functional gut alterations at earlier ages and histological correlates... - Esophageal distension induced gastric relaxation is mediated in part by vagal peripheral reflex mechanism in ratsJ Y Wei
CURE Digestive Diseases Research Center, Department of Medicine and Brain Research Institute, UCLA School of Medicine 90095, USA
J Auton Nerv Syst 63:12-8. 1997..The other 40% can be maintained without central and enteric nervous systems involvement, probably via a proposed gastric vagal afferent-esophageal collateral reflex... - 5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4 receptors in conscious miceL Wang
Digestive Diseases Research Center and Center for Neurovisceral Sciences and Woman s Health, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
Am J Physiol Gastrointest Liver Physiol 292:G419-28. 2007..These findings suggest an important role of activation of colonic myenteric neurons in the 5-HT4 receptor-mediated colonic propulsive motor response... - Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodentsG Gourcerol
CURE/Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Peptides 27:2811-9. 2006..These data show that obestatin neither influences cumulative food intake, gastric motility or vagal afferent activity nor CCK-induced satiety signaling... - Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in ratsA E Kresse
CURE: Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 281:G1203-13. 2001..These data show that colitis upregulates CRF gene synthesis in magnocellular hypothalamic neurons but dampens CRF gene transcription in the pPVN and plasma corticosterone responses to environmental acute stressors... - Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted ratsL Wang
Department of Medicine, CURE Digestive Diseases Center and Center for Neurobiology of Stress, Digestive Diseases Division, University of California at Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Neurogastroenterol Motil 24:e235-45. 2012..However, L-dopa delays gastric emptying, which dampens its absorption. We investigated whether ghrelin prevents L-dopa action on gastric emptying and enhances circulating L-dopa in rats... - Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in ratsA Stengel
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
J Physiol Pharmacol 61:399-407. 2010..The food intake reduction following sst(2) receptor blockade suggests a role of this receptor in the orexigenic drive during the dark phase... - Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferentsY Tache
CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Curr Med Chem 19:35-42. 2012..A better understanding of brain circuitries through which these peptides are released will provide new strategies to recruit integrated and multifaceted gastroprotective mechanisms... - Nesfatin-1: a novel inhibitory regulator of food intake and body weightA Stengel
Department of Medicine, CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Obes Rev 12:261-71. 2011.... - TRH stimulation and L-glutamic acid inhibition of proximal gastric motor activity in the rat dorsal vagal complexH E Raybould
Center for Ulcer Research and Education, VA Wadsworth Medical Center, Los Angeles, CA 90073
Brain Res 495:319-28. 1989..Subpopulations of neurons in the DVC may, therefore, be activated by specific neurotransmitters having opposite effects on gastric motor activity... - SMS 201-995-induced stimulation of gastric acid secretion via the dorsal vagal complex and inhibition via the hypothalamus in anaesthetized ratsM Yoneda
CURE Gastroenteric Biology Center, West Los Angeles VA Medical Center, CA 90073, USA
Br J Pharmacol 116:2303-9. 1995..The site specific pattern of acid responses to SMS 201-995 may be linked to the distribution of receptor subtypes at these sites that convey the different biological actions of somatostatin... - Peripheral PYY inhibits intracisternal TRH-induced gastric acid secretion by acting in the brainH Yang
CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine and Brain Research Institute, School of Medicine, University of California, 90073, USA
Am J Physiol Gastrointest Liver Physiol 279:G575-81. 2000..5%, respectively. These results provide supporting evidence that peripheral PYY inhibits central vagal stimulation of gastric acid secretion through an action in the brain... - Central TRH receptor 1 antisense blocks cold-induced gastric emptying but not brain c-Fos inductionV Martinez
CURE Digestive Diseases Research Center, VA Wadsworth Greater Los Angeles Health Care System, Department of Medicine, Digestive Disease Division and Brain Research Institute, University of California, Los Angeles, USA
Peptides 22:81-90. 2001..These data indicate that central activation of TRH-R1 mediates cold-induced stimulation of gastric emptying but does not influence the induction of c-Fos expression in the brain... - Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implicationsM Larauche
CURE, Digestive Diseases Research Center and Center for Neurobiology of Stress Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine UCLA and VA Greater Los Angeles Healthcare System, Angeles, California, USA
J Physiol Pharmacol 60:33-46. 2009.... - Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2)C-Y Chen
CURE: Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
Br J Pharmacol 136:237-47. 2002..rUcn action was antagonized by astressin(2)-B. 7. These data show that i.c. rUcn acts through CRF(2) receptors to inhibit central vagal gastric contractile response and postoprandial emptying... - Microinjection of bombesin into the ventrolateral reticular formation inhibits peripherally stimulated gastric acid secretion through spinal pathways in ratsT Ishikawa
CURE: Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90073, USA
Brain Res 918:1-9. 2001.... - Capsaicin-sensitive vagal afferent fibers and stimulation of gastric acid secretion in anesthetized ratsH E Raybould
CURE VA Wadsworth Medical Center, Los Angeles, CA 90073
Eur J Pharmacol 167:237-43. 1989..These results indicate that capsaicin-sensitive vagal afferent fibers mediate the vagal portion of the secretory response to gastric distension; in addition these afferents play a role in the gastric acid secretory response to histamine... - CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndromeY Tache
CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Woman s Health, West Los Angeles VA Medical Center, University of California Los Angeles, 1130 Wilshire Boulevard, Los Angeles, CA 90073, U S A
Br J Pharmacol 141:1321-30. 2004..Targeting CRF(1)-dependent pathways may have potential benefit against stress or anxiety-/depression-related functional bowel disorders... - Peripheral adrenomedullin inhibits gastric emptying through CGRP8-37 -sensitive receptors and prostaglandins pathways in ratsV Martinez
CURE Digestive Diseases Research Center, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 27:1376-82. 2006..These data indicate that peripheral AM inhibits gastric emptying through the interaction with CGRP8-37 -sensitive receptors, likely CGRP1 receptors, and the recruitment of prostaglandin-dependent mechanisms... - Synergistic interaction between CCK and leptin to regulate food intakeL Wang
CURE, Digestive Diseases Research Center, University of California at Los Angeles, USA
Regul Pept 92:79-85. 2000..These observations provide a mean through which leptin and CCK integrate short- and mid-term meal-related input signals into long-term control of energy balance... - Central neuropeptide Y and the sigma ligand, JO 1784, reverse corticotropin-releasing factor-induced inhibition of gastric acid secretion in ratsM Gue
CURE VA Wadsworth Medical Center, Department of Medicine, Los Angeles, CA
Br J Pharmacol 107:642-7. 1992..7 +/- 4.7 episodes per dog).6. It is concluded from these studies that the generation of nitric oxide contributes to the marked antiarrhythmic effects of preconditioning in the canine myocardium, probably through elevation of cyclic GMP... - Corticotropin releasing factor receptor antagonists: potential future therapy in gastroenterology?Y Tache
CURE Digestive Diseases Research Center, Bldg 115, Room 117, VA Greater Los Angeles Health Care System, 1130 Wilshire Blvd, Los Angeles, CA 90073, USA
Gut 53:919-21. 2004..New corticotropin releasing factor (CRF) antagonists in irritable bowel disease (IBS) warrant testing, and CRF1 receptors may be a promising target for the treatment of IBS... - Visceral analgesia induced by acute and repeated water avoidance stress in rats: sex difference in opioid involvementM Larauche
Department of Medicine, CURE Digestive Diseases Research Center and Oppenheimer Family Center for Neurobiology of Stress, Digestive Diseases Division at the University of California Los Angeles, CA 90073, USA
Neurogastroenterol Motil 24:1031-e547. 2012.... - Feedback regulation of thyrotropin-releasing hormone gene expression by thyroid hormone in the caudal raphe nuclei in ratsH Yang
CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Department of Medicine and Brain Research Institute, UCLA, California 90073, USA
Endocrinology 140:43-9. 1999..These findings may have important relevance to understanding autonomic-related visceral alterations induced by hypothyroidism... - High basal gastric acid secretion in somatostatin receptor subtype 2 knockout miceV Martinez
CURE Digestive Diseases Research Center, Veterans Administration Medical Center West Los Angeles, USA
Gastroenterology 114:1125-32. 1998..Somatostatin receptor subtype 2 (sst2) agonists inhibit gastric secretion. The role of sst2 in the regulation of acid secretion was assessed using sst2 knockout mice and urethane to induce somatostatin release... - Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?G Gourcerol
CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Division of Digestive Diseases, University of California, Los Angeles, USA
Regul Pept 141:1-7. 2007..Those relate not only to redefining the biological action of obestatin that should be renamed GAP, but also the identification of the native ligand for GPR39... - Peripheral secretin-induced Fos expression in the rat brain is largely vagal dependentH Yang
CURE, Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Neuroscience 128:131-41. 2004..Secretin injected i.p. may signal to the brain by interacting with secretin receptors on vagal afferent as well as on AP neurons outside the blood-brain barrier...