GERALD TABORSKY

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc The physiology of glucagon
    Gerald J Taborsky
    VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Diabetes Sci Technol 4:1338-44. 2010
  2. pmc The p75 neurotrophin receptor is required for the major loss of sympathetic nerves from islets under autoimmune attack
    Gerald J Taborsky
    Division of Endocrinology Metabolism, Veterans Affairs Puget Sound Health Care System, Seattle, WADivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, University of Washington, Seattle, WA
    Diabetes 63:2369-79. 2014
  3. pmc Minireview: The role of the autonomic nervous system in mediating the glucagon response to hypoglycemia
    Gerald J Taborsky
    Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
    Endocrinology 153:1055-62. 2012
  4. pmc Islets have a lot of nerve! Or do they?
    Gerald J Taborsky
    VA Puget Sound Health Care System and the University of Washington, Seattle, WA 98108, USA
    Cell Metab 14:5-6. 2011
  5. doi request reprint Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis
    G J Taborsky
    Division of Endocrinology Metabolism S 151, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 52:2602-11. 2009
  6. ncbi request reprint Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes
    G J Taborsky
    Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Diabetes 47:995-1005. 1998
  7. ncbi request reprint Autonomic mechanism and defects in the glucagon response to insulin-induced hypoglycaemia
    G J Taborsky
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Diabetes Nutr Metab 15:318-22; discussion 322-3. 2002
  8. ncbi request reprint The canine sympathetic neuropeptide galanin: a neurotransmitter in pancreas, a neuromodulator in liver
    G J Taborsky
    Division of Endocrinology, Metabolism and Nutrition, Seattle Veterans Affairs Puget Sound Health Care System and University of Washington 98108, USA
    Horm Metab Res 31:351-4. 1999
  9. pmc Leptin deficiency causes insulin resistance induced by uncontrolled diabetes
    Jonathan P German
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:1626-34. 2010
  10. ncbi request reprint Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemia
    Scott B Evans
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195 6560, USA
    Am J Physiol Regul Integr Comp Physiol 286:R123-8. 2004

Research Grants

  1. Glucagon Secretion and Islet Neuropathy
    GERALD TABORSKY; Fiscal Year: 2007
  2. Glucagon Secretion and Islet Neuropathy
    GERALD TABORSKY; Fiscal Year: 2006
  3. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2004
  4. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2003
  5. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2002
  6. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2001
  7. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 2000
  8. Glucagon Secretion and Islet Neuropathy
    GERALD TABORSKY; Fiscal Year: 2009
  9. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2002
  10. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 2000

Detail Information

Publications23

  1. pmc The physiology of glucagon
    Gerald J Taborsky
    VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Diabetes Sci Technol 4:1338-44. 2010
    ..The glucagon response to insulin-induced hypoglycemia is impaired soon after the development of T1DM. The mediators of this impairment include loss of beta cells and loss of sympathetic nerves from the autoimmune diabetic islet...
  2. pmc The p75 neurotrophin receptor is required for the major loss of sympathetic nerves from islets under autoimmune attack
    Gerald J Taborsky
    Division of Endocrinology Metabolism, Veterans Affairs Puget Sound Health Care System, Seattle, WADivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, University of Washington, Seattle, WA
    Diabetes 63:2369-79. 2014
    ..The p75NTR mediates this nerve loss but plays no role in mediating the loss of islet β-cells or the subsequent diabetes. p75NTR-mediated nerve loss may contribute to the impaired glucose counterregulation seen in type 1 diabetes. ..
  3. pmc Minireview: The role of the autonomic nervous system in mediating the glucagon response to hypoglycemia
    Gerald J Taborsky
    Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
    Endocrinology 153:1055-62. 2012
    ..Clinically, restoring this glucagon response would allow more aggressive treatment of the chronic hyperglycemia that is linked to the debilitating long-term complications of this disease...
  4. pmc Islets have a lot of nerve! Or do they?
    Gerald J Taborsky
    VA Puget Sound Health Care System and the University of Washington, Seattle, WA 98108, USA
    Cell Metab 14:5-6. 2011
    ..Key questions raised by this species difference have potential relevance to diabetic therapeutics...
  5. doi request reprint Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis
    G J Taborsky
    Division of Endocrinology Metabolism S 151, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 52:2602-11. 2009
    ....
  6. ncbi request reprint Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes
    G J Taborsky
    Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Diabetes 47:995-1005. 1998
    ..Finally, in the fifth section, we summarize the concepts underlying the autonomic hypothesis, the evidence for it, and the implications of the autonomic hypothesis for the treatment of type 1 diabetes...
  7. ncbi request reprint Autonomic mechanism and defects in the glucagon response to insulin-induced hypoglycaemia
    G J Taborsky
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Diabetes Nutr Metab 15:318-22; discussion 322-3. 2002
    ..These data raise the novel possibility that an autonomic defect contributes to the loss of the glucagon response to IIH in T1DM...
  8. ncbi request reprint The canine sympathetic neuropeptide galanin: a neurotransmitter in pancreas, a neuromodulator in liver
    G J Taborsky
    Division of Endocrinology, Metabolism and Nutrition, Seattle Veterans Affairs Puget Sound Health Care System and University of Washington 98108, USA
    Horm Metab Res 31:351-4. 1999
    ..In contrast, galanin had no effect on hepatic arterial blood flow. We therefore propose that in the liver galanin functions as a neuromodulator of norepinephrine's metabolic action...
  9. pmc Leptin deficiency causes insulin resistance induced by uncontrolled diabetes
    Jonathan P German
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:1626-34. 2010
    ..This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements induced by uDM...
  10. ncbi request reprint Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemia
    Scott B Evans
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195 6560, USA
    Am J Physiol Regul Integr Comp Physiol 286:R123-8. 2004
    ..The epinephrine, norepinephrine, and glucagon responses were not altered by DMH inactivation. Our finding suggests that DMH inactivation may play a specific role in decreasing the HPA axis response after repeated bouts of IIH...
  11. ncbi request reprint Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy
    Thomas O Mundinger
    Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 285:E1047-54. 2003
    ..We conclude that the early sympathetic islet neuropathy of BB D causes a functional defect of the sympathetic pathway to the alpha-cell that can, by itself, account for the impaired glucagon response to postganglionic SNS...
  12. ncbi request reprint Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats
    Qi Mei
    Division of Endocrinology and Metabolism, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes 51:2997-3002. 2002
    ..Because eSIN occurs selectively in the islet, is rapid in onset, and is associated with autoimmune but not chemically induced diabetes, it is distinct from DAN in location, time course, and mechanism...
  13. ncbi request reprint Inactivation of the PVN during hypoglycemia partially simulates hypoglycemia-associated autonomic failure
    Scott B Evans
    Departments of Psychology and of Medicine, University of Washington, Seattle 98195, USA
    Am J Physiol Regul Integr Comp Physiol 284:R57-65. 2003
    ..e., blunting the sympathoadrenal and hypothalamic-pituitary-adrenocortical axis response), but not in others (i.e., blunting the glucagon response)...
  14. pmc Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin
    Salwa al-Noori
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1446-54. 2008
    ..Collectively, these data suggest that RH stress triggers cellular changes that support synaptic plasticity, in specific neuroanatomical sites, which may contribute to the development of hypoglycemia-associated autonomic failure...
  15. pmc Impaired activation of celiac ganglion neurons in vivo after damage to their sympathetic nerve terminals
    Thomas O Mundinger
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Neurosci Res 86:1981-93. 2008
    ..We conclude that sympathetic nerve terminal damage per se is sufficient to impair ganglionic neurotransmission in vivo and that decreased nicotinic receptor production is a likely mediator...
  16. pmc The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia
    Nicole M Sanders
    Division of Endocrinology Metabolism, Veterans Affair Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 294:E853-60. 2008
    ..Instead, sertraline treatment resulted in an enhancement of hypoglycemia CRR and prevented the impaired adrenomedullary response normally observed in recurrent hypoglycemic rats...
  17. pmc Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemia
    Salwa al-Noori
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA
    Brain Res 1194:65-72. 2008
    ....
  18. pmc Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans
    Lisa K Gilliam
    Department of Medicine, University of Washington, 1959 N E Pacific Street, Box 357710, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 92:4035-8. 2007
    ..However, a direct test of the hypothesis that moderate and selective activation of these nerves is sufficient to inhibit insulin secretion in humans is lacking...
  19. pmc An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B
    Liu Yang
    Department of Orthopedics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Biochem J 369:651-7. 2003
    ..Taken together, these data suggest that ESET histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2 that participates in multiple pathways of transcriptional repression...
  20. ncbi request reprint Direct stimulation of ghrelin secretion by sympathetic nerves
    Thomas O Mundinger
    Deparyment of Medicine, Division of Metabolism, Endocrinology, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Endocrinology 147:2893-901. 2006
    ..Epinephrine failed to stimulate ghrelin secretion (Delta = +4 +/- 35%). We conclude that the neural, but not the neurohumoral, branch of the sympathetic nervous system can directly stimulate ghrelin secretion...
  21. ncbi request reprint Increased galanin expression in the celiac ganglion of BB diabetic rats
    Qi Mei
    Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Neuropeptides 40:1-10. 2006
    ....
  22. pmc Antecedent hindbrain glucoprivation does not impair the counterregulatory response to hypoglycemia
    Nicole M Sanders
    Division of Endocrinology Metabolism, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Diabetes 56:217-23. 2007
    ..However, neural substrates surrounding the third ventricle are particularly sensitive to glucoprivic stimulation and may contribute importantly to the development of defective CRRs...
  23. ncbi request reprint Differential impairment of glucagon responses to hypoglycemia, neuroglycopenia, arginine, and carbachol in alloxan-diabetic mice
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Metabolism 51:12-9. 2002
    ....

Research Grants14

  1. Glucagon Secretion and Islet Neuropathy
    GERALD TABORSKY; Fiscal Year: 2007
    ..Restoring the glucagon response to IIH will allow more intensive treatment of patients with type 1 diabetes which will in turn help prevent the long-term complications of this disease. ..
  2. Glucagon Secretion and Islet Neuropathy
    GERALD TABORSKY; Fiscal Year: 2006
    ..Restoring the glucagon response to IIH will allow more intensive treatment of patients with type 1 diabetes which will in turn help prevent the long-term complications of this disease. ..
  3. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2004
    ..Together these experiments will determine the timing, magnitude and location (nerve terminals or cell bodies) of islet sympathetic dysfunction in BB diabetic rats and its contribution to the loss of the glucagon response to IIH. ..
  4. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2003
    ..Together these experiments will determine the timing, magnitude and location (nerve terminals or cell bodies) of islet sympathetic dysfunction in BB diabetic rats and its contribution to the loss of the glucagon response to IIH. ..
  5. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2002
    ..Together these experiments will determine the timing, magnitude and location (nerve terminals or cell bodies) of islet sympathetic dysfunction in BB diabetic rats and its contribution to the loss of the glucagon response to IIH. ..
  6. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2001
    ..Together these experiments will determine the timing, magnitude and location (nerve terminals or cell bodies) of islet sympathetic dysfunction in BB diabetic rats and its contribution to the loss of the glucagon response to IIH. ..
  7. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 2000
    ..In addition, local pancreatic sympathetic neurotransmitter release will be blocked with bretylium in order to assess its role in the pancreatic hormone response to exercise. ..
  8. Glucagon Secretion and Islet Neuropathy
    GERALD TABORSKY; Fiscal Year: 2009
    ..Restoring the glucagon response to IIH will allow more intensive treatment of patients with type 1 diabetes which will in turn help prevent the long-term complications of this disease. ..
  9. Early Dysfunction of Islet Nerves in Type 1 Diabetes
    GERALD TABORSKY; Fiscal Year: 2002
    ..Together these experiments will determine the timing, magnitude and location (nerve terminals or cell bodies) of islet sympathetic dysfunction in BB diabetic rats and its contribution to the loss of the glucagon response to IIH. ..
  10. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 2000
    ..In addition, local pancreatic sympathetic neurotransmitter release will be blocked with bretylium in order to assess its role in the pancreatic hormone response to exercise. ..
  11. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 1999
    ..In addition, local pancreatic sympathetic neurotransmitter release will be blocked with bretylium in order to assess its role in the pancreatic hormone response to exercise. ..