Research Topics
Genomes and Genes | GERALD TABORSKYSummaryAffiliation: University of Washington Country: USA Publications
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Publications
The physiology of glucagonGerald J Taborsky
VA Puget Sound Health Care System, Seattle, Washington 98108, USA
J Diabetes Sci Technol 4:1338-44. 2010..The glucagon response to insulin-induced hypoglycemia is impaired soon after the development of T1DM. The mediators of this impairment include loss of beta cells and loss of sympathetic nerves from the autoimmune diabetic islet...- Minireview: The role of the autonomic nervous system in mediating the glucagon response to hypoglycemiaGerald J Taborsky
Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
Endocrinology 153:1055-62. 2012..Clinically, restoring this glucagon response would allow more aggressive treatment of the chronic hyperglycemia that is linked to the debilitating long-term complications of this disease... 
Islets have a lot of nerve! Or do they?Gerald J Taborsky
VA Puget Sound Health Care System and the University of Washington, Seattle, WA 98108, USA
Cell Metab 14:5-6. 2011..Key questions raised by this species difference have potential relevance to diabetic therapeutics...
Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitisG J Taborsky
Division of Endocrinology Metabolism S 151, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Diabetologia 52:2602-11. 2009....- Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetesG J Taborsky
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
Diabetes 47:995-1005. 1998..Finally, in the fifth section, we summarize the concepts underlying the autonomic hypothesis, the evidence for it, and the implications of the autonomic hypothesis for the treatment of type 1 diabetes... - Autonomic mechanism and defects in the glucagon response to insulin-induced hypoglycaemiaG J Taborsky
Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
Diabetes Nutr Metab 15:318-22; discussion 322-3. 2002..These data raise the novel possibility that an autonomic defect contributes to the loss of the glucagon response to IIH in T1DM... - The canine sympathetic neuropeptide galanin: a neurotransmitter in pancreas, a neuromodulator in liverG J Taborsky
Division of Endocrinology, Metabolism and Nutrition, Seattle Veterans Affairs Puget Sound Health Care System and University of Washington 98108, USA
Horm Metab Res 31:351-4. 1999..In contrast, galanin had no effect on hepatic arterial blood flow. We therefore propose that in the liver galanin functions as a neuromodulator of norepinephrine's metabolic action... - Leptin deficiency causes insulin resistance induced by uncontrolled diabetesJonathan P German
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 59:1626-34. 2010..This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements induced by uDM... - Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemiaScott B Evans
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195-6560, USA
Am J Physiol Regul Integr Comp Physiol 286:R123-8. 2004..The epinephrine, norepinephrine, and glucagon responses were not altered by DMH inactivation. Our finding suggests that DMH inactivation may play a specific role in decreasing the HPA axis response after repeated bouts of IIH... - An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/BLiu Yang
Department of Orthopedics, University of Washington School of Medicine, Seattle, WA 98195, USA
Biochem J 369:651-7. 2003..Taken together, these data suggest that ESET histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2 that participates in multiple pathways of transcriptional repression... - Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic ratsQi Mei
Division of Endocrinology and Metabolism, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Diabetes 51:2997-3002. 2002..Because eSIN occurs selectively in the islet, is rapid in onset, and is associated with autoimmune but not chemically induced diabetes, it is distinct from DAN in location, time course, and mechanism... - Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysinSalwa al-Noori
Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
Am J Physiol Regul Integr Comp Physiol 295:R1446-54. 2008..Collectively, these data suggest that RH stress triggers cellular changes that support synaptic plasticity, in specific neuroanatomical sites, which may contribute to the development of hypoglycemia-associated autonomic failure... - Impaired activation of celiac ganglion neurons in vivo after damage to their sympathetic nerve terminalsThomas O Mundinger
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
J Neurosci Res 86:1981-93. 2008..We conclude that sympathetic nerve terminal damage per se is sufficient to impair ganglionic neurotransmission in vivo and that decreased nicotinic receptor production is a likely mediator... - The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemiaNicole M Sanders
Division of Endocrinology Metabolism, Veterans Affair Puget Sound Health Care System, Seattle, WA 98108, USA
Am J Physiol Endocrinol Metab 294:E853-60. 2008..Instead, sertraline treatment resulted in an enhancement of hypoglycemia CRR and prevented the impaired adrenomedullary response normally observed in recurrent hypoglycemic rats... - Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemiaSalwa al-Noori
Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA
Brain Res 1194:65-72. 2008.... - Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humansLisa K Gilliam
Department of Medicine, University of Washington, 1959 N E Pacific Street, Box 357710, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 92:4035-8. 2007..However, a direct test of the hypothesis that moderate and selective activation of these nerves is sufficient to inhibit insulin secretion in humans is lacking... - Inactivation of the PVN during hypoglycemia partially simulates hypoglycemia-associated autonomic failureScott B Evans
Departments of Psychology and of Medicine, University of Washington, Seattle 98195, USA
Am J Physiol Regul Integr Comp Physiol 284:R57-65. 2003..e., blunting the sympathoadrenal and hypothalamic-pituitary-adrenocortical axis response), but not in others (i.e., blunting the glucagon response)... - Direct stimulation of ghrelin secretion by sympathetic nervesThomas O Mundinger
Deparyment of Medicine, Division of Metabolism, Endocrinology, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Endocrinology 147:2893-901. 2006..Epinephrine failed to stimulate ghrelin secretion (Delta = +4 +/- 35%). We conclude that the neural, but not the neurohumoral, branch of the sympathetic nervous system can directly stimulate ghrelin secretion... - Increased galanin expression in the celiac ganglion of BB diabetic ratsQi Mei
Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Neuropeptides 40:1-10. 2006.... - Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathyThomas O Mundinger
Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle, USA
Am J Physiol Endocrinol Metab 285:E1047-54. 2003..We conclude that the early sympathetic islet neuropathy of BB D causes a functional defect of the sympathetic pathway to the alpha-cell that can, by itself, account for the impaired glucagon response to postganglionic SNS... - Antecedent hindbrain glucoprivation does not impair the counterregulatory response to hypoglycemiaNicole M Sanders
Division of Endocrinology Metabolism, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Diabetes 56:217-23. 2007..However, neural substrates surrounding the third ventricle are particularly sensitive to glucoprivic stimulation and may contribute importantly to the development of defective CRRs... - Differential impairment of glucagon responses to hypoglycemia, neuroglycopenia, arginine, and carbachol in alloxan-diabetic miceBo Ahren
Department of Medicine, Lund University, Lund, Sweden
Metabolism 51:12-9. 2002....
Research Grants
- Glucagon Secretion and Islet NeuropathyGERALD TABORSKY; Fiscal Year: 2007..Restoring the glucagon response to IIH will allow more intensive treatment of patients with type 1 diabetes which will in turn help prevent the long-term complications of this disease. ..
- Early Dysfunction of Islet Nerves in Type 1 DiabetesGERALD TABORSKY; Fiscal Year: 2004..Together these experiments will determine the timing, magnitude and location (nerve terminals or cell bodies) of islet sympathetic dysfunction in BB diabetic rats and its contribution to the loss of the glucagon response to IIH. ..
- PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISEGERALD TABORSKY; Fiscal Year: 2000..In addition, local pancreatic sympathetic neurotransmitter release will be blocked with bretylium in order to assess its role in the pancreatic hormone response to exercise. ..
- Glucagon Secretion and Islet NeuropathyGERALD TABORSKY; Fiscal Year: 2009..Restoring the glucagon response to IIH will allow more intensive treatment of patients with type 1 diabetes which will in turn help prevent the long-term complications of this disease. ..