Research Topics
Genomes and Genes
| Boris TabakoffSummaryAffiliation: University of Colorado Denver Country: USA Publications
Research Grants
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Detail Information
Publications
The genomic determinants of alcohol preference in miceBoris Tabakoff
Department of Pharmacology, University of Colorado Denver School of Medicine, Mail Stop F 8303, P O Box 6511, Aurora, CO 80045 0511, USA
Mamm Genome 19:352-65. 2008..The importance of olfactory cues, learning and memory formation (Pavlovian conditioning), and cortical executive function, for regulating alcohol intake by animals (including humans), is discussed...- Genetical genomic determinants of alcohol consumption in rats and humansBoris Tabakoff
Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
BMC Biol 7:70. 2009.... - Genomic insights into acute alcohol toleranceWei Hu
Department of Pharmacology, University of Colorado School of Medicine, Mail Stop 8303, P O Box 6511, Aurora, CO 80045 0511, USA
J Pharmacol Exp Ther 326:792-800. 2008.... - Genetical genomic analysis of complex phenotypes using the PhenoGen websiteBeth Bennett
Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045 0511, USA
Behav Genet 41:625-8. 2011..These methods are briefly described here and we encourage the use of our site for both scientific discovery and as a teaching tool in quantitative genetics... 
Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviorsBoris Tabakoff
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 23:4491-8. 2003....- A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmissionLaura M Saba
Department of Pharmacology, University of Colorado Denver School of Medicine, PO Box 6511, Mail Stop 8303, Aurora, CO 80045, USA
Neuropharmacology 60:1269-80. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'... - Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genesPaula L Hoffman
University of Colorado Denver, School of Medicine, Department of Pharmacology, Aurora, CO 80045, USA
Addict Biol 16:393-404. 2011..The results demonstrate how PhenoGen can be used to identify a novel set of genes that can be further investigated for their potential role in pain, morphine analgesia and/or morphine tolerance... - Candidate genes and their regulatory elements: alcohol preference and toleranceLaura Saba
Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
Mamm Genome 17:669-88. 2006.... - A sex-specific role of type VII adenylyl cyclase in depressionLisa M Hines
Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Neurosci 26:12609-19. 2006..Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness... - Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 miceSanjiv V Bhave
Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
Alcohol Clin Exp Res 30:1659-69. 2006..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains... - Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preferencePaula L Hoffman
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Alcohol Clin Exp Res 27:155-68. 2003..4) Patterns of gene expression in brains of selected lines of mice that differ in ethanol tolerance, by Boris Tabakoff; (5) Gene expression profiling related to initial sensitivity and tolerance in gamma-protein kinase C mutants, .. - Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sexSergey P Pronko
Department of Pharmacology, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
J Pharmacol Exp Ther 334:44-52. 2010..The data provide evidence for an integral role of AC7 in the increase of plasma adrenocorticotropin and corticosterone levels during alcohol intoxication... - Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brainTimothy Donohue
University of Colorado Health Sciences Center, Department of Pharmacology, Aurora, CO 80045, USA
Alcohol Clin Exp Res 29:310-6. 2005..CONCLUSIONS: The effect of ethanol on the balance of DARPP-32 phosphorylation, especially in amygdala of wild-type versus transgenic mice, may contribute to differential motivational effects of ethanol in these animals... - Gene expression in animals with different acute responses to ethanolPaula Hoffman
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Addict Biol 10:63-9. 2005..Microarray analysis can also be used to assess changes in gene expression that accompany transgene introduction and/or gene 'knock-out', which may modulate the influence of the targeted gene on behaviour... - The biometric measurement of alcohol consumptionLawrence D Snell
Lohocla Research Corporation, Aurora, Colorado, USA
Alcohol Clin Exp Res 36:332-41. 2012..Biological (biometric) diagnostic tests that provide information on current and past quantity and frequency of alcohol consumption by an individual, prior to onset of organ damage, continue to be sought... - The PhenoGen informatics website: tools for analyses of complex traitsSanjiv V Bhave
Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
BMC Genet 8:59. 2007..Managing this diverse data and integrating with other biological data are major challenges for the bioinformatics community. Comprehensive new tools are needed to store, integrate and analyze the data efficiently... - DNA microarray and proteomic strategies for understanding alcohol actionJames M Sikela
University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, USA
Alcohol Clin Exp Res 30:700-8. 2006..Kerns; and (4) Quantitative Proteomic Analysis of AC7-Modified Mice, by Kathleen J. Grant... - Alcoholism: the dissection for endophenotypesLisa M Hines
Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045-0511, USA
Dialogues Clin Neurosci 7:153-63. 2005..This review summarizes the current literature, focused on human data, of promising endophenotypes for dissecting alcoholism... - Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug useLisa M Hines
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80045 0511, USA
Biol Psychiatry 58:955-62. 2005..We examined the relationship between various measures of AC activity and major depression, taking into account potential confounders, such as drug use and gender... - Relationships between effects of smoking, gender, and alcohol dependence on platelet monoamine oxidase-B: activity, affinity labeling, and protein measurementsLawrence D Snell
Lohocla Research Corporation, Denver, Colorado, USA
Alcohol Clin Exp Res 26:1105-13. 2002.... - Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred miceShelli L Kirstein
Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Pharmacol Exp Ther 302:1238-45. 2002..These results suggest that although ethanol sensitivity and cAMP signaling are determined by multiple genes, they may share certain genetic codetermination... - Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C deltaEric J Nelson
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 278:4552-60. 2003..Immunoprecipitation data indicated that PKCdelta could bind and directly phosphorylate AC7. The results indicate that the potentiation of AC7 activity by ethanol involves phosphorylation of AC7 that is mediated by PKCdelta... - Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumptionTom N Grammatopoulos
Department of Medicine, University of Colorado Denver, 12800 East 19th Avenue, Aurora, CO 80045, USA
Stem Cell Res Ther 1:36. 2010..We reasoned that reducing extracellular DA levels, by engrafting into NAC DA-sequestering stem cells expressing hDAT, would alter alcohol intake... - Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and DependencePaula L Hoffman
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Alcohol Clin Exp Res 26:1078-87. 2002..We have now measured platelet adenylyl cyclase activity in more than 1400 well-characterized subjects, which allows us to investigate the influence of a broad range of factors on this activity... - Streamlining microarray technology in a prototype core laboratoryBrian Soriano
University of Colorado Health Sciences Center UCHSC, 4200 E Ninth Ave, Box C 236, Denver, CO 80262, USA
Am Clin Lab 21:22-5. 2002.... - Inhibition of neuronal Na+ channels by the novel antiepileptic compound DCUKA: identification of the diphenylureido moiety as an inactivation modifierZe-Jun Wang
Department of Physiology and Biophysics and Program in Neuroscience, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Exp Neurol 178:129-38. 2002..Thus the diphenylureido moiety identified by a structural analysis of classic anticonvulsants appears to be important to the inactivation-specific Na(+) channel inhibition by this class of antiseizure agents... - WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence: analysis of demographic, behavioral, physiologic, and drinking variables that contribute to dependence and seeking treatment. International Society on Biomedical Research on AlcoholJason Glanz
Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, Colorado, USA
Alcohol Clin Exp Res 26:1047-61. 2002.... - Toward understanding the genetics of alcohol drinking through transcriptome meta-analysisMegan K Mulligan
Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 103:6368-73. 2006..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation... - Addictions biology: haplotype-based analysis for 130 candidate genes on a single arrayColin A Hodgkinson
Laboratory of Neurogenetics, NIAAA, 5625 Fishers Lane, Room 3S32 MSC9412, Rockville, MD 20852 1728, USA
Alcohol Alcohol 43:505-15. 2008..To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety... - Carbohydrate-deficient transferrin and gamma-glutamyltransferase for the detection and monitoring of alcohol use: results from a multisite studyRaymond F Anton
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
Alcohol Clin Exp Res 26:1215-22. 2002.... - Alcohol-induced neurodegeneration: when, where and why?Fulton T Crews
University at Buffalo, SUNY, NY, USA
Alcohol Clin Exp Res 28:350-64. 2004..Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal... - Complex genetics of interactions of alcohol and CNS function and behaviorDouglas B Matthews
Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
Alcohol Clin Exp Res 29:1706-19. 2005..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff... - CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative projectKatherine M Conigrave
Drug and Alcohol Department, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Sydney, Australia
Alcohol Clin Exp Res 26:332-9. 2002..The WHO/ISBRA Collaborative Study allows assessment and comparison of CDT, GGT, and aspartate aminotransferase (AST) as markers of drinking in a large, well-characterized, multicenter sample...
Research Grants
- Gene Array Technology Center for Alcohol ResearchBoris Tabakoff; Fiscal Year: 2005..Cumulatively, the GATC will provide the gene arrays, informatics power, and database management for gene expression discovery that will form the basis for new hypotheses in alcohol research. ..