Boris Tabakoff

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc The genomic determinants of alcohol preference in mice
    Boris Tabakoff
    Department of Pharmacology, University of Colorado Denver School of Medicine, Mail Stop F 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    Mamm Genome 19:352-65. 2008
  2. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
  3. pmc The neurobiology of alcohol consumption and alcoholism: an integrative history
    Boris Tabakoff
    University of Colorado School of Medicine, MS8303, 12800 E 19th Ave, Aurora, CO 80045, USA Electronic address
    Pharmacol Biochem Behav 113:20-37. 2013
  4. pmc Genomic insights into acute alcohol tolerance
    Wei Hu
    Department of Pharmacology, University of Colorado School of Medicine, Mail Stop 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    J Pharmacol Exp Ther 326:792-800. 2008
  5. pmc Genetical genomic analysis of complex phenotypes using the PhenoGen website
    Beth Bennett
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045 0511, USA
    Behav Genet 41:625-8. 2011
  6. ncbi request reprint Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors
    Boris Tabakoff
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 23:4491-8. 2003
  7. pmc Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes
    Paula L Hoffman
    University of Colorado Denver, School of Medicine, Department of Pharmacology, Aurora, CO 80045, USA
    Addict Biol 16:393-404. 2011
  8. ncbi request reprint A sex-specific role of type VII adenylyl cyclase in depression
    Lisa M Hines
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 26:12609-19. 2006
  9. ncbi request reprint Candidate genes and their regulatory elements: alcohol preference and tolerance
    Laura Saba
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Mamm Genome 17:669-88. 2006
  10. pmc A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission
    Laura M Saba
    Department of Pharmacology, University of Colorado Denver School of Medicine, PO Box 6511, Mail Stop 8303, Aurora, CO 80045, USA
    Neuropharmacology 60:1269-80. 2011

Research Grants

  1. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2005
  2. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2002
  3. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2003
  4. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2004

Detail Information

Publications37

  1. pmc The genomic determinants of alcohol preference in mice
    Boris Tabakoff
    Department of Pharmacology, University of Colorado Denver School of Medicine, Mail Stop F 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    Mamm Genome 19:352-65. 2008
    ..The importance of olfactory cues, learning and memory formation (Pavlovian conditioning), and cortical executive function, for regulating alcohol intake by animals (including humans), is discussed...
  2. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
    ....
  3. pmc The neurobiology of alcohol consumption and alcoholism: an integrative history
    Boris Tabakoff
    University of Colorado School of Medicine, MS8303, 12800 E 19th Ave, Aurora, CO 80045, USA Electronic address
    Pharmacol Biochem Behav 113:20-37. 2013
    ..Depending on one's point of view, we may, at this point in history, know more, or less, than we think we know about the neurobiology of alcoholism. ..
  4. pmc Genomic insights into acute alcohol tolerance
    Wei Hu
    Department of Pharmacology, University of Colorado School of Medicine, Mail Stop 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    J Pharmacol Exp Ther 326:792-800. 2008
    ....
  5. pmc Genetical genomic analysis of complex phenotypes using the PhenoGen website
    Beth Bennett
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045 0511, USA
    Behav Genet 41:625-8. 2011
    ..These methods are briefly described here and we encourage the use of our site for both scientific discovery and as a teaching tool in quantitative genetics...
  6. ncbi request reprint Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors
    Boris Tabakoff
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 23:4491-8. 2003
    ....
  7. pmc Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes
    Paula L Hoffman
    University of Colorado Denver, School of Medicine, Department of Pharmacology, Aurora, CO 80045, USA
    Addict Biol 16:393-404. 2011
    ..The results demonstrate how PhenoGen can be used to identify a novel set of genes that can be further investigated for their potential role in pain, morphine analgesia and/or morphine tolerance...
  8. ncbi request reprint A sex-specific role of type VII adenylyl cyclase in depression
    Lisa M Hines
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 26:12609-19. 2006
    ..Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness...
  9. ncbi request reprint Candidate genes and their regulatory elements: alcohol preference and tolerance
    Laura Saba
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Mamm Genome 17:669-88. 2006
    ....
  10. pmc A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission
    Laura M Saba
    Department of Pharmacology, University of Colorado Denver School of Medicine, PO Box 6511, Mail Stop 8303, Aurora, CO 80045, USA
    Neuropharmacology 60:1269-80. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  11. ncbi request reprint Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
    Alcohol Clin Exp Res 30:1659-69. 2006
    ..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains...
  12. pmc Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex
    Sergey P Pronko
    Department of Pharmacology, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
    J Pharmacol Exp Ther 334:44-52. 2010
    ..The data provide evidence for an integral role of AC7 in the increase of plasma adrenocorticotropin and corticosterone levels during alcohol intoxication...
  13. pmc Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption
    Lauren A Vanderlinden
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA
    PLoS ONE 8:e68878. 2013
    ..Integration of these data with human GWAS provides further information on the function of polymorphisms associated with alcohol-related traits. ..
  14. ncbi request reprint Gene expression in animals with different acute responses to ethanol
    Paula Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Addict Biol 10:63-9. 2005
    ..Microarray analysis can also be used to assess changes in gene expression that accompany transgene introduction and/or gene 'knock-out', which may modulate the influence of the targeted gene on behaviour...
  15. ncbi request reprint Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain
    Timothy Donohue
    University of Colorado Health Sciences Center, Department of Pharmacology, Aurora, CO 80045, USA
    Alcohol Clin Exp Res 29:310-6. 2005
    ..Phosphorylation of DARPP-32 on threonine-75 (T75) is regulated by cyclin-dependent kinase 5 and protein phosphatase 2A. DARPP-32 has been implicated in the motivational effects of ethanol...
  16. ncbi request reprint Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference
    Paula L Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 27:155-68. 2003
    ..4) Patterns of gene expression in brains of selected lines of mice that differ in ethanol tolerance, by Boris Tabakoff; (5) Gene expression profiling related to initial sensitivity and tolerance in gamma-protein kinase C mutants, ..
  17. pmc The biometric measurement of alcohol consumption
    Lawrence D Snell
    Lohocla Research Corporation, Aurora, Colorado, USA
    Alcohol Clin Exp Res 36:332-41. 2012
    ..Biological (biometric) diagnostic tests that provide information on current and past quantity and frequency of alcohol consumption by an individual, prior to onset of organ damage, continue to be sought...
  18. pmc The PhenoGen informatics website: tools for analyses of complex traits
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    BMC Genet 8:59. 2007
    ..Managing this diverse data and integrating with other biological data are major challenges for the bioinformatics community. Comprehensive new tools are needed to store, integrate and analyze the data efficiently...
  19. ncbi request reprint Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence
    Paula L Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 26:1078-87. 2002
    ..We have now measured platelet adenylyl cyclase activity in more than 1400 well-characterized subjects, which allows us to investigate the influence of a broad range of factors on this activity...
  20. pmc DNA microarray and proteomic strategies for understanding alcohol action
    James M Sikela
    University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, USA
    Alcohol Clin Exp Res 30:700-8. 2006
    ..Kerns; and (4) Quantitative Proteomic Analysis of AC7-Modified Mice, by Kathleen J. Grant...
  21. ncbi request reprint Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use
    Lisa M Hines
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80045 0511, USA
    Biol Psychiatry 58:955-62. 2005
    ..We examined the relationship between various measures of AC activity and major depression, taking into account potential confounders, such as drug use and gender...
  22. pmc Genetic markers of comorbid depression and alcoholism in women
    Daniela O Procopio
    Department of Pharmacology, School of Medicine, University of Colorado, Aurora, CO 80045, USA
    Alcohol Clin Exp Res 37:896-904. 2013
    ..In this work, we investigated the association of adenylyl cyclase genes (ADCY1-9), which are implicated in both AD and mood disorders, with alcoholism and comorbid depression...
  23. pmc Expression Quantitative Trait Loci and the PhenoGen Database
    Laura Saba
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, Colorado
    Alcohol Res Health 31:272-4. 2008
    ..After briefly explaining how microarray data are generated, this article describes one approach to narrowing down the resulting candidate genes and a database that can help in this analysis...
  24. pmc Alcoholism: the dissection for endophenotypes
    Lisa M Hines
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045 0511, USA
    Dialogues Clin Neurosci 7:153-63. 2005
    ..This review summarizes the current literature, focused on human data, of promising endophenotypes for dissecting alcoholism...
  25. ncbi request reprint Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice
    Shelli L Kirstein
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Pharmacol Exp Ther 302:1238-45. 2002
    ..These results suggest that although ethanol sensitivity and cAMP signaling are determined by multiple genes, they may share certain genetic codetermination...
  26. ncbi request reprint Relationships between effects of smoking, gender, and alcohol dependence on platelet monoamine oxidase-B: activity, affinity labeling, and protein measurements
    Lawrence D Snell
    Lohocla Research Corporation, Denver, Colorado, USA
    Alcohol Clin Exp Res 26:1105-13. 2002
    ..Many alcohol-dependent individuals are also tobacco users, and few studies have attempted to dissociate the effect of alcohol and tobacco use on MAO activity...
  27. ncbi request reprint Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta
    Eric J Nelson
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:4552-60. 2003
    ..Immunoprecipitation data indicated that PKCdelta could bind and directly phosphorylate AC7. The results indicate that the potentiation of AC7 activity by ethanol involves phosphorylation of AC7 that is mediated by PKCdelta...
  28. pmc Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption
    Tom N Grammatopoulos
    Department of Medicine, University of Colorado Denver, 12800 East 19th Avenue, Aurora, CO 80045, USA
    Stem Cell Res Ther 1:36. 2010
    ..We reasoned that reducing extracellular DA levels, by engrafting into NAC DA-sequestering stem cells expressing hDAT, would alter alcohol intake...
  29. ncbi request reprint WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence: analysis of demographic, behavioral, physiologic, and drinking variables that contribute to dependence and seeking treatment. International Society on Biomedical Research on Alcohol
    Jason Glanz
    Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Alcohol Clin Exp Res 26:1047-61. 2002
    ....
  30. ncbi request reprint Inhibition of neuronal Na+ channels by the novel antiepileptic compound DCUKA: identification of the diphenylureido moiety as an inactivation modifier
    Ze Jun Wang
    Department of Physiology and Biophysics and Program in Neuroscience, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Exp Neurol 178:129-38. 2002
    ..Thus the diphenylureido moiety identified by a structural analysis of classic anticonvulsants appears to be important to the inactivation-specific Na(+) channel inhibition by this class of antiseizure agents...
  31. ncbi request reprint Streamlining microarray technology in a prototype core laboratory
    Brian Soriano
    University of Colorado Health Sciences Center UCHSC, 4200 E Ninth Ave, Box C 236, Denver, CO 80262, USA
    Am Clin Lab 21:22-5. 2002
    ....
  32. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  33. pmc Addictions biology: haplotype-based analysis for 130 candidate genes on a single array
    Colin A Hodgkinson
    Laboratory of Neurogenetics, NIAAA, 5625 Fishers Lane, Room 3S32 MSC9412, Rockville, MD 20852 1728, USA
    Alcohol Alcohol 43:505-15. 2008
    ..To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety...
  34. ncbi request reprint Complex genetics of interactions of alcohol and CNS function and behavior
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 29:1706-19. 2005
    ..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff...
  35. ncbi request reprint Alcohol-induced neurodegeneration: when, where and why?
    Fulton T Crews
    University at Buffalo, SUNY, NY, USA
    Alcohol Clin Exp Res 28:350-64. 2004
    ..Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal...
  36. ncbi request reprint Carbohydrate-deficient transferrin and gamma-glutamyltransferase for the detection and monitoring of alcohol use: results from a multisite study
    Raymond F Anton
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
    Alcohol Clin Exp Res 26:1215-22. 2002
    ....
  37. ncbi request reprint CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project
    Katherine M Conigrave
    Drug and Alcohol Department, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Sydney, Australia
    Alcohol Clin Exp Res 26:332-9. 2002
    ..The WHO/ISBRA Collaborative Study allows assessment and comparison of CDT, GGT, and aspartate aminotransferase (AST) as markers of drinking in a large, well-characterized, multicenter sample...

Research Grants4

  1. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2005
    ..Cumulatively, the GATC will provide the gene arrays, informatics power, and database management for gene expression discovery that will form the basis for new hypotheses in alcohol research. ..
  2. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2002
    ..Cumulatively, the GATC will provide the gene arrays, informatics power, and database management for gene expression discovery that will form the basis for new hypotheses in alcohol research. ..
  3. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2003
    ..Cumulatively, the GATC will provide the gene arrays, informatics power, and database management for gene expression discovery that will form the basis for new hypotheses in alcohol research. ..
  4. Gene Array Technology Center for Alcohol Research
    Boris Tabakoff; Fiscal Year: 2004
    ..Cumulatively, the GATC will provide the gene arrays, informatics power, and database management for gene expression discovery that will form the basis for new hypotheses in alcohol research. ..