R Szymusiak

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Hypothalamic regulation of sleep and arousal
    Ronald Szymusiak
    Research Service 151A3, Veterans Administration, Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91434, USA
    Ann N Y Acad Sci 1129:275-86. 2008
  2. ncbi request reprint Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats
    R Szymusiak
    Research Service 151A3, V A Medical Center, 16111 Plummer St, North Hills, CA 19343, USA
    Brain Res 803:178-88. 1998
  3. ncbi request reprint Hypothalamic control of sleep
    Ronald Szymusiak
    Research Service, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
    Sleep Med 8:291-301. 2007
  4. doi request reprint Hypothalamic versus neocortical control of sleep
    Ronald Szymusiak
    Research Service, VA Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, Los Angeles, CA 91343, USA
    Curr Opin Pulm Med 16:530-5. 2010
  5. pmc A role for the preoptic sleep-promoting system in absence epilepsy
    N Suntsova
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Neurobiol Dis 36:126-41. 2009
  6. pmc GABAergic regulation of the perifornical-lateral hypothalamic neurons during non-rapid eye movement sleep in rats
    M N Alam
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    Neuroscience 167:920-8. 2010
  7. pmc A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving rats
    S Rai
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA, USA
    Neuroscience 167:40-8. 2010
  8. pmc c-Fos expression in neurons projecting from the preoptic and lateral hypothalamic areas to the ventrolateral periaqueductal gray in relation to sleep states
    K C Hsieh
    Research Service, V A Greater Los Angeles, CA 91343, USA
    Neuroscience 188:55-67. 2011
  9. pmc Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neurons
    A Kostin
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    Neuroscience 179:159-69. 2011
  10. pmc Sustained sleep fragmentation results in delayed changes in hippocampal-dependent cognitive function associated with reduced dentate gyrus neurogenesis
    N Sportiche
    Department of Psychology, UCLA, 405 Hilgard, Los Angeles, CA 90095, USA
    Neuroscience 170:247-58. 2010

Research Grants

  1. Median Preoptic Nucleus and the Control of Sleep
    Ronald Szymusiak; Fiscal Year: 2007
  2. Median Preoptic Nucleus and the Control of Sleep
    Ronald Szymusiak; Fiscal Year: 2006
  3. Median Preoptic Nucleus and the Control of Sleep
    Ronald Szymusiak; Fiscal Year: 2010

Collaborators

Detail Information

Publications49

  1. doi request reprint Hypothalamic regulation of sleep and arousal
    Ronald Szymusiak
    Research Service 151A3, Veterans Administration, Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91434, USA
    Ann N Y Acad Sci 1129:275-86. 2008
    ..Recent findings indicate that MnPN and VLPO neurons integrate homeostatic aspects of sleep regulation and are important targets for endogenous sleep factors, such as adenosine and growth hormone releasing hormone...
  2. ncbi request reprint Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats
    R Szymusiak
    Research Service 151A3, V A Medical Center, 16111 Plummer St, North Hills, CA 19343, USA
    Brain Res 803:178-88. 1998
    ..Such neurons are likely components of a rostral hypothalamic mechanism that regulates sleep onset and sleep maintenance...
  3. ncbi request reprint Hypothalamic control of sleep
    Ronald Szymusiak
    Research Service, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
    Sleep Med 8:291-301. 2007
    ....
  4. doi request reprint Hypothalamic versus neocortical control of sleep
    Ronald Szymusiak
    Research Service, VA Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, Los Angeles, CA 91343, USA
    Curr Opin Pulm Med 16:530-5. 2010
    ....
  5. pmc A role for the preoptic sleep-promoting system in absence epilepsy
    N Suntsova
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Neurobiol Dis 36:126-41. 2009
    ..Our findings suggest a pathological basis for AE-associated sleep abnormalities and a mechanism underlying association of absence seizures with wake-sleep transitions...
  6. pmc GABAergic regulation of the perifornical-lateral hypothalamic neurons during non-rapid eye movement sleep in rats
    M N Alam
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    Neuroscience 167:920-8. 2010
    ..These results suggest that GABA(A) receptor mediated increased GABAergic tone contributes to the suppression of PF-LHA neurons, including nonREM-off neurons, during spontaneous nonREM sleep...
  7. pmc A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving rats
    S Rai
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA, USA
    Neuroscience 167:40-8. 2010
    ..These findings suggest that wake-promoting PF-LHA system is subject to increased endogenous adenosinergic inhibition and that adenosine acting via A(1) receptors, in part, inhibits HCRT neurons to promote sleep...
  8. pmc c-Fos expression in neurons projecting from the preoptic and lateral hypothalamic areas to the ventrolateral periaqueductal gray in relation to sleep states
    K C Hsieh
    Research Service, V A Greater Los Angeles, CA 91343, USA
    Neuroscience 188:55-67. 2011
    ..Suppression of excitatory input to the vlPAG from the LH during sleep may have a permissive effect on REM sleep generation...
  9. pmc Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neurons
    A Kostin
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    Neuroscience 179:159-69. 2011
    ..These findings are consistent with a hypothesis that NO in the PF-LHA plays a role in sleep regulation by inhibiting its neurons...
  10. pmc Sustained sleep fragmentation results in delayed changes in hippocampal-dependent cognitive function associated with reduced dentate gyrus neurogenesis
    N Sportiche
    Department of Psychology, UCLA, 405 Hilgard, Los Angeles, CA 90095, USA
    Neuroscience 170:247-58. 2010
    ..The reduction in neurogenesis induced by sleep fragmentation is likely to underlie the delayed changes in cognitive function...
  11. ncbi request reprint Sleep-waking discharge of neurons in the posterior lateral hypothalamus of the albino rat
    T L Steininger
    Veterans Administration Medical Center, North Hills, CA 91343, USA
    Brain Res 840:138-47. 1999
    ..Furthermore, neurons with waking/REM-related and state-indifferent discharge patterns were localized within the TM. These results suggest that waking-related and/or REM-off neurons may not be exclusively histaminergic in rats...
  12. pmc Different neuronal populations of the rat median preoptic nucleus express c-fos during sleep and in response to hypertonic saline or angiotensin-II
    I Gvilia
    Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91344, USA
    J Physiol 569:587-99. 2005
    ..Findings of the present study provide evidence that separate populations of MnPN neurones are involved in the regulation of sleep and body fluid homeostasis...
  13. pmc Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized rat
    Sunil Kumar
    Research Service, Veteran Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA
    Brain Res 1234:66-77. 2008
    ..These results also suggest that MCH neurons may not be under MnPN inhibitory control. These findings are consistent with a hypothesized role of MnPN in sleep regulation...
  14. doi request reprint Salubrinal, an endoplasmic reticulum stress blocker, modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons
    M Methippara
    Department of Psychology, UCLA, 405 Hilgard, Los Angeles, CA 90095, USA
    Neuroscience 209:108-18. 2012
    ....
  15. doi request reprint Central nervous system sites of the sleep promoting effects of eszopiclone in rats
    S Kumar
    Research Service, V A Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Neuroscience 181:67-78. 2011
    ....
  16. pmc Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in rats
    M M Methippara
    VAGLAHS, Research, North Hills, CA 91343, USA
    Neuroscience 151:1-11. 2008
    ..These differential effects of local protein synthesis inhibition on sleep support a hypothesis that mechanisms controlling protein synthesis are critically involved in the regulation of both NREM sleep and REM sleep...
  17. ncbi request reprint Persistence of sleep-temperature coupling after suprachiasmatic nuclei lesions in rats
    F C Baker
    Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
    Am J Physiol Regul Integr Comp Physiol 289:R827-38. 2005
    ..Our results suggest that, in rats, the SCN modulates the timing but not the amount of sleep or the homeostatic control of sleep-wake states or T(b) during deviations in ambient temperature...
  18. ncbi request reprint Magnocellular nuclei of the basal forebrain: substrates of sleep and arousal regulation
    R Szymusiak
    Sleep Physiology Research, Dept. Veterans Affairs Medical Center, Sepulveda, CA 91343, USA
    Sleep 18:478-500. 1995
    ..Additional evidence supports a critical role for GABAergic-cholinergic interactions, both within the magnocellular BF and at cortical and diencephalic sites, in the regulation of behavioral state...
  19. ncbi request reprint Preoptic area neurons and the homeostatic regulation of rapid eye movement sleep
    Irma Gvilia
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
    J Neurosci 26:3037-44. 2006
    ..those rats exhibiting the most frequent attempts to enter REM sleep. This finding provides the first evidence that activation of subsets of MnPN and vlPOA neurons is more strongly related to REM sleep pressure than to REM sleep amount...
  20. doi request reprint Mechanisms mediating effects of nitric oxide on perifornical lateral hypothalamic neurons
    A Kostin
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA, USA
    Neuroscience 220:179-90. 2012
    ....
  21. ncbi request reprint Preoptic area sleep-regulating mechanisms
    R Szymusiak
    Research Service (151A3, V.A. Greater Los Angeles Healthcare System, Departments of Medicine and Psychology, University of California, Los Angeles, USA
    Arch Ital Biol 139:77-92. 2001
    ..POA neurons can be hypothesized to provide sleep-related inhibitory control over multiple arousal systems in the forebrain and brainstem...
  22. pmc Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat
    R Guzman-Marin
    Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
    Neuroscience 148:325-33. 2007
    ..The results show that sustained SF induced marked reduction in hippocampal neurogenesis...
  23. ncbi request reprint Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat
    Sunil Kumar
    Research Service 151A3, Veteran Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA
    Eur J Neurosci 25:201-12. 2007
    ....
  24. ncbi request reprint Homeostatic regulation of sleep: a role for preoptic area neurons
    Irma Gvilia
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
    J Neurosci 26:9426-33. 2006
    ..Our findings define potential roles for MnPN and vlPOA GABAergic neurons in homeostatic aspects of sleep regulation...
  25. ncbi request reprint Discharge patterns of neurons in cholinergic regions of the basal forebrain during waking and sleep
    R Szymusiak
    Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
    Behav Brain Res 115:171-82. 2000
    ..Fluctuations in mBF cell activity during waking behaviors may reflect changing excitatory input from neurons in the pontine and midbrain tegmentum...
  26. ncbi request reprint Interleukin 1beta enhances non-rapid eye movement sleep and increases c-Fos protein expression in the median preoptic nucleus of the hypothalamus
    F C Baker
    Department of Psychology, University of California, Los Angeles, California, USA
    Am J Physiol Regul Integr Comp Physiol 288:R998-R1005. 2005
    ..Our results support a hypothesis that IL-1 enhances NREM sleep, in part, through activation of neurons in the MnPN of the hypothalamus...
  27. pmc The median preoptic nucleus reciprocally modulates activity of arousal-related and sleep-related neurons in the perifornical lateral hypothalamus
    Natalia Suntsova
    Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
    J Neurosci 27:1616-30. 2007
    ..We hypothesize that MnPN sleep-active neuronal group has both inhibitory and excitatory outputs that participate in the inhibitory control of arousal-promoting PF/LH mechanisms...
  28. pmc Growth hormone-releasing hormone activates sleep regulatory neurons of the rat preoptic hypothalamus
    Zoltan Peterfi
    Research Service 151A3, VA Greater Los Angeles Healthcare System, 16111 Plummer St, North Hills, CA 91344, USA
    Am J Physiol Regul Integr Comp Physiol 298:R147-56. 2010
    ..These findings identify GABAergic neurons in the MnPN and VLPO as potential targets of the sleep-regulatory actions of GHRH...
  29. ncbi request reprint Preoptic area warming inhibits wake-active neurons in the perifornical lateral hypothalamus
    Melvi M Methippara
    VAMC, Research Service, Neurophysiology, 151 A3, 16111 Plummer St, North Hills, CA 91343, USA
    Brain Res 960:165-73. 2003
    ..This study supports the hypothesis that sleep induction by POA warm sensitive neurons is mediated through the inhibition of multiple arousal-related structures...
  30. pmc Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation
    Hui Gong
    Department of Psychology, School of Medicine, University of California, Los Angeles, CA, USA
    J Physiol 556:935-46. 2004
    ..They also demonstrate that sleep deprivation is associated with increased activation of GABAergic neurones in the MnPN and vlPOA...
  31. ncbi request reprint Sleep-active neurons in the preoptic area project to the hypothalamic paraventricular nucleus and perifornical lateral hypothalamus
    Aaron Uschakov
    Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
    Eur J Neurosci 23:3284-96. 2006
    ..awake rats. Inhibition of LHA and PVN neurons arising from OVLT, MnPO and vlPOA neurons may contribute to suppression of behavioral, electroencephalographic and sympathetic nervous system activation during sleep...
  32. ncbi request reprint Interleukin-1beta modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation
    Md Noor Alam
    Veteran Affairs Greater Los Angeles Health Care System, 16111 Plummer Street, North Hills, CA 91343, USA
    Eur J Neurosci 20:207-16. 2004
    ..These results suggest that the sleep-promoting effects of IL-1 may be mediated, in part, via the suppression of wake-related neurons and the activation of a subpopulation of sleep-related neurons in the POA/BF...
  33. ncbi request reprint Effects on sleep of microdialysis of adenosine A1 and A2a receptor analogs into the lateral preoptic area of rats
    Melvi M Methippara
    Research Service, VAGLAHS, Sepulveda, CA 91343, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1715-23. 2005
    ..The effects of AD could be mediated either directly or indirectly via interaction with other neurotransmitter systems. These observations support a hypothesis that AD mediated effects on sleep-wake cycles are site and receptor dependent...
  34. pmc Efferent projections from the median preoptic nucleus to sleep- and arousal-regulatory nuclei in the rat brain
    A Uschakov
    Research Service 151A3, VA Greater Los Angeles Health Care System, 16111 Plummer Street, North Hills, CA 91344, USA
    Neuroscience 150:104-20. 2007
    ..These anatomical findings support the hypothesis that MnPO neurons function to promote sleep by inhibition of orexinergic and monoaminergic arousal systems and disinhibition of sleep regulatory neurons in the ventrolateral preoptic area...
  35. ncbi request reprint Sleep-promoting functions of the hypothalamic median preoptic nucleus: inhibition of arousal systems
    D McGinty
    Veterans Administration, Sepulveda, Greater Los Angeles Health System and Departments of Psychology and Medicine, UCLA, USA
    Arch Ital Biol 142:501-9. 2004
    ....
  36. doi request reprint Functional correlates of activity in neurons projecting from the lamina terminalis to the ventrolateral periaqueductal gray
    Aaron Uschakov
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Eur J Neurosci 30:2347-55. 2009
    ..These results support the existence of functional subdivisions of LT-vlPAG-projecting neurons, and indicate three patterns of activity that correspond to thermal and sleep wake regulation, osmotic or hormonal stimuli...
  37. ncbi request reprint Hypothalamic regulation of sleep and arousal
    Dennis McGinty
    Research Service, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
    Front Biosci 8:s1074-83. 2003
    ..Mutually-inhibitory interactions between sleep-promoting and arousal-promoting systems are hypothesized to form a functional sleep-wake switch...
  38. pmc Role of adenosine A(1) receptor in the perifornical-lateral hypothalamic area in sleep-wake regulation in rats
    Md Noor Alam
    Research Service 151A3, Veterans Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, CA 91343, USA
    Brain Res 1304:96-104. 2009
    ..891, p<0.001) and increased non-REM (F=8.18, p <0.001) and REM sleep (F=30.036, p<0.001). These results suggest that PF-LHA is one of the sites where adenosine, acting via A(1) receptors, inhibits PF-LHA neurons to promote sleep...
  39. pmc Salubrinal, an inhibitor of protein synthesis, promotes deep slow wave sleep
    Melvi M Methippara
    Research Service 151A3, Department of Veterans Affairs of Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Am J Physiol Regul Integr Comp Physiol 296:R178-84. 2009
    ..Our findings support a hypothesis that sleep is facilitated by signals associated with the ER stress response...
  40. pmc GABA-mediated control of hypocretin- but not melanin-concentrating hormone-immunoreactive neurones during sleep in rats
    Md Noor Alam
    Research Service 151A3, Veteran Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    J Physiol 563:569-82. 2005
    ..In contrast, MCH neurones appear to be subject to weaker GABAergic control during sleep...
  41. pmc Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area
    Md Noor Alam
    Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    J Physiol 538:619-31. 2002
    ....
  42. pmc Sleep-waking discharge patterns of median preoptic nucleus neurons in rats
    Natalia Suntsova
    Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    J Physiol 543:665-77. 2002
    ..MnPN neurons that progressively increase activity during sustained waking and decrease activity during sustained sleep states may be involved in homeostatic regulation of sleep...
  43. pmc Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat
    Ruben Guzman-Marin
    Research Service, VA Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Sleep 31:167-75. 2008
    ..The present study assessed the effect of 4 days of REM sleep deprivation (REMD) on neurogenesis...
  44. ncbi request reprint Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats
    Ruben Guzman-Marin
    Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Eur J Neurosci 22:2111-6. 2005
    ..We hypothesize that sleep provides anabolic or signaling support for proliferation and cell fate determination...
  45. pmc Cell proliferation in the dentate gyrus of the adult rat fluctuates with the light-dark cycle
    Ruben Guzman-Marin
    Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Neurosci Lett 422:198-201. 2007
    ..Our results suggest that cell proliferation is enhanced either by sleep or by other variables coupled to the light phase of the circadian cycle...
  46. pmc Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats
    Ruben Guzman-Marin
    Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    J Physiol 549:563-71. 2003
    ..These results suggest that sleep deprivation reduces proliferation of cells in the DG of the dorsal hippocampus...
  47. pmc Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats
    Ruben Guzman-Marin
    Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills CA 91343, USA
    J Physiol 575:807-19. 2006
    ..Stepwise regression analysis suggested that loss of REM sleep underlies the effects of SD on hippocampal BDNF, Synapsin I and CREB mRNA levels, whereas loss of NREM sleep underlies the effects on CAMKII mRNA...
  48. doi request reprint Chronic recording of extracellular neuronal activity in behaving animals
    Ronald Szymusiak
    University of California, Los Angeles, California, USA
    Curr Protoc Neurosci . 2003
    ..These methods can provide stable, long-term recording of neuronal activity during a variety of behavioral paradigms...
  49. ncbi request reprint Adenosinergic regulation of sleep: multiple sites of action in the brain
    M D Noor Alam
    Sleep 29:1384-5; discussion 1387-9. 2006

Research Grants10

  1. Median Preoptic Nucleus and the Control of Sleep
    Ronald Szymusiak; Fiscal Year: 2007
    ..Proposed work will attempt to characterize the functional neuroanatomy and the neurochemical modulation of forebrain and brainstem neural circuits that underlie normal and disordered homeostatic sleep regulation. ..
  2. Median Preoptic Nucleus and the Control of Sleep
    Ronald Szymusiak; Fiscal Year: 2006
    ..Planned experiments will contribute to a more complete understanding of the role of hypothalamic mechanisms in normal and disordered sleep and arousal states. ..
  3. Median Preoptic Nucleus and the Control of Sleep
    Ronald Szymusiak; Fiscal Year: 2010
    ..Proposed work will attempt to characterize the functional neuroanatomy and the neurochemical modulation of forebrain and brainstem neural circuits that underlie normal and disordered homeostatic sleep regulation. ..