Research Topics
Species | R SzymusiakSummaryAffiliation: University of California Country: USA Publications
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Publications
Hypothalamic regulation of sleep and arousalRonald Szymusiak
Research Service 151A3, Veterans Administration, Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91434, USA
Ann N Y Acad Sci 1129:275-86. 2008..Recent findings indicate that MnPN and VLPO neurons integrate homeostatic aspects of sleep regulation and are important targets for endogenous sleep factors, such as adenosine and growth hormone releasing hormone...
Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in ratsR Szymusiak
Research Service 151A3, V A Medical Center, 16111 Plummer St, North Hills, CA 19343, USA
Brain Res 803:178-88. 1998..Such neurons are likely components of a rostral hypothalamic mechanism that regulates sleep onset and sleep maintenance...- Hypothalamic control of sleepRonald Szymusiak
Research Service, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
Sleep Med 8:291-301. 2007.... - Hypothalamic versus neocortical control of sleepRonald Szymusiak
Research Service, VA Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, Los Angeles, CA 91343, USA
Curr Opin Pulm Med 16:530-5. 2010.... 
A role for the preoptic sleep-promoting system in absence epilepsyN Suntsova
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
Neurobiol Dis 36:126-41. 2009..Our findings suggest a pathological basis for AE-associated sleep abnormalities and a mechanism underlying association of absence seizures with wake-sleep transitions...- GABAergic regulation of the perifornical-lateral hypothalamic neurons during non-rapid eye movement sleep in ratsM N Alam
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
Neuroscience 167:920-8. 2010..These results suggest that GABA(A) receptor mediated increased GABAergic tone contributes to the suppression of PF-LHA neurons, including nonREM-off neurons, during spontaneous nonREM sleep... - A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving ratsS Rai
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA, USA
Neuroscience 167:40-8. 2010..These findings suggest that wake-promoting PF-LHA system is subject to increased endogenous adenosinergic inhibition and that adenosine acting via A(1) receptors, in part, inhibits HCRT neurons to promote sleep... - c-Fos expression in neurons projecting from the preoptic and lateral hypothalamic areas to the ventrolateral periaqueductal gray in relation to sleep statesK C Hsieh
Research Service, V A Greater Los Angeles, CA 91343, USA
Neuroscience 188:55-67. 2011..Suppression of excitatory input to the vlPAG from the LH during sleep may have a permissive effect on REM sleep generation... - Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neuronsA Kostin
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
Neuroscience 179:159-69. 2011..These findings are consistent with a hypothesis that NO in the PF-LHA plays a role in sleep regulation by inhibiting its neurons... - Sustained sleep fragmentation results in delayed changes in hippocampal-dependent cognitive function associated with reduced dentate gyrus neurogenesisN Sportiche
Department of Psychology, UCLA, 405 Hilgard, Los Angeles, CA 90095, USA
Neuroscience 170:247-58. 2010..The reduction in neurogenesis induced by sleep fragmentation is likely to underlie the delayed changes in cognitive function... - Sleep-waking discharge of neurons in the posterior lateral hypothalamus of the albino ratT L Steininger
Veterans Administration Medical Center, North Hills, CA 91343, USA
Brain Res 840:138-47. 1999..Furthermore, neurons with waking/REM-related and state-indifferent discharge patterns were localized within the TM. These results suggest that waking-related and/or REM-off neurons may not be exclusively histaminergic in rats... - Different neuronal populations of the rat median preoptic nucleus express c-fos during sleep and in response to hypertonic saline or angiotensin-III Gvilia
Research Service (151A3, V.A. Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91344, USA
J Physiol 569:587-99. 2005..Findings of the present study provide evidence that separate populations of MnPN neurones are involved in the regulation of sleep and body fluid homeostasis... - Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized ratSunil Kumar
Research Service, Veteran Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA
Brain Res 1234:66-77. 2008..These results also suggest that MCH neurons may not be under MnPN inhibitory control. These findings are consistent with a hypothesized role of MnPN in sleep regulation... - Salubrinal, an endoplasmic reticulum stress blocker, modulates sleep homeostasis and activation of sleep- and wake-regulatory neuronsM Methippara
Department of Psychology, UCLA, 405 Hilgard, Los Angeles, CA 90095, USA
Neuroscience 209:108-18. 2012.... - Central nervous system sites of the sleep promoting effects of eszopiclone in ratsS Kumar
Research Service, V A Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Neuroscience 181:67-78. 2011.... - Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in ratsM M Methippara
VAGLAHS, Research, North Hills, CA 91343, USA
Neuroscience 151:1-11. 2008..These differential effects of local protein synthesis inhibition on sleep support a hypothesis that mechanisms controlling protein synthesis are critically involved in the regulation of both NREM sleep and REM sleep... - Persistence of sleep-temperature coupling after suprachiasmatic nuclei lesions in ratsF C Baker
Research Service (151A3, V. A. Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
Am J Physiol Regul Integr Comp Physiol 289:R827-38. 2005..Our results suggest that, in rats, the SCN modulates the timing but not the amount of sleep or the homeostatic control of sleep-wake states or T(b) during deviations in ambient temperature... - Magnocellular nuclei of the basal forebrain: substrates of sleep and arousal regulationR Szymusiak
Sleep Physiology Research, Dept. Veterans Affairs Medical Center, Sepulveda, CA 91343, USA
Sleep 18:478-500. 1995..Additional evidence supports a critical role for GABAergic-cholinergic interactions, both within the magnocellular BF and at cortical and diencephalic sites, in the regulation of behavioral state... - Preoptic area neurons and the homeostatic regulation of rapid eye movement sleepIrma Gvilia
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
J Neurosci 26:3037-44. 2006..those rats exhibiting the most frequent attempts to enter REM sleep. This finding provides the first evidence that activation of subsets of MnPN and vlPOA neurons is more strongly related to REM sleep pressure than to REM sleep amount... - Mechanisms mediating effects of nitric oxide on perifornical lateral hypothalamic neuronsA Kostin
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA, USA
Neuroscience 220:179-90. 2012.... - Preoptic area sleep-regulating mechanismsR Szymusiak
Research Service (151A3, V.A. Greater Los Angeles Healthcare System, Departments of Medicine and Psychology, University of California, Los Angeles, USA
Arch Ital Biol 139:77-92. 2001..POA neurons can be hypothesized to provide sleep-related inhibitory control over multiple arousal systems in the forebrain and brainstem... - Hippocampal neurogenesis is reduced by sleep fragmentation in the adult ratR Guzman-Marin
Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
Neuroscience 148:325-33. 2007..The results show that sustained SF induced marked reduction in hippocampal neurogenesis... - Effects of serotonin on perifornical-lateral hypothalamic area neurons in ratSunil Kumar
Research Service 151A3, Veteran Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA
Eur J Neurosci 25:201-12. 2007.... - Homeostatic regulation of sleep: a role for preoptic area neuronsIrma Gvilia
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
J Neurosci 26:9426-33. 2006..Our findings define potential roles for MnPN and vlPOA GABAergic neurons in homeostatic aspects of sleep regulation... - Discharge patterns of neurons in cholinergic regions of the basal forebrain during waking and sleepR Szymusiak
Research Service 151A3, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
Behav Brain Res 115:171-82. 2000..Fluctuations in mBF cell activity during waking behaviors may reflect changing excitatory input from neurons in the pontine and midbrain tegmentum... - Interleukin 1beta enhances non-rapid eye movement sleep and increases c-Fos protein expression in the median preoptic nucleus of the hypothalamusF C Baker
Department of Psychology, University of California, Los Angeles, California, USA
Am J Physiol Regul Integr Comp Physiol 288:R998-R1005. 2005..Our results support a hypothesis that IL-1 enhances NREM sleep, in part, through activation of neurons in the MnPN of the hypothalamus... - The median preoptic nucleus reciprocally modulates activity of arousal-related and sleep-related neurons in the perifornical lateral hypothalamusNatalia Suntsova
Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
J Neurosci 27:1616-30. 2007..We hypothesize that MnPN sleep-active neuronal group has both inhibitory and excitatory outputs that participate in the inhibitory control of arousal-promoting PF/LH mechanisms... - Growth hormone-releasing hormone activates sleep regulatory neurons of the rat preoptic hypothalamusZoltan Peterfi
Research Service 151A3, VA Greater Los Angeles Healthcare System, 16111 Plummer St, North Hills, CA 91344, USA
Am J Physiol Regul Integr Comp Physiol 298:R147-56. 2010..These findings identify GABAergic neurons in the MnPN and VLPO as potential targets of the sleep-regulatory actions of GHRH... - Preoptic area warming inhibits wake-active neurons in the perifornical lateral hypothalamusMelvi M Methippara
VAMC, Research Service, Neurophysiology, 151 A3, 16111 Plummer St, North Hills, CA 91343, USA
Brain Res 960:165-73. 2003..This study supports the hypothesis that sleep induction by POA warm sensitive neurons is mediated through the inhibition of multiple arousal-related structures... - Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivationHui Gong
Department of Psychology, School of Medicine, University of California, Los Angeles, CA, USA
J Physiol 556:935-46. 2004..They also demonstrate that sleep deprivation is associated with increased activation of GABAergic neurones in the MnPN and vlPOA... - Sleep-active neurons in the preoptic area project to the hypothalamic paraventricular nucleus and perifornical lateral hypothalamusAaron Uschakov
Research Service 151A3, V.A. Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
Eur J Neurosci 23:3284-96. 2006..awake rats. Inhibition of LHA and PVN neurons arising from OVLT, MnPO and vlPOA neurons may contribute to suppression of behavioral, electroencephalographic and sympathetic nervous system activation during sleep... - Interleukin-1beta modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulationMd Noor Alam
Veteran Affairs Greater Los Angeles Health Care System, 16111 Plummer Street, North Hills, CA 91343, USA
Eur J Neurosci 20:207-16. 2004..These results suggest that the sleep-promoting effects of IL-1 may be mediated, in part, via the suppression of wake-related neurons and the activation of a subpopulation of sleep-related neurons in the POA/BF... - Effects on sleep of microdialysis of adenosine A1 and A2a receptor analogs into the lateral preoptic area of ratsMelvi M Methippara
Research Service, VAGLAHS, Sepulveda, CA 91343, USA
Am J Physiol Regul Integr Comp Physiol 289:R1715-23. 2005..The effects of AD could be mediated either directly or indirectly via interaction with other neurotransmitter systems. These observations support a hypothesis that AD mediated effects on sleep-wake cycles are site and receptor dependent... - Efferent projections from the median preoptic nucleus to sleep- and arousal-regulatory nuclei in the rat brainA Uschakov
Research Service 151A3, VA Greater Los Angeles Health Care System, 16111 Plummer Street, North Hills, CA 91344, USA
Neuroscience 150:104-20. 2007..These anatomical findings support the hypothesis that MnPO neurons function to promote sleep by inhibition of orexinergic and monoaminergic arousal systems and disinhibition of sleep regulatory neurons in the ventrolateral preoptic area... - Sleep-promoting functions of the hypothalamic median preoptic nucleus: inhibition of arousal systemsD McGinty
Veterans Administration, Sepulveda, Greater Los Angeles Health System and Departments of Psychology and Medicine, UCLA, USA
Arch Ital Biol 142:501-9. 2004.... - Functional correlates of activity in neurons projecting from the lamina terminalis to the ventrolateral periaqueductal grayAaron Uschakov
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Eur J Neurosci 30:2347-55. 2009..These results support the existence of functional subdivisions of LT-vlPAG-projecting neurons, and indicate three patterns of activity that correspond to thermal and sleep wake regulation, osmotic or hormonal stimuli... - Hypothalamic regulation of sleep and arousalDennis McGinty
Research Service, V A Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA
Front Biosci 8:s1074-83. 2003..Mutually-inhibitory interactions between sleep-promoting and arousal-promoting systems are hypothesized to form a functional sleep-wake switch... - Role of adenosine A(1) receptor in the perifornical-lateral hypothalamic area in sleep-wake regulation in ratsMd Noor Alam
Research Service 151A3, Veterans Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, CA 91343, USA
Brain Res 1304:96-104. 2009..891, p<0.001) and increased non-REM (F=8.18, p <0.001) and REM sleep (F=30.036, p<0.001). These results suggest that PF-LHA is one of the sites where adenosine, acting via A(1) receptors, inhibits PF-LHA neurons to promote sleep... - Salubrinal, an inhibitor of protein synthesis, promotes deep slow wave sleepMelvi M Methippara
Research Service 151A3, Department of Veterans Affairs of Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
Am J Physiol Regul Integr Comp Physiol 296:R178-84. 2009..Our findings support a hypothesis that sleep is facilitated by signals associated with the ER stress response... - GABA-mediated control of hypocretin- but not melanin-concentrating hormone-immunoreactive neurones during sleep in ratsMd Noor Alam
Research Service 151A3, Veteran Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
J Physiol 563:569-82. 2005..In contrast, MCH neurones appear to be subject to weaker GABAergic control during sleep... - Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic areaMd Noor Alam
Research Service, V.A. Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
J Physiol 538:619-31. 2002.... - Sleep-waking discharge patterns of median preoptic nucleus neurons in ratsNatalia Suntsova
Research Service, V.A. Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
J Physiol 543:665-77. 2002..MnPN neurons that progressively increase activity during sustained waking and decrease activity during sustained sleep states may be involved in homeostatic regulation of sleep... - Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult ratRuben Guzman-Marin
Research Service, VA Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
Sleep 31:167-75. 2008..The present study assessed the effect of 4 days of REM sleep deprivation (REMD) on neurogenesis... - Sleep deprivation suppresses neurogenesis in the adult hippocampus of ratsRuben Guzman-Marin
Research Service, V.A. Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
Eur J Neurosci 22:2111-6. 2005..We hypothesize that sleep provides anabolic or signaling support for proliferation and cell fate determination... - Cell proliferation in the dentate gyrus of the adult rat fluctuates with the light-dark cycleRuben Guzman-Marin
Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
Neurosci Lett 422:198-201. 2007..Our results suggest that cell proliferation is enhanced either by sleep or by other variables coupled to the light phase of the circadian cycle... - Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in ratsRuben Guzman-Marin
Research Service, V A Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
J Physiol 549:563-71. 2003..These results suggest that sleep deprivation reduces proliferation of cells in the DG of the dorsal hippocampus... - Suppression of hippocampal plasticity-related gene expression by sleep deprivation in ratsRuben Guzman-Marin
Research Service (151A3, V. A. Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills CA 91343, USA
J Physiol 575:807-19. 2006..Stepwise regression analysis suggested that loss of REM sleep underlies the effects of SD on hippocampal BDNF, Synapsin I and CREB mRNA levels, whereas loss of NREM sleep underlies the effects on CAMKII mRNA... - Chronic recording of extracellular neuronal activity in behaving animalsRonald Szymusiak
University of California, Los Angeles, California, USA
Curr Protoc Neurosci . 2003..These methods can provide stable, long-term recording of neuronal activity during a variety of behavioral paradigms... - Adenosinergic regulation of sleep: multiple sites of action in the brainM D Noor Alam
Sleep 29:1384-5; discussion 1387-9. 2006
Research Grants
- Median Preoptic Nucleus and the Control of SleepRonald Szymusiak; Fiscal Year: 2007..Proposed work will attempt to characterize the functional neuroanatomy and the neurochemical modulation of forebrain and brainstem neural circuits that underlie normal and disordered homeostatic sleep regulation. ..
- Median Preoptic Nucleus and the Control of SleepRonald Szymusiak; Fiscal Year: 2006..Planned experiments will contribute to a more complete understanding of the role of hypothalamic mechanisms in normal and disordered sleep and arousal states. ..
- Median Preoptic Nucleus and the Control of SleepRonald Szymusiak; Fiscal Year: 2010..Proposed work will attempt to characterize the functional neuroanatomy and the neurochemical modulation of forebrain and brainstem neural circuits that underlie normal and disordered homeostatic sleep regulation. ..