Research Topics
Species | KAREN SZUMLINSKISummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive propertiesKevin D Lominac
Department of Psychology, University of California Santa Barbara, Santa Barbara, CA 93106-9660, USA
Drug Alcohol Depend 85:142-56. 2006....
Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in ratsAvi E Zayara
Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
Psychopharmacology (Berl) 213:321-35. 2011..The serotonin 5-HT(2A) and 5-HT(2C) receptors regulate the capacity of acute cocaine to augment behavior and monoamine levels within the nucleus accumbens (NAC), a brain region involved in cocaine's addictive and psychotogenic properties...- Homers regulate drug-induced neuroplasticity: implications for addictionKaren K Szumlinski
Behavioral and Neural Genetics Laboratory, Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
Biochem Pharmacol 75:112-33. 2008.... - Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J miceKaren K Szumlinski
Department of Psychology, Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
Neuropsychopharmacology 33:1365-78. 2008.... - Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamineKaren K Szumlinski
Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
Neuropsychopharmacology 32:1760-73. 2007..These data provide the first evidence that early exposure to an OTC compound produces protracted effects upon cocaine-induced changes in nucleus accumbens neurotransmission that may contribute to a 'pro-addictive' phenotype in adulthood... - Accumbens neurochemical adaptations produced by binge-like alcohol consumptionKaren K Szumlinski
Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
Psychopharmacology (Berl) 190:415-31. 2007..The Scheduled High Alcohol Consumption (SHAC) binge drinking model is a simple, partial murine model with which to investigate some of the neurobiological underpinnings of alcoholism... - Homer proteins: implications for neuropsychiatric disordersKaren K Szumlinski
Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA, 93106 9660, USA
Curr Opin Neurobiol 16:251-7. 2006.... - Homer isoforms differentially regulate cocaine-induced neuroplasticityKaren K Szumlinski
Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
Neuropsychopharmacology 31:768-77. 2006..Together, these data indicate that the enduring reduction of long Homer isoforms in the nucleus accumbens of cocaine-withdrawn rats is necessary for the expression of cocaine-induced neuroplasticity... - Homer2 is necessary for EtOH-induced neuroplasticityKaren K Szumlinski
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 25:7054-61. 2005..These data demonstrate a necessary and active role for accumbens Homer2 expression in regulating EtOH-induced behavioral and cellular neuroplasticity... - Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant miceKaren K Szumlinski
Department of Physiology and Neuroscience and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann N Y Acad Sci 1003:468-71. 2003 
Protracted 'anti-addictive' effects of adolescent phenylpropanolamine exposure in C57BL/6J miceJeffery H Penzner
Behavioral and Neural Genetics Laboratory, Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, USA
Addict Biol 13:310-25. 2008....- Dissociable roles for the dorsal and median raphé in the facilitatory effect of 5-HT1A receptor stimulation upon cocaine-induced locomotion and sensitizationKaren K Szumlinski
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Neuropsychopharmacology 29:1675-87. 2004..While the DRN is involved in the acute effects of cocaine, neuroadaptations in the MRN may regulate the long-term consequences of repeated cocaine exposure... - Homer proteins regulate sensitivity to cocaineKaren K Szumlinski
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Neuron 43:401-13. 2004..These data show that Homer deletion mimics the behavioral and neurochemical phenotype produced by repeated cocaine administration and implicate Homer in regulating addiction to cocaine... - Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholismDebra K Cozzoli
Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California 93106 9660, USA
J Neurosci 29:8655-68. 2009..Together, these data point to an important role for NAC mGluR5-Homer2-PI3K signaling in regulating binge-like alcohol consumption that has relevance for our understanding of the neurobiology of alcoholism and its pharmacotherapy... - Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated ratsPeter W Kalivas
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29465, USA
Neurotox Res 6:385-7. 2004.... - Structural and functional modifications in glutamateric synapses following prolonged ethanol exposureL Judson Chandler
Alcohol Research Center and Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 30:368-76. 2006..Alterations in the Nucleus Accumbens Following Chronic Alcohol Exposure, by Feng Zhou, Youssef Sari, and Richard Bell; and (4) An Active Role for Accumbens Homer2 Expression in Alcohol-Induced Neural Plasticity, by Karen Szumlinski. - Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex functionKevin D Lominac
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 25:11586-94. 2005.... - Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intakeZuzana Kapasova
Department of Psychology, University of California at Santa Barbara, Santa Barbara, California 93106 9660, USA
Alcohol Clin Exp Res 32:617-31. 2008..However, the relevance of alcohol-induced changes in NAC glutamate for alcohol drinking behavior is under-investigated... - Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortexOsnat Ben-Shahar
Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California 93106 9660, USA
Synapse 63:598-609. 2009..These data support the notion that altered NMDA function within the mPFC may contribute, in part, to the transition to excessive uncontrolled consumption of cocaine... - Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P ratsIlona Obara
Department of Psychology, University of California, Santa Barbara, CA, USA
Alcohol Clin Exp Res 33:1924-34. 2009.... - Prenatal stress enhances responsiveness to cocaineTod E Kippin
Department of Psychology, The Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 9660, USA
Neuropsychopharmacology 33:769-82. 2008..Thus, early environmental factors contribute to an individual's initial responsiveness to cocaine and propensity to relapse to cocaine-seeking... - Unconditioned and conditioned factors contribute to the 'reinstatement' of cocaine place conditioning following extinction in C57BL/6 miceKaren K Szumlinski
Department of Physiology and Neuroscience, Basic Science Building, Suite 403, Medical University of South Carolina, 173 Ashley Avenue, Charleston 29425, USA
Behav Brain Res 136:151-60. 2002..One or both of these processes sensitizes with the passage of time, increasing the propensity of B6 mice to approach non-preferred environments upon COC re-administration... - Impoverished rearing impairs working memory and metabotropic glutamate receptor 5 expressionMary L Gregory
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Neuroreport 19:239-43. 2008..Thus, impoverished rearing conditions produce protracted deficits in spatial working memory, in association with reduced prefrontal mGluR 5 function that may be relevant to the etiology of several neuropsychiatric disorders... - Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexoneLawrence D Middaugh
Center for Drug and Alcohol Programs, Alcohol Research Center, Department of Psychiatry and Behavioral Science, Medical University of South Carolina, Charleston 29425, USA
Alcohol Clin Exp Res 27:1892-900. 2003.... - Pretreatment with serotonin 5-HT(3) receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in ratsKaren K Szumlinski
Department of Physiology and Neuroscience, Basic Science Building, Suite 403, Medical University of South Carolina, 173 Ashely Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 165:329-36. 2003..Serotonin 5-HT(3) receptor antagonists are proposed to serve as potential anti-addictive and anti-psychotic therapies... - Contribution of early environmental stress to alcoholism vulnerabilityJoannalee C Campbell
Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
Alcohol 43:547-54. 2009..Accordingly, we are exploring the interactions between neurochemical changes produced by PNS and changes induced by consumption of alcohol in adulthood to model the biological bases of high vulnerability to alcohol abuse... - Prenatal stress alters limbo-corticostriatal Homer protein expressionAlexis W Ary
Department of Psychology, University of California, Santa Barbara, California 93106, USA
Synapse 61:938-41. 2007..These findings indicate that stress during development can produce enduring perturbations in Homer protein expression that likely contribute to glutamatergic and behavioral abnormalities observed following early environmental stress... - D2 receptor blockade in the dorsal raphe increases quinpirole-induced locomotor excitationKaren K Szumlinski
Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5
Neuroreport 13:563-6. 2002..These data suggest that D2 receptor activation in the DRN suppresses QNP-induced locomotor excitation, an effect that may be related to D2 receptor-mediated alterations in serotonin transmission...
Research Grants
- Homer proteins, glutamate and alcoholismKAREN SZUMLINSKI; Fiscal Year: 2007....
- mGluR-Homer interactions in excessive drinkingKAREN SZUMLINSKI; Fiscal Year: 2007....
- Homer-mediated signaling and cocaine addictionKaren Kathleen Szumlinski; Fiscal Year: 2010....
- Molecular regulation of CeA glutamate and binge drinkingKaren Kathleen Szumlinski; Fiscal Year: 2010....