KAREN SZUMLINSKI

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties
    Kevin D Lominac
    Department of Psychology, University of California Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Drug Alcohol Depend 85:142-56. 2006
  2. pmc Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats
    Avi E Zayara
    Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Psychopharmacology (Berl) 213:321-35. 2011
  3. pmc Homers regulate drug-induced neuroplasticity: implications for addiction
    Karen K Szumlinski
    Behavioral and Neural Genetics Laboratory, Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Biochem Pharmacol 75:112-33. 2008
  4. ncbi request reprint Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice
    Karen K Szumlinski
    Department of Psychology, Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Neuropsychopharmacology 33:1365-78. 2008
  5. ncbi request reprint Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamine
    Karen K Szumlinski
    Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Neuropsychopharmacology 32:1760-73. 2007
  6. ncbi request reprint Accumbens neurochemical adaptations produced by binge-like alcohol consumption
    Karen K Szumlinski
    Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Psychopharmacology (Berl) 190:415-31. 2007
  7. ncbi request reprint Homer proteins: implications for neuropsychiatric disorders
    Karen K Szumlinski
    Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA, 93106 9660, USA
    Curr Opin Neurobiol 16:251-7. 2006
  8. ncbi request reprint Homer isoforms differentially regulate cocaine-induced neuroplasticity
    Karen K Szumlinski
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Neuropsychopharmacology 31:768-77. 2006
  9. ncbi request reprint Homer2 is necessary for EtOH-induced neuroplasticity
    Karen K Szumlinski
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:7054-61. 2005
  10. ncbi request reprint Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice
    Karen K Szumlinski
    Department of Physiology and Neuroscience and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:468-71. 2003

Research Grants

  1. Homer proteins, glutamate and alcoholism
    KAREN SZUMLINSKI; Fiscal Year: 2007
  2. mGluR-Homer interactions in excessive drinking
    KAREN SZUMLINSKI; Fiscal Year: 2007
  3. Homer-mediated signaling and cocaine addiction
    KAREN SZUMLINSKI; Fiscal Year: 2009
  4. Homer-mediated signaling and cocaine addiction
    Karen Kathleen Szumlinski; Fiscal Year: 2010
  5. Molecular regulation of CeA glutamate and binge drinking
    Karen Kathleen Szumlinski; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties
    Kevin D Lominac
    Department of Psychology, University of California Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Drug Alcohol Depend 85:142-56. 2006
    ....
  2. pmc Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats
    Avi E Zayara
    Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Psychopharmacology (Berl) 213:321-35. 2011
    ..The serotonin 5-HT(2A) and 5-HT(2C) receptors regulate the capacity of acute cocaine to augment behavior and monoamine levels within the nucleus accumbens (NAC), a brain region involved in cocaine's addictive and psychotogenic properties...
  3. pmc Homers regulate drug-induced neuroplasticity: implications for addiction
    Karen K Szumlinski
    Behavioral and Neural Genetics Laboratory, Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Biochem Pharmacol 75:112-33. 2008
    ....
  4. ncbi request reprint Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice
    Karen K Szumlinski
    Department of Psychology, Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Neuropsychopharmacology 33:1365-78. 2008
    ....
  5. ncbi request reprint Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamine
    Karen K Szumlinski
    Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Neuropsychopharmacology 32:1760-73. 2007
    ..These data provide the first evidence that early exposure to an OTC compound produces protracted effects upon cocaine-induced changes in nucleus accumbens neurotransmission that may contribute to a 'pro-addictive' phenotype in adulthood...
  6. ncbi request reprint Accumbens neurochemical adaptations produced by binge-like alcohol consumption
    Karen K Szumlinski
    Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106 9660, USA
    Psychopharmacology (Berl) 190:415-31. 2007
    ..The Scheduled High Alcohol Consumption (SHAC) binge drinking model is a simple, partial murine model with which to investigate some of the neurobiological underpinnings of alcoholism...
  7. ncbi request reprint Homer proteins: implications for neuropsychiatric disorders
    Karen K Szumlinski
    Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA, 93106 9660, USA
    Curr Opin Neurobiol 16:251-7. 2006
    ....
  8. ncbi request reprint Homer isoforms differentially regulate cocaine-induced neuroplasticity
    Karen K Szumlinski
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Neuropsychopharmacology 31:768-77. 2006
    ..Together, these data indicate that the enduring reduction of long Homer isoforms in the nucleus accumbens of cocaine-withdrawn rats is necessary for the expression of cocaine-induced neuroplasticity...
  9. ncbi request reprint Homer2 is necessary for EtOH-induced neuroplasticity
    Karen K Szumlinski
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:7054-61. 2005
    ..These data demonstrate a necessary and active role for accumbens Homer2 expression in regulating EtOH-induced behavioral and cellular neuroplasticity...
  10. ncbi request reprint Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice
    Karen K Szumlinski
    Department of Physiology and Neuroscience and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:468-71. 2003
  11. ncbi request reprint Protracted 'anti-addictive' effects of adolescent phenylpropanolamine exposure in C57BL/6J mice
    Jeffery H Penzner
    Behavioral and Neural Genetics Laboratory, Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, USA
    Addict Biol 13:310-25. 2008
    ....
  12. ncbi request reprint Dissociable roles for the dorsal and median raphé in the facilitatory effect of 5-HT1A receptor stimulation upon cocaine-induced locomotion and sensitization
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:1675-87. 2004
    ..While the DRN is involved in the acute effects of cocaine, neuroadaptations in the MRN may regulate the long-term consequences of repeated cocaine exposure...
  13. ncbi request reprint Homer proteins regulate sensitivity to cocaine
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuron 43:401-13. 2004
    ..These data show that Homer deletion mimics the behavioral and neurochemical phenotype produced by repeated cocaine administration and implicate Homer in regulating addiction to cocaine...
  14. pmc Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism
    Debra K Cozzoli
    Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California 93106 9660, USA
    J Neurosci 29:8655-68. 2009
    ..Together, these data point to an important role for NAC mGluR5-Homer2-PI3K signaling in regulating binge-like alcohol consumption that has relevance for our understanding of the neurobiology of alcoholism and its pharmacotherapy...
  15. ncbi request reprint Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29465, USA
    Neurotox Res 6:385-7. 2004
    ....
  16. pmc Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure
    L Judson Chandler
    Alcohol Research Center and Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:368-76. 2006
    ..Alterations in the Nucleus Accumbens Following Chronic Alcohol Exposure, by Feng Zhou, Youssef Sari, and Richard Bell; and (4) An Active Role for Accumbens Homer2 Expression in Alcohol-Induced Neural Plasticity, by Karen Szumlinski.
  17. ncbi request reprint Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function
    Kevin D Lominac
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:11586-94. 2005
    ....
  18. doi request reprint Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intake
    Zuzana Kapasova
    Department of Psychology, University of California at Santa Barbara, Santa Barbara, California 93106 9660, USA
    Alcohol Clin Exp Res 32:617-31. 2008
    ..However, the relevance of alcohol-induced changes in NAC glutamate for alcohol drinking behavior is under-investigated...
  19. pmc Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex
    Osnat Ben-Shahar
    Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California 93106 9660, USA
    Synapse 63:598-609. 2009
    ..These data support the notion that altered NMDA function within the mPFC may contribute, in part, to the transition to excessive uncontrolled consumption of cocaine...
  20. pmc Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats
    Ilona Obara
    Department of Psychology, University of California, Santa Barbara, CA, USA
    Alcohol Clin Exp Res 33:1924-34. 2009
    ....
  21. pmc Prenatal stress enhances responsiveness to cocaine
    Tod E Kippin
    Department of Psychology, The Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 9660, USA
    Neuropsychopharmacology 33:769-82. 2008
    ..Thus, early environmental factors contribute to an individual's initial responsiveness to cocaine and propensity to relapse to cocaine-seeking...
  22. ncbi request reprint Unconditioned and conditioned factors contribute to the 'reinstatement' of cocaine place conditioning following extinction in C57BL/6 mice
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Basic Science Building, Suite 403, Medical University of South Carolina, 173 Ashley Avenue, Charleston 29425, USA
    Behav Brain Res 136:151-60. 2002
    ..One or both of these processes sensitizes with the passage of time, increasing the propensity of B6 mice to approach non-preferred environments upon COC re-administration...
  23. doi request reprint Impoverished rearing impairs working memory and metabotropic glutamate receptor 5 expression
    Mary L Gregory
    Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Neuroreport 19:239-43. 2008
    ..Thus, impoverished rearing conditions produce protracted deficits in spatial working memory, in association with reduced prefrontal mGluR 5 function that may be relevant to the etiology of several neuropsychiatric disorders...
  24. ncbi request reprint Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone
    Lawrence D Middaugh
    Center for Drug and Alcohol Programs, Alcohol Research Center, Department of Psychiatry and Behavioral Science, Medical University of South Carolina, Charleston 29425, USA
    Alcohol Clin Exp Res 27:1892-900. 2003
    ....
  25. ncbi request reprint Pretreatment with serotonin 5-HT(3) receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Basic Science Building, Suite 403, Medical University of South Carolina, 173 Ashely Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 165:329-36. 2003
    ..Serotonin 5-HT(3) receptor antagonists are proposed to serve as potential anti-addictive and anti-psychotic therapies...
  26. pmc Contribution of early environmental stress to alcoholism vulnerability
    Joannalee C Campbell
    Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
    Alcohol 43:547-54. 2009
    ..Accordingly, we are exploring the interactions between neurochemical changes produced by PNS and changes induced by consumption of alcohol in adulthood to model the biological bases of high vulnerability to alcohol abuse...
  27. ncbi request reprint Prenatal stress alters limbo-corticostriatal Homer protein expression
    Alexis W Ary
    Department of Psychology, University of California, Santa Barbara, California 93106, USA
    Synapse 61:938-41. 2007
    ..These findings indicate that stress during development can produce enduring perturbations in Homer protein expression that likely contribute to glutamatergic and behavioral abnormalities observed following early environmental stress...
  28. ncbi request reprint D2 receptor blockade in the dorsal raphe increases quinpirole-induced locomotor excitation
    Karen K Szumlinski
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5
    Neuroreport 13:563-6. 2002
    ..These data suggest that D2 receptor activation in the DRN suppresses QNP-induced locomotor excitation, an effect that may be related to D2 receptor-mediated alterations in serotonin transmission...

Research Grants7

  1. Homer proteins, glutamate and alcoholism
    KAREN SZUMLINSKI; Fiscal Year: 2007
    ....
  2. mGluR-Homer interactions in excessive drinking
    KAREN SZUMLINSKI; Fiscal Year: 2007
    ....
  3. Homer-mediated signaling and cocaine addiction
    KAREN SZUMLINSKI; Fiscal Year: 2009
    ....
  4. Homer-mediated signaling and cocaine addiction
    Karen Kathleen Szumlinski; Fiscal Year: 2010
    ....
  5. Molecular regulation of CeA glutamate and binge drinking
    Karen Kathleen Szumlinski; Fiscal Year: 2010
    ....